Cordyceps militaris alleviates non-alcoholic fatty liver disease in ob/ob mice

Ha-Neul Choi,Yang-Hee Jang,Min-Joo Kim,Min Jeong Seo,Byoung Won Kang,Yong Kee Jeong3,,Jung-In Kim 대한지역사회영양학회 2014 Nutrition Research and Practice Vol.8 No.2

BACKGROUND/OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is becoming an important public health problem as metabolic syndrome and type 2 diabetes have become epidemic. In this study we investigated the protective effect of Cordyceps militaris (C. militaris) against NAFLD in an obese mouse model. MATERIALS/METHODS: Four-week-old male ob/ob mice were fed an AIN-93G diet or a diet containing 1% C. militaris water extract for 10 weeks after 1 week of adaptation. Serum glucose, insulin, free fatty acid (FFA), alanine transaminase (ALT), and proinflammatory cytokines were measured. Hepatic levels of lipids, glutathione (GSH), and lipid peroxide were determined. RESULTS: Consumption of C. militaris significantly decreased serum glucose, as well as homeostasis model assessment for insulin resistance (HOMA-IR), in ob/ob mice. In addition to lowering serum FFA levels, C. militaris also significantly decreased hepatic total lipids and triglyceride contents. Serum ALT activities and tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels were reduced by C. militaris. Consumption of C. militaris increased hepatic GSH and reduced lipid peroxide levels. CONCLUSIONS: These results indicate that C. militaris can exert protective effects against development of NAFLD, partly by reducing inflammatory cytokines and improving hepatic antioxidant status in ob/ob mice.

Minimal invasive surgery (LESS) for huge cystic adnexal tumors in whole abdomen

( In Young Choi ),( Ji Hye Lee ),( Mi Hyun Park ),( Ji Kwoun Park ),( Jeong Kyu Shin1 ),( Won Jun Choi1 ),( Soon Ae Lee ),( Jong Hak Lee ),( Won Young Paik ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

Laparoendoscopic single-site surgery (LESS) is helpful if not an evidence of suspicious malignancy in huge adnexa tumors. This approach might be reasonable alternative to conventional laparoscopic surgery. We report two cases with LESS for huge cystic adnexal tumors in whole abdomen. A 58 years old multigravida woman in menopause underwent removal of a huge cystic adnexal mass that occupied her entire abdomen by LESS.(ca.5200ml aspiration) A 15 years old single nulligravida woman had a huge cystic adnexal tumor in whole abdomen reaching to the level of the xyphoid process. A needle through the transumbilical single port was inserted directly under the mass. Subsequently, 8000 ml of cystic fluid was aspirated without spillage.

스마트 미디어 환경의 시각 인터페이스 디자인에 관한 연구

최진원(Jin Won Choi),박정기(Jeong Kee Park) 한국디자인문화학회 2013 한국디자인문화학회지 Vol.19 No.3

최근 웹뿐만 아니라 모바일 전반을 아우르며 디지털 디바이스의 사용자 환경(UI :User Interface) 디자인 패러다임이 새롭게 변화하고 있다. 이러한 변화 가운데 디바이스가 다양해지고 콘텐츠들이 많아지면서 사용자들은 타 기기에서도 웹 서비스를 일관성 있게 제공받기를 원하게 되었다. 이에 본 연구에서는 스마트 미디어 환경에 대해 이해하고, 웹사이트 UI디자인 동향을 수집하여 특징을 알아보고, 그에 따라 분류된 레이아웃, 스크롤, 해상도, 그래픽요소, 기술 요소를 기준으로 브랜드, 프로모션, 쇼핑몰, 3가지 유형의 사례 분석을 진행하였다. 그 결과 레이아웃은 콘텐츠가 단순하고 비주얼이 강화된 일반 그리드, 브로슈어 레이아웃과 스마트기기에 적합한 블록 레이아웃의 형태가 나타났다. 스크롤은 전반적으로 태블릿, 폰에 좀 더 적합한 싱글 페이지 구조의 세로 스크롤 사이트가 늘어나고 있음을 알수 있었다. 해상도 반응의 경우 다양한 해상도에 대응하는 반응형 웹사이트가 늘어나고 있고, 그래픽 요소의 경우 직관적이고 신뢰할 수 있는 사진 이미지의 사용이 많았다. 기술적 요소는 스마트 기기에 적합한 html5, jQuery의 적용이 많았고, 세로 스크롤 방식을 통해 마우스 휠이 아닌 넘김 방식으로 스토리에 맞는 모션이 혼합되어 차별화된 경험을 제공했다. 이러한 결과로 도출된 동향을 통해 추후 웹사이트 제작 시기초자료로 활용할 수 있으리라 기대한다. Recently, with the web as well as mobile digital devices, the user experience (UI: User Interface) is a new design paradigm is changing. Among these changes, the device As more users are diverse and content to other devices, in addition to the PC consistently provide Web services were to be won. In this research, a smart media environment for the understanding and design trends by collecting website UI features to learn, and accordingly classified layout, scroll, resolution, design elements, technical elements, based on brand, promotion, shopping malls, three type of case analysis was conducted. As a result, the content, the layout is simple and regular grid with enhanced visuals, brochure layout and is suitable for smart devices in the form of a block layout appeared. Scroll structure as a whole tablet, phones, a more suitable structure of a single-page vertical scroll was found that increasing the site. Resolution corresponding to different resolutions reaction responsive Web sites is growing, graphic elements, the intuitive and reliable use of photographic images respectively. Technology components suitable for the smart devices html5, jQuery application of the common vertical scrolling mouse wheel over the story in a way that meets a non-feed is a mixture of motion were differentiated experience. As a result, the derived trends as a basis for making future web site can use to expect that.

난지형 조숙종 마늘 신품종 ‘올캐’ 특성

최학순(Hak Soon Choi1),채원병(Won-Byoung Chae),곽용범(Yong-Bum Kwack),정명일(Myeong-Il Jeong) 한국원예학회HST 2008 원예과학기술지 Vol.26 No.별호2

원예연구소 남해출장소에서는 원예적 특성이 우수한 유전자원을 도입 선발하여 ‘올캐’로 명명하였다. 특성평가를 2000년부터 3년간 실시하였으며 2003년부터 3년간 지역적응시험을 실시한 결과 그 특성이 우수하여 품종등록 하였다. 도입 육성한 ‘올캐’ 마늘은 난지형 조숙종 마늘로 생태형으로는 난지형이며 추대형은 완전 추대종이다. 인경의 모양은 아래가 평편한 구형이며 구색과 인편색은 약간 자색이 돈다. 인편의 배열은 동심형(concentric)으로 ‘남도’ 마늘과 같다. 초형은 직립이며 초장, 엽초경 및 잎의 수는 대비종인 ‘남도’ 마늘에 비해서 약간 작거나 적으며 잎의 색깔은 ‘남도’ 마늘에 비해서 약간 연한 녹색이다. 평균구중은 42.2g으로 ‘남도’ 마늘 40.5g 보다 약간 무거우며 인경의 모양은 대비종인 ‘남도’ 마늘과 비슷하다. ‘올캐’ 마늘의 추대기는 3월 하순으로 ‘남도’ 마늘보다 15~20일 정도 빠르며 수확기도 일주일 이상 빠르다. Namhae Sub-station of National Horticultural Research Institute has collected 240 different garlic germplasms since 1999 and has used germplasms of superior quality. Among them, ‘Namhae 57328’ is a precocious variety with superior characteristics of growth and bulb, and was named ‘Allkae’ garlic (Allium sativum) in 2006. The garlic was registered after 3 consecutive years’ assessment of the variety trait starting from 2000 and a 3 consecutive years’ adaptability test from 2003. The ecotype of ‘Allkae’ garlic is southern one and bolting one is complete bolting type. The bottom of a bulb is flat and the colors of a bulb and a clove are light purple, and the arrangement of cloves is concentric as in ‘Namdo’ garlic. The plant type is erect one and its height is slightly smaller than ‘Namdo’ garlic’ one but it’s bolting in mid March which is about 20 days ahead of ‘Namdo’ garlic. Average bulb weight is 42.2 g which is slightly heavier than ‘Namdo’ garlic (40.5 g). The shape of the bulb is similar with ‘Namdo’ garlic.

실물옵션에 기반한 한 · 미국방예산 분담금 적정성 검정

정원열(Weon Yeol Jeong),채원영(Won Young Chae),최문섭(Moon Sub Choi) 대한산업공학회 2015 대한산업공학회지 Vol.41 No.3

Due to the latest agreement between the military authorities of the Republic of Korea (ROK) and the United States (US) of America, Korea’s annual contribution to the budget of the United States Forces Korea (USFK) rose as high as close to 1 trillion won. This seemingly prohibitive amount has led to the questioning of military critics regarding determination criteria, wholesomeness of cost, alignment of incentives, and implementational transparency, etc. As these sources of mistrust can potentially undermine the congruence of alliance, we attempt to devise a scientific means to test the validity of Korea’s budget contribution. Specifically, we use the real options approach (ROA) to estimating the interval of the fair prices of maintaining the USFK. We consider the USFK as an insurance against foreign incursions, and this enables us to assume their role as a put option. Upon a hypothetical war breakout, the daily cumulative size of the Korean economy is estimated by implementing the simulated loss ratios of assets and population. As a result, the strategic value (put premium) of the USFK is exponentially higher the sooner the US forces are augmented following an intrusion. Also, Korea’s payments toward the USFK in 2011 and 2012 appear theoretically fairly valued.

난지형 조숙종 마늘 신품종 ‘올캐’ 특성

최학순(Hak Soon Choi1),채원병(Won-Byoung Chae),곽용범(Yong-Bum Kwack),정명일(Myeong-Il Jeong) 한국원예학회 2008 한국원예학회 학술발표요지 Vol.2008 No.12

원예연구소 남해출장소에서는 원예적 특성이 우수한 유전자원을 도입 선발하여 ‘올캐’로 명명하였다. 특성평가를 2000년부터 3년간 실시하였으며 2003년부터 3년간 지역적응시험을 실시한 결과 그 특성이 우수하여 품종등록 하였다. 도입 육성한 ‘올캐’ 마늘은 난지형 조숙종 마늘로 생태형으로는 난지형이며 추대형은 완전 추대종이다. 인경의 모양은 아래가 평편한 구형이며 구색과 인편색은 약간 자색이 돈다. 인편의 배열은 동심형(concentric)으로 ‘남도’ 마늘과 같다. 초형은 직립이며 초장, 엽초경 및 잎의 수는 대비종인 ‘남도’ 마늘에 비해서 약간 작거나 적으며 잎의 색깔은 ‘남도’ 마늘에 비해서 약간 연한 녹색이다. 평균구중은 42.2g으로 ‘남도’ 마늘 40.5g 보다 약간 무거우며 인경의 모양은 대비종인 ‘남도’ 마늘과 비슷하다. ‘올캐’ 마늘의 추대기는 3월 하순으로 ‘남도’ 마늘보다 15~20일 정도 빠르며 수확기도 일주일 이상 빠르다. Namhae Sub-station of National Horticultural Research Institute has collected 240 different garlic germplasms since 1999 and has used germplasms of superior quality. Among them, ‘Namhae 57328’ is a precocious variety with superior characteristics of growth and bulb, and was named ‘Allkae’ garlic (Allium sativum) in 2006. The garlic was registered after 3 consecutive years’ assessment of the variety trait starting from 2000 and a 3 consecutive years’ adaptability test from 2003. The ecotype of ‘Allkae’ garlic is southern one and bolting one is complete bolting type. The bottom of a bulb is flat and the colors of a bulb and a clove are light purple, and the arrangement of cloves is concentric as in ‘Namdo’ garlic. The plant type is erect one and its height is slightly smaller than ‘Namdo’ garlic’ one but it’s bolting in mid March which is about 20 days ahead of ‘Namdo’ garlic. Average bulb weight is 42.2 g which is slightly heavier than ‘Namdo’ garlic (40.5 g). The shape of the bulb is similar with ‘Namdo’ garlic.

Long-term outcomes of single-port laparoscopic myomectomy using a modified suture technique

( Mina Kang ),( Jihye Kim ),( Tae-joong Kim ),( Jeong-won Lee ),( Byoung-gie Kim ),( Duk-soo Bae ),( Chel Hun Choi ) 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.2

Objective To evaluate the long-term outcomes, including the pregnancy outcome and recurrence rate after single-port laparoscopic myomectomy (LM) using a modified suture technique with a Hem-o-lok clip (Choi’s LM) and conventional 4-port LM. Methods A retrospective study of patients who underwent Choi’s LM (n=55) and 4-port LM (n=102) in a single institutional hospital was conducted. Patients with <3 symptomatic myomas sized <10 cm each and operated on by a single surgeon were included. Recurrence was confirmed when a myoma measuring ≥3 cm was detected. Results The patients in both groups had similar demographic characteristics. Single (76.4% vs. 62.7%) and intramural (52.7% vs. 56.9%) tumors were commonly detected in both groups in the mean diameter (6.8±1.5 cm vs. 7.0±1.6 cm; P=0.40). In Choi’s LM, 16 patients (29.1%) needed an additional port; those who were nulliparous and/or had a large leiomyoma more frequently required an additional port (P=0.023 and 0.04, respectively). During a median follow-up period of 69 months, 17 patients (7.1% vs. 14.6%) had recurrence. The size of dominant myomas at recurrence was significantly smaller in patients who underwent Choi’s LM (3.4±0.7 cm vs. 5.7±2.4 cm; P=0.004). All 13 patients in both groups who successfully conceived had a full-term delivery. No major complications occurred during pregnancy. Conclusion Although an additional port was frequently used, the long-term outcomes of patients who experienced recurrence and pregnancy after Choi’s LM were acceptable. Considering its usability, Choi’s LM is feasible for the treatment of uterine leiomyoma.

Transport property improvements of amorphous In-Zn-O transistors with printed Cu contacts via rapid temperature annealing

Won, J.Y.,Han, Y.H.,Seol, H.J.,Lee, K.J.,Choi, R.,Jeong, J.K. Elsevier Sequoia 2016 THIN SOLID FILMS - Vol.603 No.-

The device performance of amorphous In-Zn-O (a-IZO) thin-film transistors (TFTs) with printed Cu contacts was significantly improved by the insertion of a diffusion barrier Ta layer and rapid thermal process (RTP) annealing. Furnace-annealed a-IZO TFTs with Cu/Ta contacts exhibited mobility values of 21.3cm<SUP>2</SUP>/Vs, subthreshold gate swing (SS) values of 1.9 V/decade, and I<SUB>ON/OFF</SUB> of ~10<SUP>6</SUP>. In contrast, the SS, mobility, and I<SUB>ON/OFF</SUB> ratio of RTP-annealed a-IZO TFTs with Cu/Ta contacts were 30.6cm<SUP>2</SUP>/Vs, 0.68V/decade, and 3x10<SUP>7</SUP>, respectively. We attributed the performance improvement of devices with Cu/Ta contacts to the suppression of Cu in-diffusion within the a-IZO channel due to the rapid heating associated with RTP annealing.

Puerariae Radix induces Angiogenesis in vitro and in vivo

Choi Do-Young,Kang Jung-Won,Cho Eun-Mi,Lee Jae-Dong,Hyh Jeong-Eun,Yang Ha-Ru,Baek Yong-Hyeon,Kim Deog-Yoon,Cho Yoon-Je,Kim Kang-il,Park Dong-Suk 대한침구의학회 2005 대한침구의학회지 Vol.22 No.2

Background & Objective : Angiogenesis consists of the proliferation, migration, and differentiation of endothelial cells, and angiogenic factors and matrix protein interactions modulate this process. The aim of this study was to determine whether Puerariae radix could induce angiogenic activity in human umbilical vein endothelial cells (HUVECs).Methods : The angiogenic activity of Puerariae radix were evaluated by using BrdU assay, chemotactic migration assay, tube formation assay, measurement of bFGF in HUVECs, and Matrigel plug assay in mice.Results : Puerariae radix significantly increased HUVECs proliferation in a dose-dependent manner. In addition, Puerariae radix increased migration and tube-like formation in HUVECs. Interestingly,the expression of basic fibroblast growth factor (bFGF), an angiogenesis-stimulating growth factor, was dose-dependently increased by Puerariae radix. The angiogenic activity of Puerariae radix was confirmed using an in vivo Matrigel angiogenesis model, showing promotion of blood vessel formation. Conclusion : Puerariae radix significantly induces angiogenesis in vitro and in vivo. These results suggest that Puerariae radix is a potent angiogenic agent, and a promising drug, for the induction of neovascularization.

A Randomized Controlled Study of Preemptive Lamivudine in Patients Receiving Transarterial Chemo-Lipiodolization

( Jeong Won Jang ),( Jong Young Choi ),( Si Hyun Bae ),( Seung Kew Yoon ),( U Im Chang ),( Chang Wook Kim ),( Se Hyun Cho ),( Jun Yeol Han ),( Young Sok Lee ) 대한간학회 2006 Clinical and Molecular Hepatology(대한간학회지) Vol.12 No.3(S)