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최재경,임예슬,김희진,홍영호,류범용,김근배 한국축산식품학회 2012 한국축산식품학회지 Vol.32 No.5
As an appraisal for the application of a new starter culture, more than 200 lactic acid bacteria strains were isolated from raw milk and healthy human feces. The strains showing excellent growth and acid production ability in 10% skim milk media were selected and identified as Lactobacillus casei based on the results of their API carbohydrate fermentation patterns,as well as 16S rDNA sequence analysis. To assess the effect of L. casei strains on irritable bowel disease (IBD), the inhibitory effect of the selected strains against the nitric oxide (NO) production of lipopolysaccharide (LPS)-stimulated RAW 264.7 cells was measured. Among the tested L. casei strains, L. casei MCL was observed to have the greatest NO inhibitory activity. Additionally, L. casei MCL was found to inhibit mRNA expression of pro-inflammatory cytokines (interleukin-1β, IL-6, TNF-α), as well as cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) involved in pathophysiologic processes such as inflammation. The mRNA expression of anti-inflammatory cytokines, including IL-10 and transforming growth factor-β (TGF-β) of L. casei MCL, was confirmed using quantitative real-time PCR. In conclusion,L. casei MCL showed decreases in the expression of pro-inflammatory cytokines and up-regulated expression of the anti-inflammatory cytokine.
데이터 기반 테크마이닝(tech-mining)을 통한 융합 R&D 영역 탐색: ICT 기반 산사태 예방 기술 사례를 중심으로
최재경,서성호,강종석,정현상 한국산업융합학회 2019 한국산업융합학회 논문집 Vol.22 No.5
Due to the high complexity and diversity of the problems of the future society, it is getting harder to solve with the traditional single technology. In recent years, there has been a growing interest in convergence technology, which combines or connects different types of technologies to create new technologies and industries. In this study, we explored the convergence R&D area of ICT technology related to landslide prevention/response. It is true that the world has been exposed to various disasters due to recent climate change. As a result, there is a tendency to use Big Data and ICT for disaster preparedness and recovery. Especially, in the case of landslides, it is a natural disaster that requires research not only to study actual landslides but also to predict potential landslides. Therefore, in this study, we analyzed what kind of convergence R&D is being carried out in the field of ICT for preventing and responding to landslide. Therefore, in this study, Web of Science article data were analyzed by using the scientometric analysis and 51 landslide-related ICT convergence R&D areas were derived.
최재경 대한임상건강증진학회 2008 Korean Journal of Health Promotion Vol.8 No.3
Background The significance of metabolic syndrome has been raised as a risk factor in chronic kidney disease. We examined the association between metabolic syndrome and its components and chronic kidney disease in adults. Methods A total of 5453 subjects who participated in the Korean National Health and Nutrition Examination survey 2001 were included. Metabolic syndrome was defined as the presence of 3 or more of the following components: abdominal obesity, elevated blood pressure, elevated glucose level, high triglyceride level, and low high-density lipoprotein cholesterol level according to the criteria of the American Heart Association/National Heart, Lung, and Blood Institute(AHA/NHLBI). Chronic kidney disease was defined as dipstick-positive proteinuria(≥1+) or a estimated glomerular filtration rate less than 60mL per 1.73m2. Results Compared with the odds ratios of the each components of metabolic syndrome, the crude odds ratio of the chronic kidney disease in subjects with the elevated blood pressure compared with subjects without the elevated blood pressure was 3.31(95% CI, 2.68 to 4.09) and the multivariate-adjusted odds ratio in subjects with the high triglyceride level compared with subjects without the high triglyceride level was 1.64(95% CI, 1.28 to 2.09). In subjects with metabolic syndrome compared with subjects without metabolic syndrome, the crude and multivariate-adjusted odds ratios of chronic kidney disease were 3.21(95% CI, 2.60 to 3.96) and 1.65(95% CI, 1.29-2.12) (p<0.001). Conclusions Metabolic syndrome might be an important risk factor of chronic kidney disease, independently of age, sex, education level, monthly income, current smoking, at-risk drinking, and regular exercise. 연구배경 만성 신질환의 위험 인자로서 대사증후군에 대한 중요성이 증가하고 있다. 이에 일반 성인에서 대사증후군 및 대사증후군 각 인자들과 만성 신질환과의 관계를 살펴보고자 하였다. 방 법 2001년 국민건강영양조사에 참여한 사람 중 5453명을 대상으로 하였다. 대사증후군은 복부비만, 높은 혈압, 높은 혈당, 고중 성지방혈증, 저고밀도콜레스테롤혈증의 5개 항목 중 3개 이상의 항목을 가질 때로 정의하였으며 American Heart Association/National Heart, Lung, and Blood Institute(AHA/NHLBI)에서 제안한 기준을 사용하였다. 만성 신질환은 요검사상 요단백이 1+이상 측정되거나 계산된 사구체 여과율이 60mL/min per 1.73m2 미만인 경우로 정의하였다. 결 과 대사증후군의 각 인자 별 교차비를 비교해 보았을 때 단변량 분석에서는 높은 혈압에서 만성 신질환의 교차비가 3.31(95% 신뢰구간, 2.68-4.09)로 가장 높았지만, 다변량 분석에서는 고중성지방혈증이 1.64(95% 신뢰구간, 1.28-2.09)로 가장 높았다. 대 사증후군을 갖고 있는 대상자들은 그렇지 않은 대상자들에 비해 단변량 분석에서는 만성 신질환의 교차비가 3.21(95% 신뢰 구간, 2.60-3.96), 다변량 분석에서는 1.65(95% 신뢰구간, 1.29-2.12)이였다(p<0.001). 결 론 대사증후군은 나이, 성별, 교육수준, 월평균소득, 흡연, 음주, 운동 등과 독립적으로 만성 신질환의 중요한 위험인자로 생각 된다.
최재경,양성주,김승훈 한국구조물진단유지관리공학회 2024 한국구조물진단유지관리공학회 논문집 Vol.28 No.6
본 연구에서는 콘크리트 압축강도 변화에 따른 소형 ㄱ형강에 대한 부착강도를 평가하는 것을 목적으로 푸쉬아웃실험 실시하였다. 실험변수는 ㄱ형강의 종류, 피복두께, 부착길이, 콘크리트 압축강도 등으로 계획하였다. 실험 결과로부터 최종 파괴형상은 미끄러짐 파괴, 국부 쪼갬 균열 후 미끄러짐 파괴, 쪼갬 파괴 등 세 가지 형태로 나타났다. 부착면적이 증가할수록 F1 계열 및 F2 계열 실험체의 최대 하중을 증가했으나 실험 부착응력은 다소 감소하는 경향이 나타났다. 또한 피복두께 1.25∼1.5배 증가함에 따라 평균 부착응력이 약 9.4∼21.0% 증가하였다. F1 계열 실험체(fck: 31.4 MPa)의 평균 부착응력은 1.14 MPa, 표준편차 0.25 MPa이며, F2 계열 실험체(fck: 47.7 MPa)의 평균 부착응력은1.33 MPa, 표준편차 0.29 MPa로 평가되었다. 콘크리트 압축강도 약 51.9% 증가할 때, 평균 부착응력이 약 16.7% 증가하였다. 본 연구에서는 피복두께, 콘크리트 압축강도, 부착길이 등을 변수로 한 제한된 실험 결과를 바탕으로 콘크리트 압축강도 제곱근과 부착응력 계수(0.1)의 곱으로구성된 부착강도식을 제안하였다. This study aimed to evaluate the bond strength of small L-shaped steel angles under varying concrete compressive strengths by conducting push-out tests. Specimen’s variables such as the type of angle, cover thickness, bond length, and concrete compressive strength were considered. The experimental results revealed three failure patterns: splitting failure, splitting crack and slip failure, and slip failure. As the bond area increased, the maximum load of specimens increased, but the experimental bond stress showed a slight decreasing trend. Additionally, when the cover thickness increased by 1.25 to 1.5 times, the average bond stress increased by approximately 9.4–21.0%. The average bond stress of the F1 series specimens (fck=31.4 MPa) was 1.14 MPa, with a standard deviation of 0.25 MPa, while that of the F2 series specimens (fck=47.7 MPa) was 1.33 MPa, with a standard deviation of 0.29 MPa. When the concrete compressive strength increased by approximately 51.9%, the average bond stress increased by about 16.7%. Based on the limited experimental results considering variables such as cover thickness, concrete compressive strength, and bond length, this study proposed a bond strength proposed equation consisting of the square root of the concrete compressive strength and a bond stress coefficient(0.1).