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정성철,박은숙,Eun Nam Choi,Chi Hwa Kim,Su Jin Kim,Dong-Kyu Jin 한국분자세포생물학회 2010 Molecules and cells Vol.30 No.1
Mucopolysaccharidosis type II (MPS II; Hunter syndrome) is an X-linked inherited disorder caused by a deficiency of the enzyme iduronate-2-sulfatase (IDS), which results in the lysosomal accumulation of glycosaminoglycans (GAG) such as dermatan and heparan sulfate. Here, we report the generation of IDS knockout mice, a model of human MPS II, and an analysis of the resulting phenotype. We also evalu-ated the effect of gene therapy with a pseudotyped, re-combinant adeno-associated virus 2/8 vector encoding the human IDS gene (rAAV-hIDS) in IDS-deficient mice. IDS activity and GAG levels were measured in serum and tis-sues after therapy. Gene therapy completely restored IDS activity in plasma and tissue of the knockout mice. The rescued enzymatic activity completely cleared the accu-mulated GAGs in all the tissues analyzed. This model can be used to explore the therapeutic potential of IDS re-placement and other strategies for the treatment of MPS II. Additionally, AAV2/8 vectors have promising future clinical applications for the treatment of patients with MPS II.
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CVM을 이용한 부동산 중개서비스의 지불가능용의액 추정에 관한 연구 : 중개서비스 만족도와 프롭테크 수용도를 중심으로
정성철,신우진 한국부동산연구원 2022 부동산연구 Vol.32 No.4
Consumers, real estate agents, and real estate platforms are in conflict as the burden of brokerage fees increases due to the increase in housing costs and the expansion of proptech services. This study focuses on resolving conflicts among parties of real estate transactions, and especially analyzes how consumers evaluate the value of brokerage fees incurred when using brokerage services and direct brokerage services, a core field of prop-tech. The research method employed the virtual valuation method, which is commonly used to measure the value of non-market goods such as difficult-to-measure goods and services. As an empirical measurement technique, the double bounded dichotomous choice question model was utilized in this case. A survey was used to collect analysis data and divided into five types to increase the validity of the research results. In addition, the secured sample was able to estimate the willingness to pay for real estate brokerage services using the logit model, a quantitative analysis model to measure the value and acceptability of such services. The analysis results revealed that the estimated willingness to pay for brokerage fees was 2,581,370 won for sales and 970,185 won for lease transactions. 주택가격 상승에 따른 중개보수 부담 증가와 프롭테크 서비스가 확대되면서 소비자·중개사·부동산플랫폼 사이 갈등양상을 보이고 있다. 이에, 본 연구는 부동산 거래 당사자 간의 갈등해결에 주안점을 두었고, 특히 중개서비스 이용 시 발생한 중개수수료와 프롭테크 핵심 분야인 직접중개서비스에 대한 가치를 소비자들이 어떻게 인식하는지에 대해 분석하였다. 연구방법은 측정하기 어려운 재화나 서비스 같은 비시장재화의 가치측정에 많이 쓰이고 있는 가상가치평가법(CVM)을 이용하였다. 이때 실증적 측정방법으로 이중양분선택형모형(DBDC)을 이용하였다. 분석 자료는 설문조사를 통해 수집하였으며, 연구결과의 신뢰성을 높이고자 설문유형은 다섯 가지로 구분하여 진행하였다. 또한 확보된 표본은 계량분석모형인 로짓모형을 이용하여 지불가능용의액(WTP)을 추정하여, 부동산중개서비스의 가치와 수용도를 측정할 수 있었다. 분석결과 추정된 WTP 즉, 중개수수료에 대한 지불가능용의액은 매매의 경우 2,581,370원이고, 임대차 거래의 경우 970,185원의 결과를 도출하였으며, 이를 통해 기본 가설로 세운 중개서비스 만족도와 프롭테크 수용도에 영향을 받는 것을 알 수 있었다. 또한 현행 중개보수요율과 비교하여 정책 변경 효용성에 대해 평가하였다. 그리고 선행연구의 결괏값과 비교하여, 연구모형의 특징 및 시사점을 확인하였다.
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주의력결핍 과잉행동장애 치료제 개발을 위한 카테콜아민계 표적화
정성철,조창환,김혜지,고은아,하민우,권오빈 제주대학교 의과학연구소 2021 The Journal of Medicine and Life Science Vol.18 No.3
The prevalence of attention deficit hyperactivity disorder (ADHD), a developmental neuropsychiatric disorder, is high among children and adolescents. The pathogenesis of ADHD is mediated with genetic, biological, and environmental factors. Most therapeutic drugs for ADHD have so far targeted biological causes, primarily by regulating catecholaminergic neurotransmitters. However, ADHD drugs that are clinically treated have various problems in their addictiveness and drug stability; thus, it is recommended that efficacy and safety should be secured through simultaneous prescription of multiple drugs rather than a single drug treatment. Accordingly, it is necessary to develop drugs that newly target pathogenic mechanisms of ADHD. In this study, we attempt to confirm the possibility of developing new drugs by reviewing dopaminerelated developmental mechanisms of neurons and their correlation with ADHD. Histone deacetylase inhibitors (HDACi) can regulate the concentration of intracellular dopamine in neurons by expressing vesicular monoamine transporter 2 and inducing the exocytosis of neurotransmitters to the synaptic cleft, thereby promoting the development of neurons and signal transmission. This cellular modulation of HDACi is expected to treat ADHD by regulating endogenous catecholamines such as dopamine. Although studies are still in the preclinical stage, HDAC inhibitors clearly have potential as a therapeutic agent with low addictiveness and high efficacy for ADHD treatment.
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