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Tyrosinase Inhibitory Xanthones from Cudrania tricuspidata
오상석,서은진,김회영,류영배,이진환,갈상완,박기훈,Oh, Sang-Seok,Seo, Eun-Jin,Kim, Hoi-Young,Ryu, Young-Bae,Lee, Jin-Hwan,Gal, Sang-Wan,Park, Ki-Hun Korean Society of Life Science 2007 생명과학회지 Vol.17 No.4
The methanolic roots bark extract of Cudrania tricuspidata (Carr.) Bureau was chromatographed, which yielded three xanthones 1-3 by tyrosinase inhibitory activity-guided fractionation. The structures were fully characterized by analysis of physical and spectral data. Among them, furano prenylxanthone 3, never reported as tyrosinase inhibitor, showed potent activity with $IC_{50}$ value of $16.5{\mu}M$, and appeared to inhibit the polyphenol oxidase activity of tyrosinase in an uncompetitive inhibitor($K_i=1.6{\mu}m$) when L-tyrosine was used as a substrate. Moreover, potent inhibitor furano prenylxanthone 3 had an extended lag time of 310 sec at $20{\mu}M$, while lag time of kojic acid as positive control was prolonged with 350 sec at the same concentration.