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이진호,김홍경,안원기,이승태,최종락,한승민,신새암,Jinho Lee,Hongkyung Kim,Won Kee Ahn,Seung-Tae Lee,Jong Rak Choi,Seungmin Hahn,Saeam Shin Korean Society for Laboratory Medicine 2024 Laboratory Medicine Online Vol.14 No.3
급성 백혈병에서 유전 변이를 정확하게 검출하는 것은 매우 중요하다. 간혹 종양 분율이 진단 시 높지 않은 경우, 유전 검사에서 위음성이 초래될 수 있다. 본 증례는 B림프모구백혈병에서 초진 시 골수 흡인 검체에 모세포가 7.1%로 낮았던 예이다. 초진 시의 핵형 분석 및 차세대염기서열분석 결과는 음성으로 분석되었었다. 그러나 후향적으로 검토할 때, 재발 시에 검출된 변이 중 일부가 초진 시에도 매우 낮은 분율로 존재했던 것을 확인하였다. 최근 개정된 급성 백혈병에 대한 WHO 및 International Consensus Classication의 진단 기준을 고려할 때, 초진 시 골수 내 모세포의 분율이 낮은 경우들은 더 많아질 것으로 예상된다. 본 증례는 이러한 종양 분율이 낮은 급성 백혈병에 대해, 위음성을 줄임으로써 환자의 정확한 진단과 치료에 기여하기 위한 노력들이 필요함을 시사한다. The accurate detection of genetic mutations is very important in acute leukemia. Occasionally, tumor fraction may not be high at diagnosis, thus leading to false negative genetic test results. We present a case of acute lymphoblastic leukemia with relapse where the percentage of blasts in bone marrow aspirate was only 7.1% at the initial diagnosis. Karyotyping and next-generation sequencing results appeared negative at diagnosis; however, a retrospective review of the initial tests revealed that some of the mutations detected later at relapse were present even at the initial diagnosis but at very low fractions. Given the recently revised World Health Organization classification (fifth edition) and International Consensus Classification, the probability of encountering acute leukemia with a low blast percentage in bone marrow is expected to increase. This case indicates that efforts should be made to reduce false negative assessments for low tumor fraction leukemia to obtain a more accurate diagnosis and improve treatment.
2인 제로섬 게임 기반의 효과적인 SLBM 탐지를 위한 구축함 배치 최적화
이진호,Lee, Jinho 한국시뮬레이션학회 2018 한국시뮬레이션학회 논문지 Vol.27 No.1
An SLBM (submarine-launched ballistic missile) seriously threatens the national security due to its stealthiness that makes it difficult to detect in advance. We consider a destroyer deployment optimization problem for effectively detecting an SLBM. An optimization model is based on the two-person zero-sum game in which an adversary determines the firing and arriving places with an appropriate trajectory that provides a low detection probability, and we establish a destroyer deployment plan that guarantees the possibly highest detection probability. The proposed two-person zero-sum game model can be solved with the corresponding linear programming model, and we perform computational studies with a randomly generated area and scenario and show the optimal mixed strategies for both the players in the game.
다층 대공방어 체계의 신뢰도 향상을 위한 네트워크 모델 기반의 최적 투자 계획 모델
이진호,정석문,Lee, Jinho,Chung, Suk-Moon 한국시뮬레이션학회 2017 한국시뮬레이션학회 논문지 Vol.26 No.3
This study considers an optimal investment planning for improving survivability from an air threat in the layered air defense system. To establish an optimization model, we first represent the layered air defense system as a network model, and then, present two optimization models minimizing the failure probability of counteracting an air threat subject to budget limitation, in which one deals with whether to invest and the other enables continuous investment on the subset of nodes. Nonlinear objective functions are linearized using log function, and we suggest dynamic programming algorithm and linear programing for solving the proposed models. After designing a layered air defense system based on a virtual scenario, we solve the two optimization problems and analyze the corresponding optimal solutions. This provides necessity and an approach for an effective investment planning of the layered air defense system.