알레르기성 비염 모델에서 통관산(通關散)이 Total IgE, specific IgE 생산에 미치는 영향

이승주,김윤범,Lee, Seung-Joo,Kim, Yoon-Bum 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.1

Background &Objectives : Rhinitis is an inflammation of nasal mucosa and the major symtoms are watery rhinorrhea, sneezing, itchy nose, and nasal obstruction. Rhinitis is classified into allergic rhinitis and nonallergic rhinitis. Allergic rhinitis is an immune reaction by allergen, and vasomotor rhinitis which is nonallergic and noninfectious is hypersensitive reaction. The incidence of allergic rhinitis has increased and the rate of vasomotor rhinitis is high. However there have been no studies about vasomotor rhinitis compared with allergic rhinitis. And there have been no studies so far performed on the effect of Tongkwansan. Therefore this study is aimed to find out the effects of Tongkwansan on allergic rhinitis and vasomotor rhinitis. Materials and Methods : Fifteen BALC/c mouses were divided into three groups : normal group, control group and sample group. To induce the allergic rhinitis in control group and sample group, mouses were sensitized intrapertioneally 0.1% ovalbumin solution three times at intervals of 1 week. Then intranasal sensitization was performed by diffusing 0.1 % ovalbumin solution 3 times at intervals of 2 days. After that time, mouses in the sample group were oral administration treated by Tongkwansan for 28 days. We observed changes in the segment of IL-4, IL-5, $IFN-{\gamma}$, Total IgE, and ovalvumin specific IgE in blood. We used the statistical methods of ANOVA test(p<0.05). Results : There were no significant changes statistically in $IFN-{\gamma}$, IL-4, and IL-5 in blood(p<0.05). There were also no significant changes statistically in Total IgE, OVA-specific IgE in blood(p<0.05). Conclusion : According to above results, it is supposed that Tongkwansan has no significant effects on allergic rhinitis. But it is supposed that Tongkwansan has significant effects on vasomotor rhinitis which is nonallergic and noninfectious

홈 네트워크 서비스 구축을 위한 미들웨어 설계 및 구현

이승주,Lee, Seung-Joo 한국정보기술전략혁신학회 2007 情報學硏究 Vol.10 No.4

In this paper, we propose a design and implementation of Home Network Middleware which offer integrated service of electronic products. Most senior nations setting to core paradigm to ubiquitous computing techniques and effort to get the novel information and making more power about information techniques. But, they don't have a skill to Home Network Middleware in electronic products. It is a more important in Home Network Middleware. So, we will try to study about Home Network Middleware skill. And suggest to proposition that is a novel Home Network Middleware.

GRNN 알고리즘을 이용한 비선형적 움직임 벡터 추정 및 프레임 보간연구

이승주,방민석,윤기방,김기두,Lee, Seung-Joo,Bang, Min-Suk,Yun, Kee-Bang,Kim, Ki-Doo 한국전기전자학회 2013 전기전자학회논문지 Vol.17 No.4

Under nonlinear characteristics of frames, we propose the frame interpolation using GRNN to enhance the visual picture quality. By full search with block size of 128x128~1x1 to reduce blocky artifact and image overlay, we select the frame having block of minimum error and re-estimate the nonlinear moving vector using GRNN. We compare our scheme with forward(backward) motion compensation, bidirectional motion compensation when the object movement is large or the object image includes zoom-in and zoom-out or camera focus has changed. Experimental results show that the proposed method provides better performance in subjective image quality compared to conventional MCFI methods.

기본 요분석검사의 임상적 이용

이승주,Lee, Seung Joo 대한소아신장학회 2013 Childhood kidney diseases Vol.17 No.2

Routine urinalysis is a simple, economical, and useful test that facilitates the detection of urinary system diseases and monitoring of renal disease progression. It consists of 4 parts of specimen evaluation, gross examination, a dipstick urinalysis, and a sediment microscopic urinalysis. Urine specimens should first be evaluated in terms of acceptability, and thereafter, the gross appearance is examined for color, turbidity, and odor. In particular, a dipstick urinalysis is an easy and rapid test that provides information on the multiple physicochemical properties of the urine sample. Moreover, although a sediment microscopic urinalysis is time-consuming, it provides information on the cells, microorganisms, casts, and crystals. In the present report, the clinical significance of the routine urinalysis and the problems concerning interpretation are summarized.

소아에 발생한 갑상선 악성 종양

이승주,김대연,김성철,김인구,Lee, Seung-Joo,Kim, Dae-Yeon,Kim, Seong-Chul,Kim, In-Koo 대한소아외과학회 2000 소아외과 Vol.6 No.2

Thyroid carcinoma is relatively rare in children. Eight cases of thyroid carcinoma were among 18 patients operated upon for thyroid tumors at Pediatric Surgery, Asan Medical Center in 11 years' period between 1989 and 2000. Five patients were boys and three were girls. The age distribution ranged from 10 to 14 years with a median age of 11.6 years. We studied clinical presentations, diagnostic workup, pathology, treatment, and follow-up (recurrence, mortality, and survival). All patients presented with anterior neck mass but one with multiple cervical lymph nodes enlargement. Familial history of thyroid cancer was seen in one case. All patients had a cold nodule by 1-131 thyroid scan. Fine needle aspiration (FNA) biopsy was performed in all patients. The right lobe was involved in four patients and the left lobe in two. Two had both lobes involvement. Pathologically, six cases were papillary carcinoma, one was follicular carcinoma, and one insular carcinoma. Four patients underwent unilateral lobectomy and isthmectomy. Total thyroidectomy was performed in three patients. The insular carcinoma case was preoperatively diagnosed as follicular neoplasm by FNA. After confirmation of the pathology by initial right thyroid lobectomy, total thyroidectomy was subsequently done. Cervical lymph node metastases were presented in three cases (37.5%), and lung metastasis in two cases (25%). Three patients received postoperative I-131 ablation. After a median follow-up of 53 months, all patients were alive without evidence of recurrence. In conclusion, thyroid carcinoma in children is frequently associated with lymph nodes involvement and distant metastasis, however, the prognosis is relatively good.

CT를 위한 웹기반 디지털 아카이브

이승주,황기환,Lee, Seung-Joo,Hwang, Ki-Hwan 한국정보기술전략혁신학회 2009 情報學硏究 Vol.12 No.1

Culture contents are in our life with various parts. There are much try and research managing and keeping the culture contents with growing of information technique. Digital archive was proposed the technique that is able to distribute and manage the contents. This paper proposed the web based digital archive for culture contents. Each of archive were sorted art, architecture, science technology and etc, and made the structure that can total manage.

소아 급성 신우신염에서 출력 도플러 초음파검사

이승주,이선화,Lee Seung-Joo,Lee Sun-Wha 대한소아신장학회 2002 Childhood kidney diseases Vol.6 No.2

Purpose: The purpose of this study is to assess the ability of power Doppler sonography in the detection of acute pyelonephritis. Materials and Methods: We performed gray scale sonography, power Doppler sonography, and $^{Tc-99m}DMSA$ scintigraphy of the kidney in 80 patients with symptoms suggesting upper urinary tract infection. All imaging studies were obtained within 4 days. On $^{Tc-99m}DMSA$ scintigraphy, decreased radioactivity or photopenic lesions were considered indicative of acute pyelonephritis. Triangular areas of decreased perfusion identified on power Doppler sonography were considered as parenchymal lesions of acute pyelonephritis. The results of gray scale sonography and power Doppler sonography were retrospectively analysed and compared with those of $^{Tc-99m}DMSA$ scintigraphy which was given as the standards of reference. Results: For 40(85%) of the 47 patients with scintigraphy-proven acute pyelonephritis, power Doppler sonography diagnosed this condition on the correct side. The acute pyelonephritis which was not revealed by power Doppler sonography was observed in seven patients. Also, in three patients, false-positive indication of pyelonephritis was given by power Doppler sonography. Gray scale sonography showed positive findings in 23(49%) of 47 patients with positive findings on scintigraphy. Conclusion: Power Doppler sonography seems to be less sensitive than $^{Tc-99m}DMSA$ DMSA scintigraphy but significantly more sensitive than gray scale sonography for the detection of acute pyelonephritis in children. Power Doppler sonography shows promise as a noninvasive means of assessing renal cortical perfusion in children with clinically suspected acute pyelonephritis.

Pseudomonas acidovorns 의 5S rRNA 의 구조 결정

이승주,고문주,남정이,박인원 ( Seung Joo Lee,Moon Joo Koh,Jeoung E . Nam Shin,In Won Park ) 생화학분자생물학회 1990 BMB Reports Vol.23 No.1

The primary structure of the 5S rRNA isolated from Pseudomonas acidovorans was determined by enzymatic and chemical degradation methods. It consists of 115 nucleotides and contains no modified nucleosides. Based on Knuc values calculated from the homology of sequences of ten 5S rRNAs from Pseudomonas species, a phylogenic tree was reconstructed. There exists 60 to 87% homology between the 5S rRNA of P. acidovorans and those of other Pseudomonas species. The highest homology of sequences was found between 5S rRNA of P. acidovorans and that of P. cepacia; the phylogenic tree shows that these two species are evolutionarily very close. The secondary structure of the 5S rRNA of P. acidovorans was analyzed by enzymatic and chemical modification methods. The secondary structure determined shows that it is very similar to the generalized models proposed by other workers (De Wachter et al., 1982; Wolters and Erdmann, 1988; Koh, 1989). The secondary structure of 5S rRNA from P. acidovorans consists of five helices, five loops and two bulges.

의이인 추출물이 알레르기 비염 동물의 cytokine에 미치는 영향

이승주,김윤범,Lee, Seung Joo,Kim, Yoon-Bum 대한한방안이비인후피부과학회 2013 한방안이비인후피부과학회지 Vol.26 No.2

Objective : Allergic rhinitis(AR) is an inflammation or irritaion of nasal mucosa. Usually, serum cytokine is regarded as one of the most important factors in AR. Coisis semen have been used for the diseases in digestive organs in traditional chinese medicine. Nowaday, there were some studies reported about the effects of coisis semens on serum cytokine. However the results of theses studies were varies, and moreover there was no study which have used AR animal model. Therefore this study is aimed to determine therapeutic effects of coisis semen extract by observing changes of serum cytokine(IgE, TNF-${\alpha}$, IL-$1{\beta}$, IFN-${\gamma}$ and IL-13) with AR animal model. Methods : Thirty BALB/c mice were divided into six groups : Normal group, Control group, sample I, sample II, sample III, sample IV. Except for Normal group, all the mice in other 5 groups were sensitized intraperionealy by 0.1% ovalbumin solution three times at intervals of one week. Then intranasal sensitization was performed by diffusing 0.1% ovalbumin solution three times at intervals of two days. Normal group were used Normal Saline instead of ovalbumin solution. After the first day of study, sample I, sample II, sample III, and sample IV were orally administrated coisis semen extract by 100mg/kg, 200mg/kg, 500mg/kg, and 1g/kg respectively for 28days. Then, the changes of serum IgE, TNF-${\alpha}$, IL-$1{\beta}$, IFN-${\gamma}$ and IL-13 were observed in 6 groups. We used the statistical methods of ANOVA, post hoc by duncun, and Kruskal-Wallis test(p<0.05) Results : There were statistical changes in IgE and TNF-${\alpha}$. But, there were no statistical changes in IL-$1{\beta}$, IL-13 and IFN-${\gamma}$. Conclusions : According to above results, it is supposed that coisis semen extract has not some significant effects on cytokine of AR animal model. There was no evidence for using coisis semen in relieving symptoms of allergic rhinitis.

고령친화형 식품개발을 위한 국내외 관련 연구현황

이승주,Lee, Seung-Joo 한국식품과학회 2015 식품과학과 산업 Vol.48 No.3