http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
- 검색키워드
- 저자 : 윤정구 ( Ki Baik Hahm (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
위암환자에서 수술전 Polyadenylic-Polyuridylic Acid 투여가 말초혈액과 영역림프절 단핵구의 NK 및 LAK 활성도에 미치는 영향
김원호,함기백,강진경,박인서,최홍재,전미연,노성훈,민진식,윤정구 ( Won Ho Kim,Ki Baik Hahm,Jin Kyung Kang,In Suh Park,Heung Jai Choi,Mi Youn Jun,Sung Hoon Noh,Jin Sik Min,Jung Koo Youn ) 대한소화기학회 1992 대한소화기학회지 Vol.24 No.2
Although the biological significance of the regional lymphnode as a barrier to tumor remains unclear, the clinical prognostic relevance of the neoplastic infiltration of these nodes is accepted. The most potent antitumor effector cells may be expected to be present within or around the site of tumor growth. However, lymphocytes isolated from solid tumor, cancer ascites fluid, and carcinomatous pleural effusion have been shown to expresse low natural killer (NK) activity or none at all. Similarly, it has been reported that lymphnode can be regarded as an NK-deficient tissue, since more limited cytotoxic activity is recorded in the lymphnode cells. (continue...)
-
만성 B형 활동성 간염에서 poly ( A ). poly ( U ) 의 치료 효과
함기백,김원호,한광협,임대순,전재윤,문영명,강진경,박인서,최흥재,윤정구 ( Ki Baik Hahm,Won Ho Kim,Kwang Hyub Han,Dae Soon Yim,Chae Yoon Chon,Young Myung Moon,Jin Kyung Kang,In Suh Park,Heung Jai Choi,Jung Koo Youn ) 대한소화기학회 1992 대한소화기학회지 Vol.24 No.3
The two major approaches to the treatment of chronic hepatitis B are 1) directed toward the eradication of the virus and 2) designed to modulate cellular and humoral immunity. Progress has been made in the development of antiviral chemotherapeutic agents for hepatitis B, but as yet no safe and reliably effective treatment or combmations of treatments are available. It has been demonstrated that interferon is useful in suppressing hepatitis B viral replication, but the relatively low response rate of Asian patients to interferon treatment has been documented due to the fact that mostly they acguired infections perinatally or during childhood. Poly(A). poly(U) is a double stranded helical ribopolyuncleotide complex, which stimulates both humoral and cell mediated immune response, and enhances the splenic NK activity as well as induces the production of the interferon. In this study, we have measured sequentially the leveils of alanine aminotransferase (ALT) and 2, 5-oligoadenylate synthetase (2-5 AS) activities and hepatitis B viral markers in patients with histologically proven chronic active heaptitis after weekly intravenous injection of poly(A). poly(U) to find out that poly(A). poly(U) may be used as the therapeutic agent in the treatment of chronic active hepatitis B. The results were as follows: ALT levels after the weekly administrations of poly(A).poly(U) have declined significantly to the normal level except one case as times passed, especially after 5 weeks. Serum 2-5 AS activities were elevated significantly after the administration of poly(A).poly(U). The complete responses were noted in four cases out of eleven cases (36.4%) until 5 months after discontinuance of poly(A).poly(U). The partial responses were noted in five cases (45.5%). No specific side effects were noted except the light-headness just one time in only one case. In conclusion, the administration of poly(A).poly(U) in the patients with chronic active hepatitis B seems to be effective, simple and safe method, although more extensive and detailed immunologic researches are required.
-
위장관 ( 胃腸管 ) : 위암 환자에 있어서 말초혈액 단핵구 및 국소 림프절 단핵구의 NK 및 LAK 활성도에 관한 연구
강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),박인서(In Suh Park),김원호(Won Ho Kim),노성훈(Sung Hoon Noh),함기백(Ki Baik Hahm),김태수(Tae Soo Kim),안신기(Shin Ki Ahn),윤정구(Jung Koo Youn) 대한소화기학회 1991 대한소화기학회지 Vol.23 No.2
Several lymphocytic subpopulations, such as natural killer (NK) cells and lymphokine-activated killer (LAK) cells, are involved in immunosurveillance against tumors. Whereas the biological significance of the regional lymph node as a tumoral barrier remains unclear, the clinical prognostic relevance of the neoplastic infiltration of these nodes is accepted. Although there is general agreement that the NK and LAK activities of peripheral blood mononuclear cells (PBMC) decreases in patients with various solid and leukemic tumors, this decrease remains unclear with regard to the NK and LAK activities of their regional lymph node mononuclear cells (LNMC). We measured NK and LAK activities of PBMC and LNMC in 10 patients with resectable gastric cancer by 4 hour Cr-release assay using K562, Raji cell and allogenous gastric cancer cell as a target cell. The results obtained are as follows: l) Recombinant interleukin-2 induced strong cytotoxic activities against various target cells in PBMC and LNMC. 2) In patients with gastric cancer, NK and LAK activities of LNMC against K56Z and Raji cell were lower than those of PBMC. 3) However, NK ad LAK activities against the allogenous gastric cancer cell did not differ between LNMC and PBMC. 4) NK and LAK activities of PBMC and LNMC against K562 and Raji cell were not different betveen in patient with early gastric cancer and in patients with advanced gastric cancer. 5) However, NK and LAK activities of PBMC ad LNMC against the allogenous gastric cancer cell were lower in patients with advanced gastric cancer than in patients with early gastric cancer.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
