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RISS 인기검색어
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- 저자 : 안신기(Shin Kee Ahn) (검색결과 3 건)
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신현승(Hyun Seung Shin),한광협(Kwang Hyub Han),박상진(Sang Jin Park),안신기(Shin Kee Ahn),전재윤(Chae Yoon Chon),문영명(Young Myoung Moon),강진경(Jin Kyung Kang),박인서(In Suh Park),김현숙(Hyun Sook Kim),권오웅(Oh Woong Kwoun) 대한내과학회 1994 대한내과학회지 Vol.46 No.4
Background: Epidemiologic studies shows that Korea is one of the high incidence area of hepatocellular carcinoma (HCC) and the major etiologic factor is hepatitis B virus (HBV1. Recently developed assay for circulating antibodies against hepatitis C virus (HCV) suggests the possible etiologic role of HCV for HCC in a number of countries. To evaluate the role of hepatitis virus infection and clinical characteristics in Korean patients with HCC. We studied the positive rates of anti-HCV and HBsAg and analyzed clinical aspects in patients with HCC. Methods: Three hundred twenty six patients with HCC were included from May 1990 to June 1992. We analyzed the prevalence of hepatitis virus infection (B and C) and clinical aspects of the patients with HCC. Results: Among 326 patients examined, two hundred fifteen patients were found to be carriers of hepatitis B surface antigen (HBsAg) and hepatitis C antibodies (anti-HCV) were detected in 59 patients (18.1%). Two hundred nine patients were positive for HBsAg but negative for anti-HCV (64.1%, group B), Fifty four patients were negative for HBsAg but positive for anti-HCV (16.6%, group C). Fifty eight patients were negative for both HBsAg and anti-HCV (17.8%, group Non-BC), Five patients were positive for HBsAg and anti-HCV (1.5%, group BC). The mean age of patients in group C was significantly higher than that of patients with group B (65.3 versus 51.5 years, p<0.01). Coexistence of liver cirrhosis at diagnosis of HCC was found in 254 patients (77.6%) among 326 patients and there was no significant difference between groups. But according to Child-Pugh classification, percentage of class B and C were higher in group C than group B (68.5 vs 32.5%). By the gross appearance of HCC, nodular (single or multiple) type was more common in group C than group B (68.5 vs 32.5%). Alpha-fetoprotein levels greater than 400 ng/ml were found in 187 patients (57.4%) among 326 patients, 63.6% in group B, 51.9% in group C, 39.7% in group Non-BC. Another finding was that the past history of blood transfusion was noticed in only about 11% of anti-HCU positive patients. The detection rates of second generation enzyme immunoassay (EIA) for anti-HCV in HBsAg-negative HCC patients was slightly higher than that of the first generation EIA (50.7 vs 44. 49o). Conclusion: These data suggest that although hepatitis B virus is still the most important etiologic factor for HCC in Korea, HCV infection is an another important etiologic factor in HRsAg-negative HCC patients. Patients with HCV-related HCC tended to be older in age, more frequently associated advanced cirrhosis and nodular appearance in gross finding compared with HBV related HCC.
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박정수,이진무,허갑범,이현철,임승길,이은직,김경래,안광진,정윤석,안신기 대한내분비학회 1991 Endocrinology and metabolism Vol.6 No.3
Medical records of 28 patient with pheochromocytoma diagnosed and treated at the Yonsei University Medical Center between 1971 and 1991 were reviewed. The diagnosis was confirmed with pathology. There were 17 males and 11 females, with a mean age of 44.8 years. The characteristic symptoms and signs were spells such as paroxysmal hypertension, paroxysmal headache and palpitation with average duration of 17.3 months. The overt diabetic patients were 11 cases among 20 patients with hyperglycemia. There were 5 malignant cases (17.9%), 3 bilateral cases (10.7%), 5 extraadrenal cases (17.9%) and 1 case of multiple endocrine neoplasia type Iia (pheochromocytoma, parathyroid adenoma, thyroid medullary carcinoma). The test for catecholamine showed 89.3% of sensitivity. There was no difference in sensitivity between Ucat and UVMA. The most useful localizing procedure was computed tomography. There were remakable hemodynamic changes during operation in 22 cases among 28 surgery-cases. Studies of the effect of the preoperative preparation on intraoperative blood pressure failed to demonstrate that preoperative treatment was effective. After surgical treatment, majority patient were symptom-free. There was no operative mortality. (J Kor Soc Endoornol 6:245~253, 1991)
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