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Is FAM19A5 an adipokine? Peripheral FAM19A5 in wild-type, FAM19A5 knockout, and LacZ knockin mice
성재영,Hoyun Kwak,Eun-Ho Cho,Yoo-Na Lee,Anu Shahapal,Hyo Jeong Yong,Arfaxad Reyes-Alcaraz,Yongwoo Jeong,Yerim Lee,Minhyeok Lee,Nui Ha,Sitaek Oh,Jae Keun Lee,Won Suk Lee,Won Kyum Kim,Sangjin Yoo,Soon-Gu K 한국분자세포생물학회 2024 Molecules and cells Vol.47 No.1
FAM19A5 is a novel secretory protein expressed primarily in the brain. However, a recent study reported that FAM19A5 is an adipocyte-derived adipokine that regulates vascular smooth muscle function through sphingosine-1-phosphate receptor 2 (S1PR2). In our study, we investigated FAM19A5 transcript and protein levels in peripheral tissues, including adipose tissues, from wild-type, FAM19A5 knockout, and FAM19A5-LacZ knockin mice. We found that the FAM19A5 transcript levels in the central nervous system were much greater than those in any of the peripheral tissues, including adipose tissues. Furthermore, the FAM19A5 protein levels in adipose and reproductive tissues were below detectable limits for Western blot analysis and enzyme-linked immunosorbent assay (ELISA). Additionally, we found that the FAM19A5 protein did not interact with S1PR2 in terms of G-protein-mediated signal transduction, β-arrestin recruitment, or ligand-mediated internalization. Taken together, our findings revealed basal levels of FAM19A5 transcripts and proteins in peripheral tissues, confirming its primary expression in the central nervous system and lack of significant interaction with S1PR2.
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SONOS NAND 플래시 메모리 소자에서의 lateral charge migration에 의한 소자 안정성 연구
성재영,정준교,이가원 한국반도체디스플레이기술학회 2019 반도체디스플레이기술학회지 Vol.18 No.4
As the NAND flash memory goes to 3D vertical Silicon-Oxide-Nitride-Oxide-Silicon (SONOS) structure, the lateral charge migration can be critical in the reliability performance. Even more, with miniaturization of flash memory cell device, just a little movement of trapped charge can cause reliability problems. In this paper, we propose a method of predicting the trapped charge profile in the retention mode. Charge diffusivity in the charge trapping layer (Si3N4) was extracted experimentally, and the effect on the trapped charge profile was demonstrated by the simulation and experiment.
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First Passage Time between Ends of a Polymer Chain
성재영,Sung, Jae-Young Korean Chemical Society 2007 대한화학회지 Vol.51 No.3
We improve Wilehemski-Fixmann theory for intrachain reaction dynamics of a polymer chain by taking into account excluded volume effects between reactive groups in the polymerchain. An approximate analytic expression for the intra-chain reaction dynamics is obtained for Gaussian chain model and compared to Brownian dynamics simulation results. The results of the present theory are in a better agreement to Brownian dynamics simulation results than those calculated by previously reported theories.
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Plaque Patterned Cutaneous Candidiasis on the Lower Legs: A Case Report
성재영,임지원,김창용,조영아,이양원,최용범,유다애 대한의진균학회 2023 대한의진균학회지 Vol.28 No.4
Diabetes mellitus (DM) is a metabolic disorder that causes chronic hyperglycemia, leading to immune dysfunction and increased vulnerability to infections. As a result, patients with DM are more susceptible to fungal infections, including Candida species, due of their weakened immune systems. Cutaneous candidiasis is a fungal infection that appears as a red plaque with peripheral satellite papules and pustules around the periphery. Patients with chronic mucocutaneous candidiasis may have erythematous plaques and thickened skin thickening with an overlying scale, which can mimic plaque psoriasis. Therefore, fungal infections should be considered when assessing chronic refractory psoriasiform lesions that are difficult to treat, especially in patients with DM. This report describes a case of cutaneous candidiasis in both lower legs, which was initially misdiagnosed as psoriasis.
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