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RISS 인기검색어
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- 저자 : 백용한 ( Yong Han Paik ) (검색결과 56 건)
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병사용 진단서 발급을 위해 복강경검사에서 간조직검사를 시행한 젊은 성인 남자의 간침생검 소견 : 새로운 만성간염병리분류를 기준으로
백용한(Yong Han Paik),전재윤(Chae Yoon Chon),박영년(Young Nyun Park),한광협(Kwang Hyup Han),문영명(Young Myoung Moon),박찬일(Chan Il Park) 대한소화기학회 2000 대한소화기학회지 Vol.36 No.2
Background/Aims: This study was designed to assess the etiology and characteristics of chronic liver disease among the young male adults. It was also investigated whether grades of activity and status of fibrosis defined by the new histopathologic classification system of chronic hepatitis are related with alanine aminotransferase (ALT) level and HBeAg status in HBsAg-positive case. Methods: Peritoneoscopic findings, clinical features and histopathologic features of liver were investigated for 140 young men who received liver biopsy for military medical certificate from January 1994 to December 1997. These features were evaluated according to the grade and stage of chronic hepatitis. Results: In Korea, hepatitis B virus was the main cause of chronic hepatitis (87.7%) in young male adults and the infection of hepatitis C virus was rare (1.4%). Among HBsAg-positive cases with normal ALT level, 82.2% of them revealed chronic liver disease, and 48.3% of them showed chronic active hepatitis/cirrhosis in biopsy specimens. The grade of chronic hepatitis showed weak correlation with ALT level and the stage did not. There was no significant difference in the grade and stage of chronic hepatitis according to the serum HBeAg status. Conclusions: The most common cause of chronic liver disease in Korean young male adults was hepatitis B virus, and most (92.6%) of HBsAg-positive cases were proved to have chronic liver diseases histologically, regardless of the serum ALT level. According to new histopathologic classification system of chronic hepatitis, serum ALT level correlated with necroinflammatory activity of chronic hepatitis B, but not with fibrosis in HBsAg-positive cases. (Kor J Gastroenterol 2000;36:224 - 234)
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백용한 ( Yong-Han Paik ) 대한간학회 2006 간학회 싱글토픽 심포지움 Vol.12 No.4
Liver cirrhosis results from chronic liver injuries that cause the accumulation of extracellular matrix and progression of hepatic fibrosis. There is a crying need for hepatic fibrosis research so as to understand the molecular mechanisms of hepatic fibrogenesis and to develop effective anti-fibrotic therapies. Hepatic fibrogenesis is a dynamic process and hepaitc stellate cells have a critical role in the development of hepatic fibrosis. Hepatic fibrosis research can be largely divided into in vitroand in vivostudy. Isolation and culture of primary hepatic stellate cells from rodent has been widely used for in vitrohepatic fibrosis research. Several immortal hepatic stellate cell lines have been developed and they have increasingly been applied instead of primary cells. Many investigators have been tried to find suitable animal model of liver fibrosis that resemble specific human liver diseases. However, animal models for hepatic fibrosis still have limitations to present the full spectrum of human liver diseases. In vivo animal models for hepatic fibrosis may be categorized by the causative etiologic factor such as carbon tetrachloride, hepatocarcinogens, biliary obstruction, nutritional deficiency, and alcohol. In this review, the in vitroand in vivomethods for hepatic fibrosis research were briefly reviewed.
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간세포암 환자에서 간동맥 화학색전술 후 발생한 급성 간부전의 위험인자
백용한 ( Yong Han Paik ),전재윤 ( Chae Yoon Chon ),조재용 ( Jae Yong Cho ),안상훈 ( Sang Hoon Ahn ),이관식 ( Kwan Sik Lee ),한광협 ( Kwang Hyub Han ),문영명 ( Young Myoung Moon ),이도연 ( Do Yeon Lee ),이종태 ( Jong Tae Lee ) 대한내과학회 2005 대한내과학회지 Vol.69 No.6
Background : Transcatheter Arterial Chemoembolization (TACE) has been the most widely used treatment for advanced hepatocellular carcinoma (HCC) in Korea. However a number of complications associated with TACE have been reported in many studies. Acute hepatic failure is one of the most serious complications of TACE, because of its grave prognosis. The aim of this study was to investigate the risk factors associated with acute hepatic failure after TACE. Methods : A total of 263 TACE procedures performed in 163 patients with HCC were included in this study. We reviewed retrospectively the complications that occurred after TACE and analysed the risk factors associated with acute hepatic failure after TACE. Results : Complications included post-embolization syndrome (187 cases), temporary hepatic insufficiency (90 cases), acute hepatic failure (13 cases), hepatic arterial injury (9 cases), intrahepatic biloma (4 cases), liver infarction (2 cases), liver abscess (2 cases), tumor rupture (1 cases), gastrointestinal bleeding (14 cases), septicemia (3 cases), gall bladder infarction (2 cases), thrombocytopenia (2 cases), gastric perforation (1 cases), pneumonia (1 cases), urticaria (1 cases), sensorineural hearing loss (1 cases), femoral artery aneurysm (1 cases). According to univariate analysis, risk factors associated with acute hapatic failure after TACE were serum bilirubin and albumin, prothrombin time, dose of adriamycin, pre-TACE Child-Pugh class, tumor size, diffuse tumor type, portal vein thrombosis and TNM stage. Multivariate analysis revealed that serum bilirubin {odd ratio=3.86 (95% CI: 1.59-9.32)}, and diffuse tumor type {odd ratio=5.29 (95% CI: 1.46-23.86)} were statistically significant risk factors. Conclusions : It is recommended that above mentioned risk factors should be considered carefully before TACE to prevent the occurrence of acute hepatic failure after TACE in HCC patients.(Korean J Med 69:622-630, 2005)
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