심포지움 : 간암의 원인

문영명 (Young Myung Moon) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.3

심포지움 : 간암의 원인

문영명 (Young Myung Moon) 대한소화기학회 1993 대한소화기학회 춘계학술대회 Vol.1993 No.-

심포지움 : 21세기 간학의 전망 - 임상분야에 있어서 -

문영명(Young Myung Moon) 대한내과학회 1999 대한내과학회지 Vol.57 No.4

N/A

만성바이러스성 간염의 최신지견

문영명(Moon Young Myung) 한국항공우주의학협회 1996 항공우주의학회지 Vol.6 No.4

전이 증례 간좌엽절제술 및 부신절제술로 치료한 간세포암의 우측 부신 전이

윤영준 ( Young Joon Yoon ),전재윤 ( Chae Yoon Chon ),김철 ( Chul Kim ),송건훈 ( Kun Hoon Song ),정재연 ( Jae Yeon Jung ),한광협 ( Kwang Hyub Han ),문영명 ( Young Myung Moon ),이도연 ( Do Yun Lee ),이종태 ( Jong Tae Lee ) 대한간암학회 2001 대한간암학회지 Vol.1 No.-

원발성 세균성 복막염 진단에 있어서 혈액 배양 배지를 이용한 복수 배양법의 유용성

이명래(Myung Rae Lee),전재윤(Jae Yoon Chon),문영명(Young Myoung Moon),박인서(In Suh Park),이경원(Kyung Won Lee) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.6

Background/Aims: Spontaneous bacterial peritonitis(SBP) is a serious and frequently fata1 compli- cation in cirrhotics, therefore earlier detection and earlier institution of appropriate treatment is crucial for good result. However, the conventional method of ascitic tluid culture has a low sensitivity in detecting causative organism of SBP. Methods: We have compared the sensitivity of the conventional method to the bedside inoculation of ascites into blood culture media. Two kinds of ascites culture methods were compared in cirrhotic patients with spontaneous bacterial peritoni- tis: 1) conventional(on blood agar, MacConkey agar, thioglycolate broth, and phenylethanol blood agar) and 2) blood culture media method(inoculation of each S mL of ascites into one 30-mL tryptic soy broth bottle and one30-mL thioglycolate broth bottle at the patients bedside. Results: In a 55-month period, 67 episodes of SBP in 61 cirrhotic patients were examined using simultane- ous both culture methods. The conventional method grew bacteria in 22 episodes(32.8%), whereas the blood culture media method grew in 55 episodes(82.1%), which showed a significantly higher sensitivity(p0.005). The organisms most frequently isolated in ascitic fluids in this study were aerobic gram-negative bacteria(88.37o), among them E. coli was the most most common pathogen comprising 55.0% of total isolates. The conventional method grew five species of organism whereas the b]ood culture media did eleven species. Most of E. coli were susceptible to amino- glycosides, third generation cephalosporins, aztreonam, and ofloxacin, but resistant to ampicil]in. Conclusions: It is suggested that the inoculation of ascitic fluid to a blood culture media is more sensitive than the conventional method and shou]d be routinely used for ascitic fluid culture in cirrhotic patients. (Korean J Gastroenterol 1995;27: 659 - 672)

증례 / 혈전용해치료와 혈관 내 스텐트삽입술로 치료한 상장간막동맥 혈전폐쇄 1예

김명환(Myung Hwan Kim),이도연(Do Yeon Lee),한광협(Kwang Hyub Han),조덕규(Duk Kyu Cho),송건훈(Kun Hoon Song),전재윤(Chae Yoon Chon),문영명(Young Myoung Moon),김경식(Kyung Sik Kim) 대한소화기학회 2001 대한소화기학회지 Vol.37 No.2

Superior mesenteric artery thrombosis usually occurs in an area of severe atherosclerotic narrowing, most often at the origin of the superior mesenteric artery. On angiography, the absence of collateral vessels or the presence of collaterals with inadequate filling of the superior mesenteric artery indicates an acute occlusion and demands prompt intervention. A 44-year-old man presented with epigastric and right upper quadrant pain after eating. Computed tomography and angiography showed superior mesenteric artery thrombosis. After treating with intra-arterial infusion of urokinase and intraluminal stent insertion, the patient showed clinical improvement and near complete resolution of superior mesenteric artery thrombosis. Thus, direct infusion of urokinase into the superior mesenteric artery and angioplasty with stenting for treatment of superior mesenteric artery thrombosis can be the alternative to surgery in selected patients with superior mesenteric artery thrombosis. (Korean J Gastroenterol 2001;37:132-136)

Desferoxamine 이 시험관내 인체 간암세포 성장에 미치는 영향

송시영(Si Young Song),김원호(Won Ho Kim),전미연(Mi Yun Chon),한광협(Kwang Hyub Han),정재복(Jae Bock Chung),전재윤(Chae Yoon Chon),문영명(Young Myung Moon),강진경(Jin Kyung Kang),박인서(In Suh Park),최흥재(Heung Jai Choi),윤정구(Jung 대한내과학회 1994 대한내과학회지 Vol.47 No.3

Objectives: It has been known that excessive iron promote the growth of cancer cells aad suggested that iron oversupply in cancer patients may enhance tumor growth and adversely affect cancer therapy and that desferoxamine (DFO) as a iron chelating agent may have a place in anticancer agents, which acts as a potent inhibitor of DNA synthesis via inhibition of the ribonucleotide reductase. However there have been no reports on the combined effect of DFO with other chemotherapeutics in vitro, This study was done to answer the questions: Does DFO inhibit the growth of cultured hepatoma cells? and Does the combination of DFO and chemotherapeutic agents have a synergistic effect on inhibition of tumor growth? Methods: Using PLC/PRF/5 and Hep G2 cells as hepatoma cells and normal diploid cells of WI-38 as control, the MTT assay was performed for evaluation of the cytotoxicity and an isobologram method to analyze the combined effects of DFO and other chemotherapeutic agents. Results: 1) The hepatoma cells grew faster in an iron-enriched medium than in the medium without additional iron supplementation but the normal diploid cells of WI-38 did not. 2) The 50% inhibitory concentrations (IC50) on PLC/ PRF/5 and Hep 62 cells were 75.1 and 29.1 ㎍/ml, respectively. But the growth of WI-38 was not inhibited below 74.4% with even 200 ㎍/ml of DFO. 3) On both hepatoma cells, the growth inhibitory effects of DFO were reversed with simultaneous administration of stoichiometric doses of ferric citrate. 4) Adriamycin (ADR), 5-fluorouracil (5-FU) and cisplatin (DDP) inhibited the growth of all 3 cell lines, but larger doses were required to inhibit the WI-38 to obtain the same effect. 5) When DFO was combined with chemotherapeutic agents, a marked synergistic effect was observed with the combination of DFO and 5-FU on PLC/PRF/5 cells. The synergistic effect was also noted in Hep G2 cells with all three combinations of DFO-ADR, DFO-5-FU and DFO-DDP. Conclusion: Iron oversupply may enhance the hepatoma growth and this should be taken into consideration treating patients with hepatoma. And the antitumor effect of DFO and its synergistic effect with other chemotherapeutic agents may suggest that iron chelator like the DFO may be a useful treatment for patients with hepatoma in conjuction with other anticancer drugs.

위 황색종의 광학 및 전자현미경적 관찰

권태정,김정숙,문영명,Kwon Tae-Jung,Kim Chung-Soak,Moon Young-Myung 한국현미경학회 1981 Applied microscopy Vol.11 No.1

Gastric xanthoma which is not a true neoplasm and clinically insignificant consists of the small yellowish lesion of the gastric mucosa, frequently of multiple occurrence. Histologically the lesion shows chronic superficial gastritis with intestinal metaplasia and occasional collections of foam cells within the lamina propria. Electron microscopically. the xanthoma, cells are composed of. lipid-laden histiocytes with. many autophagocytic Iysosomes surrounding the cytoplasmic lipid vacuoles. Many residual bodies are also noted. The pathogenesis of the gastric xanthoma is obscure, however it is thought that a previous focal lesion of the gastric mucosa may have been a factor. One case of gastric xanthoma is reported here and a brief review of literature is also made.

간장 ( 肝腸 ) 및 담도 ( 膽道 ) : Thallium - 201의 경직장 신티그라피를 이용한 문맥순환의 평가

최흥재(Heung Jae Choi),문영명(Young Myung Moon),김경희(Kyung Hee Kim),이관식(Kwan Sik Lee),김병철(Byung Chul Kim),김경철(Kyung Chul Kim),오제덕(Jae Duk Oh) 대한소화기학회 1990 대한소화기학회지 Vol.22 No.3

N/A A new method for evaluating portal systemic circulation by administration of Thallium-201 per rectum was performed in 8 control subjects and in 32 patients with various liver diseases. The heart-to-liver uptake ratio at 20 min after administration (H/L ratio) was used as an index of portal systemic shunting. Also H/L ratios were compared with the results of ICG R15 test and some liver function tests. The results obtained were as follows: 1) The thallium distribution and time-activity curve observed in patients with portal hypertension were clearly distinctive from those in normal control subjects. 2) The H/L ratios obtatined in each group were as, 0.29 +- 0.06 in normal controls, 0.34 +- 0.04 in asymptomatic HBsAg carrier, 0.44 +- 0.10 in patients with CPH, 0.50 +- 0.23 in patients with CAH, and 0.70 +- 0.43 in patients with ]iver cirrhosis. 3) There was a relatively good correlation between the H/L ratio and ICG R15 (indocyanine green retention rate at 15 min) test (r=0.79, p<0.001). 4) No correlation was observed between H/L ratio values and albumin, bilirubin, SGOT, SGPT, but correlations were observed between H/L ratio and prothrombin time (r=-0.70, p<0.001), and platelet counts (r= -0.45, p<0.01). The above results suggest that this noninvasive method seems to be useful in evaluating portal-to- systemic shunting in various liver diseases with portal hypertension.