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조보라(Jo, Bo-Ra),유은아(Yoo, Eun-Ah),박수진(Park, Soo-Jin),조아라(Jo, Ara),박수연(Park, Su-Youn),박서영(Park, Suh-Young),김동영(Kim, Dong-Young),김현용(Kim, Hyun-Yong),강경아(Kang, Kyung-Ah) 한국산학기술학회 2013 한국산학기술학회논문지 Vol.14 No.4
본 연구는 성별에 따라 간호대학생의 자아탄력성과 전문직 자아개념 인식정도의 차이를 분석하고 전문직 자 아개념에 영향을 미치는 요인을 비교하기 위한 서술적 조사연구이다. 서울시 소재 2개 간호대학(과)에 재학하는 학생 445명을 대상으로 하였으며 자료분석방법은 SPSS WIN 18.0 프로그램을 사용하여 서술통계, t-test, χ2.test, Fisher’s exact test, one way ANOVA, Pearson 상관관계, 다중회귀분석을 구하였다. 연구결과 남학생이 여학생에 비해서 자아 탄력성과 전문직 자아개념 정도가 유의하게 높았다. 성별에 따른 일반적 특성별 자아탄력성과 전문직 자아개념과 유 의한 차이를 보인 변수는, 여학생은 학년과 휴학유무, 남학생은 동아리 활동유무이었다. 자아탄력성과 전문직 자아개 념과의 상관관계는 남여학생 모두에서 유의한 긍정적 상관관계를 보였고, 전문직 자아개념에 영향을 미치는 유의한 요인은 자아탄력성이었다. This study was done to analyze the difference in resilience and professional self-concept and compare the influencing factors on Professional Self-Concept among different sexes of nursing students. Subjects were 445 students from two nursing schools in the Seoul city. Data were analyzed by descriptive statistics, t-test, χ2 – test, Fisher’s exact test, one way ANOVA, Pearson correlation coefficients, and multiple regression using the SPSS WIN 18.0 program. Male students had much better resilience and professional self-concept than female students. Variables which were significant differences in resilience and professional self-concept according to sexes were in the females’ case, grade and leave of absence and in the males’ case, club activities. There was a positive correlation between resilience and professional self-concept both sexes. In both groups, the factor that affected professional self-concept was resilience.
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인체 흑색종 세포군에서의 Vascular Endothelial Growth Factor(VEGF) 분비
김현조,황규왕,조문균,박영립,이종성,이성열 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2
Backgroung : Vascular endothelial growth factor(VEGF) is an angiogenic cytokine expressed by many human and animal tumors. Ultraviolet radiation(UVR) has been causally linked to melanoma initiation and progression. UVR is a known melanocyte mutagen and induces specific mutations in cellular oncogenes such as p53 and ras. Activated H-ras activates tumor angiogenesis in other cell types, and angiogenic switching is accompanied by up-regulation of VEGF. Objective : The purpose of this study was to determine whether VEGF release from human melanoma cell lines was altered by activating ras mutations or by inactivation of p53 induction and whether VEGF release of these transfected melanoma cell lines was changed after UVR radiation. Results : 1. Release of VEGF from menolayer culture of melanoma cells was significantly higher in cells with activating ras mutations and lower in cells with expression of dominant negative p53. 2. In spheroid culture, dominant negative p53 decreases VEGF release in WM35 cells, but activating ras did not affect VEGF release significantly. 3. The control cell line(WM35Neo) had higher VEGF release in the spheroid culture than in the monolayer culture, and dominant negative p53 or activating ras did not affect VEGF release significantly between these two culture systems. 4. Higher cell density increases VEGF release in all tested melanoma cell lines was shown in both spheroid and monolayer culture. This cell density effect was strongest in cells with activated ras in monolayer culture. 5. UVR inhibits VEGF release in all tested melanoma cell lines, and this effect was stronger in monolayer culture than in spheroid culture. The effect of UVR on VEGF release was significantly lower in the DNp53 transfectants. 6. UVR decreased the cell viability in a dose dependent manner regardless of the cell density or cell culture system. Conclusion : VEGF release in human melanoma was inhibited by ultraviolet radiation at cytotoxic doses, and this effect is stronger in monolayer culture than in spheroid culture. VEGF release from melanoma cell lines was also influenced by p53, ras and cell growth conditions in a complex manner.
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Influence of Mesenchymal Stem Cells on Cryopreserved Tracheal Allografts in Rabbits
김현조 대한흉부외과학회 2013 Journal of Chest Surgery Vol.46 No.5
Background: Ischemic injury and the rejection process are the main reasons for graft failure in tracheal transplantation models. To enhance the acceptance, we investigated the influence of mesenchymal stem cells (MSCs) on tracheal allografts. Methods: Extracted tracheal grafts from New Zealand white rabbits were cryopreserved for 4 weeks and orthotopically transplanted (control group A, n=8). In group B (n=8), cyclosporin A (CsA, 10 mg/kg) was injected daily into the peritoneal cavity. In group C (n=8), MSCs (1.0×107 cells/kg) from the same donor of the tracheal allograft, which had been pre-cultured for 4 weeks, were infused intravenously after transplantation. In group D (n=8), MSCs were infused and CsA was injected daily. Four weeks after transplantation, gross and histomorphological assessments were conducted for graft necrosis, measuring the cross-sectional area of the allograft, determining the degree of epithelization, lymphocytic infiltration, and vascular regeneration. Results: The morphologic integrity of the trachea was retained completely in all cases. The cross-sectional areas were decreased significantly in group A (p=0.018) and B (p=0.045). The degree of epithelization was enhanced (p=0.012) and the lymphocytic infiltration was decreased (p=0.048) significantly in group D compared to group A. The degree of vascular regeneration did not differ significantly in any of the groups. There were no significant correlations among epithelization, lymphocytic infiltration, and vascular regeneration. Conclusion: The administration of MSCs with concurrent injections of CsA enhanced and promoted epithelization and prevented lymphocytic infiltration in tracheal allografts, allowing for better acceptance of the allograft.
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