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혈관 운동 증상을 동반한 여성 갱년기 우울증 환자에서 Venlafaxine Hydrochloride Extended Release의 치료효과에 대한 개방 관찰 연구
김미루,이정구,백준형,김영훈 대한정신약물학회 2014 대한정신약물학회지 Vol.25 No.4
ObjectivezzDuring the transition to menopause, various symptoms including vasomotor symptoms and depressed mood lead to low quality of life. We investigated the effect of low-dose venlafaxine hydrochloride extended release on depressed mood and vasomotor symptoms of perimenopausal women. Methodszz33 perimenopausal women fulfilling Diagnostic and Statistical Manual of Mental Disorders, fourth edition criteria for a depressive episode were enrolled between January 2014 and May 2014. Subjects were prescribed 37.5 mg/day or 75 mg/day venlafaxine hydrochloride according to clinician’s judgement, and the dosages were maintained for 8 weeks. Depressed mood and other psychological difficulties were evaluated by using Hamilton Rating Scale for Depression (HAMD), Hamilton Rating Scale for Anxiety (HAMA), Clinical Global Impression-Severity. Climacteric symptoms including vasomotor symptoms were evaluated by using Greene Climacteric Scale (GCS). For statistical analysis, paired t-test was used. ResultszzSignificant decreases in HAMD, HAMA, GCS scores were observed after 2 weeks of treatment and the trends continued until the end of the study. The scores of HAMD significantly decreased, 28 of them reached remission (HAMD ≤7). The scores on vasomotor symptoms of GCS after 8 week treatment significantly decreased compared to baseline (13.1±5.0, p<0.01). ConclusionzzThese results suggest that venlafaxine hydrochloride is effective and tolerable treatment option for vasomotor symptoms and depressed mood in perimenopausal women. To validate our results, furthur studies with double-blind, placebo controlled will be needed. 본 연구는 갱년기 한국 여성의 우울 증상과 혈관 운동 증상에 있어 venlafaxine hydrochloride extended release의 치료 효과를 평가하였다. 혈관 운동 증상을 동반한 33명의 여성 갱년기 우울증 환자를 대상으로 37.5 mg/day, 75 mg/day 용량의 venlafaxine hydrochloride extended release를 8주간 투약하였다. HAMD, HAMA, CGI-S와 함께 갱년기 증상 평가 척도인 GCS를 통해 경과를 평가하였다. 본 연구 결과 venla-faxine hydrochloride는 8주 동안 HAMD 및 CGI, GCS를 포함한 전체 척도 점수에 있어 유의한 호전을 보였다. 33명의 대상자 중 1명이 심한 오심으로 중도 탈락했다. 이는 일반 갱년기 한국 여성의 우울 증상과 혈관 운동 증상의 치료에 있어 venlafaxine hydrochloride가 효과적인 치료안이 될 수 있다는 가능성을 보여준다. 본 연구 결과는 대조군 없이 진행된 개방 관찰 연구로 결과의 입증을 위한 장기간의 이중맹검 연구가 필요할 것이다.
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Who Benefits from Government Guarantees: Evidence from Saitdol Loans
김미루 한국개발연구원 2025 KDI Journal of Economic Policy (KDI JEP) Vol.47 No.2
This study investigates whether Saitdol loans, a type of government-guaranteed loan, were allocated to groups that would otherwise be unable to access the loan market without such a guarantee. To assess this, both non-parametric and parametric estimation methods, as proposed by Hendren (2013), were employed to examine the severity of information asymmetry between Saitdol loan borrowers and financial institutions, a potential cause of a market failure. The analysis results indicate that the information asymmetry between borrowers holding Saitdol loans and financial institutions was not severe enough to cause a market failure. This suggests that a significant number of Saitdol loans were allocated to borrowers who could have obtained loans from the private sector without government guarantees.
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The Effects of Lowering the Statutory Maximum Interest Rate on Non-bank Credit Loans
김미루 한국개발연구원 2022 KDI Journal of Economic Policy (KDI JEP) Vol.44 No.3
This paper analyzes the effects of the cut in the legal maximum interest rate (from 27.4% to 24%) that occurred in February of 2018 on loan interest rates, the default rates, and the loan approval rate of borrowers in the non-banking sector. We use the difference-in-difference identification strategy to estimate the effect of the cut in the legal maximum interest rate using micro-level data from a major creditrating company. The legal maximum rate cut significantly lowers the loan interest rate and default rate of low-credit borrowers (i.e., highcredit- risk borrowers) in the non-banking sector. However, this effect is limited to borrowers who have not been excluded from the market despite the legal maximum interest rate cut. The loan approval rate of low-credit borrowers decreased significantly after the legal maximum interest rate cut. Meanwhile, the loan approval rate of high-credit and medium-credit (i.e., low credit risk and medium credit risk) borrowers increased. This implies that financial institutions in the non-banking sector should reduce the loan supply to low-credit borrowers who are no longer profitable while increasing the loan supply to high- and medium-credit borrowers.
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