Inhibitory Activity of Plantago major L. on Angiotensin I-converting Enzyme

Nguyen Xuan Nhiem,김영호,Bui Huu Tai,Phan Van Kiem,Chau Van Minh,Nguyen Xuan Cuong,Nguyen Huu Tung,Vu Kim Thu,Trinh Nam Trung,Hoang Le Tuan Anh,조성훈,장해동,권영인 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.3

Eight compounds were isolated from methanol extract of Plantago major L. leaves and investigated for their ability to inhibit angiotensin I-converting enzyme activity. Among them, compound 1 showed the most potent inhibition with rate of 28.06 ± 0.21% at a concentration of 100 μM. Compounds 2 and 8 exhibited weak activities. These results suggest that compound 1 might contribute to the ability of P. major to inhibit the activity of angiotensin I- converting enzyme.

Evaluation of Auditors' Professional Skills in Local Auditing Firms in Hanoi

NGUYEN, Thi Hanh Duyen,LE, Van Luyen,HAU, Nguyen Van,DO, Duc Tai,THAO, Nguyen Thi Thu Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.9

In recent years, the quality of auditing human resources in domestic auditing firms in Hanoi has certain limitations in which professional skills of auditors have not been given adequate attention. The number of customers at local auditing firms is forecast to increase gradually. Therefore, the quantity and quality of auditors need to be improved to meet requirements of the workload. Data for this research were collected through surveying 120 customers of domestic auditing firms in Hanoi on the 5-point Likert scale. Based on the collected data, we employ both qualitative and quantitative methodology along with some tools such as descriptive statistics, Cronbach's Alpha, T-test and ANOVA to analysis, evaluate and measure the professional skills of auditors in local auditing firms in Hanoi. The results show that the professional skills of auditors in auditing firms include 17 attributes. The majority of respondents show appreciation for the professionalism and professional competence of auditors, while, they think that critical thinking skills and creative thinking skills are still limited and need to be improved. These findings, not only help auditors to improve themselves, but also provide solutions for managers of domestic auditing firms in Hanoi to enhance quality of audited human resources.

A Study on the Poverty of Mountain People Depending on Forests

NGUYEN, Phuong Thi Minh,NGUYEN, Song Van,DO, Duc Tai,NGUYEN, Quynh Thi Thuy,DINH, Thanh Trung,NGUYEN, Hang Phan Thu Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.7

Livelihood capitals have a clear influence on livelihood development. As for the livelihood results, it has been pointed out in the analysis of the poor households that the ability of people to escape poverty depends especially on the access to livelihood capitals. This study aims to analyze the impacts of livelihood capital on poverty among mountain people who depend on forests through human capital, social capital, natural capital, physical capital and financial capital. This research employs the model of binary regression function. Independent variables x1, x2, …, xn are targets of livelihood strategy, vulnerability context, and livelihood capitals. These variables were selected to be included in the original model with dependent variable Y as poor and non-poor households. This study surveys households living in upland areas, near forests, and households of ethnic minorities. The results show that,out of the poor household rate, nearly 4% are newly-poor households or those falling back into poverty. Therefore, the government needs to pay more attention to this disadvantaged group and implements policies such as education and training policies, credit support policies, policies to support forest development, and payment for forest environmental services in the context of emerging countries like Vietnam.

Total Peroxynitrite Scavenging Capacity of Phenylethanoid and Flavonoid Glycosides from the Flowers of <i>Buddleja officinalis</i>

Tai, Bui Huu,Jung, Bong Yong,Cuong, Nguyen Manh,Linh, Pham Thuy,Tung, Nguyen Huu,Nhiem, Nguyen Xuan,Huong, Tran Thu,Anh, Ngo Thi,Kim, Jeong Ah,Kim, Sang Kyum,Kim, Young Ho Pharmaceutical Society of Japan 2009 Biological & pharmaceutical bulletin Vol.32 No.12

<P>Nine compounds, including six phenylethanoid glycosides: acteoside (1); bioside (2); echinacoside (3); poliumoside (4); phenylethyl glycoside (5); salidroside (6) and three flavonoids; linarin (7); apigenin (8); isorhoifolin (9), were isolated from the flowers of <I>Buddleja officinalis</I> M<SMALL>AXIM</SMALL>. (Buddlejaceae). Chemical structures were confirmed by <SUP>1</SUP>H-, and <SUP>13</SUP>C-NMR, and MS spectral methods and compared with those reported in the literature. Antioxidant activities of the methanol and water extracts, and all isolated compounds were evaluated using the total oxidant scavenging capacity (TOSC) assay against peroxynitrite. Results of the assay showed that the phenylethanoid glycosides, a major class of compounds of the flowers of <I>B. officinalis</I>, possess strong antioxidant activity. Of these, acteoside, echinacoside and poliumoside have 9.9-, 9.8- and 9.5-fold TOSC value, respectively, compared with the positive control, Trolox.</P>

An evaluation of the RNase H inhibitory effects of Vietnamese medicinal plant extracts and natural compounds

Tai, Bui Huu,Nhut, Nguyen Duy,Nhiem, Nguyen Xuan,Quang, Tran Hong,Thanh Ngan, Nguyen Thi,Thuy Luyen, Bui Thi,Huong, Tran Thu,Wilson, Jennifer,Beutler, John A.,Ban, Ninh Khac,Cuong, Nguyen Manh,Kim, Yo Informa Healthcare 2011 PHARMACEUTICAL BIOLOGY Vol.49 No.10

<P><I>Context</I>: Acquired immune deficiency syndrome (AIDS) is a severe pandemic disease especially prevalent in poor and developing countries. Thus, developing specific, potent antiviral drugs that restrain infection by human immunodeficiency virus type 1 (HIV-1), a major cause of AIDS, remains an urgent priority.</P><P><I>Objective</I>: This study evaluated 32 extracts and 23 compounds from Vietnamese medicinal plants for their inhibitory effects against HIV-1 ribonuclease H (RNase H) and their role in reversing the cytopathic effects of HIV.</P><P><I>Materials and methods</I>: The plants were air-dried and extracted in different solvent systems to produce plant extracts. Natural compounds were obtained as previously published. Samples were screened for RNase H inhibition followed by a cytopathic assay. Data were analyzed using the Microsoft Excel.</P><P><I>Results and discussion</I>: At 50 μg/mL, 11 plant extracts and five compounds inhibited over 90% of RNase H enzymatic activity. Methanol extracts from <I>Phyllanthus reticulatus</I> and <I>Aglaia aphanamixis</I> leaves inhibited RNase H activity by 99 and 98%, respectively, whereas four extracts showed modest protection against the cytopathic effects of HIV.</P><P><I>Conclusion</I>: The screening results demonstrated that the butanol (BuOH) extract of <I>Celastrus orbiculata</I> leaves, methanol (MeOH) extracts of <I>Glycosmis stenocarpa</I> stems, <I>Eurya ciliata</I> leaves, and especially <I>P. reticulatus</I> leaves showed potential RNase H inhibition and protection against the viral cytopathic effects of HIV-1. Further chemical investigations should be carried out to find the active components of these extracts and compounds as potential anti-HIV drug candidates.</P>

Some Main Characteristics Of Vietnamese Confucianism

( Nguyen Tai Thu ) 충남대학교 유학연구소 2010 유학연구 Vol.21 No.-

Characteristics of Vietnamese Confucianism are investigated from several aspects. Firstly, from the perspective of the role of Confucianism for the independence and sovereignty of the feudal society of Vietnam, the author comes to the following conclusions: Confucianism as an exotic ideology was received and transformed but still retained all its essential principles. Confucianism as the ruling theory had contributed to the promotion of Vietnamese feudal society toward the centralization and unification. It was also a useful theoretical tool for thinkers in validating the patriotism and national independent movements. It also had a strong influence on Vietnamese cultural life. Secondly, from the dimension of the direction and motivation of the development of Vietnamese Confucianism, the author argues that, although feudal royal courts as well as intellectuals were aware of consolidating and developing Confucianism, their activities could only resulted in the stability of institutions. Theoretically, all these conditions were not enough to bring about any turning-point or advance. There was no great school, no discussion, and no self-reflection. Vietnamese orthodox Confucianism could not escape from the stronghold of conservatism. Thirdly, from perspective of thinking style, the author claims that almost all Vietnamese Confucians were only attracted to practical and utilitarian elements, avoiding the metaphysical; liked simplicity and conciseness whose impacts were the simplicity in thinking and working and the evasion of meditative and creative issues; revered deities; had the eclectic and combinative method of thinking which easily accepted the mixture of three teachings - Confucianism, Buddhism and Taoism, etc. Thence the author attempts to find some reasons behind these characteristics of Vietnamese Confucianism. According to him, during the history, Vietnamese Confucianism experienced many unfavorable stages: in the Chinese domination period, it was an ideology strange to Vietnamese; in the early independent period, it yielded to Buddhism; up to the period of centralizing and autocratic feudal system, it was under the influence of Confucianism of Han and Song Dynasties which were dogmatic and inflexible, and moreover must develop in the only direction of serving the feudal governance, and thus had no room for the creation. Above all, the backwardness in economy and society itself hampered the progress of Confucianism. In sum, due to the particular historical situation, the spread, study and creation of Confucianism in Vietnam only reached to the ordinary level. In the thousand-year history of Confucianism as the orthodox ideology in Vietnam, there emerged only some great thinkers.

Chemical constituents of the Annona glabra fruit and their cytotoxic activity.

Hien, Nguyen Thi Thu,Nhiem, Nguyen Xuan,Yen, Duong Thi Hai,Hang, Dan Thi Thuy,Tai, Bui Huu,Quang, Tran Hong,Tuan Anh, Hoang Le,Kiem, Phan Van,Minh, Chau Van,Kim, Eun-Ji,Kim, Seung Hyun,Kang, Hee Kyoun Swets Zeitlinger 2015 PHARMACEUTICAL BIOLOGY Vol.53 No.11

<P>Traditional Chinese medicines have attracted increasing interest as potential sources of novel drugs with a wide range of biological and pharmacological activities. Annona glabra Linn (Annonaceae) is used in traditional medicine as an anticancer drug. Phytochemical investigation of this plant led to the isolation of acetogenins, ent-kauranes, peptides, and alkaloids. In addition, compounds exhibited anticancer, anti-HIV-reserve, and antimalaria.</P>

Internal Factors Affecting Firm Performance: A Case Study in Vietnam

Van Hau NGUYEN,Thi Thu Cuc NGUYEN,Van Thu NGUYEN,Duc Tai DO 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.5

The higher the firm performance, the more chances enterprises can expand and develop their production, create jobs, and improve the workers’ living quality. The main objective of this study was to measure the internal factors influencing the firm’s performance of food and beverage (F&B) firms listed on the Hanoi Stock Exchange (HNX). Data was collected on 15 F&B firms listed on the HNX from 2015 to 2019 We use mixed research method, both qualitative and quantitative. For the quantitative research method, the supporting tool is Stata13 software. The results via Ordinary Least Squares (OLS) regression method show the impacts of internal factors with the following observed variables: the ratio of short-term debt to total liabilities (CS1) and total assets (S2) have an opposite impact (–) on ROA and ROE; debt-to-total assets ratio (CS2) has an opposite effect (–) on ROA; growth of total assets (G2) of the growth factor positively affects (+) ROA and ROE, the remaining factors do not affect ROA and ROE; and internal factors do not influence ROS. Based on the findings, some recommendations have been proposed to help the F&B firms listed on the Hanoi Stock Exchange improving their firm performance in the future.

New Pyrano-Pyrone from <i>Goniothalamus tamirensis</i> Enhances the Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells

Tai, Bui Huu,Huyen, Vu Thi,Huong, Tran Thu,Nhiem, Nguyen Xuan,Choi, Eun-Mi,Kim, Jeong Ah,Long, Pham Quoc,Cuong, Nguyen Manh,Kim, Young Ho The Pharmaceutical Society of Japan 2010 Chemical & pharmaceutical bulletin Vol.58 No.4

<P>The new pyrano-pyrone, (+)-8-epi-9-deoxygoniopypyrone (1) and (+)-9-deoxygoniopypyrone (2) were isolated from a chloroform extract of <I>Goniothalamus tamirensis</I> leaves. Their absolute stereostructures were discussed and confirmed by using infrared (IR), Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS), one (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectra, Mosher's method, and comparison with the known compounds leiocapin A (3), deoxygoniopypyrone A (4), and (−)-8-epi-9-deoxygoniopypyrone (5). At concentrations of 2.67 μ<SMALL>M</SMALL>, compounds 1 and 2 significantly increased the growth of osteoblastic MC3T3-E1 cells and caused a significant elevation of collagen content, alkaline phosphatase activity, and nodule mineralization in the cells (<I>p</I><0.05). Our data suggest that the enhancement of osteoblast function by 1 and 2 may result in the prevention of osteoporosis.</P>

Chrysoeriol isolated from the leaves of Eurya ciliata stimulates proliferation and differentiation of osteoblastic MC3T3-E1 cells.

Tai, Bui Huu,Cuong, Nguyen Manh,Huong, Tran Thu,Choi, Eun-Mi,Kim, Jeong-Ah,Kim, Young Ho Gordon and Breach ; Taylor Francis Health Sciences 2009 Journal of Asian natural products research Vol.11 No.9

<P>Chrysoeriol (1) was isolated as the main constituent from the methanol extract of the dried leaves of Eurya ciliata Merr. To investigate the bioactivities of 1 on bone metabolism, its effects on the function of osteoblastic MC3T3-E1 cells were studied. Compound 1 significantly increased the growth of MC3T3-E1 cells and caused a significant elevation of alkaline phosphatase activity, collagen content, and nodule mineralization in the cells (P < 0.05). Our data indicate that the enhancement of osteoblast function by 1 may be useful in the prevention of osteoporosis.</P>