치주 유지관리기 환자에게 PRF-K2를 함유한 nutraceutical의 효과

김유강,정현주,김세원,백동현,Kim, Yu-Kang,Chung, Hyun-Ju,Kim, Se-Won,Baek, Dong-Heon 대한치주과학회 2007 Journal of Periodontal & Implant Science Vol.37 No.1

The long term success of periodontal treatment is dependent upon the effectiveness of the main-tenance care program after active treatment. The purpose of this study was to evaluate whether nutraceutical containing PRF-K2 as natural product from plant and seaweed has beneficial effects on clinical parameters, gingival crevicular fluid (GCF) volume and GCF cytokine levels during main- tenance phase after periodontal treatment. Among the generally healthy and non-smoking. moderate to severe chronic periodontitis patients during maintenance phase in Department of Periodontics, Chonnam National University Hospital, twenty eight patients took nutraceutical containing PRF-K2 (Oscotec Inc. Cheonan, Korea) for 3 months as experimental group and sixteen patients received only maintenance care as control group. Clinical examination and GCF collection were performed at baseline, 1, 2 and 3 months of experiment. Total amounts and concentrations of GCF IL-1{\beta}, IL-1ra and $PGE_2$ were evaluated using ELISA kit. In probing pocket depth, experimental group showed the tendency of more reduction than control group after 3 months of experiment. Sulcus bleeding index (SBI) and GCF volume were significantly decreased in experimental group(p<0.05), whereas they were increased in control group. GCF IL-1{\beta} level tended to decrease in both experimental and control group and IL-1ra concentration tended to increase in experimental group and to decrease in control group. IL-1ra/IL-1{\beta} ratio tended to increase in experimental group and to decrease in control group during experimental period. GCF $PGE_2$ amount did not show any change in experimental group and tended to increase in control group. These results suggest that nutraceutical supplement which contain PRF-K2 could improve perio-dontal condition during maintenance phase after periodontal therapy.

Long-Term (5 Years), High Daily Dosage of Dietary Agmatine—Evidence of Safety: A Case Report

Gad M. Gilad,Varda H. Gilad 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.11

There is presently a great interest in the therapeutic potential of agmatine, decarboxylated arginine, for various diseases. Recent clinical studies have already shown that oral agmatine sulfate given for up to 3 weeks provides a safe and, as compared with current therapeutics, more effective treatment for neuropathic pain. These studies have ushered in the use of dietary agmatine as a nutraceutical. However, in view of information paucity, assessment of long-term safety of oral agmatine treatment is now clearly required. The authors of this report undertook to assess their own health status during ongoing consumption of a high daily dosage of oral agmatine over a period of 4–5 years. A daily dose of 2.67 g agmatine sulfate was encapsulated in gelatin capsules; the regimen consists of six capsules daily, each containing 445mg, three in the morning and three in the evening after meals. Clinical follow-up consists of periodic physical examinations and laboratory blood and urine analyses. All measurements thus far remain within normal values and good general health status is sustained throughout the study period, up to 5 years. This case study shows for the first time that the recommended high dosage of agmatine may be consumed for at least 5 years without evidence of any adverse effects. These initial findings are highly important as they provide significant evidence for the extended long-term safety of a high daily dosage of dietary agmatine—a cardinal advantage for its utility as a nutraceutical.

Kmeria duperreana (Pierre) Dandy Extract Suppresses LPS-Induced iNOS and NO via Regulation of NF-κB Pathways and p38 in Murin Macrophage RAW 264.7 Cells

Bo Ram So,Tran The Bach,Jin Hyub Paik,Sung Keun Jung 한국식품영양과학회 2020 Preventive Nutrition and Food Science Vol.25 No.2

Development of anti-inflammatory products remains in high demand due to the incidence of inflammatory diseases, including diabetes, cardiovascular disease, and neurodegenerative diseases. In this study, we examined the potential anti-inflammatory activity of the nutraceutical, Kmeria duperreana (Pierre) Dandy extract (KDE). We evaluated the ability of KDE to inhibit lipopolysaccharide (LPS)-induced inflammatory markers, including nitric oxide (NO), nuclear factor kappa-B, and mitogen-activated protein kinases, in RAW 264.7 cells. KDE suppressed LPS-induced nitrite production and inducible NO synthase (iNOS) expression in RAW 264.7 cells, but has no effect on cyclooxygenase-2 expression. KDE also suppressed LPS-induced phosphorylation of p65, IκB kinase, and p38 in RAW 264.7 cells. Through Western blot assays and immunofluorescence results, we showed that KDE suppresses LPS-induced p65 translocation from cytosol to the nucleus in RAW 264.7 cells. Moreover, KDE suppressed mRNA expression of LPS-induced interleukin (IL)-1κ in RAW 264.7 cells, but had no effect on mRNA expression of IL-6 or tumor necrosis factor-α. These results demonstrate that KDE may be a promising anti-inflammatory nutraceutical. KDE may act by suppressing iNOS expression and subsequent NO production by inhibiting phosphorylation of p65 and p38 and suppressing translocation of p65 from the cytosol to the nucleus.

Nutraceuticals as Modulators of Immune Function: A Review of Potential Therapeutic Effects

Alessandro Medoro,Sergio Davinelli,Alessandro Colletti,Valentina Di Micoli,Elisa Grandi,Federica Fogacci,Giovanni Scapagnini,Arrigo F.G. Cicero 한국식품영양과학회 2023 Preventive Nutrition and Food Science Vol.28 No.2

Dietary supplementation with nutraceuticals can promote optimal immune system activation, modulating different pathways that enhance immune defenses. Therefore, the immunity-boosting effects of nutraceuticals encompass not only immunomodulatory but also antioxidant, antitumor, antiviral, antibacterial, and antifungal properties, with therapeutic effects against diverse pathological conditions. However, the complexity of the pathways that regulate the immune system, numerous mechanisms of action, and heterogeneity of the immunodeficiencies, and subjects treated make their application in the clinical field difficult. Some nutraceuticals appear to safely improve immune system function, particularly by preventing viral and bacterial infections in specific groups, such as children, the elderly, and athletes, as well as in frail patients, such as those affected by autoimmune diseases, chronic diseases, or cancer. Several nutraceuticals, such as vitamins, mineral salts, polyunsaturated omega-3 fatty acids, many types of phytocompounds, and probiotic strains, have the most consolidated evidence in humans. In most cases, further large and long-term randomized clinical trials are needed to confirm the available preliminary positive data.

Recently Progressed Postbiotics as Nutraceuticals

정가진 건강기능식품미래포럼 2021 건강기능식품미래포럼 학술지 Vol.1 No.3

As was defined before, nutraceuticals are not only nutritional but also clinically effective to the host when administered appropriately. Traditionally it has been believed that some people take a certain food unconsciously when they have some disorders internally, and then the food they take has some clinically effective ingredients. Since the end of 19th century, the microbiological world was unveiled by some pioneers, and we are now sufficiently aware of their importance in our normal life. Nutraceuticals, basically postbiotics, are now attracting scientific attention as an alternative medicine for those hardly curable chronic diseases including immunological, cardiovascular, metabolic, psychiatric disorders and many others such as cancers, senile dementia or even obesity. Lactic acid bacteria have been key members of the worldwide fermented foods, and their metabolites are gradually recognized to have miraculous power for the patients with chronic disorders from which they have been suffering for long. Nowadays, there have been so many research articles utilizing lactic acid bacteria to provide some remedies against those unpleasant agonies of pain. Many laboratories around the world are investigating to develop new drugs from those bacteria. Surprisingly, great achievements were made in the countries where traditional folk medicine was flourished in old days. This fact suggests that the ancestors in those countries were very wise even though they did not have any scientific information. Because Korea had such wise ancestors, it is the right time for us to evaluate the nutraceuticals accurately.

Role of Nutraceuticals in Obesity Management: A Mechanism and Prospective Supported by Molecular Docking Studies

Abdel Nasser B. Singab,Esraa A. Elhawary,Yasmin A. Elkhawas,Iten M. Fawzy,Ashaimaa Y. Moussa,Nada M. Mostafa 한국식품영양과학회 2024 Journal of medicinal food Vol.27 No.2

Obesity and its comorbidities represent a major health problem worldwide. Treatment by reducing food intakeand physical activity interventions has limited success especially with elderly people with chronic diseases. Nutraceuticals arenaturally originated and successfully used for their physiological and nutritional benefit in health care. They might bealternative means to help lose weight and reduce obesity-associated metabolic disorders with the improvement of health, delaythe aging process, prevention of chronic diseases, increase of life expectancy, or support to the structure or function of thebody. The current study enumerates the inherent role of nutraceuticals in the management of obesity and its related comorbidities. The study is supported with the molecular docking studies discussing the mechanism of action. An attempt tooptimize the role of nutraceuticals is made in this article in addition to widen the scope of its use in this chronic worldwidedisease.

Testing the Short-Term Efficacy of a Lipid-Lowering Nutraceutical in the Setting of Clinical Practice: A Multicenter Study

Arrigo F.G. Cicero,Giuseppe Derosa,Livia Pisciotta,Carlo Barbagallo 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.11

The main guidelines for cardiovascular disease prevention suggest that nutraceuticals could be an efficacious tool to improve lipid pattern. Our aim was to carry out a clinical trial comparing the metabolic effects of a combined nutraceutical containing both red yeast rice and polyunsaturated fatty acids (PUFAs) and a phytosterol-based approach in a setting of clinical practice. This was a multicenter open study with parallel control. We consecutively enrolled 107 pharmacologically untreated subjects affected by primary polygenic hypercholesterolemia and metabolic syndrome, assigned to 8-week treatment with a combined treatment with red yeast rice (Dif1Stat®, including 5mg monacolin K) and 610mg PUFAs. A parallel group of 30 subjects with similar characteristics was treated with phytosterols 1600mg/die. In the combined nutraceutical group, compared with the baseline level, we observed a significant decrease in total cholesterol (TC; -42.50 ± 18.1mg/dL), low-density lipoprotein cholesterol (LDL-C; -37.6 ± 13.6mg/dL), triglycerides (TG; -19.8 ± 25.1mg/dL), and non-HDL-C (-43.1 ± 17.7mg/dL) (all P < .001). In the phytosterol-treated group, compared to the baseline level, we observed a significant decrease in TC (-13.7 ± 4.3mg/dL), LDL-C (-17.6 ± 8.5mg/dL), and non-HDL-C (-14.1 ± 5.6mg/dL) (all P< .001). When comparing the combined nutraceutical effect with that of phytosterols, we observed that the combined nutraceutical intake was associated with a significantly higher decrease in TC, LDL-C, TG, and non-HDL-C (all P < .001). In the short term, a combined nutraceutical containing red yeast rice and PUFAs is well tolerated and efficacious in reducing plasma lipid levels in subjects affected by primary polygenic hypercholesterolemia and metabolic syndrome.

Enhanced Production of δ-Aminolevulinic Acid, Bilipigments, and Antioxidants from Tropical Algae of India

Usha Pandey1,Jitendra Pandey 한국생물공학회 2009 Biotechnology and Bioprocess Engineering Vol.14 No.3

We studied the enhanced production of high quality biomass, δ-aminolevulinic acid (δ-ALA), bilipigments, and antioxidants from five tropical blue green algae (cyanobacteria) in a full factorial design using free and immobilized cells in batch culture. Production of nutraceuticals was high in spray dried powder prepared from immobilized cell cultures. Notochopsis lobatus showed superiority over rest of the species with respect to bilipigments, δ-ALA, nutritive value, antioxidant capacity, and ascorbate oxidase (APX) activity. Antioxidative capacity of phycobiliproteins extracted from these cyanobacteria (121.15 μM TE/g, Nostoc verrucosum to 217.62 μM TE/g, Nostochopsis lobatus) was invariably higher than those observed for higher plant sources and substantially increased under immobilized cell culture condition. Antioxidative enzyme, ascorbate oxidase remained stable in dry food preparations with considerably high activity under immobilized cell preparations (APXmax, 3.40 μmol/min/mg chlorophyll). These observations have important connotations in light of upcoming food and nutraceutical industries in the global market. Use of immobilized cells in batch culture could be an effective approach for scaling up production for commercial use We studied the enhanced production of high quality biomass, δ-aminolevulinic acid (δ-ALA), bilipigments, and antioxidants from five tropical blue green algae (cyanobacteria) in a full factorial design using free and immobilized cells in batch culture. Production of nutraceuticals was high in spray dried powder prepared from immobilized cell cultures. Notochopsis lobatus showed superiority over rest of the species with respect to bilipigments, δ-ALA, nutritive value, antioxidant capacity, and ascorbate oxidase (APX) activity. Antioxidative capacity of phycobiliproteins extracted from these cyanobacteria (121.15 μM TE/g, Nostoc verrucosum to 217.62 μM TE/g, Nostochopsis lobatus) was invariably higher than those observed for higher plant sources and substantially increased under immobilized cell culture condition. Antioxidative enzyme, ascorbate oxidase remained stable in dry food preparations with considerably high activity under immobilized cell preparations (APXmax, 3.40 μmol/min/mg chlorophyll). These observations have important connotations in light of upcoming food and nutraceutical industries in the global market. Use of immobilized cells in batch culture could be an effective approach for scaling up production for commercial use

식이성이 향상된 변종옥수수의 기능성물질 탐색 : 단백질과 펩티드 Study on Proteins and Peptides

김기혁 우송대학교 2004 우송대학교 논문집 Vol.9 No.-

Super-sweet corn variants were examined to investigate the possible source of physiologically active proteins or peptides. Protein patterns and fatty-acid composition showed that the variants are clearly different from it's original strain in total protein band mobility carried out on SDS-PAGE experiment and in the relative amount of fatty acids (C_(16:0), C_(18:0), C_(18:1), C_(18:2), C_(18:3)). It is noticeable that the variant corn species have less linoleic and linolenic acids. Hence the improved corn strains may be used to produce more stable corn-oil during long-term storage. Alkalase appeared to be a good candidate to solubilize corn proteins, producing readily soluble protein/peptide ingredients into water-based drinks or food. More study will identify nutraceuticals from peptide hydrolyzates.

Nutritional Interventions Using Functional Foods and Nutraceuticals to Improve Inflammatory Bowel Disease

Dong Wook Shin,Beong Ou Lim 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.11

The gastrointestinal tract, the second largest organ in the body, plays an important role in nutrient and mineral intake through the intestinal barrier. Dysfunction of intestinal permeability and related disorders commonly occur in patients with inflammatory bowel disease (IBD), one of the health problems in the Western societies that are considered to be mainly due to the Western diet. Although the exact etiology of IBD has not been elucidated, environmental and genetic factors may be involved in its pathogenesis. Many synthetic or biological drugs, such as 5-aminosalicylic acid corticosteroids as anti-inflammatory drugs, have been used clinically to treat IBD. However, their long-term use exhibits some adverse health consequences. Therefore, many researchers have devised alternative therapies to overcome this problem. Many studies have revealed that some functional nutrients in nature can relieve gastrointestinal inflammation by controlling proinflammatory cytokines. In this study, we review the ability of functional nutraceuticals such as phytochemicals, fatty acids, and bioactive peptides in improving IBD by regulating its underlying pathogenic mechanisms.