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Nanovesicle-based bioelectronic nose platform mimicking human olfactory signal transduction
Jin, Hye Jun,Lee, Sang Hun,Kim, Tae Hyun,Park, Juhun,Song, Hyun Seok,Park, Tai Hyun,Hong, Seunghun Elsevier Applied Science 2012 Biosensors & bioelectronics Vol.35 No.1
<P><B>Abstract</B></P> <P>We developed a nanovesicle-based bioelectronic nose (NBN) that could recognize a specific odorant and mimic the receptor-mediated signal transmission of human olfactory systems. To build an NBN, we combined a single-walled carbon nanotube-based field effect transistor with cell-derived nanovesicles containing human olfactory receptors and calcium ion signal pathways. Importantly, the NBN took advantages of cell signal pathways for sensing signal amplification, enabling ∼100 times better sensitivity than that of previous bioelectronic noses based on only olfactory receptor protein and carbon nanotube transistors. The NBN sensors exhibited a human-like selectivity with single-carbon-atomic resolution and a high sensitivity of 1fM detection limit. Moreover, this sensor platform could mimic a receptor-meditated cellular signal transmission in live cells. This sensor platform can be utilized for the study of molecular recognition and biological processes occurring at cell membranes and also for various practical applications such as food screening and medical diagnostics.</P> <P><B>Highlights</B></P> <P>▸ Nanovesicles containing hOR2AG1 derived from HEK-293 cells as sensing elements. ▸ CNT-based sensor transducers were functionalized with nanovesicles. <I>▸</I> Nanovesicle-based bioelectronic nose exhibited the <I>human-like detection</I> of amylbutyrate. ▸ Nanovesicle-based bioelectronic nose could mimic the receptor-mediated signal pathway of human olfactory systems.</P>
Topological Study of the Behavior of Inorganic Fine Powers and a Nanovesicle Hybridized Coating
서동성,김동표,Fan-Long Jin,박수진 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.2
In this study, the surface of inorganic fine powders is hybridized with nanovesicles containing tocopheryl acetate prepared with hydrogenated lecithin via a coating process. From AFM and SEM analyses it is found that the surface of the nanovesicle-coated fine powders lost their traditional topology and improved in terms of their roughness, skewness, and kurtosis. In addition, TEM observations revealed the formation of a 5 nm thick coating layer on the surface of the fine powders. These hybridized powders, in which bioactive materials such as tocopheryl acetate can be embedded, can be employed as a part of a drug delivery system due to their special ability to control release rate and temperature selectivity. Physical properties of the powders, i.e., the different angle and friction coefficient, were excellent.
Topological Study of the Behavior of Inorganic Fine Powers and a Nanovesicle Hybridized Coating
Seo, Dong-Sung,Kim, Dong-Pyo,Jin, Fan-Long,Park, Soo-Jin Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.2
In this study, the surface of inorganic fine powders is hybridized with nanovesicles containing tocopheryl acetate prepared with hydrogenated lecithin via a coating process. From AFM and SEM analyses it is found that the surface of the nanovesicle-coated fine powders lost their traditional topology and improved in terms of their roughness, skewness, and kurtosis. In addition, TEM observations revealed the formation of a 5 nm thick coating layer on the surface of the fine powders. These hybridized powders, in which bioactive materials such as tocopheryl acetate can be embedded, can be employed as a part of a drug delivery system due to their special ability to control release rate and temperature selectivity. Physical properties of the powders, i.e., the different angle and friction coefficient, were excellent.
Ahn, Jung Ho,Lim, Jong Hyun,Park, Juhun,Oh, Eun Hae,Son, Manki,Hong, Seunghun,Park, Tai Hyun Elsevier 2015 Sensors and actuators. B Chemical Vol.210 No.-
<P><B>Abstract</B></P> <P>We herein report an integrated olfactory system to carbon nanotube platforms for biosensing applications. In particular, this system can be used for the real-time monitoring of fungal contamination in grain through detecting 1-octen-3-ol, which is specifically generated from contaminated grain. A specific human olfactory receptor (OR) that recognizes 1-octen-3-ol was found using a cyclic adenosine monophosphate (cAMP) response element (CRE)-reporter gene assay. Then, OR-containing nanovesicles were produced from human embryonic kidney (HEK)-293 cells. The nanovesicles, which generate olfactory signals using endogenous cellular components and over-expressed ORs, were integrated into single-walled carbon nanotubes field-effect transistors (SWNT-FETs). The nanovesicles and SWNT-FETs play roles in perceiving specific odorants, and in amplifying cellular signals, respectively. Thus, the nanovesicle-integrated device was able to detect 1-octen-3-ol with excellent sensitivity and selectivity, similar to the original olfactory system. This system can be effectively utilized for the real-time measurement of fungal contamination in grain.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A bioelectronic nose that detects an indicator of fungal contamination in grain was developed. </LI> <LI> A specific olfactory receptor reacting to the indicator was determined. </LI> <LI> The sensor detected the indicator with high sensitivity and selectivity. </LI> <LI> The sensor can be used for the detection of fungal contamination in grain at an early stage. </LI> </UL> </P>
Ahn, Sae Ryun,An, Ji Hyun,Song, Hyun Seok,Park, Jin Wook,Lee, Sang Hun,Kim, Jae Hyun,Jang, Jyongsik,Park, Tai Hyun American Chemical Society 2016 ACS NANO Vol.10 No.8
<P>For several decades, significant efforts have been made in developing artificial taste sensors to recognize the five basic tastes. So far, the well-established taste sensor is an E-tongue, which is constructed with polymer and lipid membranes. However, the previous artificial taste sensors have limitations in various food, beverage, and cosmetic industries because of their failure to mimic human taste reception. There are many interactions between tastants. Therefore, detecting the interactions in a multiplexing system is required. Herein, we developed a duplex bioelectronic tongue (DBT) based on graphene field-effect transistors that were functionalized with heterodimeric human umami taste and sweet taste receptor nanovesicles. Two types of nanovesicles, which have human T1R1/T1R3 for the umami taste and human T1R2/T1R3 for the sweet taste on their membranes, immobilized on micropatterned graphene surfaces were used for the simultaneous detection of the umami and sweet tastants. The DBT platform led to highly sensitive and selective recognition of target tastants at low concentrations (ca. 100 nM). Moreover, our DBT was able to detect the enhancing effect of taste enhancers as in a human taste sensory system. This technique can be a useful tool for the detection of tastes instead of sensory evaluation and development of new artificial tastants in the food and beverage industry.</P>
Song, Hyun Seok,Jin, Hye Jun,Ahn, Sae Ryun,Kim, Daesan,Lee, Sang Hun,Kim, Un-Kyung,Simons, Christopher T.,Hong, Seunghun,Park, Tai Hyun American Chemical Society 2014 ACS NANO Vol.8 No.10
<P>The sense of taste helps humans to obtain information and form a picture of the world by recognizing chemicals in their environments. Over the past decade, large advances have been made in understanding the mechanisms of taste detection and mimicking its capability using artificial sensor devices. However, the detection capability of previous artificial taste sensors has been far inferior to that of animal tongues, in terms of its sensitivity and selectivity. Herein, we developed a bioelectronic tongue using heterodimeric human sweet taste receptors for the detection and discrimination of sweeteners with human-like performance, where single-walled carbon nanotube field-effect transistors were functionalized with nanovesicles containing human sweet taste receptors and used to detect the binding of sweeteners to the taste receptors. The receptors are heterodimeric G-protein-coupled receptors (GPCRs) composed of human taste receptor type 1 member 2 (hTAS1R2) and human taste receptor type 1 member 3 (hTAS1R3), which have multiple binding sites and allow a human tongue-like broad selectivity for the detection of sweeteners. This nanovesicle-based bioelectronic tongue can be a powerful tool for the detection of sweeteners as an alternative to labor-intensive and time-consuming cell-based assays and the sensory evaluation panels used in the food and beverage industry. Furthermore, this study also allows the artificial sensor to exam the functional activity of dimeric GPCRs.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2014/ancac3.2014.8.issue-10/nn502926x/production/images/medium/nn-2014-02926x_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn502926x'>ACS Electronic Supporting Info</A></P>
Near infrared laser-induced drug release of thermoresponsive nanovesicles containing melanin
김예슬,김미리,이창문 한국공업화학회 2018 한국공업화학회 연구논문 초록집 Vol.2018 No.0
We suggest thermoresponsive nanovesicles for inducing drug release behavior by photothermal effect using near infrared (NIR) laser. The nanovesicle is composed of phospholipids and poly-(N-isopropylacrylamide-co-acrylamide) (PNIPAM). Melanin as a photo-heat conversion material was added. Nanovesicles had the mean diameter 177±14 nm. After NIR 808 nm laser irradiation at 1.5 W/㎠ for 7 min, the temperature of nanovesicle solution has increased from 20.5°C to 51°C and observed excellent photothermal effect of melanin. In drug release study, after the laser irradiation, 5-fluorouracil loaded into the nanovesicles showed the faster drug release behavior than the group not irradiated with the laser. Furthermore, as the amount of PNIPAM increased, the rate of drug release increased more rapidly. Consequently, the nanovesicles are useful as a drug delivery carrier for inducing and drug release behavior by NIR laser irradiation.
강정이,김슬기,조중현,김진웅 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
Recent technology pays attention to exosomes, nanovesicles released from cells, since they provide a practical means of intercellular communication and transmission of macromolecules between cells. In this study, we propose an exosome-analogous drug delivery system which is established by using lipid/polymer hybrid vesicles with fusogenic peptide conjugates. Thanks to large size and slow dynamics of amphiphilic triblock copolymers at the bilayer membrane, the hybrid vesicles show long-circulating time and high drug loading efficiency. To evaluate the binding affinity of peptide conjugatedhybrid nanovesicles, the interaction force between an exosome and a cell is characterized via microscale thermophoresis. Finally, in vitro cell-penetration study demonstrates the practical applicability as a cell delivery nanocarrier system.