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영지버석(Ganoderma lucidum) 생장점으로부터 분리한 단백다당류의 면역활성
정경수(Kyeong Soo Chung),김상범(Sang Bum Kim),정수현(Soo Hyun Chung) 대한약학회 1997 약학회지 Vol.41 No.1
Two protein-polysaccharide fractions, GLA and GLB, respectively, were prepared from the pileus of the fully grown carpophores and the tips of the growing carpophores of Ganoderma lucidum. At a dose of 100mg/kg/day ip, GLA and GLB inhibited the growth of sarcoma 180 solid tumor in ICR mice by 56.3% and 81.8%, respectively. In a flow cytometric (FCM) analysis, GLA and GLB enhanced the formation of lymphoblasts of BALB/c, splenic leukocytes at a concentration of 100 mcg/ml, by 38.3% and 61, 3%, respectively. When ip injected into ICR mice, GLB exerted anti-leukopenic effect against cyclophospamide (75mg/kg, ip) in that the leukocyte counts of the peripheral blood of the normal and the cyclophosphamide-treated mice. respectively. was (11.1 +/- 3.8) x 103 and (4.0 +/- 1.8) x 103, while the GLB-cyclophosphamide treated mice showed a leukocyte count of (10.8 +/- 5.1) x 103 CELLS/mcl. These results suggest that GLB is a promising candidate for an effective, cancer immunotherapeutic agent.
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영지버섯(Ganoderma Iucidum) 생장점으로부터 분리한 단백다당류의 면역활성
정경수,김상범,정수현 충남대학교 약학대학 의약품개발연구소 1997 藥學論文集 Vol.13 No.-
Two protein-polysaccharide fractions. GLA and GLB, respectively, were prepared from the pileus of the fully grown carpophores and the tips of the growing carpophores of Ganoderma lucidum. At a dose of 100 ㎎/㎏/day ip. GLA and GLB inhibited the growth of sarcoma 180 solid tumor in ICR mice by 56.3% and 81.8%, respectively. In a flow cytometric (FCM) analysis. GLA and GLB enhanced the formation of lymphoblasts of BALB.c splenic leukocytes at a concentration of 100㎍/㎖, by 38.3% and 61.3%, respectively. When ip injected into ICR mice. GLB exerted anti-leukopernic effect against cyclopospamide (75 ㎎/㎏/day ip) in that the leukocyte counts of the peripheral blood of the normal and the cycloposphamide-treated mice, respectively, was (11.1±3.8)×10 exp(3) and (4.0±1.8)×10 exp(3), while the GLB-cyclophosphamide treated mice showed a leukocyte count of (10.8±5.1)×10 exp(3) cells/㎕. These results suggest that GLB is a promising candidate for an effective cancer immunotherapeutic agent.
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영지버섯 생장점 단백다당체 GLB-A, GLB-B 의 항암효과 및 면역 활성에 관한 유세포 분석학적 연구
오정연(Jung Yeon Oh),정경수(Kyeong Soo Chung) 대한약학회 1998 약학회지 Vol.42 No.5
In the previous study we described the antitumor effect of GLB, a protein-polysaccharide fraction separated from the growing tips of Ganoderma lucidum, against sarcoma 180 solid tumor in ICR mice. In this study, we separated an acidic protein-polysaccharide fraction, GLB-A, and a basic protein-polyaccharide fraction, GLB-B, from GLB by differential precipitation, and elucidated their antitumor and immunomodulatory activities. When ip injected at the dose of 50mg/kg/day into the ICR mice, GLB-A and GLB-B inhibited the growth of ip implantated sarcoma 180 cells by 32.4% and 21.0%, respectively. Of these, GLB-A increased the % lymphoblast in the spleen of the tumor-bearing and the normal mice by 20.9% and 123.0%, and the CD4/CD8 ratio by 73.3% and 22.4%, respectively. GLB-A also increased the expression of CD25 (IL-2 receptor alpha ch0ain) in normal mice by 82.0%. These results strongly suggest that GLB-A is a promising candidate for antitumor immunomodulatory medicine.
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영지버섯 생장점 단백다당체 GLB-A, GLB-B의 항암효과 및 면역 활성에 관한 유세포 분석학적 연구
오정연,정경수 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-
In the previous study we described the antitumor effect of GLB, a protein-polysaccharide fraction separated from the growing tips of Ganoderma lucidum, against sarcoma 180 solid tumor in ICR mice. In this study, we separated an acidic protein-polysaccharide fraction. GLB-A, and a basic protein-polysaccharide fraction. GLB-B, from GLB by differential precipitation, and elucidated their antitumor and immunomodulatory activities. When ip injected at the dose of 50 ㎎/㎏/day into the ICR mice. GLB-A and GLB-B inhibited the growth of ip implantated sarcoma 180 cells by 32.4% and 21.0%, respectively. Of these, GLB-A increased the % lymphoblast in the spleen of the tumor-bearing and the mormal mice by 20.9% and 123.0%, and the CD4/CD8 ratio by 73.3% and 22.4%, respectively. GLB-A also increased the expression of CD25 (IL-2 receptor α chain) in normal mice by 82.0%. These results strongly suggest that GLB-A is a promising candidate for antiumor immunomodulatory medicine.
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