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- 검색키워드
- 주제어 : herbal honey (검색결과 3 건)
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Chen Xiuxian,Wang Shuai,Xu Yingying,Gong Hongri,Wu Yuqi,Chen Yanping,Hu Fuliang,Zheng Huoqing 한국응용곤충학회 2021 Journal of Asia-Pacific Entomology Vol.24 No.1
Nosema ceranae, a newly emergent parasite invading western honey bees (Apis mellifera L.), is indicated to threaten honey bee health at both individual and colony levels. However, the efficient and environmentallyfriendly treatments are quite limited at present. To find alternative medicine to control Nosema diseases, the effect of 8 types of herbal extracts against N. ceranae infection were screened under laboratory condition. Of which, 1% Andrographis paniculata (A. paniculata) decoction was found to significantly decrease N. ceranae spore numbers on 7 days post infection (dpi) and 13 dpi. Then, our results further revealed that A. paniculata decoction at doses ranging from 1% to 7% displayed significant efficient inhibition of Nosema spore proliferation and improved the infected bees’ survival rates in a dose-dependent manner. A. paniculata decoction was found to protect the gut tissues of infected workers from damage cause by N. ceranae, which might be due to the regu lation of the expression of certain genes in Wnt and JNK pathways, including armadillo, basket, frizzled2 and groucho. Additionally, our study suggested that A. paniculata decoction performed this Nosema spore-reducing potential over its two monomers, andrographolide and dehydrographolide. Taken together, this work enables us to better understand A. paniculata decoction’s potential to inhibit N. ceranae infection, thus providing a new guidance for developing applicable drugs to control Nosema diseases.
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김원석 ( Won Seok Kim ),최창용 ( Chang Yong Choi ),장미경 ( Mi Kyeong Jang ),나재운 ( Jae Woon Nah ) 한국키틴키토산학회 2011 한국키틴키토산학회지 Vol.16 No.2
Chitosan is an attractive biomaterial for wound care because of its biocompatibility and intrinsic hemostatic and antimicrobial properties. Honey has been used since ancient times for the treatment of some respiratory diseases and for the healing of skin wounds. In this study, we investigated the effect of mixture of oligochitosan and herbal honey(chito/H) on atopic dermatitis treatment. The effect of chito/H was analyzed by clinical skin features of atopic dermatitis skin lesions, measuring the serum lgE, and investigated skin surface using an optical microscope. The scores of skin symptom level and the serum IgE were decreased after treatment with chito/H compared with durg as a control group. These results suggest that the chito/H may be an alternative substance for the treatment of atopic dermatitis.
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최창용,나재운,김원석,박영훈,박성철,장미경 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.2
Atopic dermatitis (AD) is a chronic inflammatory skin disease that was influenced by complexinteractions via genetic, environmental, immunologic, and biochemical factors, though the cause of AD isstill unknown. It characterized by elevated serum immunoglobulin E (IgE) levels, immunologicalabnormalities, and eosinophilia in the tissues and peripheral blood. In the present study, we applied anantimicrobial moisturizing cream containing low-molecular weight water-soluble chitosan and herbalhoney (AMCH) to remedy AD-like lesions. The inhibiting effect of AMCH on NC/Nga mice, that AD-likelesion was induced by 1-chloro-2,4-dinitrobenzene (DNCB), was evaluated by examining sensoryevaluation scores, scratching behavior, immune cells in blood, serum IgE level, infiltration of mast cells,and skin histology. The total sensory evaluation scores, scratching behavior, the level of serum IgE,interlukin-4 (IL-4), and IL-12 in AD mouse model were significantly reduced by AMCH. Moreover, itssuppressing effect resulted in decreased mast cell infiltration. Our results suggest that AMCH might bebeneficial as a potent agent for treatment of AD-like lesion.
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