전립선암을 유발시킨 누드 마우스에서 고단백식 및 성장호르몬이 종양의 성장과 체중의 변화에 미치는 영향

장석흔,우영남,권성원 大韓泌尿器科學會 1999 Korean Journal of Urology Vol.40 No.11

Impaired Cortisol and Growth Hormone Counterregulatory Responses among Severe Hypoglycemic Patients with Type 2 Diabetes Mellitus

유영아,장주영,박수연,안지현,김동림,김숙경,송기호 대한내분비학회 2019 Endocrinology and metabolism Vol.34 No.2

Background: Elevated levels of cortisol and growth hormone are critical counterregulatory responses to severe hypoglycemia. However, the proportion and clinical characteristics of patients with type 2 diabetes mellitus (DM) who fail to show appropriate cortisol and/or growth hormone secretion in response to severe hypoglycemia have not been investigated. Methods: We measured plasma cortisol and growth hormone levels in type 2 DM patients with severe hypoglycemia who visitedthe emergency department between 2006 and 2015. Results: Of 112 hypoglycemic patients, 23 (20.5%) had an impaired cortisol response (<18 μg/dL) and 82 patients (73.2%) had animpaired growth hormone response (<5 ng/mL). Nineteen patients (17.0%) had impaired responses to both cortisol and growth hormone. The patients with impaired responses of cortisol, growth hormone, and both hormones were significantly older and more likely to be female, and had higher admission rates, lower growth hormone levels, and lower adrenocorticotropic hormone levels thanthe patients with a normal hormonal response. Multivariate logistic regression analysis indicated that an impaired growth hormoneresponse was significantly associated with advanced age, shorter DM duration, a higher admission rate, and a higher body mass index (BMI). An impaired cortisol response was significantly associated with growth hormone levels. Patients with an impairedgrowth hormone response had higher admission rates than patients with a normal response. Conclusion: A considerable number of type 2 DM patients had impaired cortisol and/or growth hormone responses to severe hypoglycemia. Advanced age, shorter DM duration, and higher BMI were independently associated with an abnormal growth hormoneresponse.

성장호르몬 결핍증과 특발성 저신장증 환아에서 성장호르몬의 치료 효과

강정철,최윤석,최인경,김호성,김덕희 대한소아과학회 2004 小兒科 Vol.47 No.3

성장호르몬 결핍증에 의한 발기부전

최만수,남현종,강양호,하홍구,방성익,박남철,김영진,박현준 대한남성과학회 2008 The World Journal of Men's Health Vol.26 No.4

Growth hormone deficiency is the medical condition of inadequate production of growth hormone. Growth hormone deficiency in adults is not common, but it may feature a diminished, lean body mass, poor bone density and a number of physical and psychological symptoms, including poor memory, social withdrawal and even depression. Abnormally low growth hormone levels in adults typically result in a diminished quality of life and it can even be disabling. The physical symptoms include loss of strength, stamina, and musculature. Growth hormone deficiency can also impair the biological and physiological/functional substrate of penile erection, which can be, at least in part, restored by the normalization of the plasma levels of growth hormone. This is a report on a 63-year-old man who suffered with severe erectile dysfunction and loss of libido due to growth hormone deficiency. Upon growth hormone administration, his erectile function improved dramatically.

Efficacy and Safety of Sustained-Release Recombinant Human Growth Hormone in Korean Adults with Growth Hormone Deficiency

김영숙,이은직,홍재원,정윤석,김성운,조용욱,김진화,김병준 연세대학교의과대학 2014 Yonsei medical journal Vol.55 No.4

Purpose: The administration of recombinant human growth hormone in adults with growth hormone deficiency has been known to improve metabolic impairment and quality of life. Patients, however, have to tolerate daily injections of growth hormone. The efficacy, safety, and compliance of weekly administered sustained-release recombinant human growth hormone (SR-rhGH, DeclageTM) supplement in patients with growth hormone deficiency were evaluated. Materials and Methods: This trialis 12-week prospective, single-arm, open-label trial. Men and women aged ≥20 years with diagnosed growth hormone deficiency (caused by pituitary tumor, trauma and other pituitary diseases) were eligible for this study. Each subject was given 2 mg (6 IU) of SR-rhGH once a week, subcutaneously for 12 weeks. Efficacy and safety at baseline and within 30 days after the 12th injection were assessed and compared. Score of Assessment of Growth Hormone Deficiency in Adults (AGHDA score) for quality of life and serum IGF-1 level. Results: The IGF-1 level of 108.67±74.03 ng/mL was increased to 129.01±68.37 ng/mL (p=0.0111) and the AGHDA QoL score was decreased from 9.80±6.51 to 7.55±5.76 (p<0.0001) at week 12 compared with those at baseline. Adverse events included pain, swelling, erythema, and warmth sensation at the administration site, but many adverse events gradually disappeared during the investigation. Conclusion: Weekly administered SR-rhGH for 12 weeks effectively increased IGF-1 level and improved the quality of life in patients with GH deficiency without serious adverse events.

Mechanism of Growth Hormone Action : Recent Developments - A Review

Sodhi, R.,Rajput, Y.S. Asian Australasian Association of Animal Productio 2001 Animal Bioscience Vol.14 No.12

The interaction of growth hormone with it's receptor results in dimerization of receptor, a feature known in action of certain cytokines. The interaction results in generation of number of signalling molecules. The involvement of Janus kinases, mitogen activated kinases, signal transduction and activator of transcription proteins, insulin like substrate, phosphatidylinositol 3-kinase, phospholipase C, protein kinase C is almost established in growth hormone action. There are still many missing links in explaining diversified activities of growth hormone. Amino acid sequence data for growth hormones and growth hormone receptors from a number of species have proved useful in understanding species specific effects of growth hormone. Complete understanding of growth hormone action can have implications in designing drugs for obtaining desired effects of growth hormone.

The Effect of Human Growth Hormone on Thyroid Function in Normal Children

Kim, So Young,Lee, Byung Churl CATHOLIC MEDICAL CENTER 1993 Bulletin of the Clinical Research Institute Vol.21 No.1

Administration of human growth hormone to normal man and growth hormone deficient patients yield conflicting results concerning its impact on thyroid function. Most studies have casuistic or uncontrolled and have used pituitary derived growth hormone of varying purity, of ten contaminated with thyroid stimulating hormone. The aim of the present study was to evaluate the effects of recombinant human growth hormone on thyroid function in normal children. All 15 normal variant short stature children with aged 4.5-10.3 year had normal serum level of growth hormone and were taking no medications at the time of study. All children received recombinant human growth hormone in a dose of 0.25 IU/kg/day, subcutaneously for 5 days. Blood samples were obtained before the first injection and 24 hours after last injection of growth hormone, and serum was frozen at -20℃ for later analysis. Serum T_4, free T_4, T_3, reverse T_3, TSH and IGF-I concentration were measured by a radioimmunoassay. 1. The mean serum T_4 concentration decreased significantly from 9.28±0.55 ㎍/dl to 7.66±0.38 ㎍/dl. 2. The mean serum free T_4 concentration decreased significantly from 1.46±0.08 ng/dl to 1.21±0.07 ng/dl. 3. The mean serum T_3 concentration increased significantly from 1.46±0.06 ng/ml to 1.88±0.10 ng/ml. 4. The T_3 to T_4 ratio increased significantly from 16.3±0.9 to 25.3±1.8. 5. The mean serum reverse T_3 concentration was not changed siginificantly. 6. The mean serum TSH concentration decreased siginificantly from 2.13±0.21 μIU/ml to 1.50±0.14 μIU/ml. 7. The mean serum IGE-I concentration increased significantly from 165±30 ng/ml to 349±47 ng/ml. In conclusion, our data suggest growth hormone enhance the peripheral conversion of T_4 to T_3 and compensatory decrease in TSH secretion.

소의 theileriosis가 성장 hormone과 insulin-like growth factor-I에 미치는 영향

백병걸,변선윤,이존화,이호일,Baek, Byeong-kirl,Byoun, Sun-youn,Lee, John-wha,Lee, Ho-ill 대한수의학회 1997 대한수의학회지 Vol.37 No.2

Bovine theileriosis caused by Theileria sergenti is the tick-borne intraery- throcytic piroplasmosis, that occurs in most regions of Korea. It results in severe economic losses on a farm caused by anemia, milk production loss, abortion and death. This study was undertaken to confirm the effects of the growth hormone and the insulin-like growth factor-I which are associated in the growth of cattle infected by T sergenti. The blood of one hundred and twenty ten-month Holstein was collected and the prepared blood smear was stained with acridine orange to investigate their parasitemia. And the hematological profiles were observed. According to the value of the hematocrit, they were categorized into four groups : Group 1 was under 20 percent, groups 2 and 3 were from over 21 to under 30 percent and from over 31 to under 35 percent and group 4 was over 36 percent. As the value of the hematocrit decreased, parasitemia(%) in erythrocytes was observed to increase(Y=-1.064X + 30.537, r=0.660). The amounts of the growth hormone and the insulin-like growth factor-I in the serum were measured by the radioimmunoassay. The growth hormone in serum of the group 1, group 2, group 3 and group 4 were observed as $0.238{\pm}0.043nmol/l$, $0.21{\pm}0.024nmol/l$, $0.366{\pm}0.035nmol/l$ and $0.646{\pm}0.223nmol/l$, respectively. The quantitative of the insulin-like growth factor-I in the same groups were observed also as $209.686{\pm}18.94ng/ml$, $250.9{\pm}12.609ng/ml$, $279.3{\pm}8.883ng/ml$ and $365.9{\pm}22.45ng/ml$, respectively. It can be concluded that the growth hormone and the insulin-like growth factor-I were observed to decrease in severe anemia due to theileriosis.

성장호르몬 치료를 받고 있는 아동에게 수직점프운동 적용이 신장, 다리길이, 체질량지수에 미치는 효과

이정훈,안창식 한국신경근육물리치료학회 2023 한국신경근육재활학회지 Vol.13 No.2

This study aims to examine additional growth promoting effect of Vertical jump training in children with Growth hormone deficiency (GHD) during Growth hormone (GH) therapy. In this study, 22 children participated ,and all of them were diagnosed with GHD and receiving GH treatment. They randomly assigned to the experiential group (n=11) and the control group (n=11). The experimental group received Vertical jump training sessions along with GH therapy secretion, and the control group were given GH therapy only. GH therapy was provided for both groups once a day, 6times a week for 12 weeks. The participants in the experimental group were instructed to perform three different vertical jump sessions (4 weeks per session). After 12 weeks of the intervention exercise program, the average value of height and body mass index (BMI) of all participants were measured to examine the significant difference between the two groups. First, the vertical jump exercise group showed a significant increase in the height compared to the control group(p<0.05). Second, the vertical jump exercise group showed a significant increase in the leg length compared to the control group(p<0.05). Third, there was no significant difference in body mass index between the two groups(p>0.05). The findings of this study suggest that vertical jump performance in children being treated with growth hormone therapy may improve additional height growth. Therefore, vertical jump training as a component of the growth hormone therapy plan may play an important role to stimulate growth in children when used with GH secretion.

성장호르몬이 단구 세포주 THP-1과 U937의 활성에 미치는 영향 평가

문철,유성률,김시현,성현경 한국보건기초의학회 2022 한국보건기초의학회지 Vol.15 No.2

Growth hormone (GH) is a peptide hormone secreted by the pituitary gland and stimulates cell proliferation and division to promote tissue growth. In addition, the development of the immune system and the regulation of the immune response have been reported. Along with the research results related to the inflammatory control function, a correlation between the severe symptoms of COVID-19 in the elderly and a decrease in the secretion of growth hormone has recently been suggested. Therefore, this research team studied the effect of growth hormone on the proliferation and inflammatory cytokine secretion of monocyte cell lines THP-1 and U937. As a result, it was confirmed that the proliferation of THP-1 and the secretion of TNF-α and IL-1β induced by LPS were decreased by growth hormone. On the other hand, the proliferation of U937 cell line was increased by growth hormone treatment, whereas the secretion of TNF-α and IL-1β was hardly affected. In the future, the analysis of the GH receptors expressed by the two cell lines and the study of the molecular mechanism of GH action are required. In addition, it is considered that the cell stimulation technique using Poly(I:C) needs to be established more accurately.