컴퓨터를 이용한 속도 조절형 치과 국소마취 기구: 문헌고찰

김영진,이준형,이강희,김기덕,정복영,방난심,박원서,Kim, Young-Jin,Lee, Jun-Hyung,Lee, Kang-Hee,Kim, Kee-Deog,Jung, Bock-Young,Pang, Nan-Sim,Park, Wonse 대한치과마취과학회 2013 Journal of Dental Anesthesia and Pain Medicine Vol.13 No.4

Background: Today, there are computer controlled local anesthesia devices used clinically. The main principle is to control injection speed by computer aided system, and it relieves pain. However, there are few objective data considering this subject. In this literature review, we researched studies about computer controlled anesthetic delivery. We compared pain control effect of computer controlled to conventional local anesthetic syringe system. Methods: A bibliographic search in PubMed was performed and we reviewed original articles. Results: There were 18 publications that compared pain control effect of computer controlled to conventional system. There were 8 articles reported of children, similar pain control effect was found in 7 of them. One study showed superior pain control effect of computer controlled anesthetic delivery. For adults, 10 studies showed superior pain control effect in computer aided system. Conclusions: Computer controlled anesthetic delivery has similar or superior pain control effect compared to conventional local anesthetic syringe system. For both children and adults, computer controlled anesthetic delivery could be clinically useful, still it may be more effective for adults.

Light-switchable systems for remotely controlled drug delivery

Shim, Gayong,Ko, Seungbeom,Kim, Dongyoon,Le, Quoc-Viet,Park, Gyu Thae,Lee, Jaiwoo,Kwon, Taekhyun,Choi, Han-Gon,Kim, Young Bong,Oh, Yu-Kyoung Elsevier 2017 Journal of controlled release Vol.267 No.-

<P><B>Abstract</B></P> <P>Light-switchable systems have recently received attention as a new mode of remotely controlled drug delivery. In the past, a multitude of nanomedicine studies have sought to enhance the specificity of drug delivery to target sites by focusing on receptors overexpressed on malignant cells or environmental features of diseases sites. Despite these immense efforts, however, there are few clinically available nanomedicines. We need a paradigm shift in drug delivery. One strategy that may overcome the limitations of pathophysiology-based drug delivery is the use of remotely controlled delivery technology. Unlike pathophysiology-based active drug targeting strategies, light-switchable systems are not affected by the heterogeneity of cells, tissue types, and/or microenvironments. Instead, they are triggered by remote light (i.e., near-infrared) stimuli, which are absorbed by photoresponsive molecules or three-dimensional nanostructures. The sequential conversion of light to heat or reactive oxygen species can activate drug release and allow it to be spatio-temporally controlled. Light-switchable systems have been used to activate endosomal drug escape, modulate the release of chemical and biological drugs, and alter nanoparticle structures to control the release rates of drugs. This review will address the limitations of pathophysiology-based drug delivery systems, the current status of light-based remote-switch systems, and future directions in the application of light-switchable systems for remotely controlled drug delivery.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Pixhawk 및 엣지컴퓨팅을 이용한 목적기반 배달로봇 하이브리드 제어 기법 연구

Hisham Abdalla,Oualid Doukhi,홍대명,이덕진 제어·로봇·시스템학회 2024 제어·로봇·시스템학회 논문지 Vol.30 No.5

Delivery robots have emerged as a technology that can revolutionize the delivery process across various industries. Utilization of autonomous robots within urban environments holds great promise for transforming purpose-based delivery systems. In this study, practical system design and control techniques of purpose-based delivery robots are investigated in a real-world outdoor environment, and a lab-fabricated Bravo delivery robot is reported. The robot follows predefined waypoints while seamlessly transitioning into obstacle avoidance mode when encountering obstacles in its path by using GPS signals and a Pixhawk-based navigation module. However, when GPS is unavailable, pre-embedded visual-inertial localization, mapping techniques, and deep-learning-based object detection are used by the robot to autonomously navigate and avoid obstacles through its onboard sensors and an NVIDIA Edge computer. A model predictive control technique is programmed inside the computer for the precise path tracking and obstacle avoidance of the delivery robot. Experimental results show the adaptability and responsiveness of the Bravo robot in dynamic settings, providing valuable insights into its real-world deployment for last-mile deliveries. The proposed approach offers an architectural design and algorithms to control a delivery robot. In addition, various design aspects, including mobility systems, sensing technologies, communication systems, path planning, obstacle avoidance, and control, are discussed. Thus, an autonomous delivery robot can be implemented in urban environments.

Controlled release and targeted drug delivery with poly(lactic-co-glycolic acid) nanoparticles: reviewing two decades of research

ZEB ALAM,Gul Maleeha,Nguyen Thi-Thao-Linh,맹한주 한국약제학회 2022 Journal of Pharmaceutical Investigation Vol.52 No.6

Background Controlled release and targeted delivery of the drug payload are the two most fascinating applications of nanoparticle-based systems explored in the recent past. The advantages of achieving control over drug release kinetics include prolonged therapeutic effects, reduced dosing frequency, and fewer plasma level fluctuations and side effects, whereas targeted delivery offers enhanced drug accumulation at the site of action and reduced off-target toxicity, thereby improving the management of chronic diseases. Poly(lactic-co-glycolic acid) nanoparticles (PLGA-NPs) hold tremendous promise for such applications because of their ability to modulate drug release, pharmacokinetics, the biodistribution profiles of drugs, and the surface functionalization for targeted delivery. Area covered This review primarily highlights the applications of PLGA-NPs based on the controlled release of therapeutics after oral, parenteral, pulmonary, ocular, intranasal, and dermal administration and tissue engineering. The potential of PLGA-NPs for targeted delivery to various diseases, such as cancer, rheumatoid arthritis, inflammatory bowel disease, and neurological disorders, has also been extensively reviewed. This review concludes with a description of the limitations of PLGA-NPs and the hurdles associated with their clinical application. Expert opinion PLGA-NPs stand out among other nanoparticles because of their excellent biocompatibility and biodegradability. Although the presented data suggest that they are the major shareholders in controlled-release and targeted-delivery systems, no PLGA-NP formulation has reached clinics. Therefore, further insights into the rational design of PLGA-NPs and clinically relevant testing are required to narrow the gap between the bench and bedside realities.

외식 배달앱에서 서비스품질요인이 고객만족에 미치는 영향에서 필터링 기준의 조절효과 연구

박진영,홍경옥 한국외식산업학회 2022 한국외식산업학회지 Vol.18 No.3

This study aimed to examine the influential relationship between delivery service quality and customer satisfaction. The study also tested the moderating effect of the filtering function, which provides a criterion for selecting stores in food delivery applications in a relationship between service quality and customer satisfaction; then, it is used it as a grounds for proposing marketing plans based on the future delivery costs of the food service industry. The results of this study are summarized below. First, the effects of the five delivery service quality factors on customer satisfaction were empirically analyzed. The results indicated that food quality was the most influential factor on customer satisfaction, and system quality also had a positive impacton customer satisfaction. Safety quality, delivery/delivery person quality, and usefulness quality, however, showed no significant influence on customer satisfaction. Second, the moderating effect of a filtering function, which provides a criterion for store selection, was tested in a relationship between delivery service quality and customer satisfaction. The findings revealed that all the filtering functions, including delivery time, delivery tip, number of orders, ratings, and distance, demonstrated a positive moderating effect. As these study results prove, all filtering functions that were proposed as criteria for selecting stores showed a moderating effect on a causal relationship between delivery service quality and customer satisfaction, implying the growing importance of the filtering functions. The ordering in the list of businesses is determined by the filtering criteria that consumers choose. Considering the nature of the delivery business, where exposure to customers on the top list is directly linked to their choices, continuous and active management of the five proposed filtering criteria is absolutely necessary.

Development of Controlled Release Oral Drug Delivery System by Membrane-Coating Method-I - Preparation and pharmaceutical evaluation of controlled release acetaminophen tablets-

Shim, Chang-Koo,Kim, Ki-Man,Kim, Young-Il,Kim, Chong-Kook The Pharmaceutical Society of Korea 1990 Archives of Pharmacal Research Vol.13 No.2

In order to develop a controlled-release oral drug delivery system (DDS) which sustains the plasma acetaminophen (AAP) concentration for a certain period of time, microporous membrane-coated tablets were prepared and evaluated in vitro. Firstly, highly water-soluble core tablet of AAP were prepared with various formulations by wet granulation and compression technique. Then the core tablets were coated with polyvinychloride (PVC) in which micronized sucrose particles were dispersed. Effect of formula compositions of core tablets and coating suspensions on the pharmaceutical characteristics such as drug release kinetics and membrane stability of the coated tablets was investigated in vitro. AAP was released from the coated tablets as a zero-order rate in a pH-independent manner. This independency of AAP release to pH change from 1.2 to 7.2 is favorable for the controlled oral drug delivery, since it will produce a constant drug release in the stomach and intestine regardless of the pH change in the GI tract. Drug release could be extended upto 10 h according to the coating condition. The release rate could be controlled by changing the formula compositions of the core tablets and coating suspensions, coat weight per each tablet, and especially PVC/sucrose ratio and particle size of the sucrose in the coating suspension. The coated tablets prepared in this study had a fairly good pharmaceutical characteristics in vitro, however, overall evaluation of the coated tablet should await in vivo absorption study in man.

국제우편물에 대한 세관검사와 통제배달

전승수 한국형사판례연구회 2015 刑事判例硏究 Vol.23 No.-

In these days, transnational illicit trafficking cases in narcotic drugs like methamphetamine, marijuana as well as smuggling cases of buying illicit drugs directly from a foreign seller on the internet are increasing sharply. Customs inspection and controlled delivery are recognized to be one of the most effective tools to combat transnational drugs trafficking cases by an international mail. The 2013do7728 ruling of the Supreme Court of Korea has a meaning that it is the first ruling about the legal character of Customs inspection of an international mail and the legality of controlled delivery. In this case, the Supreme Court of Korea decided that customs inspection of an international mail without a search and seizure warrant is legal because considering the purpose of Customs Act and the procedures provided in the Act, notifications and instructions of Korea customs service, customs inspection is not a legal disposition in the criminal procedure but an administrative investigation. Controlled delivery enables the law enforcement agencies to specifically identity, arrest and prosecute not only the carriers and couriers but also the principals, organizers and financiers of such illicit activities. Under the controlled delivery system, the delivery of an international mail such as narcotic drugs is monitored closely by law enforcement officers in order to identify as many members of a trafficking network as possible and to arrest them at a point where legal proof is most readily available. And the Court decided that controlled delivery is not a seizure as a legal disposition of taking possession of a property and after the delivery, the seizure of narcotic drugs by the investigative authority with a consent of the accused is also legal.

Glycosaminoglycan-based biomaterials for growth factor and cytokine delivery: Making the right choices

Hachim, Daniel,Whittaker, Thomas E.,Kim, Hyemin,Stevens, Molly M. Elsevier 2019 Journal of controlled release Vol.313 No.-

<P><B>Abstract</B></P> <P>Controlled, localized drug delivery is a long-standing goal of medical research, realization of which could reduce the harmful side-effects of drugs and allow more effective treatment of wounds, cancers, organ damage and other diseases. This is particularly the case for protein “drugs” and other therapeutic biological cargoes, which can be challenging to deliver effectively by conventional systemic administration. However, developing biocompatible materials that can sequester large quantities of protein and release them in a sustained and controlled manner has proven challenging. Glycosaminoglycans (GAGs) represent a promising class of bio-derived materials that possess these key properties and can additionally potentially enhance the biological effects of the delivered protein. They are a diverse group of linear polysaccharides with varied functionalities and suitabilities for different cargoes. However, most investigations so far have focused on a relatively small subset of GAGs – particularly heparin, a readily available, promiscuously-binding GAG. There is emerging evidence that for many applications other GAGs are in fact more suitable for regulated and sustained delivery. In this review, we aim to illuminate the beneficial properties of various GAGs with reference to specific protein cargoes, and to provide guidelines for informed choice of GAGs for therapeutic applications.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Modified translationally controlled tumor protein-derived protein transduction domain enhances nasal delivery of exendin-4 as shown with insulin

Bae, Hae-Duck,Kim, Moonhee,Lee, Joohyun,Lee, Kyunglim TaylorFrancis 2018 Drug delivery Vol.25 No.1

<P><B>Abstract</B></P><P>Protein transduction domains (PTDs) have been shown to promote the delivery of therapeutic proteins or peptides into the living cells. In a previous study, we showed that the double mutant of TCTP-PTD 13, TCTP-PTD 13M2, was more effective in the delivery of insulin than the wild-type TCTP-PTD 13. In this study, we applied this approach to the nasal delivery of a different peptide, exendin-4, using as carriers, several modified TCTP-PTDs, such as TCTP-PTD 13M1, 13M2, and 13M3. Nasal co-administration of TCTP-PTD 13M2 with exendin-4 showed the highest exendin-4 uptake among the three analogs in normal rats, and also decreased blood glucose levels by 43.3% compared with that of exendin-4 alone and by 18.6% compared with that of exendin-4 plus TCTP-PTD 13 in diabetic mice. We also designed an additional covalently linked conjugate of TCTP-PTD 13M2 and exendin-4 and evaluated its hypoglycemic effect after subcutaneous or intranasal delivery. Subcutaneous administration of exendin-4 that its C-terminus is covalently linked to TCTP-PTD 13M2 showed hypoglycemic effect of 42.2% compared to that in untreated group, whereas intranasal delivery was not successful in diabetic mice. We conclude that a simple mixing TCTP-PTD 13M2 with peptide/protein drugs can be potentially a generally applicable approach for intranasal delivery into animals.</P>

Enhanced cytosolic drug delivery using fully biodegradable poly(amino oxalate) particles

Seong, K.,Seo, H.,Ahn, W.,Yoo, D.,Cho, S.,Khang, G.,Lee, D. Elsevier Science Publishers 2011 Journal of controlled release Vol.152 No.2

Rapid endosomal escape of drug carriers is crucial to enhancing the efficacy of their macromolecular payload, especially proteins that are susceptible to lysosomal degradation. In this paper, we report poly(amino oxalate) (PAOX) as a new protein delivery system that is capable of disrupting endosomes and mediating cytosolic drug delivery. A cationic fully-biodegradable PAOX was synthesized from a one-step reaction of oxalyl chloride, cyclohexanedimethanol and piperazinediethanol. The incorporation of tertiary amine groups in the backbone of PAOX enhanced its hydrolytic nature, which results in a fast drug release. The studies of confocal fluorescence imaging using calcein and LysoTracker Red revealed that PAOX particles disrupted endosomes via ''proton sponge'' effects and mediated the cytosolic delivery of membrane-impermeable calcein. A protein delivery efficiency of PAOX particles was evaluated using catalase as a model protein. Catalase-loaded PAOX microparticles significantly inhibited hydrogen peroxide generation in Phorbol-12-myristate-13-acetate (PMA)-stimulated macrophages, in a dose-dependent manner. Given the excellent biocompatibility and physicochemical properties, we anticipate that PAOX is a promising cytosolic protein delivery system and is useful for the treatment of acute inflammatory diseases.