http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Lishan Lv,Xiaoming Li,Genmei Liu,Ran Li,Qiliang Liu,Huifang Shen,Wei Wang,Chunyi Xue,Yongchang Cao 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.2
Infectious bronchitis virus (IBV) poses a severe threat to thepoultry industry and causes heavy economic losses worldwide. Vaccination is the most effective method of preventing infectionand controlling the spread of IBV, but currently availableinactivated and attenuated virus vaccines have somedisadvantages. We developed a chimeric virus-like particle(VLP)-based candidate vaccine for IBV protection. The chimericVLP was composed of matrix 1 protein from avian influenzaH5N1 virus and a fusion protein neuraminidase (NA)/spike 1 (S1)that was generated by fusing IBV S1 protein to the cytoplasmicand transmembrane domains of NA protein of avian influenzaH5N1 virus. The chimeric VLPs elicited significantly higherS1-specific antibody responses in intramuscularly immunizedmice and chickens than inactivated IBV viruses. Furthermore,the chimeric VLPs induced significantly higher neutralizationantibody levels than inactivated H120 virus in SPF chickens. Finally, the chimeric VLPs induced significantly higher IL-4production in mice. These results demonstrate that chimericVLPs have the potential for use in vaccines against IBV infection.
Won Seok Gwak,Ji Hoon Lee,Dong Jun Kim,Hwi Geon Yun,Ji In Ma,Soo Dong Woo 한국응용곤충학회 2017 한국응용곤충학회 학술대회논문집 Vol.2017 No.10
Viral particles of Porcine epidemic diarrhea virus (PEDV) consist of a four structural proteins. Among them Spikeprotein mediated responsible for receptor binding and membrane fusion during viral infection and therefore the main targetof neutralizing antibodies. Virus-like particles (VLPs) are consisted of one or more viral structural proteins, and theirmorphologies closely resemble those of the native virus. VLPs have no virulence and can elicit robust immune responsesas compared with inactivated or live-attenuated virus vaccines. Thus, in this study, we tried two methods for VLP constructionin Bombyx mori, one is traditional method and the other is chimeric VLP method using the influenza matrix protein.Both methods could produce successfully PEDV VLPs.