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윤효인,배순이 충남대학교 수의과대학 동물의과학연구소 1998 動物醫科學硏究誌 Vol.6 No.-
The objective of the study was to evaluate the antibacterial activity of onion shells, which are discarded as industrial wastes, against fish pathogenic bacteria using various extractants such as water, ethanol, ethyl acetate and butanol. Water onion extracts did not show any antibacterial activity in the tested bacteria but butanol onion extracts showed antibacterial activity against Bacillus subtilis and Escherichia coli BE 1186. Ethyl acetate and ethanol onion extracts showed antibacterial activity for all the test bacteria. Ethanol, an edible stuff, was possible to use as an extractant of onion shells in industrial process to make marketed products. We further studied the effects of heat and PH on the antibacterial activity of ethanol onion extract against fish pathogenic bacteria. Heating did not change the antibacterial activity of the ethanol extract. However, ethanol extract showed a decreasing antibacterial activity toward alkaline (pH 11). These results indicate that the ethanol onion extracts is suitable for use as supplementary antibacterials.
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The Antibacterial Mechanism of Zn(II) Frame Supported on Alginate Membrane
Dan Luo,Ruo-Wei Lu,Cui-Juan Wang,Yan Tong,Cheng Liu,Yu-Mei Xiao,Yan-Xia Chen 대한화학회 2020 Bulletin of the Korean Chemical Society Vol.41 No.11
In order to solve the problem of antibiotic-resistant bacteria caused by excessive use of antibiotics, herein, an antibacterial membrane composed of natural sodium alginate (ALG), zeolite imidazolate skeleton (ZIF-8) and niflumic acid (NIF) was reported. The membrane serves as a versatile platform for local antibacterial. This report carried out in-depth research on the physical properties and antibacterial mechanism of the synthesized sodium alginate composite film. The data shows that the sodium alginate-based antibacterial film has a continuous antibacterial effect, and the release of antibacterial molecules can be controlled according to changes in the external environment. The results show that the complex has stronger mechanical and bacteriostatic properties. Niflumic acid and Zn(II) have synergistic antibacterial effect. The complex promotes bacterial death by hindering bacterial respiratory metabolism and destroying cell membrane structure.
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Dyeability and Antibacterial Finishing of Hemp Fabric Using Natural Bioactive Neem Extract
Thitirat Inprasit,Kanjana Motina,Penwisa Pisitsak,Pisutsaran Chitichotpanya 한국섬유공학회 2018 Fibers and polymers Vol.19 No.10
Two functional compounds were successfully extracted from neem (Azadiracta indica): a tannin-rich natural dye and an antibacterial agent. The dye was extracted from the bark using water, and the antibacterial from the leaf using methanol. These were used to dye hemp fabrics. Higher color strength values (K/S) were found when dyeing was conducted at a higher dye concentration, elevated temperature, and longer dyeing time. Optimal results were achieved when using 5 %w/v of extracted powder at 100 oC for 60 min. The resulting fabrics appeared reddish-brown, and were rated as good to excellent for color fastness against washing, water, sea water, and perspiration. The antibacterial agent from the neem leaf was extracted by Soxhlet apparatus at 65 oC with methanol as solvent. The dyed and antibacterial-finished hemp fabrics were tested against Staphylococcus aureus, following the percentage reduction test of AATCC 100. The treated fabrics demonstrated a 99.99 % reduction in Staphylococcus aureus.
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Lu Yang,Ying Zhang,Xianjin Hu,Bing-Chiuan Shiu,Ching-Wen Lou,Jia-Horng Lin,Ting-Ting Li 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.120 No.-
Drug-resistant pathogens pose significant pressures and challenges for medical protective materials withhighly effective antibacterial/antiviral and rechargeable properties. In this study, a clean, rechargeablephotodynamic antibacterial/antiviral strategy was proposed after nanofibrous membranes were graftedby photosensitive 4,4, -terephthalic di-phthalic anhydride (TDPA) and natural polyphenol chlorogenicacid (CA) antibacterial agent. The resultant membrane released the maximumOH and H2O2 capacitiesof 6188.56 lg/g and 842.00 lg/g, respectively, exhibited the storage antibacterial stability even storedfor 30 days in the dark. After seven quenching, the charging capacity retained more than 70% of the original. The antibacterial efficiency of the membrane showed more than 99%. In addition, the antibacterialefficiency decreased by only 3% after water washing. Moreover, it demonstrated an excellent antiviralproperty whose antiviral activity against H3N2 achieved 3.6 PFU/mL. This daylight-driven rechargeablenanofibrous membrane can be used to develop reusable medical protective materials with rechargeableantibacterial and antiviral efficiency.
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Methylotrophic Yeast, Pichia pastoris에서 사람 락토페린의 발현 및 항균성 연구
이상오,임은미,남은주,이현환,Lee Sang O,Im Eun Mi,Nam Eun Joo,Lee Hyune Hwan 한국미생물학회 2004 미생물학회지 Vol.40 No.4
사람의 모유에 많이 함유된 human lactoferrin(hLF)은 항균 및 항 바이러스 작용이 있는 것으로 보고되고 있다. 본 연구에서는 hLf를 메탄올자화 효모인 Pichia pastoris에 cloning하고 그 발현을 RT-PCR, Northern blotting, SDS-PAGE및 Western blotting으로 확인하였다. 그 결과 2.1 kb의 hLf 유전자가 P.pastoris의 염색체 DNA로 끼어들어가 안정적으로 hLf를 발현하였다. 이 재조합 P.pastotis로부터 hLf를 포함하는 세포 추출액을 얻어 항균 작용을 연구하였다. 발현된 재조합 hLf는 Staphylococcus aureus, Micrococcus flavus 등의 그람 양성균에 대해 강력한 항균작용을 보일 뿐만 아니라 그람 음성 동물성 병원균인 Pseudomonas fluorescens ID 9631, E. coli ATCC8739, 25922,35 등과 Salmonella typhimurium 114,115 등 다양한 균에 대해서도 강력한 항균작용을 보였다. 이는 재조합 hLf가 생물학적 활성이 있다는 것을 보여준다. The expression and antibacterial. activity of recombinant human lactoferrin (hLf) was studied from methylotrophic yeast Pichia pastoris. The gene encoding hLf, isolated from human breast cDNA library, was subcloned into the expression vector, pPIC3.5K under the control of AOX1 promoter. The gene was integrated into the host chromosome and was identified by Southern blotting. The expression of the integrated gene was investigated by RT-PCR, Northern blotting, SDS-PAGE and Western blotting. Discrete band corresponding to hLf was detected from the SDS-PAGE, which was confirmed by Western blotting. The expression was also confirmed by RT-PCR and Northern blotting. The antibacterial activity of the recombinant hLf (rhLf) was investigated using Staphylococcus aureus ATCC 6538P and Micrococcus flavus ATCC 10240 as test organisms. The rhLf showed strong antibacterial activities against the bacteria. Furthermore, many Gram-negative animal pathogens such as E.coli ATCC8739, 25922, and Salmonella typhimurium 114 and 115, Pseudomonas fluorescens ID 963 I, P. aeruginosa KCCM 11802, and Gram-positive bacteria Bacillus mesentericus were also inhibited in their growth by the rhLf.
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Antibacterial device using UVA-LED and TiO2 films for air-conditioner evaporator
Young-Hwan Lee 한양대학교 세라믹연구소 2013 Journal of Ceramic Processing Research Vol.14 No.2
Recently, photocatalysis with TiO2 was very restricted because of the lack of an appropriate UV source. In this work, in order to increase antibacterial properties of UVA-LED, photoreactive TiO2 film was coated on aluminum substrates by rf-magnetron sputtering. The number of Escherichia coli which remained after irradiation under each time was counted. The photocatalytic TiO2 films on aluminum after irradiation at 365 nm have the comparable antibacterial ability to the uncoated sample irradiated at 280 nm. A sterilization system integrating TiO2 film with UVA-LED has the potential for air purification in automobile and would find wide use in the field of antibacterial.
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Outstanding Antibiofilm Features of Quanta-CuO Film on Glass Surface
Tripathy, Nirmalya,Ahmad, Rafiq,Bang, Seung Hyuck,Khang, Gilson,Min, Jiho,Hahn, Yoon-Bong American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.24
<P>Intelligently designed surface nanoarchitecture provides defined control over the behavior of cells and biomolecules at the solid liquid interface. In this study, CuO quantum dots (quanta-CuO; similar to 3-5 nm) were synthesized by a simple, low-temperature solution process and further formulated as paint to construct quanta-CuO thin film on glass. Surface morphological characterizations of the as-coated glass surface reveal a uniform film thickness (similar to 120 +/- 10 nm) with homogeneous distribution of quanta-CuO. The antibiofilm assay showed a very high contact bacteria-killing capacity of as coated quanta-CuO glass surfaces toward Staphylococcus aureus and Escherichia coli. This efficient antibacterial/antibiofilm activity was ascribed to the intracellular reactive oxygen species (ROS) generated by the quanta-CuO attached to the bacterial cells, which leads to an oxidative assault and finally results in bacterial cell death. Although there is a significant debate regarding the CuO nanostructure's antibacterial mode of action, we propose both contact killing and/or copper ion release killing mechanisms for the antibiofilm activity of quanta-CuO paint. Moreover, synergism of quanta-CuO with conventional antibiotics was also found to further enhance the antibacterial efficacy of commonly used antibiotics. Collectively, this state-of-the-art design of quanta-CuO coated glass can be envisioned as promising candidates for various biomedical and environmental device coatings.</P>
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Morteza Montazerozohori,Sahar Yadegari,Asghar Naghiha,Somayeh Veyseh 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.1
A novel symmetrical Schiff base ligand was prepared by condensation reaction of 2,2-dimethyl-1.3-diaminopropane and (E)3-(2nitrophenyl)acrylaldehyde. The ligand and its Zn(II) coordinationcompounds were well characterized by the elemental analysis, FTIR, 1H, 13C NMR, UV–vis spectraand molar conductance. Thermal behaviors of all compounds were investigated from the roomtemperature to 600 ℃ with a heating rate of 10℃/min. Furthermore some decomposition thermo-kinetic parameters were evaluated by Coats–Redfern equation at each decomposition step. Electrochemical properties of ligand and its complexes were studied by cyclic voltammetry technique. Also antibacterial/antifungal activities of the ligand and its complexes were tested against three Gramnegativebacteria Escherichia coli (ATCC 25922), Salmonella spp. and Pseudomonas aeruginosa (ATCC 9027)and two Gram-positive bacteria Staphylococcus aureus (ATCC 6538) and Corynebacterium renale and alsothree fungi (Aspergillus niger, Penicillium chrysogenum and Candida albicans). The results exhibitedsuitable antibacterial/antifungal properties for ligand and Zn(II) complexes. The study has shown thatthe complexation of ligand to zinc center lead to enhancement of antibacterial/antifungal activity.
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Boldbaatar, Khaliun,Dashnyam, Khandmaa,Knowles, Jonathan C.,Lee, Hae-Hyoung,Lee, Jung-Hwan,Kim, Hae-Won Elsevier 2019 ACTA BIOMATERIALIA Vol.83 No.-
<P><B>Abstract</B></P> <P>Inhibition of bacterial growth with the simultaneous promotion of angiogenesis has been challenging in the repair and regeneration of infected tissues. Here, we aim to tackle this issue through the use of cobalt-doped silicate microspheres that can sustainably release dual ions (silicate and cobalt) at therapeutically-relevant doses. The cobalt was doped up to 2.5 wt% within a sol-gel silicate glass network, and microspheres with the size of ∼300 μm were generated by an emulsification method. The cobalt and silicate ions released were shown to synergistically upregulate key angiogenic genes, such as HIF1-α, VEGF and the receptor KDR. Moreover, the incorporation of ions promoted the polarization, migration, homing and sprouting angiogenesis of endothelial cells. Neo-vascular formation was significantly higher in the dual-ion delivered microspheres, as evidenced in a chicken chorioallantoic membrane model. When cultured with bacterial species, the cobalt-doped microspheres effectively inhibited bacteria growth in both indirect or direct contacts. Of note, the bacteria/endothelial cell coculture model proved the efficacy of dual-ion releasing microcarriers for maintaining the endothelial survivability against bacterial contamination and their cell-cell junction. The current study demonstrates the multiple actions (proangiogenic and antibacterial) of silicate and cobalt ions released from microspheres, and the concept provided here can be extensively applied to repair and regenerate infected tissues as a growth factor- or drug-free delivery system.</P> <P><B>Statement of Significance</B></P> <P>While several ions have been introduced to biomaterials for therapeutic purposes, relaying the effects of antibacterial into tissue regenerative (e.g., angiogenesis) has been a significant challenge. In this study, we aim to develop a biomaterial platform that has the capacity of both ‘antibacterial’ and ‘proangiogenic’ from a microsphere sustainably releasing multiple ions (herein cobalt and silicate). Here, dual-actions of the microspheres revealed the stimulated endothelial functions as well as the inhibited growth of different bacterial species. In particular, protecting endothelial survivability against bacterial contamination was reported using the bacterial/endothelial co-culture model. The current concept of drug-free yet multiple-ion delivery biomaterials can be applicable for the repair and regeneration of infected tissues with dual actions of angiogenesis and suppressing bacterial activity.</P> <P><B>Graphical abstract</B></P> <P>Dual ions (silicate and cobalt ions) released from microspheres promote angiogenesis while simultaneously inhibiting bacteria growth, as demonstrated by the salvaged survivability of endothelial cells against bacterial contamination. The multiple ion-delivery microspheres can be potentially useful for the repair and regeneration of infected tissues as a drug-free biomaterial platform.</P> <P>[DISPLAY OMISSION]</P>
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