자연과학분야 : 댄스화 굽 높이에 따른 댄스스포츠 실시가 폐경기 비만여성의 Adipocytokines 및 골대사에 미치는 영향

황예선 ( Ye Seon Hwang ),오수일 ( Su Ill Oh ),이웅배 ( Woong Bae Lee ) 한국무용과학회 2014 한국무용과학회지 Vol.31 No.2

본 연구는 폐경기 비만여성을 대상으로 하여 댄스스포츠 수행 시 서로 다른 굽 높이의 댄스화(7cm, 3cm) 착용에 따른 Adipocytokines 및 골대사에 어떠한 영향을 미치는지 알아보았다. 연구대상자들은 폐경이후 %fat 30이상인 비만 여성 24명(7cm-11명, 3cm-13명)을 대상으로 하였다.운동 프로그램은 댄스스포츠 차차차(1-6주)와 자이브(7-12주)를 12주간, 주 3회, 90분간, 운동강도 60-85%HRmax로 실시하였다. 자료처리는 t-test(independent & paired), pearson``s의 상관분석 및 단순회귀분석을 실시하였다. 연구 결과, adipocytokines 항목 중 adiponectin에서 두 집단 모두 운동 후 유의하게 증가하였으며 골대사 호르몬에서는 두 집단 모두 운동 후 OC은 유의한 감소를, CTx는 유의한 증가를 나타냈다. adipocytokines과 골대사 호르몬의 상관 및 회귀 결과에서는 adiponectin이 OC과 유의한 정적 상관을 보였으며, 회귀분석 결과 약 9%의 설명력을 보였다. 폐경기 비만 여성들에게 있어 12주 간의 댄스스포츠 운동이 adiponectin 증가에 긍정적인 영향을 미치는 것을 알 수 있었다. 골대사에서는 골교체율과 운동 강도 측면에서 긍정적, 혹은 부정적인 결과로 해석할 수 있어 좀 더 장기적이고 다각적인 연구가 필요할 것으로 생각된다. This study examined the effects of dance sports on 24 postmenopausal obese women`` adipocytokines and bone metabolism hormone when they performed dance sports for 12 weeks while wearing 7cm & 3cm heeled dance shoes, respectively. The study subjects were 24 obese postmenopausal women who had more than %fat 30 (7cm-11 persons, 3cm-13 persons). The exercise program was Cha cha cha (1 to 6 weeks) and Jive (7 to 12 weeks) of dance sports. It was performed 12 weeks, three times a week, 90 minutes each time. The exercise intensity was 60-85%HRmax. The data were analyzed by used t-test(independent & paired), Pearson correlation coefficient and simple regression analysis. After exercise, the two groups (Cha cha cha group and Jive group) showed a significant increase in adiponectin among adipocytokines items. In the case of bone metabolism hormones, after exercise the two groups had a significant fall in OC, but a significant rise in CTx. According to correlation and regression analysis of adipocytokines and bone metabolism hormones, adiponectin had significantly positive correlation with OC, and the regression analysis result showed around 9% explanation power. The 12-week dance sports exercise positively affected a rise in obese postmenopausal women`` adiponectin. As for bone metabolism, the exercise brought about the positive or negative result in the aspects of bone turnover and exercise intensity, and thus it is considered that more long-time and diversified research is required.

저항성 운동이 노인의 성장관련 동화호르몬과 아디포사이토카인에 미치는 영향

소위영 ( Wi Young So ),송미순 ( Mi Soon Song ),조비룡 ( Be Long Cho ),박연환 ( Yeon Hwan Park ),임재영 ( Jae Young Lim ),김선호 ( Seon Ho Kim ),송욱 ( Wook Song ) 대한스포츠의학회 2009 대한스포츠의학회지 Vol.27 No.2

The purpose of this study was to examine the effects of resistance exercise on anabolic hormones and adipocytokines of the elderly. The subjects were randomly assigned into the resistance exercise group (n=20), and the control group (n=16). An exercise session composed of three phases (warm-up phase, main exercise phase, and cool-down phase) was performed for 60 minutes during which various types of resistance exercises were given to the exercise group of the elderly using dumbbell. Exercise session was performed 3 times per week for 12 weeks. The analyses represented that average GH (F=4.587, p=0.043) was significantly increased by the 12-week band exercise, whereas average IGF-I, IGFBP-3, TNF-α, IL-1β, IL-6, and CRP were not significantly changed (p>0.05). For the elderly people, resistance exercise did not appear to bring positive effects on anabolic hormones and adipocytokines.

비만 여성들의 저칼로리 식이와 복합 운동이 신체조성 및 adipocytokines에 미치는 영향

이강옥(Kang Ok Lee) 한국사회체육학회 2007 한국사회체육학회지 Vol.0 No.31

The purpose of this study was to investigate the effects the low calorie diet and combined exercise on the body composition and adipocytokines in the obese women. The subjects were 75 obese women whose age were 30~40year old. Subjects were classified 4 groups that were control group(n=19), diet group(n=18), exercise group(n=20), and diet-exercise group(n=18). All subjects were participated in the diet program and combined exercise program during 12 weeks except for control group. In diet period, diet and diet-exercise group took the low calorie diet and the special of Beautiful-Life Co, which daily calorics were 900~1,300kcal/d. Combined exercise program carried out by exercise and diet-exercise group was constricted with combined exercise after exercise testing. The conclusions of this study were as follows;All group except for control group, body weight, % body fat, and fat weight were significantly decreased after 12 weeks conditioning. But, body water of these groups were significantly increased after 12 weeks conditioning, which indicated the decrement of weight and % body fat were not a passing phenomenon by reduction of body water. In diet-exercise group, leptin, TNF-α, and IL-6 were decreased, adiponectin were increased after 12 weeks conditioning. But, in diet group were showed no significantly different. In conclusion, after 12 weeks combined exercise and low calorie diet program, body composition were improved. But afterward to prevent of the decrements of body composition and adipocytokines and safely control her body weight and fat, it appears that a combination of diet and exercise program was suggested and prescribed to obese women.

복합운동과 세트간 스트레칭 프로그램 적용이 비만중년여성의 내장지방 및 Adipocytokine에 미치는 영향

박기범(Ki Bum Park),이원재(Won Jae Lee),김진환(Jin Hwan Kim) 한국사회체육학회 2010 한국사회체육학회지 Vol.0 No.41

This study investigated how combined exercises and stretching per set affect body composition, visceral fat and dipocytokines obese middle-aged women, and results are as follows. 1. All three groups have built up muscles when we compared before and after the exercises. Those in stretching group per set have toned up much more muscles than walking group. 2. Body fat rates have decreased for all three groups. 3. All three groups have improved their hand grip strength, abdominal strength and flexibility after the exercises, while hip and waist sizes have decreased after exercises. 4. For both stretching groups per set and walking groups, subcutaneous fat has decreased, while visceral fat and area of muscles have decreased significantly among those in stretching groups per set. 5. Adiponectin also did not have consistent results within each group, however, resistin has decreased after the exercises among three groups, but there were no significant differences among the groups. As we can see from these results, we could prove the effectiveness of combined exercises to reduce obesity. However, doing stretching exercises with other exercises did have positive effects on muscle activations and visceral fat reductions but did not bring consistent results for adipocytokines changes. The reason for these results seems to be related to the problem on preparatory studies including standard of group divisions in the study and changes from amount of exercises for each program. Thus, if we carry on a following study, which can resolve these problems together with improved combined exercises and arious programs per set with systematic preliminary reviews, we will have a significant material that can help us when we develop exercise programs for obese prevention and reduction.

복합트레이닝이 비만청소년의 복부지방과 Adipocytokines에 미치는 영향

박상갑 ( Sang Kab Park ),김은희 ( Eun Hee Kim ),권유찬 ( Yoo Chan Kwon ) 대한스포츠의학회 2005 대한스포츠의학회지 Vol.23 No.3

복합운동이 복부내장지방 비만 남성의 심장 구조 기능 및 아디포싸이토카인 농도에 미치는 영향

박상갑 ( Sang Kab Park ),김은희 ( Eun Hee Kim ),권유찬 ( Yoo Chan Kwon ) 대한스포츠의학회 2008 대한스포츠의학회지 Vol.26 No.1

The purpose of this study was to investigate the effects of 12 weeks aerobic and resistance exercise on cardiac structure and function, and adipocytokines. The participants, who were middle-aged visceral obese men, performed 12 weeks combined exercise program. The combined exercise program included aerobic(50∼70% of HRR) and resistance exercise(70% 1RM) for 80 min during 12weeks(four times per week). Combined exercise decreased abdominal visceral fat, improved cardiac function. In addition, combined exercise improved significantly IGF-1, NT-pro BNP and IL-6 concentration. Therefore, it might be thought that combined exercise would be a positive role for body composition, cardiac function and adipocytokines in abdominal visceral obese men.

비만아에서의 leptin, adiponectin, interleukin-6, tumor necrosis factor-α에 대한 연구

길주현,이정아,김지영,홍영미,Gil, Joo Hyun,Lee, Jung Ah,Kim, Ji Young,Hong, Young Mi 대한소아청소년과학회 2008 Clinical and Experimental Pediatrics (CEP) Vol.51 No.6

목 적 : 비만은 지방세포의 축적과 인슐린 내성으로 제 2형 당뇨병을 초래하고, 고 인슐린혈증과 고혈당이 염증 과정의 전구 물질과 함께 작용하여 혈관 내피의 이상, 혈청 지질의 이상, 고혈압과 혈관 염증을 일으켜 동맥경화와 심혈관 질환을 야기하는 것으로 알려져 왔다. Leptin은 adiopnectin과 함께 지방 세포로부터 생산되는 가장 풍부한 adipocytokine으로서, 일차적으로는 식욕 조절과 체내 지방 축적 조절의 기능을 하지만, IL-6, IL-12, TNF-${\alpha}$와 같은 다른 사이토카인과 함께 염증과정의 전구 물질이 되며 여러 면역 관련 질환에서 중요한 매개체가 된다. 이번 연구에서는 비만 청소년에서 leptin과 여러 cytokine과의 상관관계를 알아보고자 하였다. 방 법 : 16세 이상부터 18세 미만의 66명의 중등도 이상의 비만 청소년을 대상군으로 하였고, 같은 연령의 정상 청소년 26명을 대조군으로 하였다. 신장, 체중을 이용하여 비만도와 체질량지수를 산출하였고, 혈청 지질, 간 효소치를 측정하였다. 효소면역 측정법을 이용하여 IL-6, TNF-${\alpha}$를 측정하였고, 방사면역 측정법을 이용하여 adiponectin, leptin, 인슐린을 측정하였다. 이 후 leptin과 각 측정치와의 상관성을 알아보았다. 결 과 : Leptin은 비만군에서 대조군보다 유의하게 높았고, TNF-${\alpha}$와 IL-6도 비만군에서 대조군보다 유의하게 높았다. 인슐린도 비만군에서 대조군보다 유의하게 높았고 adiponectin은 비만군에서 유의하게 낮았다. Leptin은 비만도, 체질량지수, IL-6과 유의한 양의 상관관계를 보였으며, 또한 IL-6와 TNF-${\alpha}$간에 유의한 양의 상관관계를 보였다. 결 론 : 비만 청소년에서 leptin, TNF-${\alpha}$, IL-6와 같은 cytokine과 insulin이 성인병으로 진행되는데 중요한 요소가 될 것이며, leptin을 성인병의 예측 인자 및 임상치료의 척도로 사용하기 위해 더 많은 연구가 필요할 것으로 생각된다. Purpose : Obesity is associated with insulin resistance. Insulin resistance and the presence of pro-inflammatory mediators are thought to cause a state of vascular endothelial dysfunction, an abnormal lipid profile, hypertension, and vascular inflammation. These chronic inflammatory responses, which are characterized by abnormal cytokine production, lead to activation of a pro-inflammatory signaling pathway. Leptin is an important mediator of inflammatory processes and immune-mediated diseases. The purpose of this study was to investigate the relationship between leptin and various cytokines associated with obesity in adolescents. Methods : Sixty-six obese adolescents (between 16-17 years of age, obesity index >130%) and 26 normal controls were included in this study. Obesity index and body mass index (BMI) were calculated. Serum lipid profile, AST and ALT were tested after 10 hours of fasting. Tumor necrosis factor alpha (TNF-${\alpha}$) and Interleukin-6 (IL-6) levels were measured by ELISA. Insulin, adiponectin, and leptin levels were estimated by radioimmunoassay. Results : Leptin was significantly higher in the obese adolescents compared to the control adolescents ($12.0{\pm}6.8ng/mL$ vs $6.3{\pm}1.0ng/mL$). TNF-${\alpha}$, IL-6, and insulin were significantly higher in the obese adolescents. Adiponectin was significantly lower in the obese group than the control group ($3.3{\pm}1.9{\mu}g/mL$ vs $5.0{\pm}1.4{\mu}g/mL$). Leptin had positive correlations with obesity index, BMI, and IL-6. Conclusion : In obese adolescents, leptin, TNF-${\alpha}$, IL-6, and insulin might be important mediators of obesity. Further clinical research is necessary to ascertain leptin as a predictor of cardiovascular diseases and to develop a guideline for clinical intervention.

12주 중재프로그램이 직장인의 심혈관질환 위험요인, 아디포사이토카인과 영양소 섭취에 미치는 영향

문기은 (Moon,Kieun ),박일근 (Park,Ill Keun ),조연상 (Jo,Yeon Sang ),장윤균 (Chang,Yun Kyun ),백윤미 (Paek,Yun Mi ),최태인 (Choi,Tae In ) 韓國營養學會 2011 Journal of Nutrition and Health Vol.44 No.4

Adipocytokines (adiponectin, leptin and resistin) are known to play a major role in development of cardiovascular disease (CVD) and intervention program is effective in reducing CVD risk factors. However, intervention program to improve the CVD risk factors including adipocytokines has been less studied. This study investigated the effects of 12-weeks worksite intervention program on cardiovascular risk factors, adipocytokines and nutrients intakes in industrial workers. 157 industrial male workers (32 metabolic syndrome (MS) subjects, 125 healthy subjects using age-matched stratified random sampling) received 5 face-to-face counseling based on their health profiles. Anthropometry, biochemical parameters and nutrients intakes were measured. The diagnosis of MS was adapted from modified NCEPATP III criteria (2001) and Asia-Pacific definition criteria (2000) for waist circumference (WC). After the intervention program, WC, BMI, SBP, insulin, leptin and intakes of total energy and fiber were significantly decreased (p < 0.05), while adiponectin was significantly increased (p < 0.05) in MS subjects. The WC, BMI, SBP, total cholesterol, LDL and HDL-cholesterol, HbA1c, leptin and intakes of total energy, protein and fat were significantly decreased (p < 0.05) and adiponectin was significantly increased (p < 0.05) in normal subjects. Multiple linear regression revealed that adiponectin was positively correlated with HDL-cholesterol (p < 0.01). Leptin was positively correlated with WC (p < 0.01), and resistin was positively correlated with HbA1c (p < 0.05) and intakes of total energy (p < 0.05), and negatively correlated with HDL-cholesterol (p < 0.05). The results of the 12 weeks intervention showed a positive impact on adipocytokines and nutrients intakes of industrial workers to reduce cardiovascular risk factors. Further research is needed to verify a tailored long-term worksite intervention program including adipocytokines as a protective factor for the CVD. (Korean J Nutr 2011 44(4): 292 ~ 302)

Study of Serum Adipocytokines and Their Association with Insulin Sensitivity in Morbidly Obese Individuals Undergoing Bariatric Surgery

Astha Sachan,Archna Singh,Sakshi Shukla,Sandeep Aggarwal,Ishfaq Mir,Rakhee Yadav 대한비만학회 2020 The Korean journal of obesity Vol.29 No.4

Background: Obese adipose tissue secretes a variety of adipocytokines that act as metabolic regulators with complex mechanisms. Our objective was to compare serum concentration of a panel of adipocytokines between obese and non-obese individuals and identify any distinct patterns correlating with insulin sensitivity in obesity. Methods: We designed a cross-sectional study among obese (body mass index [BMI] ≥30 kg/m2, n=62) and non-obese (BMI <25 kg/m2, n=32) individuals to compare circulating levels of the adipokines, such as adiponectin and resistin in conjunction with the measurement of the levels of inflammatory cytokines including C-reactive protein (CRP), interleukin (IL)-6, IL-8, monocyte chemoattractant protein (MCP)-1, and tumor necrosis factor (TNF)-α using Luminex multiplex immunoassay with drop array technology. Correlations between circulating adipocytokine levels and those of multiple well-established markers of insulin resistance including homeostatic model assessment of insulin resistance (HOMA-IR), homeostatic model assessment of β-cell function (HOMA-β) and quantitative insulin sensitivity check index were also established. Results: CRP, IL-8, MCP-1, and TNF-α levels were higher in obese than non-obese individuals; the CRP and IL-8 differences were statistically significant. CRP correlated significantly with markers of insulin resistance (fasting plasma insulin, HOMA-IR, and QUICKI), and adiponectin correlated with HOMA-β in obese individuals. We divided the group of obese individuals on the basis of HOMA-IR levels into insulin-resistant (IR; HOMA-IR ≥2.5) and insulin-sensitive (IS; HOMA-IR <2.5) groups; and 43 out of 62 participants were IR despite comparable BMIs. An overall proinflammatory profile was compared between IR and IS obese, though the values were higher in IR obese but the difference was not significant. Conclusion: Obesity is associated with a general inflammatory milieu and a crosstalk between adipocytokines and insulin resistance is complex as well as multifactorial.

The Effect of Visceral Fat Area and Adipocytokines on Acute Myocardial Infarction: A Case-Control Study in Adult Korean Population

이강건,서영성,염근상 대한비만학회 2012 The Korean journal of obesity Vol.21 No.1

Background: This study aimed to analyze visceral fat area (VFA) and the pattern of secretion of adiponectin,leptin, TNF-α, IL-6, and IL-10. It also studies the effect of VFA and adipocytokines on the risk of Acute myocardial infarction (AMI) in adult Korean population. Methods: A patient group (PG) consisting of 121patients, who were hospitalized for AMI from 2008 to 2009,and a control group (CG) consisting of 115 healthy adults,who visited the same hospital for health examination within the same period, were included in this study. Physical measurements were performed and VFA was measured using computed tomography. Lipid, metabolic index,adipocytokine levels were also measured after 12 hours of fasting. Results: BMI, waist circumference, levels of leptin, TNF-α,and IL-6 were significantly higher in the PG, while adiponectin level was significantly higher in the CG. According to the comparison study analyzed by gender,VFA level was significantly higher in the PG, and IL-10level was significantly higher in the CG. After adjusting for the conventional risk factors (CRF) of AMI, regression analysis showed that adiponectin and IL-10 levels reduced the risk of AMI; whereas VFA, TNF-α, leptin, and IL-6increased the same risk. Conclusion: It is postulated that adipocytokines and VFA will act as independent risk factors of AMI regardless of CRF of coronary artery disease.