Analysis of clinical characteristics and incidence in nail tumors

( Jun Hyeong Park ),( Sook Jung Yun ),( Seung-chul Lee ),( Jee-bum Lee ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: While individual cases of various tumor arising from nail unit have been reported in Korea, few study about incidence and clinical characteristics of nail tumors has been reported. Objectives: To evaluate the incidence and clinical characteristic of nail tumors in single center in Korea. Methods: We retrospectively reviewed clinical photographs and medical records of the patients with nail tumors who visited Chonnam National University Hospital between January 2015 and December 2019. 54 cases of nail tumor were diagnosed by skin biopsy. Results: Distal mucous cyst (22.2%) was the most common tumor and malignant melanoma (20.4%) was the second most. The third most tumor was glomus tumor (16.7%) and followed by melanoma in situ (14.8%). And other tumors were onychopapilloma (7.4%), pyogenic granuloma (5.6%), subungal exostosis (3.7%), myxoid pseudocyst (1.9%), ungal fibrokeratoma (1.9%), squamous cell carcinoma (1.9%), verrucous carcinoma (1.9%), superficial acral fibromyxoma. (1.9%). Of these, malignant nail tumors accounted for 22.3%. Conclusion: Our study showed that various nail tumors from nail occurred. For optimal treatment of nail tumors, we are needed to figure out the incidence and clinical characteristics of nail tumors.

성인 고환 생식세포종양: 임상적 고찰 및 재발 위험인자

이상은,김대영,서성일,정진수,박문수,이은식,최황,이종욱 大韓泌尿器科學會 1999 Korean Journal of Urology Vol.40 No.9

한국인에서 눈물언덕종양의 임상양상 및 병리학적 특징

백재우,백성욱,최지영,이민정 대한안과학회 2019 대한안과학회지 Vol.60 No.11

Purpose: To investigate the clinical characteristics and histological features of tumors in caruncles. Methods: We conducted a retrospective chart review of 126 eyes of 126 patients who underwent incisional or excisional biopsy of conjunctival masses between March 2008 and December 2016. Results: Twenty-four patients (19.0%) including 10 males and 14 females had a mass located on the caruncle. The mean age at diagnosis was 41.8 ± 13.4 years (range, 15-67 years). Most patients (75%) visited us for a cosmetically visible mass without other symptoms. The mean duration of symptoms was 73.8 ± 113.0 months (range, 1-240 months). The most common histological diagnosis was a melanocytic tumor (50%) followed by a sebaceous gland tumor (12.5%), an epidermoid cyst (12.5%), and papilloma (12.5%). The symptom duration of the melanocytic tumor was significantly longer than other types of tumors (153.6 ± 139.8 months, p = 0.025). Conclusions: Caruncular tumors accounted for 19% of all conjunctival tumors. The most common pathological diagnosis of a caruncular tumor was a melanocytic tumor, which had a characteristically long symptom duration. 목적: 눈물언덕에서 발생한 종양의 임상양상 및 조직병리학적 특징에 대해 알아보고자 하였다. 대상과 방법: 2008년 3월부터 2016년 12월까지 결막종양으로 절개 혹은 절제 생검을 시행받은 126명(126안)의 환자 중 종양이 눈물언덕에 위치하였던 환자들의 의무기록을 후향적으로 조사하였다. 결과: 눈물언덕에 종양이 위치하였던 환자는 24명으로 전체 결막종양의 19.0%를 차지하였다. 대상 환자는 남자 10명, 여자 14명이었고, 진단 당시 평균 연령은 41.8 ± 13.4세(15-67세)였다. 대부분의 환자(75%)는 동반된 증상 없이 미용적으로 보이는 종물을 주소로 내원하였으며, 병변 인지 후 진단까지의 기간은 73.8 ± 113.0개월(1-240개월)이었다. 조직학적 진단을 분석해 보았을 때, 멜라닌세포모반(50%)이 가장 흔하였으며, 피지샘 관련 종양(12.5%), 표피낭종(12.5%), 유두종(12.5%) 순서였다. 특징적으로 모반의 병변 인지 후 진단까지의 기간이 다른 종류의 종양에 비해 유의하게 길었다(153.6 ± 139.8개월, p=0.025). 결론: 눈물언덕종양은 전체 결막종양 중 19% 정도로 나타났다. 눈물언덕종양의 병리 진단 중 가장 흔한 것은 모반이었으며, 병변 인지 후 진단까지의 기간이 긴 특징을 나타내었다.

후두개와 종양의 병리조직학적 검색

최윤정,김태승 대한병리학회 1994 Journal of Pathology and Translational Medicine Vol.28 No.3

Gamma Knife Surgery for Brain Metastasis from Renal Cell Carcinoma : Relationship Between Radiological Characteristics and Initial Tumor Response

Kim, Jin-Wook,Han, Jung-Ho,Park, Chul-Kee,Chung, Hyun-Tai,Paek, Sun-Ha,Kim, Dong-Gyu The Korean Neurosurgical Society 2007 Journal of Korean neurosurgical society Vol.42 No.2

Objective : The authors have speculated that metastatic brain lesions from renal cell carcinoma (RCC) show diverse radiological patterns and tumor responses after Gamma knife surgery (GKS), and have hypothesized that these can be predicted from tumor radiological characteristics. The goal of the current study was to identify the radiological characteristics of RCC brain metastases and the predictors of initial radiosurgical response after GKS. Methods : A retrospective analysis was performed on 48 lesions in 18 patients with RCC brain metastasis treated by GKS. The radiological characteristics of these lesions in magnetic resonance images (MRI) were classified into 3 categories according to enhancement patterns in T1-weighted images and signal intensity characteristics in T2-weighted images. Responses to GKS were analyzed according to these categories, and in addition, other potential predictive factors were also evaluated. Results : MRI findings in the three categories were diverse, though numbers of the lesion were comparable. At 2-month MRI follow-ups after GKS, response rate was 54% and the local tumor control rate 83%. T2 signal intensity was found to be the principal predictive factor of response to GKS, namely negative predictive factor. Other variables such as age, sex, tumor volume, dose, duration from initial diagnosis to GKS, and previous systemic therapies failed to show significant relationships with treatment response by multivariate analysis. Conclusion : Careful evaluation of the radiological characteristics of brain metastases from RCC is important prior to GKS because MRI heterogeneity has predictive value in terms of determining initial tumor response.

골의 거대세포종에 동반된 동맥류성 골 낭종의 임상적 특징

이형민(Hyung Min Lee),박세경(Se Kyung Park),조은미(En Mi Cho),오선주(Sun Ju Oh),정소학(So Hak Chung) 대한정형외과학회 2016 대한정형외과학회지 Vol.51 No.5

목적: 골의 거대세포종 환자들 중에서 동맥류성 골 낭종 동반 유무에 따른 임상적 특징과 경과 및 예후와의 상관관계를 알아보고자 하였다. 대상 및 방법: 2009년 3월부터 2013년 4월까지 골 종양으로 수술적 치료를 받고, 거대세포종으로 확진된 환자들 33예를 후향적으로 검토하였다. 임상적 특징으로 발생연령, 성별, 발생 위치, 종양 크기, 병적 골절 유무, Campanacci 등에 의한 종양 등급, 국소재발 및 전이, 그리고 악성화의 유무를 조사하였고, 이 항목들에 대해 동맥류성 골 낭종의 동반 여부에 따른 두 군 간에 차이가 있는지 Student t-test 및 Fisher’s exact test를 이용하여 분석하였다. 결과: 국소재발은 전체 33예 중에서 6예에서 발견되었고 동맥류성 골 낭종이 동반된 군에서 3예, 그렇지 않은 군에서 3예로 통계적 의미를 둘 수 없었으며(p=0.643), 병적 골절은 전체 9예로 전자에서 7예, 후자에서 2예로 통계적으로 유의한 차이를 보였다(p=0.013). 그 외 두 군 간에 통계적으로 유의한 차이를 보이는 항목은 없었다. 결론: 거대세포종에서 동맥류성 골 낭종의 동반 유무에 따라 거대세포종의 국소 재발률은 차이가 없었으며 병적 골절의 경우 동맥류성 골 낭종이 동반된 군에서 더 높은 빈도로 발생하였다. Purpose: The purpose of this study was to evaluate the difference in clinical features, process, and prognosis depending on the presence of secondary aneurysmal bone cysts (ABCs) in patients with giant cell tumors. Materials and Methods: A total of 33 patients who underwent surgery for giant cell bone tumors between March 2009 and April 2013 were selected. Data on clinical features were obtained from medical records and pathological and radiological review, including age, sex, location, and size of the tumor, and Campanacci grade, as well as whether there was any pathological fracture, local recurrence, distant metastasis, or malignant transformation. The Student t-test and Fisher exact test were used for comparison of the differences in clinical features by the presence or absence of ABCs. Results: Local recurrence occurred in 6 of the 33 cases, 3 each were in the groups with and without ABCs; however, the difference was not statistically significant. In total, nine cases had pathological fractures, seven were in the group with ABC and two were in the group without ABC (p=0.013). No statistically significant differences in age, sex, location and size of the tumor, or Campanacci grade were observed between the groups with and without ABCs. Conclusion: There was no difference in the frequency of local recurrence between the groups with and without ABCs. However, pathological fracture occurred more frequently in the group with ABCs compared to the group without ABCs.

온열치료효과 분석을 위한 CRL-1888 마우스 종양 세포주의 배양 온도 변화에 따른 증식 특성 연구

황은미,김영곤 한국생체재료학회 2008 생체재료학회지 Vol.12 No.1

The purpose of this study is to investigate the proliferation characteristics of CRL-1888 mouse tumor cell line for standardization of the hyperthermic animal model. Proliferation characteristics of the CRL-1888 mouse tumor cell line at hyperthermic environment was tested at eleven different culturing temperatures (36, 37, 38, 39, 40, 41, 42, 43, 45, 46℃) and for seven different culturing times (24, 48, 72, 96, 120, 144, 168hours). The result shows that the proliferation curves of the CRL-1888 mouse tumor cell line are well in accord with the theoretical formula LogN = LogN0 + kt. Where N is a measured number of cells, N0 is the initially inoculated number of cells and k is the proliferation characteristic constant which was calculated from the interpolated slope of the proliferation curves. The maximum value of the proliferation constant was 0.021 at 39℃ incubation test. However, it was 0.011 for normal incubation test temperature of 37℃. These results were well in accord with the results of the microscopic observation for CRL- 1888 proliferation tests. And the value of the proliferation constant k was conversed to negative value at the temperature above 42℃. Therefore, the effectiveness of hyperthermia treatment for CRL-1888 can be expected at the temperature above 42℃.

위 유암종의 임상병리학적 특징

정진호 ( Jin Ho Chung ),오승종 ( Seung Jong Oh ),정국현 ( Kuk Hyun Jung ),황윤선 ( Yoon Sun Hwang ),최민규 ( Min Gew Choi ),노재형 ( Jae Hyung Noh ),손태성 ( Tae Sung Sohn ),배재문 ( Jae Moon Bae ),김성 ( Sung Kim ),최성희 ( Seon 대한임상종양학회 2011 Korean Journal of Clinical Oncology Vol.7 No.2

목적: 본원에서 진단된 위 유암종의 임상병리학적 특성과 치료방법 및 예후에 대해 분석하였다. 방법: 1997년 1월 1일부터 2009년 12월 31일 까지 본원에서 병리조직검사 결과 위의 유암종으로 진단 및 치료 받은 52명의 환자를 대상으로 Rindi 분류에 따라 진단, 치료, 및 경과에 대해 후 향적 연구를 통해 분석하였다. 결과: 남자가 29명, 여자가 23명 (1.26:1) 이었고 평균나이는 54.6세이고 평균추적관찰 기간은 36개월이었다. 그 중 1형은 45 예로 40예(88.9%)에서 단일결절이며 만성위축성위염과 동반된 소견을 보였다. 2형은 2예로 복합내분비신생물 1형 증후군과 병발하였다. 3형은 5예로 모두 T2 이상의 병변이었다. 이들 환자중 절제가 가능한 49예중 12예에서 수술이 시행되었으며 37예에서 내시경적 용종절제술 및 점막하 절제술이 시행되었다. 52명중 3명이 사망하였고 1명이 유암종으로 인한 사망이었다. 결론: Rindi 분류를 통한 국내의 위 유암종은 악성빈혈이 동반되지 않았으며 남성이 더 많이 발생하며 단일결절이 많아 외국의 보고와는 다른 특징을 보였다. Purpose: We analyzed the clinicopathologic characteristics of patients with gastric carcinoid tumor, which is a rare gastric tumor Methods: We reviewed 52 carcinoid patients who were treated from 1997 to 2009. Carcinoids were classified as 3 types along the Rindi et al. The clinicopathologic characteristics, the treatment modalities were retrospectively analysed. Results: There were 29 man, and 28 woman patients.(1.26:1) The mean age of onset was 54.6 years. The average follow up period was 36 months. There were 40 of 45 type I patients who had solitary lesion and all of 45 patients combined with chronic atrophic gastritis. There were 2 type II paitents who combined with Multiple Endocrine Neoplasm type-1. There were 5 type III patients who had above T2 lesions. In the 49 patients who can resection, 12 underwent surgery, and 37 underwent endoscopic polypectomy and submucosal dissection. 3 of 52 patients death and only 1 case were death by disease. Conclusion: Higher incidence of gastric carcinoid tumor with man, less multiplicity, and no concurrence of pernicious anemia were identified in our study compared with previous reports.

양성 신경성 종양과 유사한 방사선학적 소견을 걸인 격리 수핵 탈출증 2례 - 증례 보고 -

김석준,송준혁,김명현,박향권,김성학,신규만,박동빈 대한신경외과학회 1997 Journal of Korean neurosurgical society Vol.26 No.4

Axillary LN meta가 있는 유방암에서 액와 림프절의 FDG uptake가 가지는 임상적 의미

고수희 ( Soo Hee Go ),서형일 ( Hyung Il Seo ),이지연 ( Jee Yeon Lee ),정윤주 ( Youn Joo Jung ) 대한임상종양학회 2010 Korean Journal of Clinical Oncology Vol.6 No.2

Purpose: 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography(18F-FDG PET/CT) has been recommended as a diagnostic modality for preoperative staging of breast cancer. But, the information for FDG uptake on axillary lymph node(ALN) is not sufficient. Authors investigated the FDG uptake on ALN in preoperative 18F-FDG PET/CT and tumor characteristics to figure out their association and its clinical significance. Materials and Methods: From Jan. to Dec. 2007, 176 patients had been performed preoperative 18F-FDG PET/CT. Only sixty-five cases were confirmed as ALN metastasis in pathologic report. Thirty-one patients with high FDG uptake of ALN (SUVmax>1.0) and thirty-four with low FDG uptake (SUVmax≤1.0) in 18F-FDG PET/CT were classified as group A and B, respectively. Results: The FDG uptake of ALN showed significant relationship with poor prognostic factors of primary tumor(worse histologic grade, negativity of estrogen and progesterone receptor, positivity of p53 and c-erbB2 gene, tumor necrosis, lymphovascular invasion) and ALN metastasis. In multivariate analysis, FDG uptake of ALN showed larger tumor size (p=0.001), higher Ki-67 (p=0.004), bigger and more metastatic ALN (p=0.017, <0.001) compared to low FDG uptake of ALN. The cut-off values of high FDG uptake were 1.85 cm of primary tumor size, 17.5% of Ki-67, 2.5 and 0.95 cm of number and size of metastatic ALN. Conclusion: The most valuable sensitivity and specificity of FDG uptake in metastatic ALN were shown when the number and size of ALN was more than 3 or 0.95 cm and they would be large enough to perform ultrasonographyguided biopsy. We recommend preoperative ALN biopsy for the cases of FDG uptake on ALN in preoperative 18FFDG PET/CT and the sentinel lymph node biopsy might be skipped if metastasis is confirmed on biopsy.