자궁근종 색전술전 자궁난소 문합부위의 선택적 코일 색전에 의한 난소의 보호: 2예 보고

양승부,임한혁,장윤우,구동억 대한영상의학회 2006 대한영상의학회지 Vol.55 No.3

자궁근종 색전술시 원치 않는 합병증으로 난소의 기능 장애로 인한 조기 폐경이 발생할 수 있다. 이러한 난소의 기능 장애에 대한 원인은 분명하지 않으나 난소의 비표적 색전(nontarget embolization)이 하나의 가능성으로 생각되고 있다. 저자들은 자궁근종 색전술시 비표적 색전으로부터 난소를 보호하기 위해 자궁동맥에서 난소동맥으로의 문합부위를 코일을 이용하여 차단한 후 자궁근종 색전술을 시행한 2예를 보고한다. Premature menopause can be developed as a result of undesired nontarget ovary embolization during the performance of uterine fibroid embolization. The etiology of ovarian failure after uterine fibroid embolization is not yet clearly defined, but one of the leading possibilities is nontarget embolization of the ovaries. We report here on two cases in which superselective coil embolization of distal uterine artery collateral pathways to the ovary was performed during uterine fibroid embolization.

가토 간 생검후 지혈에 관한 실험적 연구 : N-buty1 2-cyanoacrylate(NBCA) 주입과 고주파 전기소작

박성진 대한영상의학회 1997 대한영상의학회지 Vol.36 No.4

암 치료를 위한 항체치료제에 대한 고찰: 면역항암제

유한진(HanJin Yu),홍세영(Seyoung Hong),권미지(Miji Kwon),이지현(Jihyeon Lee),박희호(Hee Ho Park),임광석(Kwang Suk Lim) 한국생물공학회 2020 KSBB Journal Vol.35 No.2

Recently, biopharmaceutical drugs take a big part in the pharmaceutical market with the development of genetic engineering. Therapeutic antibodies, one of the representative biopharmaceuticals, have strong therapeutic efficacy in various diseases such as autoimmune disease, rheumatism and cancer. Antibodies are widely used as targeted delivery systems, diagnostics and therapeutics because of their high specific recognition ability. In addition, the market for therapeutic antibodies is expanding further with the development of new biologic drugs such as biosimilar and biobetter. In particular, cancer immunotherapy has shown excellent efficacy for the treatment of cancer by regulating the immune response. In recent years, antibody-drug conjugates (ADCs), immune checkpoint inhibitors and therapeutic antibodies have been developed by many researchers and pharmaceutical companies and approved by U.S. food and drug administration as a potential strategy for the treatment of cancer. Although cancer immunotherapy has a strong therapeutic efficacy, there are still limitations to overcome such as for the treatment of solid tumor, immunogenicity and resistance. To solve these problems, new biomarkers, bispecific antibodies and combinatorial therapy with chemotherapy are being investigated. In this review, we describe the mechanism of immune response with respect to antibody therapeutics, characteristics of target cancers and discuss the potentials of cancer immunotherapy.

CIC-3 chloride channel blockade protects mouse photoreceptorderived 661W cells against ischemia-reperfusion-induced injury in vitro

Shi Wei Huang,Yuan Yin,Ya Juan Zheng,Ya Ru Dong 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.1

Exposure to ischemia/reperfusion leads to the development and progression of retinal degenerative diseases. However, the exact mechanisms are not fully understood. In this article, the role of CIC-3 chloride channel in OGD-R (oxygen-glucose deprivation followed by reperfusion)-induced retinal damage was examined. Mouse photoreceptor-derived 661W cells were treated with the CIC-3 antisense oligonucleotide before exposure to OGD-R. Cell viability, mitochondrial membrane potential, cytochrome-c level, DNA fragmentation, caspase activity and protein expression were detected. Pretreatment of 661W cells with CIC- 3 antisense oligonucleotide significantly decreased OGD-R-mediated toxicity. In addition, apoptosis-related biochemical indicators showed that pre-incubation of CIC-3 antisense oligonucleotide would elevate the mitochondrial membrane potential, decrease the release of cytochrome-c as well as formation of DNA fragmentation, and inhibit activities of caspase-3 and caspase- 9 in exogenous OGD-R-treated 661W cells. Moreover, treatment with CIC-3 antisense oligonucleotide changed the expression of apoptosis-related protein. These results suggest that CIC-3 chloride channel mediates OGD-R-induced apoptosis, at least partially through mitochondrial membrane potential pathway and increasing the levels of proapoptotic molecules in 661W cells. CIC-3 chloride channel blockade may provide a new therapeutic approach for preventing ischemia/reperfusion- induced retinal neural damage.

간세포암환자에서 간동맥색전술이 내당력에 미치는 영향에 관한 전향적 연구

서흥석,이은희 한양대학교 의과대학 1991 한양의대 학술지 Vol.11 No.2

To study the influence of transcatheter hepatic embolization on glucose metabolism, glucose tolerance tests were performed in thirty patients of heptocellular carcinoma (contral group) and forty-five patients of diabetes mellitus with hepatocellular carcinoma (diabetic group) befroe and after embolotherapy using Lipiodol and Gelfoam containing anticancer drugs, either alone or combined. The author evaluated changed of glucose tolerance after oral glucose loading, changes of fasting blood glucose(FBG) in relation to the degree of diabetes, changes of FBG in relation to embolic materials, and the relationship between FBG and the liver function(SGPT value) in both groups, before and after embolotherapy. The results were as follows: 1. The glucose tolerance after embolotherapy is significantly impaired at 60, 90, and 120 mimutes after glucose loading (P<0.05) in the control group, and 30, 60, 90, 120, and 180 minutes after goucose loading (P<0.01) in the diavetic group. 2. The FBG level had a tendency to elevate as the degree of diabetes mellitus advanced. 3. FBG elevation had no relation to the difference of embolic materials. 4. There is no significant relationship between the liver function (SGPT value) and the FBG. From the results, the author concluded that embolotherapy for hepatochllular carcinoma sometimes may cause signigicant impairment of glucose tolerance, especially in the patients with advanced diabetes mellitus, therefore careful management of diabetes before and after embolotherapy should be carried out for improvement of the patient's prognosis.

상장간맥 동맥과 간문맥사이의 동정맥 단락:코일을 이용한 치험 1예

강성권 대한영상의학회 1996 대한영상의학회지 Vol.34 No.1

최근 저자들은 복부자상 후 발생한 동정맥단락을 코일을 이용하여 성공적으로 치료 하였기에 이를 보고한다. 환자는 8년전 복부자상의 기왕력이 잇는 환자로 복부자상을 받은 직후 응급으로 수술을 시행하여 위와 장간막을 봉합하였으며 그이후로 복부에서 들리는 진 동과 심계항진이 있었으나 치료하지 않고 지내다 심계항진이 심해지고 실신을 두차례 경험 하였다. 환자의 기왕력과 증상 및 복부 이학적검사상 동정맥단락을 의심하고 혈관조영검사 를 시행하였다. 상장간막 동맥의 선택적 조영검사상 동맥기에 상장간막 정맥과 간문맥이 조 영되었으며 두군데에서 동맥과 정맥사이의 단락이 발견되었고 코일을 이용하여 성공적으로 치료하였다. 환자는 코일을 이용한 색적술직후 심계항진은 없어졌으며 복부에서 들리던 진 동도 들리지 않았다. We recently encountered a case of posttraumatic SMAVF(Superior mesenteric arteriovenous fistula), which hastreated by coil embolization. He had history of stab wound and emergent operation. Operative diagnosis was gastricperforation and mesenteric laceration which was simply repaired. After history of abdominal stab woung andoperation, he developed palpitation and thrill in left upper abdomen. Recentrly he have experienced syncope twice.On superior mesenteric arteriogram, early visualiation of superior mesenteric vein and portal vein was noted. Weembolized the SMAVF by using coils. Since coil embolization, palpitation and thrill disappreared.

소아의 비장 둔상시 경도관 동맥색전술의 효과

박시균 대한영상의학회 1998 대한영상의학회지 Vol.38 No.6

Purpose : To evaluate the efficacy of transcatheter arterial embolization(TAE) in children with blunt splenicinjury. Materials and Methods : The results of transcatheter splenic arterial embolization in nine children whosuffered splenic injury after blunt abdominal trauma were retrospectively studied. This injury was demonstrated byCT, and the findings were evaluated according to the classification of Mirvis et al. ; two patients were grade 3and seven were grade 4. All were carefully observed in intensive care before embolization. TAE was performed if apatient satisfied the following criteria : (1) transfusion and/or fluid replacement required to maintainhemodynamic stability ; or (2) rapid Hb/Hct decrease ; or (3) both. Splenic function was subsequently estimatedaccording to the results of 99mTc-sulfur colloid scintigraphy and/or CT scanning. Result : TAE was suscessful inall nine children. Two were embolized with a coil only, three with gelfoam, and four with gelfoam and a coil.Seven were embolized in the main trunk of the splenic artery and others in both the main trunk and its branches.Splenic function was preserved in all nine children, during follow-up, none suffered rebleeding. Conclusion : TAEof the splenic artery can be a safe and effective nonsurgical approach to the management of blunt splenic injuryin children, and can preserve splenic function.

위십이지장 동맥 가성동맥류의 색전치험 : 1예보고

한영민,강성수,이정민,정진영,이상용,정경호,김종수,손명희,최기철 대한영상의학회 1997 대한영상의학회지 Vol.36 No.1

위십이지장동맥류는 비교적 희귀한 질환이며 만성췌장염에서 췌장 효소의 자가소화 로 인하여 발생하는 생명을 위협하는 합병증이다. 경피적경관색전술은 가성동맥류의 치료에 우선적으로 선택하는 치료방법이다. 수술적인 치료방법은 높은 이환율과 사망률을 가지고 있다. 저자들은 만성췌장염을 가진 30세 남자 환자에서 추적 복부 전산화단층촬영상 위십이 지장동맥에 발생한 가성동맥류을 코일을 이용한 경피적경관색전술로 성공적으로 치료한 1예 를 보고하고자 한다. Gastroduodenal artery pseudoaneurysm is a relatively rare and potentionally life-threatening complication of chronic pancreatitis, which is thought to occur because of autodigestion of arterial walls by pancreatic enzymes. Embolotherapy should probably be the first method of treatment, since surgical treatment carries a high risk of mortality and morbidity. We report the case of 30-year-old male with gastroduodenal artery pseudoaneurysm caused by chronic pancreatitis which was successfully treated by transcatheter embolization using Gianturco spring coils.

간세포암의 화학색전요법:장기생존율과 예후인자

박재형 대한영상의학회 1996 대한영상의학회지 Vol.35 No.3

Purpose : To analyse the long-term survival rate after transcatheter arterial chemoembolization (TACE) ofhepatocellular carcinoma and to determine prognostic factors. Materials and Methods : In 1067 hepatocellularcarcinoma patients who had undergone TACE, of long-term survival rate and prognostic factors were retrospecfivelyanalysed. Chemoembolization was accomplished by hepatic arterial infusion of a mixture of Lipiodol andAdriamycin(51%) or by Gelfoam embolization after infusion of the Lipiodol mixture(49%). The survival rate wascalculated by the Kaplan-Meier method and multivariate analysis using the weibull model was applied to determinewhich prognostic factors were statistically significant. Results : Among the 1067 patients, survival rates were asfollows : one-year, 60.6% ; two-year 42.3% ; three-year, 29.1% ; four-year, 23.7% ; and five-year, 14.7 %. The oneyear survival rate and median survival period of 432 patients with tumors 5cm in diameter or smaller were 77.7%and 33 months respectively, significantly higher than those of patients with larger tumors for whom thecorresponding figures were 44.8% and 11 months. Other significant prognostic factors(p<0.0001) shown bymultivariate analysis included type of tumor, portal vein invasion and child-pugh classification. Conclusion : Theone-year survival rate agter chemoembolization in 1067 patients with hepatocellular carcinoma was 60.6%. Thesignificant prognostic factors were size and type of the tumor, portal vein invasion, and Child-Pughclassification.

췌장염에 의한 가성동맥류의 치료에 있어서 경동맥색전술의 의의

김상기 대한영상의학회 1998 대한영상의학회지 Vol.39 No.5

Purpose : To evaluate the significance of transcatheter arterial embolization(TAE) of pseudoaneurysm complicating pancreatitis. Materials and Methods : This study was based on a retrospective analysis of eight cases, in which TAE for the control of pseudoaneurysm complicating pancreatitis was attempted. All patients were males, and were aged between 35 and 65(mean, 47) years. Seven had a history of episodes of chronic pancreatitis and one case was the result of acute pancreatitis. All patients underwent diagnostic angiography and superselective embolization. Results : Arteries in which pseudoaneurysm had occurred were the gastroduodenal(n=5), inferior pancreaticoduodenal (n=1), superior mesenteric artery root (n=1), and the celiac axis (n=1). Six cases were treated successfully without complications, but in two, embolization failed due to a wide aneurismal neck arising from the superior mesenteric artery root and celiac axis. In four successful cases, pseudoaneurysms were completely resolved within three to six months of embolization. One of the other two remained as a pseudocyst, while in the other, also a pseudocyst, surgery was performed. Conclusion : Because TAE in patients with pseudoaneurysm complicating pancreatitis has a high success rate, and also leads to absolute resorption of a pseudocyst, TAE is the preferred pre-surgical treatment mode