Adult Type Granulosa Cell Tumor of Testis

김동준,송동우,이상엽,윤운용,정태융 대한비뇨의학회 2008 Investigative and Clinical Urology Vol.49 No.1

Testicular granulosa cell tumor(GCT) is a rare neoplasm. We report here on an incidentally discovered testicular granulosa cell tumor in a 36-year-old man. The serum tumor markers were within the normal limits. The ultrasonographic findings revealed a mass with a heterogenous hypoechoic echotexture, including multiple variable sized cystic components. The histology on the orchiectomy specimen demonstrated a gonadal stromal tumor with granulosa cell features. Testicular granulosa cell tumor of the adult type is a very rare tumor, and there have been several isolated case reports and small serial studies described in the literature. (Korean J Urol 2008;49:95-97)

Successful onco-testicular sperm extraction from a testicular cancer patient with a single testis and azoospermia

Kuroda, Shinnosuke,Kondo, Takuya,Mori, Kohei,Yasuda, Kengo,Asai, Takuo,Sanjo, Hiroyuki,Yakanaka, Hiroyuki,Takeshima, Teppei,Kawahara, Takashi,Kato, Yoshitake,Miyoshi, Yasuhide,Uemura, Hiroji,Iwasaki, The Korean Society for Reproductive Medicine 2018 Clinical and Experimental Reproductive Medicine Vol.45 No.1

Onco-testicular sperm extraction is used to preserve fertility in patients with bilateral testicular tumors and azoospermia. We report the case of a testicular tumor in the solitary testis of a patient who had previously undergone successful contralateral orchiectomy and whose sperm was preserved by onco-testicular sperm extraction. A 35-year-old patient presented with swelling of his right scrotum that had lasted for 1 month. His medical history included a contralateral orchiectomy during childhood. Ultrasonography revealed a mosaic echoic area in his scrotum, suggesting a testicular tumor. The lesion was palpated within the normal testicular tissue along its edge and semen analysis showed azoospermia. Radical inguinal orchiectomy and onco-testicular sperm extraction were performed simultaneously. Motile spermatozoa were extracted from normal seminiferous tubules under microscopy and were frozen. Eventual intracytoplasmic sperm injection using the frozen spermatozoa is planned. Onco-testicular sperm extraction is an important fertility preservation method in patients with bilateral testicular tumors or a history of a previous contralateral orchiectomy.

Primary testicular carcinoid tumor with marked lymphovascular invasion

이현정,박준영,김소영,황정수,이정희,신동훈,김지연 대한병리학회 2021 Journal of Pathology and Translational Medicine Vol.55 No.6

Testicular carcinoid tumors are very rare, accounting for less than 1% of all testicular tumors. We report a rare case of a testicular carcinoid tumor with extensive lymphatic invasion. A 42-year-old man presented with a painless, enlarged right testicular mass. There was no history of injury or discomfort in this region. Right radical orchiectomy was performed, which showed a well-defined, non-encapsulated solid white mass with calcification (7.0 × 4.5 × 3.5 cm) and absence of cystic components. Microscopic examination using hematoxylin and eosin staining of the tumor sections identified organoid, trabecular, and solid patterns with rosette formation. Extensive multifocal lymphatic invasion was observed. Immunohistochemistry was positive for synaptophysin, chromogranin, and CD56. Testicular carcinoid tumors usually show good prognoses; however, there was extensive lymphovascular invasion in this case. Thus, in the case of unusual presentation of the disease, close follow-up is necessary.

성인 고환 생식세포종양에 대한 치료 및 장기 추적결과

박서용(Seo Young Park),임수현(Soo Hyun Lim),이건석(Geonseok Lee),서성일(Seongil Seo),전성수(Seongsoo Jeon),이현무(Hyun Moo Lee),최한용(Han Yong Choi),정병창(Byong Chang Jeong) 대한비뇨기종양학회 2011 대한비뇨기종양학회지 Vol.9 No.2

Purpose: To present the therapeutic strategies and long-term follow-up results of testicular germ cell tumors (GCT) based on an 11-year single center experience. Materials and Methods: The medical records of testis cancer cases diagnosed between January 1996 and November 2006 were reviewed. Patient demographics, cancer histopathology and stage, adjuvant therapy, survival data are reviewed and analyzed. Results: A total of 51 testicular GCT, including seminoma in 31, and non-seminomatous GCT (NSGCT) in 20 were enrolled in the present study. Mean patient age at diagnosis was 35.6 years (range 18-69), with a median follow-up of 53 months (range 5-163). There were no cases with bilateral testicular GCT in this study cohort. Among 51patients, 30 (58.8%) were stage I, 10 (19.6%) were stage IIA/IIB, and 11 (21.6%) were IIC/III. Of the 30 patients with stage I testicular GCT, two patients who had been under surveillance showed relapse at retroperitoneal lymph nodes, and both patients cured with salvage chemotherapy. Meanwhile, there was no recurrence in 14 patients who received adjuvant chemo or radiotherapy after radical orchiectomy. The overall 5-year cancer specific survival was 95.9%. Conclusions: Our long-term follow-up results confirm the excellent prognosis for patients with testicular GCT, and indicate that surveillance does not compromise survival. In stage I testicular germ cell tumor, active surveillance could minimize treatment-related morbidity. Before deciding surveillance, however, psychological impacts on patients, economic and social costs in addition to patients’ compliance should also be considered.

Unusual Presentation of a Testicular Lymphoma Mimicking a Missed Testicular Torsion: A Case Report

Kim Mi Jin,Lee Young Hwan,Kim Youe Ree 대한영상의학회 2021 대한영상의학회지 Vol.82 No.5

Testicular lymphoma is an uncommon testicular tumor that usually presents as a painless mass. It usually shows hypervascularity on color Doppler ultrasound (US) and a mild enhancement on enhanced CT or MRI. We present an unusual case of a testicular lymphoma mimicking a missed testicular torsion in a 67-year-old male patient with right scrotal swelling and intermittent pain for 2 months. Color Doppler US demonstrated the absence of vascularity in the enlarged right testis, and the initial diagnosis was a missed testicular torsion. CT demonstrated a poorly enhancing mass rather than a missed testicular torsion with enhanced small nodular foci at the periphery. The final pathological diagnosis was testicular lymphoma.

Clinical Profile, Treatment and Survival Outcome of Testicular Tumors: A Pakistani Perspective

Bhatti, Abu Bakar Hafeez,Ahmed, Irfan,Ghauri, Rashid Khan,Saeed, Qamar,Mir, Khurram Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1

Background: Testicular cancer management is considered a marvel of modern science with excellent treatment results. Pakistan has a distinct ethnic variation and geographic distribution but data regarding clinical presentation of testicular tumors and their management is under reported. The objective of this study was to determine clinical profile, treatment modalities and survival outcome of testicular tumors in the Pakistani population. Materials and Methods: A retrospective review of patients who received treatment for testicular cancer at Shaukat Khanum Cancer Hospital from January 2009 to December 2012 was performed. Patient demographics, clinical features at presentation and treatment modalities were assessed. For categorical variables chi square test was used. Survival was calculated using Kaplan Meier survival curves and Log rank test was employed to determine significance. Results: The most common tumor was mixed germ cell tumor in 49% patients. For all tumor variants except seminoma, stage III was the most common clinical stage at presentation. Majority of patients with non seminomatous germ cell tumors presented in the15-30 year age group as compared to seminoma which was most prevalent in the 30-40 year age group. Orchiectomy followed by chemotherapy was the most common treatment modality in 80% patients. Expected 5 year survival for seminomas and non-seminomatous germ cell tumors was 96% and 90% respectively which was not significantly different (p=0.2). Conclusions: Despite a distinct clinical profile of testicular tumors in Pakistani population, survival is comparable with published reports.

Solitary Testicular Metastasis of Prostate Cancer Mimicking Primary Testicular Cancer

권세윤,정현수,이정국,최석환,권태균,김태환 대한비뇨의학회 2011 Investigative and Clinical Urology Vol.52 No.10

We report a rare case of testicular metastasis from prostate cancer. A 68-year-old patient presented with a right testicular mass with discomfort. He had a history of robot-assisted laparoscopic radical prostatectomy and had received adjuvant radiation therapy and had been treated with androgen deprivation therapy continuously at another institution. We performed a right inguinal orchiectomy. The testicular mass was diagnosed as a metastasis from prostate carcinoma.

Overview of Pediatric Testicular Tumors in Korea

정재민,이상돈 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.12

Prepubertal testicular tumors are rare compared with postpubertal testicular tumors. The incidence of prepubertal testicular tumors peaks at 2 years of age, tapers off after4 years of age, and then begins to rise again at puberty. Prepubertal and postpubertaltesticular tumors show many differences, including the typical tumor histology, molecularbiological differences, and the malignant potential of tumors at different ages. Pediatric testicular tumors are classified as benign or malignant on the basis of theirclinical behavior and histologically are divided into germ cell and gonadal stromal(nongerm cell) tumors. Many histological and biological studies have further confirmedthe distinct nature of prepubertal and postpubertal testicular tumors. These differenceshave led to various management strategies for prepubertal and postpubertaltumors. Because overall about 75% of prepubertal testicular tumors are benign, a testis-sparing approach is becoming more common in children. Orchiectomy and observationwith very selective use of chemotherapy has become the standard approachwhen a malignant tumor is identified. Retroperitoneal lymph node dissection and radiationtherapy play very limited roles.

우심실 종괴로 나타난 고환 태생암의 심장 전이

심만식,김욱성,성기익,이영탁,박표원,임호영 대한흉부외과학회 2010 Journal of Chest Surgery (J Chest Surg) Vol.43 No.1

Metastases to the heart are rarely diagnosed before the patient dies. A 26-year-old man was admitted with multiple metastasis of a testicular embryonal carcinoma and he was found to have intracardiac metastasis. Echocardiography showed that he had a mass rising from the interventricular septum and it was floating through the right ventricular outflow tract. The histology of the mass we removed from the right ventricle was consistent with testicular embryonal carcinoma. The patient made a smooth recovery after surgical intervention and chemotherapy. We believe this is the first reported case of testicular embryonal carcinoma that metastasized to the heart and that was successfully removed via surgery in Korea. 심장 전이는 환자가 사망하기 전에 진단되는 경우가 드물다. 저자들은 고환 융모암의 다발성전이를 보였던 26세 남자에서 심장 전이를 진단하였고 심장초음파에서 심실중격에서 기원하여 우심실유출로에 유동하는 종괴를 확인할 수 있었다. 우심실로부터 제거한 종괴의 조직학적 소견은 고환 융모암에 합당한 소견을 보였고 환자는 수술적 치료 및 항암화학요법 후에 안정된 회복을 보였다. 국내에는 고환 융모암의 심장 전이를 수술적으로 제거함으로써 성공적인 치료 효과를 보였던 증례 보고가 없어 보고하고자 한다.

Extensive Systemic Sarcoidosis with Testicular Involvement Mimicking Metastatic Testicular Cancer

김윤범,정연구,김상진,김세중,안현수,주희재,김선일 대한비뇨의학회 2011 Investigative and Clinical Urology Vol.52 No.4

Sarcoidosis is an idiopathic, multisystem disease that rarely involves the genitourinary tract. Here we present an unusual case of testicular sarcoidosis with extensive lymphadenopathy that mimicked a metastatic testicular tumor. A 27-year-old male presented with a palpable right testicular mass accompanied by multiple palpable inguinal lymph nodes. The scrotal ultrasound showed a hypoechoic lesion at the inferior portion of the right testis. Extensive enlarged lymph nodes were noted in multiple areas on the abdominal computed tomography. Preoperative testicular tumor markers were within the normal range. Exploration of the right testis with a frozen section analysis of the right testicular mass and of a palpable right inguinal lymph node showed granulomatous inflammation. The testis was salvaged and the final pathological diagnosis was sarcoidosis. Treatment with high-dose corticosteroids resulted in complete resolution of the intratesticular mass and a significant decrease in the extent of the lymphadenopathy.