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- 주제어 : Sorghum ethanol extract (검색결과 2 건)
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Extraction of bioethanol from fermented sweet sorghum bagasse by batch distillation
Guangming Li,Jihong Li,Shizhong Li,Xu Zu,Lei Zhang,Lisong Qi,Weiliang Xu 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.1
Extraction of bioethanol, a potential alternative to fossil fuel in the transport industry, from sweet sorghum stems [Sorghum bicolor (L.) Moench] using solid-state fermentation (SSF) technology has become a popular research topic worldwide. Because SSF technology can directly convert fermentable sugars into target products without juice squeezing and water input, this method can potentially reduce energy and water consumption. However, ethanol extraction from fermented sweet sorghum bagasse requires further investigation. We used batch solid-state distillation to investigate the optimal operating parameters in a distillation column (diameter, 400 mm) via a single-factor experiment. Results showed that the optimal steam flow rate and loading height were 8-10 kg·h−1 and 700-1,000 mm, respectively. Under optimal conditions, an energy consumption of 3.82 tons of steam per ton of ethanol and distillate concentration of 60.9% (v/v) were obtained. The pseudo-first-order rate equation was used to describe the distillation kinetics, and good correlations were obtained. Therefore, solid-state distillation can be effectively used to extract ethanol from fermented sweet sorghum bagasse.
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수수 추출물에 의한 primary 전립선 암세포의 caspase 의존성 apoptosis 유도 및 대식세포 면역활성 증가
조현동(Hyun-Dong Cho),김정호(Jeong-Ho Kim),홍성민(Seong-Min Hong),이주혜(Ju-Hye Lee),이용석,김두현(Du-Hyun Kim),서권일(Kwon-Il Seo) 한국생명과학회 2016 생명과학회지 Vol.26 No.12
본 연구에서는 수수 에탄올 추출물(ethanol extract of Sorghum bicolor L., SE)을 이용하여 RC-58T/h/SA#4 primary 인체 전립선 암세포에 대한 apoptosis 유도효과 및 RAW 264.7 마우스 대식세포에 대한 면역활성 증진효능에 대해 알아보고자 하였다. SE의 처리는 RC-58T/h/SA#4 세포의 증식을 억제하였으며 세포수축을 통한 형태학적 변화를 유발하였다. 또한 apoptosis 관련 지표현상인 apoptotic body 및 핵의 형태변화를 관찰할 수 있었다. RC-58T/h/SA#4 세포에 SE를 처리하였을 때 caspase-8, -9, -3 단백질 활성을 증가시켰으며 pro-apoptotic 단백질인 Bax, p53, 분절된 PARP 및 세포질의 cytochrome c 단백질은 증가시킨 반면, anti-apoptotic 단백질인 Bcl-2 단백질은 감소시켰다. 이는 z-VAD-fmk로 caspase 활성을 억제시켰을 때 SE에 의한 세포증식 억제효과가 감소되었으며 이를 통해 SE에 의한 세포증식 억제효과는 caspase 의존적임을 확인할 수 있었다. 면역반응에서 nitric oxide(NO)의 증가는 면역활성 지표로 여겨지며, 본 연구에서 SE를 처리하였을 때 RAW 264.7 세포에서 NO 생성능이 증가하는 것으로 나타났다. 본 연구의 결과들은 SE가 primary 전립선 암세포에서 caspase 의존형 apoptosis를 유도하며 대식세포의 면역활성을 증가시킨다는 것을 나타낸다. 따라서 수수를 전립선 암 예방 및 면역활성을 증진효능이 있는 기능성 식품 소재로 활용할 수 있을 것으로 생각된다. Sorghum bicolor L. is one of the important minor cereals in Asia, Africa, and the central United States, and it is considered a rich source of polyphenols, flavonoids, and dietary fiber. However, there is a lack of data on the anti-cancer activity of Sorghum in prostate cancer cells and immune activity in macrophages. This study aims to investigate the potential effects of an ethanol extract of S. bicolor L. (SE) on inducing apoptosis in RC-58T/h/SA#4 cells and immunomodulatory activity in RAW 264.7 cells. SE significantly inhibited the viability of RC-58T/h/SA#4 primary prostate cancer cells in a dose-dependent manner. The morphology of RC-58T/h/SA#4 cells treated with SE was shrunken and involved the formation of an apoptotic body and nuclear condensation. In addition, SE markedly activated caspase-8, -9, and -3; increased the protein levels of Bax, p53, cleaved PARP, and cytosolic cytochrome c; and decreased Bcl-2 protein expression. Furthermore, the inhibition of caspases in RC-58T/h/SA#4 cells with z-VAD-fmk attenuated SE-induced cell growth inhibition. The production of nitric oxide (NO) was also elevated by SE treatment, as revealed by immune response parameters. These results suggest that SE inhibits growth and induces apoptosis in primary human prostate cancer cells in a caspase-dependent manner, and it modulates the immune functions in macrophages. Therefore, Sorghum bicolor L. may be used as a functional food to prevent prostate cancer and enhance immune activity.
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