Clinical characteristics of arsenic-induced non-melanoma skin cancer

( Jun-oh Shin ),( Kihyuk Shin ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: Chronic arsenic exposure has been found to be associated with skin cancer and internal malignancy. However, clinical research on characteristics of arsenic-induced skin cancer has been rarely reported. Objectives: The aim of this study was to investigate the clinical characteristics of arsenic-induced skin cancer. Methods: We performed a retrospective review of medical chart and clinical photos of the 26 patients diagnosed with skin cancer among patients with definite arsenic keratosis (ArK) and arsenical exposure history in the Pusan National University Hospital (Busan and Yangsan) from 2004 to 2018. Results: We included 26 patients diagnosed with skin cancer among patients with ArK and the total number of skin cancer lesions they had was 46. Among 26 patients, 22 (84.6%) patients were diagnosed with squamous cell carcinoma (SCC), and 4 (15.4%) patients were diagnosed with basal cell carcinoma (BCC). Patients with ArK had multiple skin cancer lesions, and the skin cancer developed at a younger age. And the site of cancer was more sun-protected area than non-arsenical skin cancer. Arsenical SCC is more aggressive in tumor size, its differentiation, Mohs micrographic surgery stage and more often metastasized than non-aresenical SCC. Conclusion: Our study could be helpful for dermatologist to encountering arsenic-induced skin cancer. This study revealed that arsenic-induced skin cancer is more aggressive, therefore, regular check-up for skin and metastasis is important.

The 28-year incidence and characteristics of post-transplant skin cancers: comparative analysis of past and recent 10-year experience

( Hee Joo Yang ),( Young Jae Kim ),( Chang Jin Jung ),( Gyeong-hun Park ),( Chong Hyun Won ),( Sung Eun Chang ),( Jee Ho Choi ),( Mi Woo Lee ),( Woo Jin Lee ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Since primary skin cancers in organ transplant recipients (OTRs) are rare, little is known about the characteristics and risk factors of skin cancer in OTRs. Objectives: To improve understanding of primary skin cancers in OTRs. Methods: The database of the Asan Medical Center was searched for OTRs diagnosed with primary post-transplant skin cancers from January 1990 to December 2018.The standardized incidence ratios (SIR), defined as the ratio of the observed number of cancers divided by the expected number of cancers were determined for each cancers. Results: Of 13,469 OTRs, 113 (0.8%) were diagnosed with skin cancers over the 28 years. The most common skin cancer was squamous cell carcinoma, followed by basal cell carcinoma and Kaposi’s sarcoma. The cumulative incidence of skin cancers at 28 years was 5.3%. Over the 10 year period from January 2009 to December 2018, the SIR for premalignant in situ skin lesions increased, whereas the SIR for skin cancers decreased, and the types of post-transplant skin cancers became more diverse. Age at transplantation and treatment with more than two immunosuppressive agents were risk factors for the development of new skin cancers in OTRs. Conclusion: Over the most recent 10 year period, post-transplant skin cancers have been found earlier and to be more diverse than in previous periods. Older age and treatment with more than two immunosuppressive agents increase the risk of post-transplant skin cancers.

A survey of counseling and behavior regarding skin cancer

( Young Bin Shin ),( Chang Il Kwon ),( Jeong Won Jo ),( Yun Sun Moon ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: As the incidence of skin cancer increases, more information and education on skin cancer are needed. Although skin cancer is not rare, most patients are little known about general awareness of skin cancer. Objectives: The purpose of this study is to investigate the post-education effects on skin cancer in our hospital outpaitents and carers. Methods: We reviewed a written questionnaire and patients’ self-checked records including patients’ basic medical information and knowledge of skin cancer protective modalities. Results: In total 340 cases, 215 (63.2%) patients were female and 125 (36.8%) patients were male. 6 people in their teens, 56 people in their 20s and 30s, 156 people in their 40s and 50s, 122 people in their 60s or older. Before education, 142 people said sunlight can cause a skin cancer and 178 did not. After education, 246 people said Yes and 94 people did not. When asked how you wanted to get more information on skin cancer, 104 (30.6%) people said that they were printed handout, 142 (41.8%) were visit to dermatologists, 52 (15.3%) were photos of skin symptoms, and 42 (12.3%) were phone calls. Conclusion: This result showed that people are little known about risk factor of skin cancer such as sunlight and artificial tanning. However, we found that through education, people's perceptions could change. The education on behavior for skin cancer prevention should be continued so that the awareness of the risk of skin cancer can be changed.

P063 A correlation between skin cancer and vitiligo in 27,507 gastroesophageal reflux disease patients

( Jaewon Lee ),( Hyun-sun Yoon ),( Soyun Cho ),( Hyun-sun Park ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: There can be various explanations about the relationship between vitiligo and skin cancer as regards pathogenesis of vitiligo. The autoimmunity in vitiligo can promote anti-cancer immunity so that skin cancer might be less common in vitiligo patients. On the other hand, if the destruction of melanocytes disrupts natural protection from ultraviolet radiation, the risk of skin cancer might be increased. Objectives: To investigate the relationship between vitiligo and skin cancer. Methods: We retrospectively reviewed medical records (from Jan. 2000 to Mar. 2016) of SMG-SNU Boramae Medical Center. We extracted data from 27,507 patients with gastroesophageal reflux disease, which is, in general, known to be associated with neither vitiligo nor skin cancer. The following data were obtained: demographics, the number of dermatology clinic visits, and the presence of vitiligo or skin cancer. Results: We found that the prevalence of skin cancer had a positive correlation with that of vitiligo and this correlation was persistent after control of age and sex. However, there was no correlation of vitiligo and skin cancer when ‘the number of visit’ was controlled. Conclusion: In our study, increased prevalence of skin cancer in vitiligo patients may not demonstrate true association and result from more frequent dermatologic clinic visits. Further studies are required to establish relationship between vitiligo and skin cancer.

A survey of knowledge and behavior regarding self examination of skin cancer

( Jeong Won Jo ),( Young Bin Shin ),( Hae Bong Jeong ),( Yun Sun Moon ),( Do Seon Jeong ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: The recognition of self examination of cancer has increased more than before. Although skin cancers are almost always curable when found and removed early, most patients are little known about general awareness of skin cancer. Objectives: In this study, we survey on satisfaction of clinic education to the 40 patients treated with skin cancer and affection to behavioral change. Methods: We reviewed a written questionnaire and patients’ self-examination records including patients’ age, method of self-examination, and skin check point. Results: The most patients replay (90%, 36/40) and want to know the warning signs of skin cancer and what to look for during the self-examination (88%, 32/36). The results show the most of patients want to help you make the next your dermatologist’s appointment (81%, 29/36). At time of check self-examination, the patients use the record paper prepared from our clinic (69.4%, 25/36). Conclusion: Although the patients treated with precancer and cancer area aware that the risk of skin cancer and they want to know about self-examination of skin cancer. Therefore, most popular skin cancer education and prevention program include self-skin examination is more required and dermatologist should play a major role in this action.

Skin Cancer: Clinico-Pathological Study of 204 Patients in Southern Governorates of Yemen

Al-Zou, Amer Bin,Thabit, Mazen Abood Bin,Al-Sakkaf, Khalid Abdulla,Basaleem, Huda Omer Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7

Background: Skin cancer is a group of heterogeneous malignancies, in general classified into non-melanoma skin cancer (NMSC) and melanoma skin cancer (MSC). Incidences are high in many parts in the world with considerable geographical and racial variation. In the Yemen, there has been scarce information about skin cancer. The aim of this study was to evaluate the demographic characteristics and histological trend of skin cancer in Southern Governorates of Yemen. Materials and Methods: This retrospective study covered 204 cases of skin cancer at the Modern Histopathology Laboratory and Aden Cancer Registry and Research Center, Faculty of Medicine and Health Sciences, University of Aden, for the period 2006-2013. Data were classified regarding different demographic and tumor related variables and analyzed using CanReg-4 for cancer registry and SPSS (version 21). Results: The commonest encountered skin cancer was NMSC (93.1%). Generally, skin cancer appears slightly more frequently in females than males with a 1:1.06 male: female ratio, with a mean age of 62.9 years. Slightly higher than one-third (36.3%) were from Aden governorate. The head and neck proved to be the most common site in both males and females (58%). Basal cell carcinoma (BCC) is the most common histological type of skin cancer (50.5%). Conclusions: Skin cancer is a common cancer in patients living in southern governorates of Yemen. The pattern appears nearly similar to the international figures with a low incidence of MSC.

11년간 경험한 피부의 악성종양에 대한 임상적 고찰

이태성,변재경,문구현,방사익,오갑성,임소영 대한성형외과학회 2008 Archives of Plastic Surgery Vol.35 No.3

Purpose: The incidence of skin cancer is increasing throughout the world including Asian countries such as Korea. Still there are only limited reports of the clinical features of skin cancer in Korea, especially in the fields of plastic surgery. This study is to demonstrate the recent clinical trends of skin cancer and the treatment of skin cancer in Korea by analyzing a single institution’s experience.Methods: During a 11-year period, 370 patients visited our department for the excision of skin cancer. Data of the patients such as histopathologic diagnosis, primary site of the tumor, age and sex of the patient, operative methods were reviewed retrospectively. Results: We had 370 patients, 215 men and 155 women. The ages ranged from 10 to 95 years with a mean of 58.8 years. A total of 143 patients were diagnosed as basal cell carcinoma, while 100 were malignant melanoma, 80 were squamous cell carcinoma, 17 were dermatofibrosarcoma protuberans, and 30 were other miscellaneous skin cancers. Local flaps were the most frequently used reconstructive method after wide excision of the cancer, which was followed by primary closure, split-thickness skin graft, free flap and full- thickness skin graft.Conclusion: There was a gradual increase in the incidence of skin cancer after the year 2000. Basal cell carcinoma had the highest incidence which frequently involved the sun-exposed regions in the old ages. Malignant melanoma showed a relatively high incidence compared with other previous studies in Korea. The extremities were the most frequent location for malignant melanoma. Clinical features of other various skin cancers were also reported in this study. The reconstructive method highly depends on the primary site of the cancer, while local flaps were the mostly used operative technique.

Clinicopathological study on metastatic skin cancer

( Chang Il Kwon ),( Seo Mi Gon Jeong ),( Young Bin Shin ),( Yun Sun Moon ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Various primary tumors can cause metastatic skin cancer. Metastatic skin lesion should be distinguished from other skin lesion. Objectives: We studied patients with metastatic skin cancer to find out average age, gender distribution, frequency of primary tumor, time interval between manifestation and primary cancer, and their clinical appearance, location and other metastatic sites. Methods: We reviewed the medical records, clinical photographs and histopathologic records of patients who had been diagnosed with metastatic skin cancer. Results: In the comparison according to clinical records, the mean age at the time of diagnosis was 60.6 years. The ratio of men to women was 1.05:1. The most frequent primary tumors were breast cancer (22.0%), lung cancer (17.0%), head and neck cancer (17%), melanoma (17.0%), gastrointestinal cancer (11%), urologic cancer (11%), and gynecologic cancer (6%). Metastatic skin cancers usually presented as discrete, painless, hard nodules, with sudden onset (88%). Conclusion: Based on the results of this study, it is believed that it is important to recognize the metastatic lesion between various skin lesion such as infections and granulomatous changes of other cause due to drugs and reactive changes.

암전문 3차의료기관 피부과에 내원한 고형암에 의한 전이피부암 191예의 임상 및 조직병리학적 고찰

박형건 ( Hyung Keon Park ),윤숙정 ( Sook Jung Yun ) 대한피부과학회 2023 대한피부과학회지 Vol.61 No.1

Background: Metastatic skin cancers occur when cancer cells metastasize to the skin as the primary cancer progresses, but few studies in Korea have included a large number of patients. Objective: To analyze the clinicopathological characteristics of metastatic skin cancers originating from solid cancers. Methods: A total of 191 patients with metastatic skin cancer diagnosed by skin biopsy from April 2004 to December 2021 were retrospectively analyzed. Data on age, sex, duration, symptoms, clinical manifestations, metastatic sites, and histopathological findings were obtained from medical records and photographs. Results: The mean age of onset was 65.3 years, the male/female ratio was 80:111, and the mean duration was 3.3 months. Most patients were asymptomatic (65.4%), and the most frequent manifestation was nodular lesions (64.4%). Among the 191 metastatic skin cancers, the most common primary cancers were breast cancer (31.9%), lung cancer (25.7%), and melanoma (18.8%). The most common primary cancer in males was lung cancer (52.5%), and that in females was breast cancer (54.1%). The most common sites of metastatic skin cancer were the chest (26.6%), scalp (17.9%), abdomen (10.6%), and back (9.2%). The most common histopathological finding of metastatic skin cancer was adenocarcinoma (53.4%), followed by melanoma (18.8%) and squamous cell carcinoma (14.7%). Conclusion: We believe that this study will be helpful in diagnosing metastatic skin cancer in patients with a history of cancer or a newly diagnosed primary cancer. (Korean J Dermatol 2023;61(1):13∼21)

A survey of knowledge and behavior regarding skin cancer.

( Young Bin Shin ),( Jeong Won Jo ),( Hae Bong Jeong ),( Yun Sun Moon ),( Do Seon Jeong ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: The recognition of prevention and early detection of skin cancer has been increased more than before. Although skin cancer is not rare, most patients are little known about general awareness of skin cancer. Objectives: In this study, we survey the awareness and knowledge of skin cancer and sun protection behavior among South-Gyeongnam province. Methods: We reviewed a written questionnaire and patients’ self-checked records including patients’ basic medical information and knowledge of skin cancer protective modalities. Results: In total 284 subjects (94.7%(284/300), 67%(190/284) females, mean age 57.4 years) completed the survey. Most people (77.5%, 220/284) knew that the sun was most dangerous for their skin but relatively large portion of them (42.7%, 94/220) had no action to protective attitude like sun screen, large hat and gloves. Conclusion: The results show that many participants had known necessity of skin cancer prevention and importance of early detection, but didn’t have had any protective action. Therefore, a more effective skin cancer education and prevention program is needed. We suggest that the measurement of effects of a multimodal educational intervention on knowledge of sun protection practices and engagement in self sun-protection behaviors also need to be check.