유리체 수술 중 안내 주입한 실리콘기름의 결정화

정진욱,박규형 대한안과학회 2005 대한안과학회지 Vol.46 No.6

Purpose: To report three cases of unexpected intraocular foreign bodies which were detected during silicone oil removal procedure following pars planar vitrectomy and silicone oil injection due to the severe vitreoretinal proliferations. Methods: The medical records of three male patients, aged 61, 40, and 38 years, were reviewed retrospectively. We performed pars planar vitrectomy and silicone oil injection due to submacular hemorrhage with vitreous hemorrhage, tractional retinal detachment with proliferative diabetic retinopathy, and proliferative vitreoretinopathy, respectively. After the retinas were stabilized, we performed silicone oil removal at postoperative 1, 6, and 5 months, respectively. During the silicone oil removal procedure, intraocular foreign bodies were detected and removed with the vitreoretinal forceps. Results: The intraocular foreign bodies were approximately 6 mm × 1 mm in size, transparent, rod-shaped, solid materials. Histopathologic findings didn`t show any cellular or intraocular tissue components in and around the foreign bodies. Using electron spectroscopy for chemical analysis, the elemental compositions of the intraocular foreign bodies were determined to be the same as that of the silicone oil that had been previously injected in the eye. We therefore confirmed that those foreign bodies that were removed from the eyes were crystallized remnants of the silicone oil. Conclusions: Silicone oil can be crystallized after intraocular injection. Therefore, meticulous fundus examination including peripheral fundus is mandatory at the end of the silicone oil removal procedure to prevent any solid silicone foreign bodies from remaining in the eyes. Further investigations are needed to reveal the mechanisms of intraocular crystallization of the silicone oil.

Changes in Refraction and Axial Length According to the Viscosity of Intraocular Silicone Oil

Man Seong Seo,Sun Taek Lim,Hyun Dong Kim,Byeong Il Park 대한안과학회 1999 Korean Journal of Ophthalmology Vol.13 No.1

We performed this study to evaluate the changes in refraction and axial length induced by intraocular silicone oil, and to compare with various clinical parameters between 1,000 and 5,000 cSt silicone oil. The refraction length was measured with an autorefractometer, and the axial length was measured with A-scan ultrasonography. These measurements were performed before and after removal of the silicone oil, using a clear cornea technique in which the silicone oil was injected in combination with pars plana vitrectomy. The mean age of the 25 patients was 38.73 years. On average the intraocular retention after the removal of the silicone oil lasted 5.13 months, and the follow-up time following silicone oil removal was 4.37 months. The changes in refraction and axial length were 6.32 diopters and 12.02 mm, respectively. Eyes injected with 5,000 cSt (11 eyes) tended to have higher changes in the refraction (5.84 vs 6.86 diopters) and axial length (11.70 vs 12.34 mm) than did eyes injected with 1,000 cSt silicone oil (14 eyes). Statistically significant differences were shown for the changes in refraction (p = 0.010) and intraocular pressure (0.63 vs 2.00 mmHg; p = 0.006), whereas but not for the changes in axial length (p = 0.306) and visual acuity (14/100 vs 15/100; p = 0.125). Intraocular silicone oil induced changes in refraction and axial length, and these changes seemed to vary with different viscosities.

실리콘오일 에멀전 및 비실리콘 오일이 소포성에 미치는 영향

전수지 ( Su-ji Jun ),조세현 ( Se-hyun Jo ),김태근 ( Tae-geun Kim ) 한국수처리학회 2021 한국수처리학회지 Vol.29 No.1

In many industrial plants, foaming at liquid surfaces can reduce process efficiency and cause environmental problems with waste discharge. In most industrial sites, such as wastewater treatment plants, it is necessary to remove foam to improve water quality and process efficiency. The formation of persistent foams can be a critical problem in wastewater treatment since it can lead to operational issues and reduce the overall system performance. For basic research for the development of new defoamers, we tested defoamers for wastewater treatment. A 50% (v/v) water-dispersible foaming liquid was prepared using a foaming agent-A. Two types of defoaming agents were tested: silicone emulsion anti-foaming agents, B and C, and non-silicone oil anti-foaming agents, corn oil and mineral oil. The defoaming properties of these substances were tested as a function of pH, defoamer concentration, viscosity of defoamer dispersion, and defoamer storage period. At a pH of 3, 5, and 7, the defoaming by the silicone oil emulsion and non-silicone oil was greater than 80% effective. The foam quantity (L/min) of the silicone-based defoamer was lower even at lower concentrations than the non-silicone corn oil and mineral oil. At lower pH, the viscosity of the defoamer dispersions was slightly higher. We observed little difference in defoaming capacity after 30 days of storage.

실리콘 오일에 의한 휘발성 유기화합물의 흡수 특성: n-nonane, 1¸2¸4-trimethylbenzene, toluene, xylene, isopropyl alcohol 및 methyl ethyl benzene

강수경,장시내,윤정희,조경숙 한국냄새환경학회 2020 실내환경 및 냄새 학회지 Vol.19 No.3

n-Nonane, 1¸2¸4-trimethylbenzene (124-TMB), toluene, total xylene (TXYL), isopropyl alcohol (IPA), and methyl ethyl alcohol (MEK) are major volatile organic compounds (VOCs) emitted from printing industries. The absorption amount of a single VOC per unit weight of silicone oil was as follows in the order of 189.5 g/kg-silicone oil for n-nonane, 91.7 g/kg-silicone oil for 124-TMB, and 60.1 g/kg-silicone oil for TXYL. Although hydrophobic VOCs were more absorbed in silicone oil than hydrophilic VOCs such as IPA and MEK, IPA and MEK, which had log Kow values of 1 or less, also were absorbed more than 26.0 g/kg-silicone oil. In two and three mixed VOCs of n-nonane, 124-TMB, and toluene, the absorption amount of each in silicon oil was less than that of single a VOC. The total absorption amount of two mixed VOCs ranged from 47.9 g to 138.7 g/kg-silicone oil, and the total absorption amount of three mixed VOCs was 65.8 g/kg-silicone oil. These results suggest that silicone oil is a promising pretreatment solution capable of absorbing high concentrations of VOCs that are intermittently emitted from printing industries. The absorption information of VOCs obtained in this study can be used as the design parameters of a damping device for the pretreatment of VOCs.

실리콘기름이 주입된 무수정체안에서 인공수정체 굴절력 예측의 정확도

이수민,김우진,김수환,이승우 대한검안학회 2023 Annals of optometry and contact lens Vol.22 No.3

목적: 실리콘기름이 주입된 무수정체안에서 실리콘기름제거 및 인공수정체를 모양체고랑에 삽입을 시행했을 때 수술 전 목표 굴절력과 수술 후 실제 굴절력 사이의 차이를 알아보았다. 대상과 방법: 실리콘기름이 주입된 무수정체안에서 실리콘기름을 제거하면서 동시에 인공수정체를 모양체고랑에 삽입을 시행한 환자들(1군)과 무수정체안에서 유리체절제술을 하면서 동시에 인공수정체를 모양체고랑에 삽입했던 환자들(2군)의 기록을 조사하였다. IOL master® 700을 이용하여 안구 길이 및 안구생체계측을 시행하고 굴절이상예측값과 수술 후 현성굴절이상값을 후향적으로 조사하여 비교하였다. 결과: 모양체고랑에 삽입하는 것을 기준으로 가장 정시에 가까운 근시 값의 인공수정체의 도수에서 1.0 D 뺀 굴절이상예측값은 1군은0.50 ± 0.12 D, 2군은 0.45 ± 0.20 D였다. 술 후 6개월 후 평균 굴절이상값은 1군은 -0.76 ± 0.49 D, 2군은 -0.23 ± 0.49 D로수술 전에 비해 유의한 근시편위를 보였다(p < 0.001, p < 0.001). 1군이 2군에 비해 더 유의한 근시 편위를 보였으며(p = 0.001), 특히 유리체내 실리콘기름이 불충분하게 충전되어 있던 3안에는 -1.5 D 이상의 근시 편위를 보였다. 결론: 실리콘기름이 있는 무수정체안에서 실리콘기름을 제거하면서 인공수정체를 모양체고랑에 삽입하는 경우 안구생체계측에는 어려움이 있으며, 수술 후 근시 편위가 대조군에 비해 더 크게 나타나며, 특히 실리콘기름이 유리체내에 완전히 충만되지 않는 경우굴절값의 오차가 크게 나타나 이에 대한 보정이 필요할 것으로 생각된다. Purpose: To compare preoperative refractive power estimation and actual postoperative refraction after combined silicone oil removal and intraocular lens (IOL) sulcus implantation in silicone oil-filled aphakic eyes. Methods: Records of patients with silicone oil-filled aphakic eyes who received simultaneous silicone oil-removal and IOL sulcus implantation (Group1) and aphakic patients who received vitrectomy combined with IOL implantation (Group 2) were reviewed. Optical biometry including axial length measurements were obtained using IOL master® 700 and predicted refractive errors, actual postoperative refractive errors were examined retrospectively. Results: Predicted refractive errors, calculated by subtracting 1 diopter (D) from myopic lens power closest to plano based on sulcus implantation, were 0.50 ± 0.12 D in Group 1, 0.45 ± 0.20 D in Group 2. Six months after operation, mean refractive errors measured -0.76 ± 0.49 D in Group 1, -0.23 ± 0.49 D in Group 2, showing significant myopic shift (p < 0.001, p <0.001). Group 1 showed larger significant myopic shift compared to Group 2 (p = 0.001), especially in 3 eyes with insufficient filling of intravitreal silicone oil showing -1.5 D myopic shift. Conclusions: Ocular biometry of silicone oil-filled aphakic eyes undergoing simultaneous silicone oil removal and IOL sulcus implantation are difficult to measure, showing postoperative myopic shift compared to control. Incomplete intravitreal silicone oil filling showed larger refractive errors needing additional compensations.

실리콘기름 주입안에서 점도에 따른 레이저 간섭계와 초음파로 측정된 안축장과 전방 깊이 비교

이민호,한영상,이종수,Min Ho Lee,Young Sang Han,Jong Soo Lee 대한안과학회 2008 대한안과학회지 Vol.49 No.2

`Purpose: To evaluate differences between partial coherence laser interferometry (IOL-Master, Zeiss) and A-scan measurement of axial length and anterior chamber depth in silicone oil-filled eyes according to viscosity. Methods: Using IOL-Master and A-scan, axial length and anterior chamber depth in silicone oil-filled eyes (n=54) and normal eyes (control, n=54) were measured and analyzed. In silicone oil-filled eyes, calculated axial lengths by A-scan using conversion factors, axial length multiplied by 0.71, and vitreous cavity multiplied by 0.64 (classic method) were compared with those calculated by IOL-Master. Anterior chamber depths were also analyzed., and axial lengths and anterior chamber depths were compared according to the viscosities of silicone oil for measurement by A-scan. Results: Axial length and anterior chamber depth using IOL-Master were shorter than those using A-scan by 9.45±1.81 mm (p<0.05) and 0.11±1.29 mm, respectively. In normal eyes, axial length and anterior chamber depth using IOL-Master and A-scan were not significantly different. In silicone oil-filled eyes, axial length using IOL-Master and conversion factor was also not significantly different. At the highest silicone oil viscosity the difference in measured axial length was greatest (p<0.05) while the difference in anterior chamber depths was smallest. Conclusions: In silicone oil-filled eyes, axial length by IOL-Master was more accurate than that by A-scan, regardless of silicone oil viscosity. Thus, IOL-Master is more useful than A-scan when measuring axial length in silicone oil-filled eyes.`

Is Silicone Oil an Effective Treatment for Infectious Endophthalmitis?

Kyu Young Shim,Yu Cheo Kim 대한검안학회 2017 Annals of optometry and contact lens Vol.16 No.1

Purpose: We report a case of infectious endophthalmitis in which treatment with silicone oil had an adverse outcome. Case summary: A 72-year-old woman underwent uneventful 23-gauge pars plana vitrectomy with cataract surgery for vitreous hemorrhage due to proliferative diabetic retinopathy. On postoperative day 10, postoperative endophthalmitis was diagnosed, so we promptly irrigated the vitreous cavity and anterior chambers with antimicrobial mixed balanced salt solution and injected silicone oil. Pus was found below the silicone oil, 2 days after the silicone oil tamponade. On the next day, the silicone oil was removed. The ghost vessels at inferior retina were identified during removal of the silicone oil and they had not improved. Conclusion: Silicone oil may accelerate the damage occurring at the inferior retina in patients with infectious endophthalmitis.

실리콘이 충전된 눈에서 부분결합간섭계를 이용한 인공수정체 도수계산

강승범(Seungbum Kang),노영정(Young Jung Roh) 대한검안학회 2012 Annals of optometry and contact lens Vol.11 No.1

목적: 실리콘이 충전된 눈에서 부분결합간섭계를 이용한 인공수정체 도수결정의 정확성을 알아보고자 하였다. 대상과 방법: 실험군은 실리콘이 충전된 눈에서 부분결합간섭계를 이용하여 인공수정체 도수를 정하고 실리콘기름 제거술과 인공수정체 삽입술을 동시에 시행한 10안을 대상으로 하였다. 대조군은 실리콘 기름을 제거한 후 초음파를 이용한 A-scan (Tomey, Nagoya, Japan)으로 인공수정체의 도수를 계산하고 단계적으로 인공 수정체를 삽입한 12안을 대상으로 하였다. 술 후 3개월째 실제 굴절값을 측정하였고, 목표 굴절값과 차이인 굴절예측이상값을 구하여 두 군의 굴절예측이상값의 평균을 비교하였다. 결과: 실험군의 술 후 3개월째 실제 굴절값의 평균은 -1.30±1.57디옵터였고 굴절예측이상값의 평균은 -0.08±1.04디옵터였다. 대조군의 술 후 3개월째 실제 굴절값이 평균은 -1.63±1.75디옵터였고, 굴절예측이상값의 평균은 -0.48±1.27디옵터였다. 두 군의 굴절예측이상값 사이의 평균은 통계적으로 유의하지 않았다(p=0.674). 결론: 부분결합간섭계는 실리콘이 충전된 눈에서 인공수정체 도수를 결정할 경우 유용하게 사용될 수 있다. Purpose: To evaluate the accuracy of intraocular lens (IOL) power calculation in eyes that have been operated on by silicone oil removal combined with IOL implantation using partial coherence interferometry. Methods: 10 eyes of 10 patients with silicone oil tamponade were included in this study. The IOL power calculation for 10 eyes was performed using partial coherence interferometry. 12 eyes of 12 patients with silicone oil tamponade were also included in this study as control group. 12 eyes in control group had IOL implantation after silicone oil removal. The IOL power calculation for control group was performed using conventional ultrasound A-scan (Tomey, Nagoya, Japan). Three months after silicone oil removal combined with IOL implantation, actual refraction was measured. To compare the difference between the actual and target refraction, refractive prediction error was calculated. It is defined as substraction of target refraction from actual refraction. Results: At three months, actual refraction and refractive prediction error of the group using partial coherence interferometry were -1.30±1.57 diopter and -0.08±1.04 diopter, respectively. At three months, actual refraction and refractive prediction error of the control group using ultrasound A-scan were -1.63±1.75 diopter and -0.48±1.27 diopter, respectively. There was no statistically significant difference between two values (p=0.674). Conclusions: Partial coherence interferometry seems to be satisfactory accurate method to calculate IOL power in silicone oil-filled eye.

유리체강 내 실리콘기름의 대뇌로의 이동으로 인한 반대편안의 이측 시야결손

이성복,신경섭,조영준 대한안과학회 2011 대한안과학회지 Vol.52 No.5

Purpose: To report a case of temporal hemianopsia of a healthy eye occurring in the contralateral silicone oil-filled eye due to migration of silicone oil into the optic chiasm and lateral ventricle. Case summary: A 56-year-old man visited our clinic with temporal hemianopsia for 10 days in the left eye. Three months before, the patient had presented with decreased vision and ocular pain in the right eye as well as a headache. The patient underwent vitrectomy at another hospital for the management of retinal detachment occurring in the right eye 8 years earlier. In addition, for recurred retinal detachment, reoperations were performed twice with silicone oil injection. Funduscopy revealed findings such as glaucomatous optic disc and an intraocular pressure of 54 mmHg in the right eye. On visual field examination, the temporal hemianopsia was detected in the left eye. Under the suspicion of cerebral lesions, a magnetic resonance imaging (MRI) examination was performed. On the right side of the optic chiasm and the suprasellar region, materials were present whose signal intensity was identical to silicone oil in the right vitreal cavity. During a follow-up, the migration of silicone oil into the lateral ventricle and the alteration of its location with the positional change were observed. Conclusions: In a patient who received silicone oil injection following vitrectomy, the silicone oil migrated to the optic chiasm and induced the occurrence of visual field defect in the contralateral eye. The visual field defect improved because of the migration into the lateral ventricle. J Korean Ophthalmol Soc 2011;52(5):633-638

안구 내 실리콘기름주입술 이후 발생한 위눈꺼풀의 지방육아종 염증 및 눈꺼풀처짐

한동진(Dong Jin Han),최헌진(Hun Jin Choi),이종현(Jong Hyun Lee),서지원(Ji Won Seo) 대한안과학회 2020 대한안과학회지 Vol.61 No.12

목적: 안구 내 실리콘기름주입술 이후 위눈꺼풀로 실리콘기름 이동, 지방육아종 염증 및 눈꺼풀처짐이 발생한 환자를 경험하였고 이를 치료한 사례를 보고하고자 한다. 증례요약: 83세 여자 환자가 2개월 전부터 좌안에 발생한 위눈꺼풀의 부종과 눈꺼풀처짐을 주소로 내원하였다. 내원 5개월 전 좌안의 당뇨망막병증에 의한 유리체출혈, 홍채신생혈관 및 신생혈관녹내장 진단 하에 좌안 유리체절제술, 실리콘기름주입술 및 평면부에 아메드밸브삽입술을 시행받았다. 수술 1개월째 좌안 안구 내 실리콘기름이 약 절반만 남아 있어 실리콘기름제거술 후 실리콘기름주입술을 재시행하였다. 점차 진행하는 좌안 위눈꺼풀의 부종과 눈꺼풀처짐에 대해 피부절개를 통한 안와격막 앞쪽 공간의 종괴절제술 후 조직검사를 계획하였다. 조직검사를 통해 괴사된 지방 조직과 지방육아종염증을 확인하였고, 수술 1주일째 좌안의 눈꺼풀처짐은 호전되었으며 수술 4개월째 좌안의 눈꺼풀부종과 눈꺼풀처짐의 재발은 보이지 않았다. 결론: 안구 내 실리콘기름주입술을 받은 환자에서 위눈꺼풀부종과 안구 내 실리콘기름양의 감소가 확인되면 실리콘기름의 위눈꺼풀이동과 이로 인한 합병증을 고려하여야 한다. Purpose: We report a rare case of injected silicone oil migration into the upper eyelid, accompanied by lipogranulomatous inflammation and ptosis, after vitrectomy using a silicone oil tamponade. Case summary: An 83-year-old female presented to our clinic with left upper eyelid swelling and ptosis 2 months in duration. Five months prior, she had undergone 23-gauge pars plana vitrectomy combined with Ahmed valve implantation to treat neovascular glaucoma. Four months prior, only about half the original volume of intraocular silicone oil remained, and a second oil injection was thus administered after removal of the remaining original oil. We found a mass in front of the left orbital septum; this was associated with gradual progression of the left upper eyelid swelling and ptosis. We resected the mass via a left upper eyelid skin incision 2 months after presentation. Histological examination of the excised tissue revealed necrotic fat consistent with lipogranulomatous inflammation. One week after excision, the ptosis disappeared. At the 4-month follow-up, the left upper eyelid was normal with no sign of recurrence. Conclusions: To the best of our knowledge, this is the first report in South Korea of lipogranulomatous inflammation and ptosis induced by migration of injected silicone oil into the upper eyelid. Clinicians should be aware that swelling of the upper eyelid and a substantial decrease in the silicone oil level in the vitreous cavity, reflecting silicone oil leakage, maybe one of complications of vitrectomy.