신바로 약침의 국내 임상 연구 동향: 스코핑 리뷰

김영민,한윤희,최승관,조정호,전병현,우현준,하원배,이정한 한방재활의학과학회 2023 한방재활의학과학회지 Vol.33 No.4

Objectives This study aimed to investigate domestic clinical research trends in Shinbaro pharmacopuncture, identify diseases managed using Shinbaro pharmacopuncture, and suggest the direction for future studies to increase its clinical utilization. Methods This study used five steps proposed by Arksey and O'Malley and the PRISMA-extension for scoping reviews checklist. We examined published literature on Shinbaro pharmacopuncture studies reported until June 5, 2023, in the following eight databases (Research Information Sharing Service, Science ON, Oriental Medicine Advanced Searching Integrated System, KMBASE, The Society of Internal Korean Medicine, PubMed, EMBASE, and the Cochrane Library). The search terms used were ‘Shinbaro’ or ‘Sinbaro’. Results A total of 47 studies were included in our analysis. Of these, 37 (78.7%) were interference time series studies. Shinbaro pharmacopuncture was the most frequently used treatment for lumbosacral disease (n=15). In the facial area, ST4 and ST6 were used in five out of six studies, and in the shoulder area, TE14 and LI15 were used in all studies. Nine of the 15 studies in the lumbosacral area used the EX-B2. The other parts mostly used the pressure points. Compared to other pharmacopuncture methods, the treatment effect was similar to that of bee venom, and faster than that of jungsongouhyul. Conclusions This is the first scoping review of Shinbaro pharmacopuncture therapy in South Korea. Studies with a high level of evidence based on sole treatment, large capacities, and standardization of Shinbaro pharmacopuncture need to be conducted to increase its clinical utilization. (J Korean Med Rehabil 2023;33(4):125-144)

SD (Sprague-Dawley) 랫드와 비글견을 이용한 신바로3 약침의 단회 근육투여 독성실험

이진호 ( Jin Ho Lee ),이인희 ( In Hee Lee ),이재웅 ( Jae Woong Lee ),김은지 ( Eun Jee Kim ),김민정 ( Min Jeong Kim ) 한방재활의학과학회 2015 한방재활의학과학회지 Vol.25 No.2

Objectives To assess the safety of Shinbaro3 Pharmacopuncture by analyzing the potential single-dose intramuscular toxicity of Shinbaro3 Pharmacopuncture at various dose levels in SD (Spraque-Dawley) rats and Beagle dogs. Methods For evaluation of single-dose intramuscular toxicity of Shinbaro3 Pharmacopuncture, 40 SD rats (20 male and 20 famale) and 4 Beagle dogs (2 male and 2 female) were used. The rats were divided in four groups of 10 each, and treated intramuscularly with Shinbaro3 Pharmacopuncture at doses of 0.3, 0.6 and 1.2 mg/kg in distilled water, and distilled water as a vehicle control group, respectively. The Beagle dogs were divided into two groups of 2 each, and treated intramuscularly with Shinbaro3 Pharmacopuncture at doses of 0.15, and 0.3 mg/kg in distilled water, respectively, and signs of toxicity were observed. After a wash-out period of 3 days, the procedure was repeated with Shinbaro3 Pharmacopuncture at doses of 0.6, and 1.2 mg/kg in distilled water, respectively. Mortality, body weight changes, and necropsy findings were examined during the study period. Results There were no mortalities in either the SD rats or Beagle dogs. There were also no significant differences in adverse effects, body weight, or necropsy findings between the Shinbaro3 Pharmacopuncture and control groups. Conclusions There results suggest that the lethal dose 50 (LD50) and approximate lethal dose (ALD) value of the test substance Shinbaro3 Pharmacopuncture are higher than 1.2mg/kg in SD rats and Beagle dogs. (J Korean Med Rehab 2015;25(2):73-80)

요추추간판탈출증에 대한 신바로약침의 효과 : 무작위 대조군 시험

전병철,김은수,김동섭,김태헌,김지용,Jun, Byung-Chul,Kim, Eun-Soo,Kim, Dong-Sub,Kim, Tae-Hun,Kim, Jee-Yong 척추신경추나의학회 2011 척추신경추나의학회지 Vol.6 No.2

Objective : The aim of this study is to investigate the effectiveness of ShinBaro Pharmacopuncture in the treatment of patients with Lumbar spine Herniated Nucleus Pulposus. Methods : We investigated 20 cases of patients with lumbar disc herniation and devided into two groups. Experimental group were treated with ShinBaro Pharmacopuncture with integrated package treatment and control group were treated the same therapies without ShinBaro Pharmacopuncture. To evaluate the treatment effects of two groups, we used numeric rating scale(NRS), oswestry disability index(ODI). Results : In NRS of lumbar and sciatica pain and ODI, that of experimental group was much more improved than control group, and decrement of NRS of lumbar pain showed statistical significance along with the duration of treatment. Conclusions : ShinBaro Pharmacopuncture was thought to be effective for relieving symptoms of lumbar spine herniated nucleus pulposus, although further study is needed.

신바로 약침의 한약재 확인시험 및 HPLC-DAD를 통한 표준화 연구

이진호,김민정,이재웅,김미령,이인희,김은지 대한침구의학회 2015 대한침구의학회지 Vol.32 No.2

Objectives : The present study was an evaluation and standardization of herbal components in order to establish the efficacy and safety of Shinbaro pharmacopuncture. Methods : Among the raw materials of Shinbaro pharmacopuncture, the components Cibotii Rhizoma, Eucommiae Cortex, and Ledebouriellae Radix were assessed through ingredient verification experiments using thin-layer chromatography(TLC) and ultraviolet rays(UV) lamps. In addition, we standardized Acanthopanacis Cortex and Achyranthis Radix through validation using high performance liquid chromatograph-diode array detector(HPLC-DAD). Results : As result appeared a blue-white fluorescence under ultraviolet rays; changed to dark green after adding 1 % ferric chloride solution(due to Cibotii Rhizoma), and presented a yellow-green fluorescence when mixed with an ethyl ether under UV lamps by way of the ethyl ether layer, confirming Eucommiae Cortex. Ledebouriellae Radix was confirmed as dark brown spots at Rf values of 0.56 and 0.71 using TLC. Additionally, Acanthopanacis Cortex and Achyranthis Radix HPLC test results showed that linearity was R2≥0.99, and detection limit and quantitation limit were 0.23 to 1.29 μg/mL, and 0.71 to 3.90 μg/mL, respectively. Further- more, precision and accuracy were confirmed to have relative standard deviation(RSD) values of 0.10 to 1.89 % and 96.19 to 103.72 %, respectively. Shinbaro pharmacopuncture did not have any overlapping or interference from other peaks in detection under the above- mentioned analysis conditions. Conclusions : In conclusion, we confirmed that maintenance of Shinbaro pharmacopuncture validity was possible by means of quality control of Cibotii Rhizoma, Eucommiae Cortex, and Ledebouriellae Radix through ingredient identification and Acanthopanacis Cortex and Achyranthis Radix through high performance liquid chromatograph(HPLC) analysis. Further, we hope to contribute to the development strategy of herbal industry acupuncture.

Three cases meniscus injury treated with Shinbaro pharmacopuncture therapy

Lee, So Jin,Yoon, Tae Kyung,Shin, Soo Ji,Ahn, Sang Min,Lee, Seong Jin,Won, Jeong Yoon,Jang, Yeo Jin Korean AcupunctureMoxibustion Medicine Society 2017 대한침구의학회지 Vol.33 No.4

Objectives : The purpose of this report was to show that oriental therapy, specifically Shinbaro pharmacopuncture is effective for improvement of symptoms and and range of motion (ROM) in patients diagnosed with meniscus tears in the knee. Methods : Three patients were treated with herbal medicine, acupuncture, cupping, Shinbaro pharmacopuncture. The efficacies of the treatments in the three cases were assessed and the progress of the three cases were measured Numerical Rating Scale (NRS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), European Quality of Life five dimensions dimensions (EQ-5D), and range of motion (ROM) measurements. Results : After all the treatments, NRS, WOMAC, and EQ-5D decreased. Active and passive ROM of the knee increased. Conclusion : These reports show the effect of Shinbaro pharmacopucture on a meniscus tear. Due to the small number of cases in this study, further case reports are needed.

Three cases meniscus injury treated with Shinbaro pharmacopuncture therapy

이소진,윤태경,신수지,안상민,이성진,원정윤,장여진 대한침구의학회 2017 대한침구의학회지 Vol.33 No.4

Objectives : The purpose of this report was to show that oriental therapy, specifically Shinbaro pharmacopuncture is effective for improvement of symptoms and and range of motion (ROM) in patients diagnosed with meniscus tears in the knee. Methods : Three patients were treated with herbal medicine, acupuncture, cupping, Shinbaro pharmacopuncture. The efficacies of the treatments in the three cases were assessed and the progress of the three cases were measured Numerical Rating Scale (NRS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), European Quality of Life five dimensions dimensions (EQ-5D), and range of motion (ROM) measurements. Results : After all the treatments, NRS, WOMAC, and EQ-5D decreased. Active and passive ROM of the knee increased. Conclusion : These reports show the effect of Shinbaro pharmacopucture on a meniscus tear. Due to the small number of cases in this study, further case reports are needed.

신바로3 약침시술을 병행한 한방치료로 호전된 극상근건염 및 삼각근하 점액낭염 환자 치험 1례

윤영웅 ( Yeong Ung Yun ),정재현 ( Jai Hyeon Chung ),정승현 ( Seong Hyun Cheong ),문병헌 ( Byung Heon Moon ),최영준 ( Young Jun Choi ),유수빈 ( Su Bin Yoo ),이정훈 ( Jung Hun Lee ),신동재 ( Dong Jae Shin ) 한방재활의학과학회 2015 한방재활의학과학회지 Vol.25 No.4

Objectives The objective of this study is to report the improved case of Korean medicine treatment with Shinbaro3 pharmacopuncture for supraspinatus tendinitis and subdeltoid bursitis. Methods We used Shinbaro3 pharmacopuncture with other Korean medicine treatment (acupuncture, herbal medicine, cupping and chuna) for this patient. This case is measured and assessed by Numerical Rating Scale (NRS), shoulder range of motion (ROM) and shoulder physical examination. Results The NRS decreased from 10 to 2 and the patient showed nearly full shoulder range of motion. Also physical examination of shoulder was improved. Conclusions Korean medicine treatment with Shinbaro3 pharmacopuncture is proved to be helpful to relieve pain and recover function on shoulder joint. (J Korean Med Rehab 2015;25(4):161-167)

극상근건염과 견봉하점액낭염 및 심각근하점액낭염으로 진단받은 견비통 환자를 대상으로 대용량 신바로 약침치료를 통한 통증경감과 가동범위 호전에 대한 증례보고

송광찬,서지연,송승배,조명의,최봉석,류원형,김두리,전용현 大田大學校 附屬 韓方病院 2017 惠和醫學 Vol.26 No.1

The purpose of this research is to show the effectiveness of the Korean medical treatment on patients diagnosed with supraspinatus tendinosis, subacromial bursitis and subdeltoid bursitis treated by Korean medical treatment Including megadose shinbaro pharmacopuncture. Methods : We used megadose shinbaro pharmacopuncture on patients who received treatment at Bucheon Jaseng Korean medicine hospital from December, 2016 to January, 2017. Also we checked NRS, SPADI, range of motion(ROM) and shoulder physical examination to follow the scale showing the improvement of the symptoms of the patients. Results : All 4 patientes showed the improvement of NRS, SPADI range of motion(ROM) and shoulder physical examination. Conclusion : This research showed that megadose shinbaro pharmacopuncture was effective on the treatment of shoulder pain patients diagnosed with supraspinatus tendinosis, subacromial bursitis and subdeltoid bursitis. 어깨 부위의 통증은 다양한 원인에 의해 발생되지만 대부분은 회전 근개 및 견봉하점액낭과 삼각근하점액낭의 염증에 의해서 발생된다1). 견관절 통증의 치료는 서양의학에서는 크게 보존적 치료와 수술적 치 료로 대별된다. 보존적 치료 방법으로는 휴식, 약물요법, 물리치료, 주 사요법 등이 있으며, 이러한 보존적 치료로도 증상 경감이 없을 경우 수술적 치료 방법을 고려할 수 있다2). 견관절 및 어깨 부위의 한의학적 치료는 침치료, 약침치료 및 한약치료를 같이 활용할 수 있다. 그 중에서도 약침치료는 효과적 인 치료법으로 많이 활용되고 있다3). 여러 가지 약침치료 방법 중에서 대용량 약침치료는 한의사가 변증결과를 바탕으로 여러 경혈 또는 유관 부위에 0.1∼수cc의 약침제제를 주입 하는 기존의 약침 치료형식과 다르게 MRI를 통한 해부학적 지식을 바탕으로 목표를 정하고 주입한다는 차별성이 있다. 용량은 요추 추간판탈 출증 환자에 대하여 4cc를 기준으로 사용한다4). 본 연구는 MRI상 극상근건염과 견봉하점액낭염 및 삼각근하 점액낭염으로 진단받은 환자를 대상으로 대용량 약침치료를 병 행한 한방치료를 시행한 결과 호전을 보인 사례가 있어 보고하 는 바이다.

극상근건염과 견봉하점액낭염 및 심각근하점액낭염으로 진단받은 견비통 환자를 대상으로 대용량 신바로 약침치료를 통한 통증경감과 가동범위 호전에 대한 증례보고

송광찬,서지연,송승배,조명의,최봉석,류원형,김두리,전용현,Song, Kwang Chan,Seo, Ji Yeon,Song, Seung Bae,Cho, Myoung Ui,Choi, Bong seok,Ryu, Won Hyung,Kim, Doo Ri,Jeon, Yong Hyun 대전대학교 한의학연구소 2017 혜화의학회지 Vol.26 No.1

Objectives : The purpose of this research is to show the effectiveness of the Korean medical treatment on patients diagnosed with supraspinatus tendinosis, subacromial bursitis and subdeltoid bursitis treated by Korean medical treatment Including megadose shinbaro pharmacopuncture. Methods : We used megadose shinbaro pharmacopuncture on patients who received treatment at Bucheon Jaseng Korean medicine hospital from December, 2016 to January, 2017. Also we checked NRS, SPADI, range of motion(ROM) and shoulder physical examination to follow the scale showing the improvement of the symptoms of the patients. Results : All 4 patientes showed the improvement of NRS, SPADI range of motion(ROM) and shoulder physical examination. Conclusion : This research showed that megadose shinbaro pharmacopuncture was effective on the treatment of shoulder pain patients diagnosed with supraspinatus tendinosis, subacromial bursitis and subdeltoid bursitis.

교통사고 이후 MRI상 경추 추간판 탈출증 진단을 받은 환자에 대한 신바로약침과 봉약침의 치료효과 비교 연구: 후향적 환자군 관찰 연구

김기원,이민정,전재윤,임수진,이종환,김해솔,하인혁 대한침구의학회 2014 대한침구의학회지 Vol.31 No.1

Objectives : The purpose of this study is to compare the effect of Shinbaro pharmacopuncture treatment and bee venom pharmacopuncture treatment on cervical disc herniation and whiplash injury induced by traffic accident. Methods : This study was carried out on the 59 patients with whiplash injury by traffic accident and diagnosed as cervical disc herniation. The patients were divided into 2 groups ; Shinbaro pharmacopuncture group was treated with Shinbaro pharmacopuncture along with herbal medicine and general acupuncture. Bee venom pharmacopuncture group was treated with bee venom pharmacopuncture along with herbal medicine and general acupuncture. We measured verbal numerical rating scale(VNRS) and neck disability index(NDI) before the treatment and 1, 2, 3 weeks afterwards. Results : Shinbaro pharmacopuncture group and Bee venom pharmacopuncture both showed significant decrease in VNRS and NDI. Shinbaro pharmacopuncture group showed significant decrease over Bee venom pharmacopuncture group in VNRS decrement in the first week, while Bee venom pharmacopuncture group showed significant decrease over Shinbaro pharmacopuncture group in the secone week of treatment. Conclusion : According to the result of this study, it is suggested that Shinbaro pharmacopuncture group is more effective in reducing pain in the earlier period of treatment. Also suggests that further study on the effect of Shinbaro pharmacopuncture on patients diagnosed as cervical disc herniation after traffic accident for longer period of treatment.