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( Geun Hyeong Jo ),( Soon Young Shin ),( Young Giu Lee ),( Ji Ye Hyun ),( Kwang Sik Dong ),( Jun Cheol Park ),( Hyun Su Kim ),( Young Han Lee ),( Yoong Ho Lim ) 한국응용생명화학회(구 한국농화학회) 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.4
A compound was isolated from the root of Rumex japonicus. Based on spectroscopic data including nuclear magnetic resonance spectroscopy and mass spectrometry, the chemical structure of the compound was determined to be 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione. The compound exhibits antitumor activity due to inhibition of clonogenicity and induction of tumor suppressor early growth response gene-1 in HCT116 colon cancer cells.
Effects of Compounds Isolated from the Fruits of Rumex japonicus on the Protein Glycation
Jang, Dae Sik,Kim, Jong Min,Kim, Junghyun,Yoo, Jeong Lim,Kim, Young Sook,Kim, Jin Sook WILEY-VCH Verlag 2008 Chemistry & biodiversity Vol.5 No.12
<P>An anthraquinone, emodin (1), and five flavonoids, kaempferol-3-O-β-D-glucoside (2), quercetin (3), quercitrin (4), isoquercitrin (5), and (+)-catechin (6), were isolated from an AcOEt-soluble extract of the fruits of Rumex japonicus. Their structures were determined by spectroscopic data interpretation. All the isolates were evaluated for their potential to inhibit AGEs (advanced glycation end products) formation and AGEs cross-linking, and to break already formed AGEs cross-links.</P>
A New Epoxynaphthoquinol from Rumex japonicus
Zee, Ok Pyo,Kim, Dae Keun,Kwon, Hak Cheol,Lee, Kang Ro 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
A new epoxynaphthoquinol derivative, 3-acetyl-2-methyl-1, 5-dihydroxy-2,3-epoxynaphthoquinol(Ⅰ), was isolated from the root of Rumex japonicus. The structure was elucidated by high field 1D and 2D NMR techniques.
A New Epoxynaphthoquinol from Rumex japonicus
Zee, Ok-Pyo,Kim, Dae-Keun,Kwon, Hak-Cheol,Lee, Kang-Ro The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.4
A new epoxynaphthoquinol derivative, 3-acetyl-2-methyl-1, 5-dihydroxy-2,3-epoxynaphthoquinol (I), was isolated from the root of Rumex japonicus. The structure was elucidated by high field 1D and 2D NMR techniques.
A Compound Isolated from Rumex japonicus Induces Early Growth Response Gene-1 Expression
Jo, Geun-Hyeong,Shin, Soon-Young,Lee, Young-Giu,Hyun, Ji-Ye,Dong, Kwang-Sik,Park, Jun-Cheol,Kim, Hyun-Su,Lee, Young-Han,Lim, Yoong-Ho The Korean Society for Applied Biological Chemistr 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.4
A compound was isolated from the root of Rumex japonicus. Based on spectroscopic data including nuclear magnetic resonance spectroscopy and mass spectrometry, the chemical structure of the compound was determined to be 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione. The compound exhibits antitumor activity due to inhibition of clonogenicity and induction of tumor suppressor early growth response gene-1 in HCT116 colon cancer cells.
A Compound Isolated from Rumex japonicus Induces Early Growth Response Gene-1 Expression
Geunhyeong Jo,신순영,Younggiu Lee,Jiye Hyun,Kwang Sik Dong,Jun Cheol Park,Hyun Su Kim,이영한,임융호 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.4
A compound was isolated from the root of Rumex japonicus. Based on spectroscopic data including nuclear magnetic resonance spectroscopy and mass spectrometry, the chemical structure of the compound was determined to be 1,8-dihydroxy-3-methoxy-6-methylanthracene-9,10-dione. The compound exhibits antitumor activity due to inhibition of clonogenicity and induction of tumor suppressor early growth response gene-1 in HCT116 colon cancer cells.
Constituents of the Fruits of Rumex japonicus with Inhibitory Activity on Aldose Reductase
Kim, Jong-Min,Jang, Dae-Sik,Lee, Yun-Mi,Lee, Ga-Young,Kim, Jin-Sook The Korean Society for Applied Biological Chemistr 2008 Journal of Applied Biological Chemistry (J. Appl. Vol.51 No.1
Five anthraquinones, emodin (1), ${\omega}$-hydroxyemodin (2), chrysophanol-8-O-${\beta}$-D-glucoside (3), emodin-8-O-${\beta}$-D-glucoside (4), and physcion-8-O-${\beta}$-D-glucoside (5), and five flavonoids, kaempferol-3-O-${\beta}$-D-glucoside (6), quercetin (7), quercitrin (8), isoquercitrin (9), and (+)-catechin (10), were isolated from the EtOAc-soluble extract of the fruits of Rumex japonicus. The structures of 1-10 were identified by spectroscopic methods including NMR studies. This is the first report on the isolation of compounds 3-5 from this plant. The isolates were subjected to in vitro bioassays to evaluate their inhibitory activities on the rat lens aldose reductase (RLAR), among which two anthraquinones (1 and 4), and five flavonols (5-9) showed significant activities on RLAR.
( Yinda Qiu ),( Aoding Li ),( Jina Lee ),( Jeong Eun Lee ),( Eun-woo Lee ),( Namki Cho ),( Hee Min Yoo ) 한국미생물생명공학회(구 한국산업미생물학회) 2020 Journal of microbiology and biotechnology Vol.30 No.12
Rumex japonicus Houtt (RJH) is a valuable plant used in traditional medicine to treat several diseases, such as scabies and jaundice. In this study, Jurkat cell growth inhibitory extracts of R. japonicus roots were subjected to bioassay-guided fractionation, resulting in the isolation of three naphthalene derivatives (3-5) along with one anthraquinone (6) and two phenolic compounds (1 and 2). Among these compounds, 2-methoxystypandrone (5) exhibited potent anti-proliferative effects on Jurkat cells. Analysis by flow cytometry confirmed that 2-methoxystypandrone (5) could significantly reduce mitochondrial membrane potential and promote increased levels of mitochondrial reactive oxygen species (ROS), suggesting a strong mitochondrial depolarization effect. Real-time quantitative polymerase chain reaction (qPCR) analysis was also performed, and the results revealed that the accumulation of ROS was caused by reduced mRNA expression levels of heme oxygenase (HO-1), catalase (CAT), glutathione peroxidase (GPx), and superoxide dismutase (SOD). In addition, 2-methoxystypandrone (5) triggered strong apoptosis that was mediated by the arrest of the G0/G1 phase of the cell cycle. Furthermore, 2-methoxystypandrone (5) downregulated p-IκB-α, p-NF-κB p65, Bcl<sub>2</sub>, and Bcl-xl and upregulated BAX proteins. Taken together, these findings revealed that 2-methoxystypandrone (5) isolated from RJH could potentially serve as an early lead compound for leukemia treatment involving intracellular signaling by increasing mitochondrial ROS and exerting anti-proliferative effects.
양제근( Rumex japonicus HOUTT.)분획의 항염증 효과
허준영 ( Jun Yong Huh ),조현진 ( Hyun Jin Cho ),박기정 ( Ki Jeong Park ),박선동 ( Sun Dong Park ) 대한본초학회 2012 大韓本草學會誌 Vol.27 No.4
Objectives : The aim of this study was to authenticate whether fractionated extract of Rumex japonicus HOUTT. (RJ) has anti-inflammatory effects in mouse macrophage, RAW264.7 cells. Methods : Roots of RJ were extracted by methanol for 48hours. The methanol that gained was filtered and freeze dried. The methanol extract was dissolved in water and dichloromethane (DCM). After that, two layers were separated. Ethyl acetate (EA) added to the water layer and separated again. All the layers were filtered and freeze dried and the extracts were tested. Cytotoxic activity of extracts on RAW 264.7 cells was measured using MTS assay. The nitric oxide (NO) production was measured and proinflammatory cytokines and PGE2 were measured by ELISA kit. The levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), I κ-B-α and nuclear NF-κB p65 expression were detected by western blot. Results : Our results indicated that DCM and EA extracts of RJ inhibited the LPS-induced NO, PGE2 production and iNOS, COX-2 expression accompanied by an attenuation of TNF-α, IL-1β and IL-6 production in RAW 264.7 cells most effectively. DCM and EA extracts also had suppression effects of LPS-induced NF-κB and MAPKs activation. Conclusions : This results demonstrate that fractionated extract of RJ has anti-inflammatory effects and among the fractioned extract, dichloromethane and ethyl acetate extract have best anti-inflammatory effects.
김대근,최상운,류시용,이강노,지옥표 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
Activity-guided fractionation and repeated column chromatography afforded two cytotoxic compounds R-3 and R-4 from the root of Rumex japonicus HOUTT. Compounds were identified as musizin and emodin, respectively, by the physicochemical and spectral data. Besides R-3 and R-4, two compounds R-1 and R-2, chrysophanol and physcion, respectively, were also isolated. The compound R-3 and R-4 exhibited cytotoxicity against cultured human tumor cell lines. A-549, SK-OV-3, SK-MEL-2, XF498 and HCT15 with ED_50 values ranging from 2.68 to 10.06㎍/㎖.