Solid Dispersions of ihydroartemisinin in Polyvinylpyrrolidone

Muhammad Tayyab Ansari,Vivian Bruce Sunderland 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.3

In the present study the physicochemical characteristics of dihydroartemisinin, polyvinylpyrrolidone and their solid dispersions were evaluated at various proportions of drug and polyvinylpyrrolidone. These properties were investigated with X-ray diffraction, fourier transform infrared spectrophotometry, differential scanning calorimetry, equilibrium solubility at twenty five and thirty seven degree centigrade. X-ray diffraction analysis detected that dihydroartemisinin became more amorphous as drug carrier ratio was enhanced in solid dispersions. Fourier transform infrared spectra suggested that there was a hydrogen bonding interaction between dihydroartemisinin and polyvinylpyrrolidone in all solid dispersions. These interactions reflected the changes in crystalline structures of dihydroartemisinin. The thermal behavior of dihydroartemisinin was unusual as it exhibited melting exotherm instead of endotherm. In solid dispersions containing varying contents of polyvinylpyrrolidone, enthalpy change and peak area were enhanced while melting onset temperature decreased with increase in polyvinylpyrrolidone proportion. This was attributed to a solid-state interaction. Equilibrium solubility of dihydroartemisinin increased sixty-fold due to induction of polyvinylpyrrolidone. When this solubility was compared among thirty-seven and twenty five degree centigrade in solid dispersions, it was up to seven times more at higher temperature. Physicochemical characteristics of solid dispersions containing drug carrier ratio of one: nine prepared in acetonitrile, ethanol, methanol and tetrahydrofuran showed differences which indicated that properties of medium i.e. dielectric constant, dipole moment and structure, influenced the amount of amorphousness and related properties of dihydroartemisinin.

Solid Dispersions of Dihydroartemisinin in Polyvinylpyrrolidone

Ansari, Muhammad Tayyab,Sunderland, Vivian Bruce 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.3

In the present study the physicochemical characteristics of dihydroartemisinin, polyvinylpyrrolidone and their solid dispersions were evaluated at various proportions of drug and polyvinylpyrrolidone. These properties were investigated with X-ray diffraction, fourier transform infrared spectrophotometry, differential scanning calorimetry, equilibrium solubility at twenty five and thirty seven degree centigrade. X-ray diffraction analysis detected that dihydroartemisinin became more amorphous as drug carrier ratio was enhanced in solid dispersions. Fourier transform infrared spectra suggested that there was a hydrogen bonding interaction between dihydroartemisinin and polyvinylpyrrolidone in all solid dispersions. These interactions reflected the changes in crystalline structures of dihydroartemisinin. The thermal behavior of dihydroartemisinin was unusual as it exhibited melting exotherm instead of endotherm. In solid dispersions containing varying contents of polyvinylpyrrolidone, enthalpy change and peak area were enhanced while melting onset temperature decreased with increase in polyvinylpyrrolidone proportion. This was attributed to a solid-state interaction. Equilibrium solubility of dihydroartemisinin increased sixty-fold due to induction of polyvinylpyrrolidone. When this solubility was compared among thirty-seven and twenty five degree centigrade in solid dispersions, it was up to seven times more at higher temperature. Physicochemical characteristics of solid dispersions containing drug carrier ratio of one: nine prepared in acetonitrile, ethanol, methanol and tetrahydrofuran showed differences which indicated that properties of medium i.e. dielectric constant, dipole moment and structure, influenced the amount of amorphousness and related properties of dihydroartemisinin.

기체 촉진수송을 위한 polyvinylpyrrolidone/AgBF4/Al(NO3)3 전해질 분리막 제조

윤기완,강상욱 한국막학회 2016 멤브레인 Vol.26 No.1

Polyvinylpyrrolidone (PVP), which is glassy polymer to have amide functional group, was induced to fabricate the facilitated olefin transport membranes for olefin/paraffin separation. Separation performance for the mixed gas consisting of propylene and propane (50 : 50 vol%) was measured by gas chromatography and bubble flow meter. The properties of membranes were confirmed by scanning electron microscope and FT-IR. The results of long-term separation tests showed the selectivity of 15 and permeance of 1.3 GPU. The membranes was compared with poly(2-ethyl-2-oxazoline) (POZ)/AgBF4/Al(NO3)3 membranes and the characteristics were confirmed as polymer matrix for facilitated transport membranes. 올레핀/파라핀 혼합 기체의 분리를 위한 올레핀 촉진 수송 분리막의 제조를 위해 amide 작용기를 가지며 glassy한특성을 보이는 polyvinylpyrrolidone (PVP) 고분자를 분리막의 matrix로서 사용하였다. 분리막의 기체 투과 실험은 propylene 과 propane 50 : 50의 부피비로 혼합된 기체를 사용하였고, bubble meter와 gas chromatography를 사용해 투과도와 선택도를측정하였다. 또한 SEM image와 FT-IR을 통해 막의 특성을 조사하였다. 100시간의 장시간 성능 측정 결과 선택도는 약 15, 투과도는 약 1.3 GPU 이상을 각각 유지하였다. 기존의 poly(2-ethyl-2-oxazoline) (POZ)/AgBF4/Al(NO3)3 분리막과 비교함으로써, 고분자 matrix로서의 PVP 특성을 확인하였다.

Polyvinylpyrrolidone을 이용한 은 나노 입자 합성 및 안경테 항균 코팅 연구

김영미,김기홍 대한시과학회 2022 대한시과학회지 Vol.24 No.3

Purpose : In this study, paying attention to the need for eyeglass frames with antibacterial function, silver nanoparticles were synthesized using polyvinylpyrrolidone (PVP), a polymer material, and coated on a metal eyeglass frame material substrates to evaluate antibacterial properties and coating properties. Methods : Silver nanoparticles were synthesized by using PVP, a highly stable polymer material, as a reducing agent, dispersing agent, and stabilizer, and varying the synthesis temperature. The properties of the synthesized samples were analyzed using UV-visible spectrophotometer, SEM, EDS, and the antibacterial properties were evaluated by the paper disk diffusion method. The synthesized silver nanocolloids were coated on titanium and stainless steel substrates, which are metal eyeglass frame materials, and the properties and antibacterial properties of the coating film were measured. Results : Silver (Ag) was detected in all samples synthesized using PVP, confirming the generation of silver nanoparticles. The size difference of silver nanoparticles according to the synthesis temperature was confirmed, and in the case of , , the silver nanocolloid synthesized at 45℃ showed the , and greatest antibacterial activity. After coating this on the metal eyeglass frame material substrates, the antibacterial properties were confirmed. Conclusion : As a result of coating silver nanocolloids synthesized using PVP on a metal eyeglass frame material substrate, the antibacterial properties of the coating film were confirmed, suggesting that it could be used as an antibacterial material when manufacturing eyeglass frames with antibacterial function. 목적 : 본 연구는 항균 기능을 갖춘 안경테의 필요성에 주목하여 고분자 물질인 Polyvinylpyrrolidone(PVP)을 사용하여 은 나노 입자를 합성하고, 금속 안경테 소재에 코팅하여 항균성과 코팅 특성을 평가해 보고자 한다. 방법 : 안정성이 높은 고분자 물질인 PVP를 환원제, 분산제, 안정제로 사용하고 합성 온도를 달리하여 은 나노 입자를 합성하였다. 합성한 시료의 특성은 UV-visible spectrophotometer, SEM, EDS를 사용하여 분석하였으 며 paper disk diffusion method로 항균성을 평가하였다. 합성한 은 나노콜로이드를 금속 안경테 소재인 티타 늄, 스테인리스스틸 기판에 코팅하고 코팅막의 특성과 항균성을 측정하였다. 결과 : PVP를 사용하여 합성한 시료 모두에서 은(Ag)이 검출되어 은 나노 입자의 생성을 확인할 수 있었다. 합성 온도에 따른 은 나노 입자의 크기는 차이를 보였으며, , 의 경우 45℃에서 합성한 은 나노콜로이드의 항균활성이 가장 크게 나타났다. 이를 금속안경테 소재 기판에 코팅한 후 항균성을 확인한 결과 코팅막의 항균력을 확인할 수 있었다. 결론 : PVP를 사용하여 합성한 은 나노콜로이드를 금속 안경테 소재 기판에 코팅한 결과 코팅막의 항균성이 확인되어 항균 기능을 가진 안경테 제작 시 항균 물질로 활용될 수 있을 것이라 사료된다.

기체 촉진수송을 위한 polyvinylpyrrolidone/AgBF₄/Al(NO₃)₃ 전해질 분리막 제조

윤기완,강상욱,Yoon, Ki Wan,Kang, Sang Wook 한국막학회 2016 멤브레인 Vol.26 No.1

올레핀/파라핀 혼합 기체의 분리를 위한 올레핀 촉진 수송 분리막의 제조를 위해 amide 작용기를 가지며 glassy한 특성을 보이는 polyvinylpyrrolidone (PVP) 고분자를 분리막의 matrix로서 사용하였다. 분리막의 기체 투과 실험은 propylene과 propane 50 : 50의 부피비로 혼합된 기체를 사용하였고, bubble meter와 gas chromatography를 사용해 투과도와 선택도를 측정하였다. 또한 SEM image와 FT-IR을 통해 막의 특성을 조사하였다. 100시간의 장시간 성능 측정 결과 선택도는 약 15, 투과도는 약 1.3 GPU 이상을 각각 유지하였다. 기존의 poly(2-ethyl-2-oxazoline) $(POZ)/AgBF_4/Al(NO_3)_3$ 분리막과 비교함으로써, 고분자 matrix로서의 PVP 특성을 확인하였다. Polyvinylpyrrolidone (PVP), which is glassy polymer to have amide functional group, was induced to fabricate the facilitated olefin transport membranes for olefin/paraffin separation. Separation performance for the mixed gas consisting of propylene and propane (50 : 50 vol%) was measured by gas chromatography and bubble flow meter. The properties of membranes were confirmed by scanning electron microscope and FT-IR. The results of long-term separation tests showed the selectivity of 15 and permeance of 1.3 GPU. The membranes was compared with poly(2-ethyl-2-oxazoline) $(POZ)/AgBF_4/Al(NO_3)_3$ membranes and the characteristics were confirmed as polymer matrix for facilitated transport membranes.

Polyvinylpyrrolidone/Carbon Nanotube/Cotton Functional Nanocomposite: Preparation and Characterization of Properties

Farbod Alimohammadi,Mazeyar Parvinzadeh Gashti,Abolfazl Mozaffari 한국섬유공학회 2018 Fibers and polymers Vol.19 No.9

In the last decade, preparation of multifunctional composites have attracted researchers around the World for multi-purpose application. In this regard, we produced polyvinylpyrrolidone/carbon nanotubes/cotton (PVP/CNTs/cotton) nanocomposite by coating cotton fabric via pad-dry-cure under UV irradiation. Several characterization methods were used to investigate the functionality and durability including scanning electron microscopy, thermo-gravimetric analysis, flammability test, reflectance spectroscopy, tensile strength test, water absorption and antibacterial analysis. The interactions among PVP molecular chains, CNT particles and cellulose were confirmed by Raman spectroscopy. We observed a uniform coating of PVP/CNTs on the fiber surface. An advantage of our developed method was the strong interfacial interaction among compositions, high durability along with multifunctional properties. PVP/CNT nanocomposite was able not only to improve the thermal stability of cotton, but also provided a reduced flammability and good antibacterial properties. Here, we confirm a simple and versatile method for fabrication of PVP/CNTs/cellulose nanocomposite for multi-purpose applications.

Large-Scale Synthesis of High Electrochemical Performance LiNi0.5Mn1.5O4 by using a Polyvinylpyrrolidone-Assisted Citric-Acid Sol-Gel Combustion Method

Yun Boseon,Hong Jongin,Kim Myung-Gil 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.77 No.4

For large-scale cathode-material synthesis, the sol-gel process with an atomically mixed metal precursor could provide a facile route to achieve a homogeneously mixed oxide-based cathode material. However, the industrial feasibility of this strategy could be limited by the high preparation cost of the precursors. Although this can be addressed by utilizing low-cost reagents and simplifying the calcination step, typically a trade-off would exist between the cost and the performance. In this study, we demonstrate the facile large-scale synthesis of lithium nickel manganese oxide (LiNi0.5Mn1.5O4) by using a polyvinylpyrrolidone-assisted citric-acid sol-gel combustion method. After single-step calcination at 900 °C for 12 h, the LiNi0.5Mn1.5O4 particles with a truncated octahedron morphology showed a superb discharge capacity (130.8 mAh·g-1) and cyclability (90.9% after 200 cycles).

기체 촉진수송을 위한 polyvinylpyrrolidone/AgBF4/Al(NO3)3 전해질 분리막 제조

윤기완,강상욱 한국막학회 2016 멤브레인 Vol.26 No.1

올레핀/파라핀 혼합 기체의 분리를 위한 올레핀 촉진 수송 분리막의 제조를 위해 amide 작용기를 가지며 glassy한 특성을 보이는 polyvinylpyrrolidone (PVP) 고분자를 분리막의 matrix로서 사용하였다. 분리막의 기체 투과 실험은 propylene 과 propane 50 : 50의 부피비로 혼합된 기체를 사용하였고, bubble meter와 gas chromatography를 사용해 투과도와 선택도를 측정하였다. 또한 SEM image와 FT-IR을 통해 막의 특성을 조사하였다. 100시간의 장시간 성능 측정 결과 선택도는 약 15, 투과도는 약 1.3 GPU 이상을 각각 유지하였다. 기존의 poly(2-ethyl-2-oxazoline) (POZ)/AgBF4/Al(NO3)3 분리막과 비교함으 로써, 고분자 matrix로서의 PVP 특성을 확인하였다. Polyvinylpyrrolidone (PVP), which is glassy polymer to have amide functional group, was induced to fabricate the facilitated olefin transport membranes for olefin/paraffin separation. Separation performance for the mixed gas consisting of propylene and propane (50 : 50 vol%) was measured by gas chromatography and bubble flow meter. The properties of membranes were confirmed by scanning electron microscope and FT-IR. The results of long-term separation tests showed the selectivity of 15 and permeance of 1.3 GPU. The membranes was compared with poly(2-ethyl-2-oxazoline) (POZ)/AgBF4/Al(NO3)3 membranes and the characteristics were confirmed as polymer matrix for facilitated transport membranes. Keywords:

Polyvinylpyrrolidone과 1,2-indanedione 혼합물을 이용한 감열지에 부착된 혈흔지문의 증강

김동만(Dongman Kim),류혜연(Heayeon Ryu),정승훈(Seunghoon Jeong),주인선(Inseon Joo),홍성욱(Sungwook Hong) 한국분석과학회 2021 분석과학 Vol.34 No.3

열분해성 고분자 도입에 따른 탄소분자체막의 기체 투과 특성

Young Moo Lee,Youn Kook Kim,Ji Min Lee,Ho Bum Park 한국막학회 2003 멤브레인 Vol.13 No.3

Polyvinylpyrrolidone을 포함하는 폴리이미드 전구체의 열분해 공정을 통해 탄소분자체막을 제조하였으며 열분해성 고분자를 포함하는 전구체를 통해 제조된 막의 구조 및 기체 투과 특성에 대해 연구 하였다. 열분해성 고분자를 포함하는 전구체의 열적 특성을 조사한 결과 열적으로 안정한 폴리이미드의 경우 550℃에서 분해되는 것을 확인할 수 있었으며 열분해성 고분자의 경우 400℃에서 분해가 시작되는 것을 TCA를 통해 확인하였다 제조된 탄소분자체막의 기체 투과 특성을 조사한 결과 최종 열분해 온도가 증가됨에 따라 기체 투과도는 감소하였으며 열분해성 고분자를 포함한 전구체로부터 제조된 탄소분자체막의 경우 기체 투과가 향상됨을 알 수 있었다. 열분해성 고분자를 함유하는 전구체로부터 550℃에서 열분해를 통해 제조된 탄소분자체막의 경우 O2 투과도 808 Barrer [10-10cm3 (STP)cm/cm2scmHg]과 O2/N2선택도 7을 나타내었다. Carbon molecular sieve (CMS) membranes were prepared by the pyrolysis of polyvinylpyrrolidone containing polyimide precursors. We have prepared the polymer precursors, pyrolyzed polymer and investigated the effect of pyrolyzing polymer on the characteristics of carbon structures and gas separation properties of the CMS membranes. Thermogravimetric analysis (TGA) showed the two-step decomposition of polymer precursor. First decomposition of the pyrolyzing polymer began around 400℃ while carbonizing polymer showed the decomposition around 550℃. The gas permeabilities through the CMS membranes were enhanced by the introduction of the pyrolyzing polymer and decreased with increased final pyrolysis temperature. The CMS membrane pyrolyzed at 550℃. derived from precursor containing 5wt% PVP as a pyrolyzing polymer showed gas permeability for O2 of 808 Barrers [10-10cm3 (STP)cm/cm2scmHg] and O2/N2 selectivity of 7.