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      • KCI등재

        New Direct Torque Neuro-Fuzzy Control Based SVM-Three Level Inverter-Fed Induction Motor

        Toufouti Riad,Benalla Hocine 제어·로봇·시스템학회 2010 International Journal of Control, Automation, and Vol.8 No.2

        In this paper, a novel direct torque neuro-fuzzy control (DTCNF) scheme combining with space voltage modulation (SVM) technique of a three levels inverter is presented. Using neuro-fuzzy technique, the reference space voltage vector can be obtained dynamically in terms of torque error, stator flux error and the angle of stator flux. Compared with conventional direct torque control (C_DTC), in this new technique, the ripples of both torque and flux are reduced remarkable, and switching frequency is maintained constant. Simulation results verify the validity of the proposed method.

      • KCI등재

        고주파유도가열 철부하의 FTPM 및 PSPM 제어에 관한 연구

        임영도,김두영 전력전자학회 2000 전력전자학회 논문지 Vol.5 No.2

        본 논문은 고주파 유도 가열기의 전력조절을 위해 뉴로-퍼지 알고리즘을 이용하고, IGBT를 사용한 위상 전이 펄스변조(PSPM)와 주파수 추종 펄스변조(FEPM) 가 조절되는 공진 고주파 인버터를 응용한 유도가열기를 설명한다. 이는 실제로 산업 현장에서 20KHz~500KHz 유도 가열 및 유도 용해 전원장치용으로 쓰인다. 위상 전이 펄스변조 (PSPM) 정전력 조절 기술을 바탕으로 한 적응 주파수 추종기법은 스위칭 손실을 최소화하고 전력조절을 용이하게 하기 위해 소개되어졌다. 뉴로-퍼지제어기를 사용하여 만들어진 실험장치는 성공적인 논증과 토의가 되어졌다. This paper describes a Phase-Shift Pulse Modulation(PSPM) and Frequency Trad이ng Pulse Modulation(FTPM) s series resonant high-frequency inverter using IGBT for the power control of high-frequency induction heating u using Neuro-Fuzzy, which is practically applied for 20kHz~500kHz induction-heating and melting power supply in i indust껴aJ fields. The adaptive frequency tracking based on the PSPM(phase-shifting pulse modulation) r regulation scherne is presented in or$\tau$ler to l11lmmlZe svvitching losses. The trially-produced breadboards using N Neuro Fuzzy controller are successfully demonstrated cUld cliscussed.

      • SCIESCOPUSKCI등재

        Immune inflammatory modulation as a potential therapeutic strategy of stem cell therapy for ALS and neurodegenerative diseases

        ( Seung Hyun Kim ),( Ki-wook Oh ),( Hee Kyung Jin ),( Jae-sung Bae ) 생화학분자생물학회(구 한국생화학분자생물학회) 2018 BMB Reports Vol.51 No.11

        With emerging evidence on the importance of non-cell autonomous toxicity in neurodegenerative diseases, therapeutic strategies targeting modulation of key immune cells. including microglia and Treg cells, have been designed for treatment of ALS and other neurodegenerative diseases. Strategy switching the patient’s environment from a pro-inflammatory toxic to an anti-inflammatory, and neuroprotective condition, could be potential therapy for neurodegenerative diseases. Mesenchymal stem cells (MSCs) regulate innate and adaptive immune cells, through release of soluble factors such as TGF- β and elevation of regulatory T cells (Tregs) and T helper-2 cells (Th2 cells), would play important roles, in the neuroprotective effect on motor neuronal cell death mechanisms in ALS. Single cycle of repeated intrathecal injections of BM-MSCs demonstrated a clinical benefit lasting at least 6 months, with safety, in ALS patients. Cytokine profiles of CSF provided evidence that BM-MSCs, have a role in switching from pro-inflammatory to anti-inflammatory conditions. Inverse correlation of TGF-β1 and MCP-1 levels, could be a potential biomarker to responsiveness. Thus, additional cycles of BM-MSC treatment are required, to confirm long-term efficacy and safety. [BMB Reports: Perspective 2018; 51(11): 545-546]

      • KCI등재

        Opuntia dillenii: A Forgotten Plant with Promising Pharmacological Properties

        Reza Shirazinia,Vafa Baradaran Rahimi,Ashrafali Rezaie Kehkhaie,Amirhossein Sahebkar,Hassan Rakhshandeh,Vahid Reza Askari 대한약침학회 2019 Journal of pharmacopuncture Vol.22 No.1

        Generative and vegetative parts of the cactuses have had a long-lasting position in folk medicine and their effects could partly be confirmed in scientific experiments. Nowadays, the cactus, fruits, and cladodes are the focus of many studies because of their desirable properties. Therefore, the summarized reports of valu-able properties of medicinal plants may be a good way to familiarize researches with a new source of drugs with lower side effects and higher efficacy. Opuntia dillenii, a well-known member of the Cactaceae family, is used as a medicinal plant in various countries and grows in the desert, semi-desert, tropical and sub-tropical areas. It shows diverse pharmacological activities such as: antioxidant, anti-inflammatory, anti-tumor, neuroprotective, hepatoprotective, hypotensive etc. OD fruit also possesses valuable constitutes for instance: betalains, ascorbic acid, total phenol, protein as well as essential elements which suggest the significant potential of this plant as a complementary therapy against several pathological conditions. This review describes experimental evidence about pharmacological and therapeutic potential of OD in order to give the basis of its application in the prevention and treatment of some chronic diseases. More studies on OD can help better understanding of its pharmacological mechanism of action to explain its traditional uses and to identify its potential new therapeutic applications.

      • SCOPUSKCI등재

        Opuntia dillenii: A Forgotten Plant with Promising Pharmacological Properties

        Shirazinia, Reza,Rahimi, Vafa Baradaran,Kehkhaie, Ashrafali Rezaie,Sahebkar, Amirhossein,Rakhshandeh, Hassan,Askari, Vahid Reza KOREAN PHARMACOPUNCTURE INSTITUTE 2019 Journal of pharmacopuncture Vol.22 No.1

        Generative and vegetative parts of the cactuses have had a long-lasting position in folk medicine and their effects could partly be confirmed in scientific experiments. Nowadays, the cactus, fruits, and cladodes are the focus of many studies because of their desirable properties. Therefore, the summarized reports of valuable properties of medicinal plants may be a good way to familiarize researches with a new source of drugs with lower side effects and higher efficacy. Opuntia dillenii, a well-known member of the Cactaceae family, is used as a medicinal plant in various countries and grows in the desert, semi-desert, tropical and sub-tropical areas. It shows diverse pharmacological activities such as: antioxidant, anti-inflammatory, anti-tumor, neuroprotective, hepatoprotective, hypotensive etc. OD fruit also possesses valuable constitutes for instance: betalains, ascorbic acid, total phenol, protein as well as essential elements which suggest the significant potential of this plant as a complementary therapy against several pathological conditions. This review describes experimental evidence about pharmacological and therapeutic potential of OD in order to give the basis of its application in the prevention and treatment of some chronic diseases. More studies on OD can help better understanding of its pharmacological mechanism of action to explain its traditional uses and to identify its potential new therapeutic applications.

      • KCI등재후보

        Non-Invasive Brain Stimulation Technology for Stroke Patients: tDCS, rTMS, PBM

        박지수(Park, Ji-Su),황나경(Hwang, Na-Kyoung),정영진(Jung, Young-Jin) 한국노인작업치료학회 2021 한국노인작업치료학회지 Vol.3 No.2

        서론 : 최근 뇌기능 조절을 위한 다양한 뇌 기능조절 기술들이 선보이고 있는 가운데, 뇌졸중 환자를 위한 비침습적 뇌 자극 방법들의 기전 및 임상적 효과 그리고 사용 시 고려사항에 대한 다양한 논문이 최근 다수 출판되었다. 특히, 비침습적 뇌 자극 방법 중 임상에서 사용되기 시작한 경두개 직류 자극, 반복적경두개 자기 자극, 광생체조절을 중심으로 최근 출판된 논문을 리뷰하였다. 본론 : 경두개 직류 자극, 반복적 경두개 자기 자극과 광생체조절은 미세 전류와 자기장 또는 근적외선을 이용하여 뇌 활성도를 조절(대뇌피질의 흥분도를 억제 또는 증가)하는 방법으로 뇌졸중 환자의 뇌 기능 향상에 긍정적인 영향을 미치며 이는 운동기능 및 인지기능 향상에 도움을 줄 수 있다고 보고되었다. 그럼에도 불구하고 이러한 비침습적 뇌 자극 방법에 대한 정확한 기전은 여전히 불명확하며 또한 임상 적용과 관련하여 중재 기간, 강도, 적용 영역 등 명확한 가이드라인이 부재한 실정이다. 결론 : 향후, 뇌졸중 재활을 위한 명확한 기전과 효율적인 임상 적용을 위한 다양한 동물 실험 및 추가적인 임상 연구를 통해 보다 명확한 근거와 구체적인 임상 가이드라인이 연구될 것이라 기대된다. Introduction : The purpose of this study was to review the mechanisms, clinical effects, and considerations for the use of non-invasive brain stimulation methods for stroke patients. This study reviewed recently published papers focusing on tDCS, rTMS, and PBM, which are mainly used in clinical practice among non-invasive brain stimulation methods. Discussion : tDCS, rTMS, and PBM control brain activity (inhibit or increase cortical excitability) by stimulating the brain using micro-currents (1~2mA), magnetic field change, and near infrared radiation. As a result, it has a positive effect on the improvement of brain function in stroke patients, and was found to be effective in improving motor and cognitive functions. Nevertheless, the exact mechanism of this non-invasive brain stimulation method is still unclear, and clear guidelines such as the intervention period, intensity, and application area in relation to clinical application have not yet been fully developed. Conclusion : In the future, it is expected that clearer evidence and specific clinical guidelines will be studied through various animal experiments and additional clinical studies for a clear mechanism for stroke rehabilitation and efficient clinical application.

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