http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Woo Il Kim ),( Jae Young Heo ),( Ho Jung Lee ),( Ryung Kwon ),( Euy Hyun Chung ),( Sang Hoon Lee ),( Moon Kyun Cho ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Fractional CO<sub>2</sub> laser combined with narrow-band ultraviolet B (NB-UVB) was shown to induce more improvement compared with NB-UVB monotherapy for treating stable non-segmental vitiligo. Objectives: This study aimed to confirm the safety and efficacy of fractional CO<sub>2</sub> laser combined with NB-UVB compared with NB-UVB monotherapy in stable nonsegmental vitiligo. Methods: We searched Cochrane, Embase, and PubMed up to January 2020. Four randomized controlled trials (RCTs) for comparison between fractional CO<sub>2</sub> laser plus NB-UVB and NB-UVB monotherapy in patients with stable non-segmental vitiligo were included. We performed meta-analyses for repigmentation improvement and patient satisfaction as well as subgroup analyses based on acral or non-acral vitiligo. Results: The combination treatment showed more superior results than NB-UVB monotherapy (≥ 75% repigmentation, RR 4.60, 95% CI 1.19-17.74; ≥ 50% repigmentation, RR 2.24, 95% CI 0.45-11.17; < 25% repigmentation, RR 0.81, 95% CI 0.60-1.08). Also, fractional CO<sub>2</sub> laser plus NB-UVB significantly improved acral and non-acral vitiligo compared with NB-UVB monotherapy (standard mean difference (SMD) 1.24, 95% CI 0.66-1.82; SMD 1.14, 95% CI 0.67-1.60, respectively), while it increased markedly patient satisfaction compared with NB-UVB monotherapy (SMD 1.12, 95% CI 0.66-1.58). Conclusion: This study suggested that fractional CO<sub>2</sub> laser combined with NB-UVB might be more effective for treating non-segmental vitiligo than NB-UVB monotherapy.
Choi, C. P.,Kim, Y. I.,Lee, J. W.,Lee, M. H. WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-
Background. Ultraviolet (UV) irradiation induces chronic skin diseases, such as skin cancer and photoageing, and the mechanisms of this skin damage are associated with the upregulation of matrix metalloproteinases (MMPs) and decreased collagen synthesis. Narrowband ultraviolet B (NB-UVB) radiation is a relatively new treatment modality for vitiligo and psoriasis. However, the mechanism of NB-UVB action on photoageing is not completely understood. Aims. We investigated the effects of NB-UVB on the expression of MMP-l, transforming growth factor (TGF)-βl and typeI collagen in cultured human skin fibroblasts. Methods. Cultured human fibroblasts were irradiated with either NB-UVB (50-800 mJ/cm^(2)) or broadband UVB (BB-UVB; 25 mJ/cm^(2)). The expression of MMP-l. TGF-βl and typeI collagen mRNA was determined by reverse-transcription PCR. Expression of MMP-l and TGF-βl protein was determined by ELISA and that of typeI collagen by Western blotting. Results. NB-UVB induced the expression of MMP-l and reduced the expression of TGF-βl and type I collagen at the mRNA and protein levels in a dose-dependent manner. The expression of type I collagen protein decreased more after irradiation with 25 mj/cm^(2) of BB-UVB than 400 mj/cm^(2) of NB-UVB. Conclusions. This study indicates that NB-UVB irradiation reduces type I collagen synthesis in human skin fibroblasts by inhibiting TGF-βl expression and stimulating the release of MMP-l. It also suggested that the photoagelng-related etTects of NB-UVB are weaker than those of BB-UVB in vitro.
( Seung Hyun Chun ),( Jae Beom Park ),( Byoung Joon So ),( Min Gun Yoo ),( Sang Wook Son ),( Il Hwan Kim ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Study in western nations showed NB-UVB treatment results in increased level of serum 25-hydroxyvitamin D(25(OH)D) level. Furthermore, symptoms of urticaria tends to improve when serum 25(OH)D level is high. Objectives: To find if NB-UVB treatment leads to both increased serum 25(OH)D level and additional symptom improvement of urticaria in Korean population. Methods: Total of 23 patients diagnosed as chronic urticaria from March to August of 2014 were enrolled. Patients underwent oral antihistamine medications and concurrent NB-UVB therapy for 3 months. We measured Urticaria Severity Score through questionnaire and serum 25(OH)D level by bloodwork. The measurement was performed at the initial visit and after 3 months of NB-UVB treatment. Three patients were excluded due to follow up loss. So far 6 patients completed the session and were evaluated. Results: At initial visit mean value of serum 25(OH)D level and USS was 17.89 and 35.5 respectively. At the end of 3 months of NB-UVB therapy the mean values were 27.55 and 23 respectively. Serum 25(OH)D level increased by 54.05% and USS was decreased by 35.21%. Conclusion: This study revealed that application of NB-UVB on urticaria patient leads to increased serum 25(OH)D level and has additional positive effect on symptom improvement. We are at present continuing on further research to exclude the effect of confounding variable such as sex, age, frequency of NB-UVB treatment, and effect of concurrent oral medication.
Narrowband UVB 치료에 의해 호전된 습진양 자반병
정영인 ( Young In Jeong ),허준원 ( Joon Won Huh ),김건 ( Geon Kim ),주민숙 ( Mihn Sook Jue ),박향준 ( Hyang Joon Park ),김은정 ( Eun Jung Kim ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.4
Eczematid-like purpura of Doucas and Kapetanakis is a type of pigmented purpuric dermatoses. It is clinically characterizedby pruritic seasonal eruptions occurring in the spring and summer, and histopathologically characterized byspongiosis and parakeratosis in the epidermis and by the lymphocyte-mediated leakage of erythrocytes from capillariesin the papillary dermis. We report a case of eczematid-like purpura of Doucas and Kapetanakis that showedclinical improvement with narrowband UVB (NB-UVB). The patient was a 66-year-old man with pruritic,well-demarcated scaly purpuric patches on his feet that appeared 2 months prior. A histopathological study showedmild superficial perivascular lymphocytic infiltration, focal spongiosis with exocytosis, and erythrocyte leakage. Weinitiated treatment with an oral antihistamine, ascorbic acid, and a topical steroid, but the lesion was aggravated. Wetherefore treated the patient with NB-UVB for 6 months, and the lesions regressed progressively with residual postinflammatoryhyperpigmentation.