Effects of Hand Individual Finger Exercise after 1 ㎐ Low-Frequency rTMS on Cerebral Motor Evoked Potential and Latency in Patients with Stroke

Sung-Ryong Ma,Jong-Bae Choi 한국자기학회 2023 Journal of Magnetics Vol.28 No.4

This study aimed to investigate the effects of individual finger exercise under the residual effect after low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) on cerebral motor-evoked potential amplitude (MEP amplitude) and cerebral MEP latency (MEP latency) in patients with stroke. This study conducted an intervention program in two groups of patients with chronic stroke (experimental group, individual finger exercise including residual effect after LF-rTMS group; IFE-rTMS group, individual finger exercise; IFE group, each comprising 10 patients). The program, which was conducted five times a week for 1 week, evaluated the MEP amplitude and MEP latency before and after the experiment. In an inter-group test of MEP amplitude and latency, all groups demonstrated an increase between the pre- and post-test evaluations. In an inter-group examination of MEP amplitude and latency, a significant difference was observed between the IFE-rTMS and IFE groups.

The Effects of Motor Imagery Combined with Neuromuscular Electrical Stimulation on Using Transcranial Magnetic Stimulation in Stroke Patients

Jong-Bae Choi,Man-Seok Han,Bo-Kyoung Song 한국자기학회 2019 Journal of Magnetics Vol.24 No.4

The purpose of this study was to investigate the effect of motor imagery combined with neuromuscular electrical stimulation (MI-NMES) on cerebral cortex excitability in stroke patients. We examined the effect of MINMES on cerebral cortex excitability using transcranial magnetic stimulation (TMS) of motor evoked potential (MEP) amplitude and latency, quantitative electroencephalography (QEEG) of δα ratio (DAR) and power ratio index (PRI) assessments. This study was to evaluate 30 stroke patients who were satisfied the selection criteria of the study. Experiments were divided into MI-NMES group, motor imagery (MI) group. This study showed that there was a significant difference for all evaluations within the MI-NMES group, with significant differences in MEP amplitude and latency, QEEG DAR, and PRI index values in the comparison that those of the MI group. MI-NMES is suggested to be an effective approach for cerebral cortex excitability in stroke patients.

Correlation of the Motor Evoked Potentials Amplitude and Hand Function of the Affected Side in Stroke

Soo-Youn Son,고명환,박성희,서정환 대한재활의학회 2011 Annals of Rehabilitation Medicine Vol.35 No.1

Objective To investigate the correlation between the motor evoked potentials (MEPs) amplitude of 1st dorsal interosseus in affected limbs and affected hand function after stroke. Method We enrolled 109 patients with acute and subacute 1st attack stroke. Transcranial magnetic stimulation (TMS) was applied to the motor cortex and MEP was recorded at the 1st dorsal interossei (DI) muscle. MEP parameters were latency of the affected side, latency ratio (latency of affected side/latency of unaffected side), amplitude of affected side and amplitude ratio (amplitude of affected side/latency of unaffected side). Hand function tests (HFT) including hand power measures and a nine hole peg test (NHPT) were conducted and the ratios of the value of the affected hand to unaffected hand were used for the analysis. The Korean version of the modified Barthel index (K-MBI) and the manual muscle test (MMT) of finger flexion were also evaluated. Correlation between MEP parameters and the clinical variables such as HFT, K-MBI and MMT grades were analyzed. Results While MEPs in the affected 1st DI were recorded in fifty six patients, MEPs were not recorded in forty nine patients. The responsiveness of MEPs was significantly correlated with the HFT, K-MBI and MMT grades. The amplitude ratio had the most significant correlation with the HFT and MMT grade in this MEP study. Also, the amplitude ratio had more significant correlations with the K-MBI score compared with other MEP parameters. Conclusion We concluded that the amplitude ratio may be a useful MEPs parameter for indicating hand function.

Effects of Hand Intrinsic Muscle Facilitation and Functional Task Training on Cerebral Motor Evoked Potential after 1 Hz Low-Frequency rTMS in Stroke Patients

Sung-Ryoung Ma,Bo-Kyoung Song Korean Magnetics Society 2018 Journal of Magnetics Vol.23 No.4

The purpose of this study was to investigate the effects of hand intrinsic muscles facilitation and functional task training with 1 Hz repetitive transcranial magnetic stimulation (rTMS) on cerebral motor cortex activity in stroke patients and to investigate the effectiveness of stroke rehabilitation. In this study, 20 adult stroke patients were randomly selected and divided into two groups of 10 each other. In the experimental group, hand intrinsic muscles facilitation and functional task training were performed after 1 Hz low frequency for 20 minutes and simple upper limb task training was performed in the control group. To investigate the changes of cerebral motor cortex activity after intervention, we measured Motor evoked potential (MEP) amplitude and latency. In both groups, MEP amplitude increased and MEP latency decreased after intervention. There was a significant difference between the two groups in MEP amplitude and latency (p < 0.01) (p < 0.05). Therefore, hand intrinsic muscles facilitation and functional task training with 1 Hz low frequency (rTMS) of stroke patients showed positive results in MEP amplitude and latency change of the injured cerebral cortex after stroke.

The effects of Task-Oriented Activity after applying Low Frequency Repetitive Transcranial Magnetic Stimulation on Cerebral Motor Evoked Potential Emplitude and Latency in Stroke Patients

Sung-Ryoung Ma,Man-Seok Han,Bo-Kyoung Song 한국자기학회 2017 Journal of Magnetics Vol.22 No.4

To investigate the effects of task-oriented activities under the residual effect after repetitive transcranial magnetic stimulation (rTMS) on cerebral motor evoked potential (MEP) amplitude, cerebral motor evoked potential (MEP) latency in stroke patients, this study conducted an intervention program on two groups (experimental group - TIL, control groups – GRT, each consisting of 10 patients) of chronic stroke patients. The program−which was conducted three times a week for 6 weeks−evaluated the MEP amplitudes, MEP latency before and after the experiment. In an inter-group test of MEP amplitude and MEP latency, all groups showed an increase between pre- and post-test evaluations. In an intergroup examination on MEP amplitude and MEP latency, a significant difference was observed between the TIL and GRT groups.

The effects of motor imagery combined with functional electrical stimulation on cerebral cortex excitability in stroke patients

Jong-Bae Choi,Bo-Kyoung Song,Man-Seok Han 한국자기학회 2019 한국자기학회 학술연구발표회 논문개요집 Vol.29 No.2

Comparison of Propofol and Ketofol on Transcranial Motor Evoked Potentials in Patients Undergoing Thoracolumbar Spine Surgery

Khandelwal Ankur,Chaturvedi Arvind,Sokhal Navdeep,Singh Akanksha,Sharma Hanjabam Barun 대한척추외과학회 2022 Asian Spine Journal Vol.16 No.2

Study Design: This was a double-blind randomized study. Purpose: The primary purpose was to compare the effects of propofol and ketofol on amplitudes and latencies of transcranial motor evoked potentials (TcMEPs) during thoracolumbar spine surgery. In addition, intraoperative hemodynamics and muscle power were compared. Overview of Literature: Propofol is commonly used during intraoperative TcMEP monitoring. However, propofol inhibits TcMEP amplitudes and causes hypotension in a dose-dependent fashion. Methods: Amplitude and latency of TcMEPs were recorded bilaterally from the abductor pollicis brevis (APB) and abductor hallucis (AH) muscles in 38 adult American Society of Anesthesiologists I and II patients undergoing thoracolumbar spine surgery. Baseline recordings of TcMEPs in both groups were recorded under propofol infusion. Group X patients then received propofol and fentanyl (1 mcg/kg/hr), and group Y patients received ketofol and fentanyl (1 mcg/kg/hr). Bispectral index was maintained at 40–60 in both groups. Amplitude and latency were recorded at 30 minutes intervals for 2 hours. Results: Propofol caused no significant changes in amplitude and latency in any muscle. In contrast, amplitude increased significantly at all time points in the bilateral APB muscles and 60, 90, and 120 minutes in the left AH muscle without changes in latency in response to ketofol. When the two groups were compared, ketofol induced significantly higher amplitudes at 60, 90, and 120 minutes in the (left) APB, at all time points in the (right) APB, and at 120 minutes in both AH muscles, compared with propofol. Blood pressures were lower and fluid and vasopressor requirements were higher in group X. Muscle power was similar between the two groups. Conclusions: Ketofol facilitates TcMEP amplitudes without affecting latency. Use of ketofol resulted in a better and more stable hemodynamic profile than did use of propofol.

The Effect of Low-frequency Repetitive Transcranial Magnetic Stimulation on Muscle Tone Reduction and Cerebral Activity in Stroke Patients

Sung-Ryoung Ma,Jung-Woo Jeong 한국자기학회 2022 Journal of Magnetics Vol.27 No.4

An intervention program was conducted with two groups of patients who had experienced stroke: one which received low-frequency rTMS and occupational therapy (rTMS-OT Group), and one which received occupational therapy only (OT group). The treatment was provided three times per week for 4 weeks followed by a 1- week evaluation of MEP amplitude and latency, and muscle tone. In an intergroup test of MEP amplitude and latency, and muscle tone, all groups showed increases between pre-and post-test evaluations. As a result of the study, during the treatment intervention of the experimental group and the control group, the experimental group rTMS-OTG and the control OTG group showed MEP amplitudes of 0.161 mV and 0.114 mV, respectively, and the experimental group showed more improvement. The MEP latency of the rTMS-OTG group was -2.83 ms and the MEP latency of the OTG group was -1.49 ms. The experimental group, rTMS-OTG, responded faster. However, in the case of muscle tone evaluation, there was no significant difference between the two groups. In conclusion, we determined that rTMS may be safely applied to the directly damaged cerebral cortex and is considered to be an effective treatment for patients recovering from stroke.

Effects of Action Observation Training with 1 Hz Low Frequency Repeated Transcranial Magnetic Stimulation on Cerebral Cortex Activity and Hand Function in Patients with Ideomotor Apraxia after Stroke

Byung-Il Yang,Sung-Ryoung Ma,Bo-Kyoung Song 한국자기학회 2019 Journal of Magnetics Vol.24 No.4

The aim of this study was to investigate the effects of action observation training with low frequency repeated transcranial magnetic stimulation (rTMS) on cerebral cortex activity and hand function in patients with ideomotor apraxia after Stroke. Fourteen patients were randomly divided into two groups which in action observation training (AOT) with 1 Hz low-frequency rTMS and AOT without rTMS. Motor evoked potential (MEP) amplitude and latency were examined by TMS for cerebral cortex activity and hand function was evaluated by manual function test (MFT). As a result, there was a significant difference in MEP amplitude in group, but only AOT with rTMS group was a significant difference in MEP latency and MFT. In addition, there was a significant difference of MEP amplitude, latency and MFT between groups. These results suggest that application of AOT and rTMS can have a positive effect on the recovery of hand function in ideomotor apraxia after patients.