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마이크로/나노-운반체를 이용한 톡소이드 항원의 효과적인 전달 방법
박가영(Ga-Young Park),안근아(Gna Ahn),이세희(Se Hee Lee),김상범(Sang Bum Kim),김양훈(Yang-Hoon Kim),안지영(Ji-Young Ahn) 한국생명과학회 2018 생명과학회지 Vol.28 No.4
톡소이드는 독성은 제거되고 항원성은 유지시킨 독소 단백질로써, 다양한 병원체의 감염 및 질병 예방을 위해 지속적으로 연구 되었다. 그러나, 톡소이드의 활성 감소 및 이와 함께 사용하는 어쥬번트의 부작용 등이 지속적으로 보고되면서, 면역성은 강화하고 어쥬번트의 사용은 줄일 수 있는 톡소이드 항원 전달 시스템이 필요하게 되었다. 따라서, 이러한 단점을 개선하고자 최근 새로운 백신과 약물 전달수송을 위해 다양한 분야에서 활용하고 있는 마이크로/나노 운반체를 톡소이드 항원에 도입하고 있다. 이와 같은 마이크로/나노 운반체는 미생물 자체를 이용하거나 미생물을 통해 생산해 낼 수도 있으며, 더 나아가 다양한 소재의 폴리머를 이용하여 제작할 수 있다. 본 총설에서는 톡소이드 항원 전달을 위한 마이크로/나노 운반체를 미생물 유래의 ghost cells (GCs), 그람 음성 세균이 분비하는 outer membrane vesicles (OMVs) 및 고분자 폴리머로 구성된 nanoparticles (NPs)으로 분류하였다. 마지막으로 각 운반체에 대한 톡소이드 항원의 전달 방식 및 이를 적용하였을 때 일어나는 면역반응에 대하여 서술하였으며, 이를 통해 향후 톡소이드의 효율 및 부작용이 개선되기를 기대한다. Immunization has been performed for centuries and is generally accepted as a sustainable method of controlling bacteria, viruses, and mediated and infectious diseases. Despite many studies having been performed on animal subjects to demonstrate the importance of toxin immunity, the use of toxoid vaccines in humans and animals has been limited for a long time. Recently, the development of the toxoid antigen delivery system has been facilitated using novel nano-medicinal technology. The micro/nano-carrier has been used to improve vaccination coverage as well as reduce vaccine costs. A micro/nano-carrier is a micro/nano-sized material that delivers immune cargo, including recombinant or peptide toxoid antigens. These toxoid antigens are either encapsulated in the interior or displayed on the surface of micro/nano-carriers as a way to protect them from the cellular machinery. In particular, the combination of toxoid antigens and micro/nano-carriers can induce phagocytosis through the specific interactions between GCs and macrophages; thus, the toxoid antigens can be delivered easily into the macrophages. This paper reviews recent achievements of micro/nano-carriers in the field of vaccine delivery systems such as microbial ghost cells (GCs, Bacterial ghost cells and Yeast ghost cells), gene-manipulated outer membrane vesicles (OMVs) and biocompatible, polymer-based nanoparticles (NPs, NP-Carrier and NP-Cage). Finally, this review shows various aspects in terms of the hosts’ immune responses.
약물전달체로 이용하기 위한 자기복합체 키토산 활용 가능성 연구
이은성 ( Eun Seong Lee ),백구 ( Gu Baek ),유아영 ( Ah Young Yoo ),이창원 ( Chang Won Lee ),박용일 ( Yong Il Park ),박제권 ( Jae Kweon Park ) 한국키틴키토산학회 2013 한국키틴키토산학회지 Vol.18 No.4
Self-Assembled chitosan (SAC) was formed using high molecular weight chitosan (HMWC) by oxidative reaction with potassium persulfate or ammonium persulfate. Prepared SAC was tested to elucidate a potential drug delivery carrier (DDC) which can sustain and release chemicals tested; copper sulfate, bovine serum albumin (BSA), purified curcumin, anthocyanin, maysin and microalgal antioxidant astaxanthin. Our data demonstrated that SAC with different sizes of micro-particles ranging from 4 to 11 mm can be used as a potential DDC for various agents tested in this study.
Light responsive drug release using IR780 encapsulated micro drug carriers
김현웅,심민석,임용준,봉기완 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.0
정상세포에 도달하는 항암제의 농도를 낮추면서 암에만 국소적으로 높은 농도를 전달하는 약물 전달체가 개발되면 항암제의 부작용을 줄일 수 있다. 지금까지는 근적외선이 빛의 파장 중 가장 피부 침투력이 좋으며, 비침습성을 가지고 있기 때문에, 근적외선을 통한 약물전달이 활발하게 연구되어 왔다. 하지만, 대부분의 약물 전달체는 합성 고분자로 이루어져 있기 때문에 세포 독성과 염증 반응을 유발할 수 있으므로, 생체 안정성이 높은 물질을 이용한 약물전달체의 개발이 필요하다. 우리는, 지방 알코올인 1-tetradecanol을 원료로 하고, 빛을 받으면 발열하며, IR780를 함유하는 마이크로 입자를 미세유체 공정을 통해를 개발하였다. 이 입자에 빛을 조사하였을 때, IR780의 흡광에 의한 발열로 인해 입자가 액화되는 것을 확인하였다. 또한, 항암제인 DOX를 함유한 마이크로 입자에 빛을 조사하였을 때, 약물이 방출되는 것을 정량적으로 증명하였다.
Lee Seong Hyuk The Korean Society of Mechanical Engineers 2005 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.19 No.6
This work provides the fundamental knowledge of energy transport characteristics during very short-pulse laser heating of semiconductors from a microscopic viewpoint. Based on the self-consistent hydrodynamic equations, in-situ interactions between carriers, optical phonons, and acoustic phonons are simulated to figure out energy transport mechanism during ultrafast pulse laser heating of a silicon substrate through the detailed information on the time and spatial evolutions of each temperature for carriers, longitudinal optical (LO) phonons, acoustic phonons. It is found that nonequilibrium between LO phonons and acoustic phonons should be considered for ultrafast pulse laser heating problem, two-peak structures become apparently present for the subpicosecond pulses because of the Auger heating. A substantial increase in carrier temperature is observed for lasers with a few picosecond pulse duration, whereas the temperature rise of acoustic and phonon temperatures is relatively small with decreasing laser pulse widths. A slight lagging behavior is observed due to the differences in relaxation times and heat capacities between two different phonons. Moreover, the laser fluence has a significant effect on the decaying rate of the Auger recombination.
Noh, Juran,Kim, Jin,Kim, Jin Sic,Chung, Young Soo,Chang, Suk Tai,Park, Juhyun Elsevier 2018 Carbohydrate Polymers Vol.182 No.-
<P><B>Abstract</B></P> <P>Oil/water microencapsulation by microfluidic systems has been a prominent delivery method to prepare functional microcapsules in the food, cosmetic, and pharmaceutical industries because it is an easy way to control the shape and size of structures and functionalities. We prepared biocompatible and multi-component microcapsules using the precipitation and ionic crosslinking of pectin in a poor solubility environment and with multivalent cations, respectively. When the aqueous solution (including calcium ions and ethanol) in a sheath flow met the flow of a pectin aqueous solution containing oil droplets, ethanol-gelation and ionic cross-linking occurred, enclosing the inner oil phase droplets by solidified pectin shells. Furthermore, the resulting microcapsules stabilized by pectin shells exhibited functionalities using a hydrophobic agent and nanoparticles of a hydrophilic species that were dissolved and dispersed, respectively, in the oil phase.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pectin microcapsules were fabricated using a microfluidic system. </LI> <LI> Pectin shells enclosing oil droplets were solidified by precipitation and ionic cross-linking. </LI> <LI> Nanoparticles of a hydrophilic agent were prepared and dispersed in inner oil droplets. </LI> <LI> A hydrophobic agent was dissolved in the oil droplets. </LI> <LI> Pectin microcapsules carried both hydrophilic and hydrophobic agents. </LI> </UL> </P>
양경원,김창규 ,이종문,김민남 한국동력기계공학회 2006 한국동력기계공학회 학술대회 논문집 Vol.- No.-
Making Al composition in the base metal interface of spray coating film then after forming the inclination composition coation(the second-film) of AIN composition in the surface, holding a exfoliation of the coating film and trying to make Al/AIN complex-film contained a much of nitrides were obtained below result. As cooling of the base metal hold a thermal expansion of the base metal, it can know effected holding a exfoliation of coating film and not affected a bad effect to nitration reaction. According the spray distance was longer, the nitration reaction controled and the coating film was delicately formed. In case RF input power was 3㎾, coating film is very well formed. Following the increase of a flux of carrier gas, a thickness of coating film tended to decrease and as using the powder of diameter 3 ㎛ the best suitable situation was thought to powder supply of 31/min. the value of average hardness nearby the base metal interface was 45(Hv) and the value of average hardness nearby the surface of coating film was 5l4(Hv).
김진,노주란,김진식,정영수,장석태,박주현 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1
Oil/water microencapsulation by microfluidic systems has been a prominent delivery method to prepare functional microcapsules in the food, cosmetic, and pharmaceutical industries because it is an easy way to control the shape and size of structures and functionalities. We prepared biocompatible and multifunctional microcapsules using the precipitation and ionic crosslinking of pectin in a poor solubility environment and with multivalent cations, respectively. When the aqueous solution (including calcium ions and ethanol) in a sheath flow met the flow of a pectin aqueous solution containing oil droplets, ethanol-gelation and ionic cross-linking occurred, enclosing the inner oil phase droplets by solidified pectin shells. Furthermore, the resulting microcapsules stabilized by pectin shells exhibited multifunctionality using a hydrophobic agent and nanoparticles of a hydrophilic species that were dissolved and dispersed, respectively, in the oil phase