상악암에서 중합효소연쇄반응을 이용한 인형유두종바이러스와 Epstein-Barr virus의 검출

조재식,임상철,정형수,임회정,김정현 대한이비인후과학회 2001 대한이비인후과학회지 두경부외과학 Vol.44 No.5

상악동의 선양낭성암종

금기창(Ki Chang Keum),박희철(Hee Chul Park),김귀언(Gwi Eon Kim),서창옥(Chang Ok Suh),정은지(Eun Ji Chung),김세헌(Se Heon Kim),김영호(Young Ho Kim),홍원표(Won Pyo Hong) 대한두경부종양학회 1996 대한두경부 종양학회지 Vol.12 No.2

A retrospective analysis was performed to assess the relationship between the treatment modalities and treatment results in patients with adenoid cystic carcinoma of the maxillary sinus. From Feb. 1977 to March 1994, 10 patients with the disease were treated at the Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine. Six men and 4 women were presented with median age of 57 years. According to AJCC TNM system, all patients except one had advanced T3 and T4 disease. Only one patient had the regional metastasis to lymph node but none of them had hematogenous metastasis on initial admission. One patient(Group 1) was treated with surgery alone, 3 patients(Group 2) were treated with definitive radiotherapy and 6 patients(Group 3) were treated with combination of surgery and radiotherapy. One patient who was treated with surgery alone had experienced a locoregional recurrence 9 months later and 3 patients who were treated with radiation therapy alone had PRs(partial response) followed by the subsequent progression of the local disease. Whereas all patients who were treated with combination of surgery and radiation therapy had CRs(complete response). Among them, only one patient was recurred in the primary site, who was salvaged by reoperation and reirradiation therapy. In conclusion, combination of surgery and radiotherapy resulted in the best treatment modality for adenoid cystic carcinoma of the maxillary sinus. Improved radiotherapy technique and development of multimodality treatment are needed to improve the local control and the survival rate in patients with advanced adenoid cystic carcinoma of the maxillary sinus.

상악동 편평상피암의 방사선치료

정은지(Eun Ji Chung),김귀언(Gwi Eon Kim),이창걸(Chang Geol Lee),김우철(Woo Cheol Kim) 대한두경부종양학회 1995 대한두경부 종양학회지 Vol.11 No.2

A retrospective analysis was performed to ascertain the relationship between the treatment modalities and their treatment results. From July 1980 to June 1993, 115 patients with squamous cell carcinoma of the maxillary sinus were: treated at the Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University. There were 88 men and 27 women with median age of 57 years. According to AJCC TNM system of 1992. eight patients of T2, 54 patients of T3 and 53 patients of T4 were available, respectively. Cervical lymph node metastases at diagnosis was observed in 11 patients. 87 patients were treated with radiotherapy and 28 patients were treated with combination of surgery and radiotherapy. The overall 5 year survival rate was 32 %, patients that were treated with radiotherapy alone had a 5 year survival rate 24.3 % and patients who were treated with combination of surgery and radiation therapy had a 5 year survival rate of 52.8 % (p<0.05). Combination of surgery and radiotherapy resulted in a better treatment modality for squamous cell carcinoma of the maxillary sinus. Improved radiotherapy technique and development of multimodality treatment are needed to improve the local control and the survival rate in patients with advanced maxillary sinus carcinoma.

Comparison of Results according to the Treatment Method in Maxillary Sinus Carcinoma

정웅기(Woong Ki Chung),조재식(Jae Sik Jo),안성자(Sung Ja Ahn),남택근(Taek Keun Nam),나병식(Byung Sik Nah),박승진(Seung Jin Park) 대한방사선종양학회 1995 Radiation Oncology Journal Vol.13 No.1

목적 : 상악동암의 적절한 치료 방법을 알기 위하여 후향적 분석을 시행하였다. 대상 및 방법 : 1986년 1월 부터 1992년 12월 까지 전남대학교 병원에서 치료받은 상악동에서 발생한 편평상피세포암 33명을 대상으로 하였다. 남자가 24명 여자가 9명이었고 연령의 중앙값은 55세였다. 1988년에 제시된 AJCC 병기 분류법에 따른 종양의 병기는 T2 1명, T3 10명, T4 22명이었으며 경부임파절 전이는 5명에서 관찰되었다(N1;4명, N2b;1명). 치료방법에 따라 3군으로 분류하여 분석하였으며 첫 군(FAR 군으로 명명, 16명)은 수술전 경동맥 항암화학요법(5-FU, 평균 3078mg)과 방사선치료(평균 3433cGy)및 비타민 A(50,000 IU, daily)를 병용하고 이어서 상악전적출술과 술후 방사선치료(평균 2351cGy)를 시행하였다. 방사선총량은 5255cGy였다. 둘째군(SR 군으로 명명, 7명)은 상악전적출술과 술후 방사선 치료(평균 5920cGy)를 시행하였다. 셋째군(R 군으로 명명, 6명)은 근치적 목적의 방사선 치료(평균 7164cGy)만 시행하였다. 생존율 분석에는 Kaplan-Meier법을 이용하였고 두 군간의 차이에 대한 검정은 Mantel-Cox법으로 하였다. 결과 : 국소종양 제어율은 2년에 FAR, SR, R군에서 각각 100%, 50%, 27.7%로 나타났다. 무병생존율은 2년에 FAR, SR, R군에서 각각 88.9%, 33.3%, 0%였다. 전체적인 생존율은 2년에 FAR, SR, R군에서 각각 88.9%, 40%, 50%였다. FAR군과 SR군간에, 그리고 FAR군과 R군간에 국소종양 제어율, 2년 무병생존율, 2년 생존율에 있어서의 차이는 통계학적으로 유의하였다. 그러나 SR군과 R군과의 차이는 통계학적 유의성이 없었다. 결론 : 수술전 경동맥 5-FU와 비타민 A 그리고 방사선 치료를 병용 치료하여 종양의 부분적 관해를 유도한 후 상악전적출술과 추가적인 방사선 치료를 시행한 FAR군이 상악전적출술후 방사선치료를 시행한 군이나 방사선 단독치료군보다 더 좋은 성적을 보였다. 앞으로 이에 대한 전향적 연구가 필요할 것으로 사료된다. Purpose : A retrospective analysis was performed to investigate the proper management of maxillary sinus carcinoma. Materials and Methods : Authors analysed 33 patients of squamous cell carcinoma of maxillary sinus treated at Chonnam University Hospital from January 1986 to December 1992. There were 24 men and women with median age of 55 years. According to AJCC TNM system of 1988 a patient of T2, 10 patients of T3 and 22 patients of T4 were available respectively. Cervical lymph node metastases was observed in 5 patients(N1;4/33, N2b;1/33). Patients were classified as 3 groups according to management method. The first group, named as "FAR" (16 patients), was consisted of preoperative intra-arterial chemotherapy with 5-fluorouracil(5-FU;mean of total dosage; 3078mg) through the superficial temporal artery with concurrent radiation(mean dose delivered;3433cGy, daily 180-200 cGy) and vitamin A(50,000 IU daily) and followed by total maxillectomy and postoperative radiation therapy(mean dose:2351cGy). The second group named as "SR"(7 patients) was treated with radiation alone(mean dose;7164cGy). Kaplan-Meier product limit method was used for survival analysis and Mantel-cox test was performed for significance of survival difference between two groups. Results : Local recurrence free survival rate in the end of 2 year was 100%, 50% and 0% in FAR, SR and R group, respectively. Disease free survival rate in 2 years was 88.9%, 28.6% and 0% in FAR, SR and R group. respectively. Overall survival rate in 2years was 88.9%, 40% and 50% in FAR, SR and R group, respectively. There were statistically significant difference between FAR and SR or FAR and R group in their local recurrence free, disease free and overall survival rates. But difference of each survival rate between SR and R group was not significant. Conclusion : In this study FAR group revealed better results than SR or R group. In the future prospective randomized study is in need.

상악동 내 전이성 신세포암에 대한 Tyrosine Kinase 억제제 치료 경험 1예

김영효,김재은,박성민,장태영 대한이비인후과학회 2012 대한이비인후과학회지 두경부외과학 Vol.55 No.11

Renal cell carcinoma is a rare metastatic malignant neoplasm of the paranasal sinus. The clinical picture and radiologic findings might sometimes be insufficient to suspect metastatic renal cell carcinoma. Therefore, the definite diagnosis should be made according to the result of intra-operative biopsy. Recently, tyrosine kinase inhibitor, sunitinib, is considered as an effective agent in the treatment of metastatic renal cell carcinoma. We report a case of 69-year-old patient with metastatic renal cell carcinoma of the right maxillary sinus with accompanying fungal sinusitis. After 6 times of chemotherapy with sunitinib malate, there was no sign of recurrence or local advancement of the tumor during the 1-year follow-up period.

Adenoid Cystic Carcinoma on the Left Maxillary Sinus Showed Symptoms Analogous to Temporomandibular Disorder

Lee, Sunhee,Park, Yang Mi,Heo, Jun-Young,Jeong, Sung-Hee,Ahn, Yong-Woo,Ok, Soo-Min Korean Academy of Orofacial Pain and Oral Medicine 2016 Journal of Oral Medicine and Pain Vol.41 No.1

Malignant tumors located in the head and neck areas intermittently show symptoms similar to a temporomandibular disorder (TMD). In our case, a patient who first visited us complaining of TMD-like symptoms, such as trismus and temporomandibular joint (TMJ) pain on the left side, was identified as a sufferer of adenoid cystic carcinoma (ACC) that arose from the left maxillary sinus. The patient may have a TMD symptom, but we are skeptical because the patient also complained of a spontaneously developed numbness on the same side of his upper lip. We observed the panoramic radiograph closely and found the blurred maxillary sinus inferior wall. Dental cone-beam computed tomography confirmed the tentative diagnosis of malignancy on the maxillary sinus. After he had been referred to the Department of Otolaryngology, the diagnosis of the ACC was confirmed. Adequate diagnosis is vital for a quick treatment of the malignancy. There are some keys for differential diagnosis of TMD-like symptoms.

반상경피형 기저세포암으로 오인한 상악동암

백유상 ( Yoo Sang Baek ),이정우 ( Jung Woo Lee ),안재우 ( Jae Woo Ahn ),김주하 ( Joo Ha Kim ),전지현 ( Jiehyun Jeon ),송해준 ( Hae Jun Song ),오칠환 ( Chil Hwan Oh ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.5

Squamous cell carcinoma (SCC) of the maxillary sinus is the most common malignant neoplasm of the paranasal cavity. The most frequent initial symptoms are swelling of the cheek, nasal obstruction, epistaxis, and nasal discharge. Herein, we report the case of a 62-year-old Korean male who initially presented with a whitish irregular depressed plaque with an indurated border in his left cheek. After a several-week delay in diagnosis, he was eventually diagnosed with maxillary sinus carcinoma. (Korean J Dermatol 2014;52(5):349∼352)

낭성 병소로 오인된 상악동의 비각화 상피세포암종의 증례보고

박정현,최은주,박혁,김현실 대한구강악안면병리학회 2012 대한구강악안면병리학회지 Vol.36 No.4

Malignant tumor of the paranasal sinus is a rare, occurring most frequently in the maxillary sinus. Carcinomas of the maxillary sinus are usually diagnosed at the advanced stage because most tumors have no symptom or nonspecific symptoms such as pain, nasal obstruction, rhinorrhea, and epistaxis. In addition to these features, it is difficult to distinguish carcinoma from inflammatory or cystic lesion on imaging study until the carcinoma destroys the surrounding structures. Therefore, the diagnosis is prone to be delayed. Here, we report a case of an 83‐year‐old male with nonkeratinizing carcinoma on the maxillary sinus, which was initially misdiagnosed as a cystic lesion. The aim of this study is to emphasize the effort for early diagnosis in order to improve prognosis and avoid inadequate treatment

낭성 병소로 오인된 상악동의 비각화 상피세포암종의 증례보고

박정현,최은주,박혁,김현실 대한구강악안면병리학회 2012 대한구강악안면병리학회지 Vol.36 No.4

Malignant tumor of the paranasal sinus is a rare, occurring most frequently in the maxillary sinus. Carcinomas of the maxillary sinus are usually diagnosed at the advanced stage because most tumors have no symptom or nonspecific symptoms such as pain, nasal obstruction, rhinorrhea, and epistaxis. In addition to these features, it is difficult to distinguish carcinoma from inflammatory or cystic lesion on imaging study until the carcinoma destroys the surrounding structures. Therefore, the diagnosis is prone to be delayed. Here, we report a case of an 83‐year‐old male with nonkeratinizing carcinoma on the maxillary sinus, which was initially misdiagnosed as a cystic lesion. The aim of this study is to emphasize the effort for early diagnosis in order to improve prognosis and avoid inadequate treatment.

양측 진균성 부비동염을 동반하여 진단이 지연된 상악동 소세포암 1예

구범모,김형규,조현상,박보나 대한이비인후과학회 2020 대한이비인후과학회지 두경부외과학 Vol.63 No.6

Extrapulmonary small cell carcinoma originated from the paranasal sinus is extremely rare, andits local and distant metastasis is common and the prognosis is poor. We recently experienceda rare case of small cell carcinoma that originated from the maxillary sinus. However, the diagnosiswas delayed for several reasons, one of which included accompanied bilateral fungal sinusitis. The patient received chemotherapy for four times, but the therapy was discontinued dueto poor general conditions. We report our case with a review of the literature.