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두드러기 혈관염의 임상조직학적 연구: 65명의 환자를 대상으로 한 한국의 단일 기관 연구
김지선,구대원,이중선 대한피부과학회 2022 대한피부과학회지 Vol.60 No.9
Background: Urticarial vasculitis (UV) is a rare disorder that can be diagnosed with clinical and histopathologicstudies. There are classical clinical criteria; however, histopathological evidence is required for a definite diagnosis. Few studies have reported on the clinical and histological features of UV. Objective: To analyze the clinical and histopathologic features of patients diagnosed with UV at a single center inthe Republic of Korea. Methods: We performed a retrospective study of the medical records, clinical photographs, and histopathologicalslides of patients who visited the Department of Dermatology at Daejeon Eulji Medical Center for urticarial whealsor purpuric plaques lasting more than 24 hours from January 2013 to October 2021. Results: A total of 65 patients and 95 slides were analyzed. Clinically, most patients had wheal-like plaquedominant lesions (55 patients, 84.6%) rather than purpura and presented with pruritus. In the histopathological study,lymphocytic vasculitis (65 of 69 slides, 94.2%) was more dominant than leukocytoclastic vasculitis. However, itsseverity was milder than that of leukocytoclastic vasculitis. Conclusion: This study performed a more in-depth clinical and histological analysis of UV, and histologically, itshowed more diversity than previously known leukocytoclastic vasculitis. This might be used as basic research datafor more large-scale studies of UV in the future.
( Se Jin Oh ),( Young Hwan Choi ),( Hyun Jeong Byun ),( Seung Hwan Oh ),( Ji-hye Park ),( Jong Hee Lee ),( Dong-youn Lee ),( Joo-heung Lee ),( Jun-mo Yang ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Cutaneous vasculitis is a histopathologic entity that is characterized by neutrophilic transmural inflammation of the vessel wall and is associated with fibrinoid necrosis, which is also termed leukocytoclastic vasculitis. Recombinant granulocytic colony-stimulating factor (G-CSF) is clinically used for the treatment of neutropenia associated with chemoteherapy. However, vasculitis has been reported in a few cases of solid as well as hematologic malignancies and with granulocyte colony-stimulating factor therapy. A 66-year-old woman was diagnosed with multiple myeloma. The patient had been given a bortezomib treatment for 3 months and no skin lesion was developed before. Filgrastim was given to improve neutropenia. There was a rise in absolute neutrophil count and on day 14 of G-CSF, the patient developed tender and erythematous plaques on the upper chest and back. Skin biopsy revealed leukocytoclastic vasculitis. G-CSF was discontinued and complete resolution of vasculitis was achieved. Drug-induced vasculitis was usually reported to present with palpable purpura on lower extremities, unlike that in our patient who tender plaque on trunk. The aim of this case report is to highlight the importance of monitoring patients on granulocytic colony-stimulating factor therapy.
( Se Jin Oh ),( Young Hwan Choi ),( Hyun Jeong Byun ),( Ji-hye Park ),( Jong Hee Lee ),( Dong-youn Lee ),( Joo-heung Lee ),( Jun-mo Yang ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Approximately 15-20% of pediatric patient with inflammatory bowel disease develop extraintestinal manifestations. The most common cutaneous extraintestinal manifestation of ulcerative colitis is erythema nodosum, pyoderma gangrenosum, and psoriasis. It It is reported that leukocytoclastic vasculitis can rarely be associated with ulcerative colitis. A 14-year-old girl was admitted to our hospital for evaluation of intestinal symptoms such as abdominal pain, nausea, vomiting and diarrhea for 2 days. Two days later, she presented with bloody diarrhea 2-3 times a day. Colonoscopy revealed edematous mucosal erythema and exudates, mucosal friability, and bleeding on the entire colon and the rectum, which is diagnosed as ulcerative colitis. Two weeks later, she was referred to the department of dermatology for tender, purpuric patches and bullae on her left buttock, right shoulder and lower abdomen. A biopsy specimen of right shoulder demonstrated leukocytoclastic vasculitis. IV cyclosporine was administered and the dose of methylprednisolone was slowly tapered with subsequent resolution of the skin eruption and intestinal symptoms. She was still well with oral mesalazine and azathioprine. In conclusion, dermatologists should be aware that leukocytoclastic vasculitis may occur with the diagnosis of ulcerative colitis, although it is rare. Appropriate treatment and careful follow-up is needed to improve both vasculitis and ulcerative colitis.
( Tae Lim Kim ),( Young Wook Ko ),( Se Kwang Park ),( Hyun-min Seo ),( Joung Soo Kim ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Immunoglobulin G (IgG) 4-related disease (IgG4-RD) is a newly recognized fibroinflammatory entity characterized by elevated serum levels of IgG4 and histological infiltration of IgG4+ plasma cells. Several inflammatory diseases like autoimmune pancreatitis and Mikulicz’s disease were previously regarded as independent, organ-specific diseases but they are now unified as IgG4-RD in terms of IgG4. However, since there have been reported that Anti-neutrophil cytoplasmic antibodies (ANCA) has close connection with an increased IgG4 immune response, IgG4-RD may overlap with ANCA-associated vasculitis. A 46-year-old man presented with violaceous papules on both legs for 3 days. He complaint for fever and cough over 3 weeks and followed by polyarthralgia and petechia. C-ANCA was detected and serum IgG4 levels were elevated on laboratory examination. Skin biopsy specimen from his right leg showed features of leukocytoclastic vasculitis with perivascular granulomatous lymphoplasmacytic infiltration. Chest X-ray revealed pneumonic infiltration in the left lower lobe and percutaneous lung biopsy was performed. From the lung biopsy specimen, diffuse fibrosis with heavy lymphoplasmacytic infiltrates were observed and abundant IgG4+ cells were identified. From the laboratory and histologic findings, he was diagnosed with IgG4-RD overlapped with ANCA-associated vasculitis.
Kim, Joo-Hee,Moon, Jun-Il,Kim, Jeong Eun,Choi, Gil-Soon,Park, Hae-Sim,Ye, Young-Min,Yim, Hyunee The Korean Academy of Asthma, Allergy and Clinical 2010 Allergy, Asthma & Immunology Research Vol.2 No.1
<P>Anti-tuberculosis drugs frequently result in cutaneous adverse reactions, including pruritus, maculopapular exanthems, and urticaria. However, anti-tuberculosis drug-associated cutaneous leukocytoclastic vasculitis (CLV) has been rarely reported. We describe a case of CLV induced by rifampin and pyrazinamide. A 38-year-old male had been diagnosed with pulmonary tuberculosis two months ago and then he started standard anti-tuberculosis therapy with isoniazid, rifampin, ethambutol, and pyrazinamide. Purpuric lesions developed in the extremities after 1.5 months of anti-tuberculosis medication; the lesions progressively spread over the entire body. Histopathology of the purpuric skin lesion was consistent with leukocytoclastic vasculitis. The skin lesion improved after cessation of anti-tuberculosis medications and treatment with oral corticosteroids and antihistamines. Anti-tuberculosis drugs were rechallenged one at a time over 3 days. Purpura recurred on the right forearm and forehead after taking 300 mg of rifampin. The skin lesion disappeared after taking oral prednisolone. Finally, 1,500 mg of pyrazinamide was readministrated, and then purpuric lesions recurred on both forearms. This report describes a case of leukocytoclastic vasculitis secondary to rifampin and pyrazinamide therapy.</P>
( You Jin Ha ),( You Jin Han ),( You Won Choi ),( Ki Bum Myung ),( Hae Young Choi ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.4
A 24-year old woman presented with hemorrhagic vesicles on her legs. She had taken sibutramine (Reductil(R), Abbott Labs., Seoul, South Korea) for 3 months and developed skin lesions the week before. A skin biopsy showed leukocytoclastic vasculitis with conspicuous eosinophilic infiltration of the tissue. These lesions showed improvement after discontinuation of sibutramine. However, 3 months later the skin lesions recurred on other sites on the lower extremities when the patient was rechallenged with the same drug for 2 weeks. Herein, we report the first case of necrotizing vasculitis induced by sibutramine. (Ann Dermatol 23(4) 544 ~547, 2011)
( Sung Soo Ahn ),( Lucy Eunju Lee ),( Jung Yoon Pyo ),( Jason Jungsik Song ),( Yong-beom Park ),( Sang-won Lee ) 대한류마티스학회 2022 대한류마티스학회지 Vol.29 No.1
Objective. This study retrospectively reviewed the process of classifying antineutrophil cytoplasmic antibody (ANCA)-negative granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) in a cohort of patients with ANCA-associated vasculitis (AAV), and investigated the association between recurrent idiopathic cutaneous leukocytoclastic angiitis and ANCA-negative MPA. Methods. The medical records of 242 patients with AAV were retrospectively reviewed. Of 49 patients with ANCA-negative AAV, 24 patients with ANCA-negative eosinophilic GPA (EGPA) were excluded, because ANCA positivity or negativity is not critical in classifying EGPA. Ultimately, 25 patients with ANCA-negative GPA and MPA were analysed in this study. The classification of GPA and MPA were based on the 2007 European Medicines Agency algorithm for AAV. Results. The median age of patients with ANCA-negative GPA and MPA was 54.0 years and 24% were male. Of the 25 patients without ANCA, 8 patients were classified as GPA and 17 as MPA. Eight patients with ANCA-negative GPA were easily confirmed as definitive GPA. Fourteen of the 17 patients ANCA-negative MPA were classified as MPA based on histological features suggestive of AAV without granuloma formation and the absence of surrogate markers for GPA. Meanwhile, three of the patients that were ANCA-negative exhibited only recurrent idiopathic cutaneous leukocytoclastic angiitis without other major organs affected and thus were classified as possible MPA. Within one year, they were classified as definitive MPA based on ANCA positivity and/or renal histology. Conclusion. Recurrent idiopathic cutaneous leukocytoclastic angiitis may be associated with ANCA-negative MPA in patients who exhibit cutaneous necrotising vasculitis. (J Rheum Dis 2022;29:40-45)
Pulmonary Leukocytoclastic Vasculitis as an Initial Presentation of Myelodysplastic Syndrome
( Seung Hyun Lee ),( Jae Hyung Kim ),( Sejin Park ),( Chang Youn Won ),( Joo-hyun Lee ),( Seong Yoon Yi ),( Hye Kyeong Park ),( Sun Hee Chang ),( Hoon Jung ),( Sung-soon Lee ),( Hyeon-kyoung Koo ) 대한결핵 및 호흡기학회 2016 Tuberculosis and Respiratory Diseases Vol.79 No.4
Systemic vasculitis involving the lung is a rare manifestation of myelodysplastic syndrome (MDS), and secondary vasculitis is considered to have poor prognosis. A 44-year-old man presented with fever and dyspnea of 1 month duration. A chest radiograph revealed bilateral multiple wedge shaped consolidations. In addition, the results of a percutaneous needle biopsy for non-resolving pneumonia were compatible with pulmonary vasculitis. Bone marrow biopsy was performed due to the persistence of unexplained anemia and the patient was diagnosed with MDS. We reported a case of secondary vasculitis presenting as non-resolving pneumonia, later diagnosed as paraneoplastic syndrome of undiagnosed MDS. The cytopenia and vasculitis improved after a short course of glucocorticoid treatment, and there was no recurrence despite the progression of underlying MDS.
Pulmonary Leukocytoclastic Vasculitis as an Initial Presentation of Myelodysplastic Syndrome
Lee, Seung Hyun,Kim, Jae Hyung,Park, Sejin,Won, Chang Youn,Lee, Joo-Hyun,Yi, Seong Yoon,Park, Hye Kyeong,Chang, Sun Hee,Jung, Hoon,Lee, Sung-Soon,Koo, Hyeon-Kyoung The Korean Academy of Tuberculosis and Respiratory 2016 Tuberculosis and Respiratory Diseases Vol.79 No.4
Systemic vasculitis involving the lung is a rare manifestation of myelodysplastic syndrome (MDS), and secondary vasculitis is considered to have poor prognosis. A 44-year-old man presented with fever and dyspnea of 1 month duration. A chest radiograph revealed bilateral multiple wedge shaped consolidations. In addition, the results of a percutaneous needle biopsy for non-resolving pneumonia were compatible with pulmonary vasculitis. Bone marrow biopsy was performed due to the persistence of unexplained anemia and the patient was diagnosed with MDS. We reported a case of secondary vasculitis presenting as non-resolving pneumonia, later diagnosed as paraneoplastic syndrome of undiagnosed MDS. The cytopenia and vasculitis improved after a short course of glucocorticoid treatment, and there was no recurrence despite the progression of underlying MDS.
한봉균,정재훈,김유찬,박향준,신용우,배현주 대한피부과학회 2002 大韓皮膚科學會誌 Vol.40 No.7
Rheumatoid vasculitis usually occurs in patients with long standing, seropositive, erosive rheumatoid arthritis. It involves typically small to medium-sized vessels and is associated with peripheral neuropathy, digital gangrene, nail fold infarcts, livedo reticularis, and palpable purpura. Histologic examination of skin biopsy specimens usually shows leukocytoclastic vasculitis. We report a case of rheumatoid vasculitis developed on both extremities in a 63-year-old female with rheumatoid arthritis for 15 years.