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RISS 인기검색어
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- 주제어 : Integrase Interactor-1 (검색결과 2 건)
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홍승기 ( Seung Gi Hong ),조선영 ( Sun Young Jo ),노기웅 ( Ki Woong Ro ),허은필 ( Eun Phil Heo ) 대한피부과학회 2019 大韓皮膚科學會誌 Vol.57 No.5
An atypical teratoid/rhabdoid tumor (AT/RT) is a rare malignancy occurring in the first few years of life. This tumor shows rapid growth, a poor response to treatment, and poor prognosis. Cutaneous metastases presents as hamartomatous lesions mimicking skin tags. Immunohistochemical examination shows varied patterns of expression based on the sites of the body affected. Integrase interactor-1 (INI-1) gene sequencing and loss of expression of INI-1 observed with immunostaining can confirm AT/RT. In our patient, the skin lesion was identified at birth. Histopathological examination of the skin lesion could not establish an accurate diagnosis. Two months later, the patient presented with a brain tumor. Immunohistochemical examination of the brain lesion revealed complete loss of INI-1 expression in tumor cells, and the lesion was diagnosed as AT/RT. After that, we can detect the loss of INI-1 expression in the skin on the back. We report a rare case of AT/RT affecting the brain with cutaneous metastasis diagnosed with immunohistochemical staining. (Korean J Dermatol 2019;57(5):274∼278)
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A case of atypical teratoid/rhabdoid tumor (AT/RT) presenting as unusual cutaneous lesion
( Seung Gi Hong ),( Sun Young Jo ),( Ki Woong Ro ),( Eun Phil Heo ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Atypical teratoid/rhabdoid tumor (AT/RT) is a rare malignant tumor that occurs in children especially in the first few years of life. It is a tumor with high malignancy, rapid growth, poor response to treatment, and very poor prognosis. Skin metastasis has been reported very rarely and appears to be a hamartoma pattern mimicking skin tag. Immunohistochemistry is a complex result that is expressed differently in different parts of the body depending on histologic features. Integrase Interactor-1 (INI-1) immunostaining and tumoral and leukocytes INI-1 gene sequencing assays are used as confirmatory tests in cerebral tumors. In skin biopsies, INI-1 immunostaining is used as a confirmatory test. In immunohistochemical staining, loss of INI-1 is characteristic. In our case, a skin examination revealed a cluster of multiple papules with pale erythema on the right side of the back. At 2 months of age, chondromyxoid fibroma was seen on histologic examination. Two months later, he was admitted to the hospital with seizure. After surgery, AT/RT was diagnosed by INI-1 loss of expression in immunochemical staining. Then, additional immunochemical staining was performed on the skin specimens, and INI-1 loss of expression was detected, In patients with macrocephaly, hydrocephalus, and intracranial tumors, loss of expression through INI-1 immunostaining may be helpful in the diagnosis of unusual skin lesions such as polypoid soft fibroma.
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