http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 주제어 : Hydrophobic heparin (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
소수성 다중복합 헤파린 결합체로 코팅한 항혈전성 혈관용 카테타의 평가
문현태,한준구,전옥철 한국생체재료학회 2004 생체재료학회지 Vol.8 No.3
An antithrombogenic angio-catheter was developed by coating hydrophobic multicomponent heparin conjugates, and named as MCK-Hepafilm (2K). MCK-Hepafilm (2K) using polyacrylic acid and octadecylamine cross linked with heparin conjugates, were prepared by Mediplex Corp. Korea. It has good organic solvent solubility for making an antithrombogenic coat on different medical devices. Coating both inside and outside of a polyurethane angio-catheter with MCK-Hepafilm (2K) showed excellent and stable coating, which was confirmed by SEM and the coloring test with azure-A. Varying the concentration of the coating solution can control the coating thickness: for 1.0, 3.0, and 5.0 wt%, thickness of 0.2, 0.6, and 1.1 mm were obtained, respectively. The coated surface had reduced contact angle and skin friction of rat was reduced to 152.7 g compared to 362.7 g of bare surface. Platelet adhesion was remarkably reduced, and whole blood clots were completely prevented in vitro condition. Safety and toxicity of coated angio-catheter have passed for variety of standard toxicity tests such as ISO and OECD guideline with 7 items, which were evaluated by Korea Test Laboratory (KTL). Dog experiment has been carried out for the MCK-Hepafilm (2K) coated angio-catheter (5F). The amount of thrombus formed on coated catheter was greatly reduced (103.7?9.9 mg) compared to non-coated catheter (374.6?1.6 mg). With these successful results, we propose that the MCK-Hepafilm (2K) coating technology can be applied as a potent platform technology for hemocompatibility of blood-contacting medical devices, including angio-catheter.
-
항응고제 코팅기술을 이용한 PVC와 실리콘 제품의 고기능성 흡입 배액용구의 개발
문현태,한준구,김진화 한국생체재료학회 2004 생체재료학회지 Vol.8 No.3
Advanced anticoagulant suction drainage was prepared by anticoagulant coating with the hydrophobic multicomponent heparin conjugates, and named as MCK-Hepafilm (15K). The coating surface was analyzed by the staining test of azure-A and scanning electron microscope (SEM), which shows excellent coating effect on silicone as well as PVC. The coating condition of silicone tube was optimized to 3.0 wt% concentration of coating solution and the solvent casting temperature to 35 oC. In vitro anticoagulant effect is confirmed by observation of platelet adhesion, blood coagulation and adhesion of bacteria. Platelet adhesion on coating surface of PVC and silicone drainage tube was remarkably reduced, and completely prevented from whole blood clots of rabbit. The adhered number of Escherichia coil (E. coil) bacteria on coated surface of PVC drainage tube was reduced with 7.2?.0 CFU/cm2 as compared to the non-coated surface of 10.1?.2 CFU/cm2. Rabbit experiment has been carried out for the MCK-Hepafilm (15K) coated suction drainage device. The efficacy of the MCK-Hepafilm coat was examined by measuring the debris weight forming clogging in the tube (MCK-Hepafilm coated & uncoated) and analyzing the change in blood flow pressure through it, over a period of time, after insertion in the abdomen of the rabbit. In the coating tube, the internal resistance of PVC was reduced, and also the debris weight of silicone was reduced to 315.5?.4 mg as compared with non-coated 555.7?0.6 mg. The obtained results indicate the effectiveness of this MCK-Hepafilm (15K) coating technology for blood contacting medical devices including suction drainage devices in improving their hemocompatibility.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
