인체모낭 기관배양 시 모낭의 형태와 성장속도에 영향을 미치는 배양인자에 관한 연구

김윤성 ( Yoon Sung Kim ),김경훈 ( Kyung Hoon Kim ),이우재 ( Woo Jae Lee ),정지원 ( Ji Won Jung ),송계용 ( Kyae Yong Song ),서기범 ( Ki Beom Suhr ),이증훈 ( Jeung Hoon Lee ),박장규 ( Jang Kyu Park ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.2

Background: In order to study hair biology, a hair organ culture system is necessary. However satisfactory hair culture systems have not been established. Objective : The purpose of this study was to examine the effectiveness of growth factors and to establish a hair organ culture system for studying hair biology and to evaluate the effectiveness of growth factors. Method: After the healthy human anagen hair follicles were collected without any visible damage, they were cultured in William E medium with several combinations of growth factors including insulin, hydrocortisone, sodium selenite, human transfemn, fetal calf serum and epidermal growth factor at 37C in an atmosphere of 5% CO2/air incubation. The culture medium was changed every 3 days. The results were evaluated by measuring hair growth and hair follicle morphology. Results : The results of this study are summarized as follows; 1) In the medium composed of insulin, hydrocortisone,sodium selenite and human transferrin, the human hair follicles continued to grow at an in vivo rate of 0.3mm in a day over 10 days without change of gross and microscopic morphology. 2) In the medium containing insulin and/or hydrocortisone the growing rate of the human hair follicles was similar to that in vivo, but the follicles revealed premature entry into catagen at 2-6 days in the culture macroscopically and microscopically. 3) Adding fetal calf serum to the above medium made the hair follicles retain the freshly isolated hair follicles morphology for 10 days in culture, even though they grew somewhat slower than the in vivo rate from 6 days in culture. 4) The effectiveness of EGF mimics the in vivo depilation of EGF in sheep. Conclusion : To supplement insulin, hydrocortisone, sodium selenite, transferrin as growth factors, William E medium was necessary for maintenance of an in vivo growth rate and the morphology the anagen hair follicles. This culture system is not enough, but it might be useful for investigation of the physiology, biology of hair follicles as well as pharmacology and toxicology in hair. (Korean J Dermatol 1998;36(2): 210-216)

광학 현미경을 이용한 모발 내부 다공성 평가 및 모발 내부 밀도 증가를 통한 윤기 증가 연구

박현섭,손성길,강내규,이익현 사단법인 대한화장품학회 2023 대한화장품학회지 Vol.49 No.3

본 연구에서는 모발 내부의 다공성 구조를 광학 현미경을 이용하여 모발의 손상 없이 관찰하였으며, 해당 결과를 이용하여 모발 내부 다공성을 정량적으로 표현하고자 하였다. 모발 내부 밀도 저하가 모발의 굽힘및 인장 특성에 미치는 영향에 대한 실험을 진행하였으며, 모발 내부의 밀도 저하를 발생시키는 원인에 대하여알아보고자 내인적 요인과 외인적 요인에 대한 실험을 실시하였다. 내인적 요인으로는 노화의 대표 증상의 하나인 흰머리의 다공성을 평가 정상 모발과 비교하였다. 외인적 요인으로는 일상생활에서 대표적으로 모발의 손상을유발할 수 있는 요인인 계면활성제와 열에 의하여 모발 내부 밀도가 감소 하는 것을 관찰하였다. 또한, 아미노산과모발 지질 소질을 방지할 수 있는 소재를 이용하여 모발 내부 밀도를 증가시키고 윤기를 증가시킬 수 있음을확인하였다. In this study, the porous structure inside the hair were observed using an optical microscope without damaging the hair, and the porosity inside the hair was quantitatively expressed using the results. Experiments were conducted on the effect of the decrease in density inside the hair on the bending and tensile properties of the hair, and experiments on endogenous and extrinsic factors were conducted to find out the causes of the decrease in density inside the hair. As for the endogenous factor, the porosity of gray hair, one of the representative symptoms of aging, was compared with normal hair. As for extrinsic factors, it was observed that the internal density of hair decreased by surfactant and heat, which are factors that can cause hair damage in daily life. In addition, we confirmed whether it is possible to increase the internal density and luster of the hair by using an amino acids and material that can prevent hair lipid predisposition.

염색(染色) 후(後) 경시적(經時的)인 모발(毛髮)의 형태변화(形態變化)와 염색(染色) 영향인식(影響認識)

이진옥 ( Jin Ok Lee ),이주영 ( Ju Young Lee ) 한국미용학회 2008 한국미용학회지 Vol.14 No.2

This study wished to search about shape changing of hair and recognition of hair-coloring effect after hair-coloring treatment. First, in view of a result after measuring changes of hair thickness before and after the hair-coloring of normal hair, average thickness of measured object hair was increased, but there was not any special difference in statistical data in comparing before hair-coloring with after 2 and 4 weeks. Second, in observing cuticles with SEM, each scale layer in the hair cuticle layer before the hair-coloring treatment was adhered closely in regular space. Third, in observing cuticles with TEM, it could be seen border membrane of cuticle layer and cuticle layer became clear border without any damage in the normal hair before the hair-coloring treatment. Forth, analysis showed that five causes were special factors of hair loss people who had experienced the hair-coloring in test as a result of multi logistic recurrence analysis.

일개 대학 신입생의 모발 염색 실태와 관련 증상

이관,임현술,Lee, Kwan,Lim, Hyun-Sul 대한예방의학회 2003 Journal of Preventive Medicine and Public Health Vol.36 No.3

Objectives : This study was carried out tn investigate the prevalence and symptoms related to hair dyeing among university freshmen. Methods : The authors conducted a questionnaire survey among 1,499 university freshmen from Mar 11 to 15, 2002. Results : The study group contained 710 tenses and 789 males. Up until 2002, 62.7% of the subjects had experienced hair dyeing, and this was significantly higher in females (66.2%, p<0.05), The period of first experience of hair dyeing was in high school for 361 cases (38.4%), after high school for 345 cases (36.7%t and before high school for 234 cases (24.9%), The major reasons of hair dyeing were 'to improve their appearance' in 465 cases (49.6%), and 'to follow the hair dyeing fashion' in 169 cases (18.0%). The prevalence of hair dyeing in 2002 was 47.8%, and again was significantly higher in females (53.7%, p<0.05). The major symptoms related to hair dyeing were 'cleaved and nonelastic hair' in 495 cases (69.0%), and 'thin and easily breakable hair' in 359 cases (49.3%). Of those, 361 eases (50.4%) appealed to three or more symptoms related to hair dyeing, Through multiple logistic regression, factors significantly associated with symptoms related to hair dyeing were found to be female (OR=2.14, 95% CI; 1.61-2.83), use of hair dryer (OR=1.36, 95% CI; 1.004-1.054), a frequency of hair dyeing of three or more (OR=1,40, 95% CI; 1.04-2.09), and a duration of processing hair dyeing of over 60 minutes (OR=2.18, 95% CI; 1.50-3.18). Conclusions : The prevalence and experience of hair dyeing were generally high among university freshmen. Therefore, more extensive epidemiological studies on the symptoms related to hair dyeing should be conducted.

보조호르몬요법을 받는 여성 유방암 환자의 모발 변화와 치료 실태에 대한 기초 연구

이재경 ( Jae Kyung Lee ),김창현 ( Chang-hyun Kim ),홍동균 ( Dongkyun Hong ),정경은 ( Kyung Eun Jung ),서영준 ( Young-joon Seo ),김창덕 ( Chang-deok Kim ),이진선 ( Jin Sun Lee ),권인선 ( In Sun Kwon ),박상현 ( Sanghyun Park ),이영 대한피부과학회 2021 대한피부과학회지 Vol.59 No.7

Background: Hormone therapy, which includes tamoxifen and aromatase inhibitors, is the most common adjuvant therapy used for breast cancer. However, only a few studies have reported endocrine therapy induced alopecia. Objective: We investigated the effects of long-term adjuvant hormone therapy on hair in patients with breast cancer, in addition to patients’ concerns and current treatment for hair loss. Methods: Patients completed a questionnaire that included information on self-perceived hair changes after each adjuvant therapy session, distress, and current treatment for hair loss. Using a folliscope, we measured hair density and thickness in each patient and in healthy controls. Results: The study included 93 patients with breast cancer (mean age 51.9±9.8 years). The density and hair thickness were 106.36±21.85 hairs/cm2 and 0.07±0.01 mm in the patient group and 147.86±30.67 hairs/cm2 and 0.07±0.01 mm in the control group (n=98, mean age 52.10±8.40 years), respectively. The mean hair density was significantly lower in the patient group than in the control group; however, no statistically significant intergroup difference was observed in hair thickness. Among 76 patients who perceived hair changes after adjuvant therapy, 71.1% (n=54) were distressed with regard to hair changes. However, only 7.8% of the patients, including two who were treated by dermatologists, currently received treatment for hair changes. Conclusion: Dermatologists should be familiar with hair changes in patients with breast cancer and provide appropriate education to encourage patients to consult dermatologists for hair loss and thinning after breast cancer treatment. (Korean J Dermatol 2021;59(7):521∼526)

신체적 헤어스타일 결정요인과 유행하는 헤어스타일 모방수준의 관련성 연구

홍성희,당수민 한국피부과학연구원 2013 대한피부미용학회지 Vol.11 No.6

This article aims at introducing the need to the most impressive hair-style and offering research dataof preparing the basis of customer satisfaction and a business strategy, as finding the way to decideher hair-style depending on her body type and the effect on it for adult female. The subject of studywere 400 adult-females who are in Daegu-gyeongbuk, it was examined from the 1st of May to 30thof June, 2010 through the self-administered questionnaire. The results of study are as follows: Therewere the effect of the hair form on the decision of hair-style in the 5factors such as how much sheconcern herself about a trendy hair-style, how much frequency she follows a trendy hair-style generally,how much effect of a trendy hair-style there are in the decision of her own hair-style, how much shetalks to others about a trendy hair-style and how much she will imitate a trendy hair-style in the future. When put together the results above, this article found that women select their own hair-style depending ontheir hair form, and there were a wide range in the decision level of a hair-style, considering their various hairform and they were into it as well. So it needs to offer the information for deciding a hair-style to learn a basicknowledge that needs to decide the most idealistic hair-style, and to offer a service including the cheap pricesand the systematic hair management system considering women’s attributes.

반복 염색 시 케라틴 콜라겐 전처리와 헤어클리닉 후처리의 모발 성상 변화에 대한 연구

김종선 ( Jong-sun Kim ),박은준 ( Eun-jun Pack ) 한국미용학회 2019 한국미용학회지 Vol.25 No.3

The hair color maximizes the image of an individual by emphasizing the characteristics and personality of the individual. But the chemical treatment such as perm and dyeing damages the hair. In this study, keratin and collagen were pretreated before dyeing hair to reduce the hair damage when applying the chemical treatment applying the hair clinic as a post-treatment after dyeing, the hair was dyed from once to three times; and in order to check out the residual amount for the pre- and post-treatments, after conducing 30 Shampoos, the hair thickness, amino acid, and cuticles in the groups of pre- and post-treatments were histologically analyzed. In case of the pretreatment group, due to the addition of protein, the hair thickness became thicker and the total amount of amino acids increased. However, as the damage progressed through the repetitive dyeing, the difference became larger and the elution quality of the total amount of amino acid became eluted about 10 times more; and the difference in the number of the cuticle layer from the post-treatment group was identified. In the post-treatment group, the hair thickness and total amount of amino acids did not increase. However, as the damage progressed repeatedly, the total amount of amino acids in the pre-treatment group were eluted about 10 times less than that in the post-treatment. Therefore, pre- treatment helps to recover the inside of the hair, and post - treatment helps to prevent internal damage.

Hair Art 정의와 분류에 관한 연구

안현경 ( Hyeon Kyeong An ) 한국미용학회 2010 한국미용학회지 Vol.16 No.2

This thesis aimed to give a definition and classification of hair art based on general art and fashion art`s theories. This will solve the problems of confusing definition and classification of hair art made by few basis. The results of this thesis are as belows. 1. The category of hair art enlarged from applied art to fine art. 2. The definition and classification of hair art are as belows. 1) unwearable hair art : It`s a field of fine art. It`s unwearable on human head and hair but related only motif and inspiration with head and hair. 2) wearable hair art : It`s a field of applied art. It`s wearable on human head and hair. It is divided two categories according to practicality of daily uses. (1) aesthetic wearable hair art : It`s a field of applied art near to fine art. It can be wearable but not pragmatic for daily use. It only stress on hair designer`s aesthetic sensibility. It can directly lead creating a new hair styles. (2) pragmatic wearable hair art : It`s a field of applied art. It can be wearable and pragmatic for daily use. It has relations with hair industry, hair fashion trend, hair design, and cooperative system with hair designers and customers. 3. Hair art definition concludes fine arctic & applied arctic ones. So traditional definition of hair art must be revised. 4 The previous researches of hair art definition, which are designate only fine artic hair art to hair art, are must be revised.

발모제가 발모효과에 미치는 영향에 관한 연구

최경임,이진태,안봉전,최은영,박찬익 경산대학교 생명자원개발연구소 2002 생명자원과 산업 Vol.6 No.-

지금까지의 발모관리는 의학적인 차원에서 원형탈모, 남성형 탈모증 및 약제에 의한 병리학적인 연구가 있었으나 미용적인 관리에 대한 연구가 거의 없었다. 따라서 본 논문에서는 약품을 사용하지 않고 순수한 발모촉진 화장품과 두피관리 프로그램을 중심으로 발모관리를 통해 탈모개선 효과를 비교검토하였다. 탈모자를 여러 그룹으로 선발하고 발모제를 달리 처방하여 모발의 굵기, SEM 촬영, 수분측정, 정상인의 모발상태와 탈모자의 모발상태를 TEM 촬영하여 비교 분석하였다. 먼저 두피관리 전과 후의 수분함량의 차이는 평균 16% 상승하였다. 발두께 비교실험에서는 정상모에 비해 탈모자의 모발이 최대 38.6%가 작은 것으로 나타났으며, 모유두와 모간의 촬영사진에서는 탈모자의 모유두는 덜 발달되어 있었고, 변형된 모유두 형태가 많았다. 전자현미경을 통한 모표피의 SEM촬영에서는 탈모자나 정상모나 표면적으로 큰 차이는 없었다. 오히려 탈모자의 경우에는 모발이 약하고 건강하지 못하기 때문에 화학적인 처방을 하는 염색이나 펌 등을 하지 않아서 모발의 큐티클 층은 정상인의 모발보다 건강한 상태로 보였다. 두피측정에서는 관리 후 A, B, C 군의 비교에서 세 그룹 모두 두피의 현저한 개선효과를 보였다. 육모제를 사용한 A, B, Group과 영양제를 사용하지 않고 스캘링과 관리를 한 C군 모두 발모효과가 있었으며, 두피관리를 전혀 하지 않는 D군은 발모효과나 두피의 개선효과는 전혀 없었다. 전자 현미경을 통한 모발의 단면 촬영에서는 정상모발이 탈모자의 모발보다 피질이 부드럽고 풍성하게 잘 형성되어 있었다. 탈모자의 경우는 매우 심각한 고민거리인데 본 실험의 결과 가장 효과적인 발모 관리는 육모제로 두피의 혈액순환을 도와주고 평소생활에서 Brushing으로 모공이 막히지 않도록 꾸준한 손질을 함으로써 발모 및 두피개선이 될 수 있다는 것을 확인할 수 있었다. Twenty working people from 30s to 50s whose hairs were in the process of losing were selected for this study. They were divided into four groups as A, B, C and D. Their hairs were sampled to compare the thickness of the hairs through a optical microscope. Using hair care products from two marketing companies, once a week, Group A and B were treated scalp scaling and steam treatment during ten minutes. After applying vitamin cream the scalp was examined using a bio-beam every 5 minutes. Group C did not receive any vitamin cream but had the same treatment as A and B. Group D used no vitamin cream and receives no treatment. The results were as follows: In Comparison losing hair surface with healthy hair surface by electronic microscope, losing hair took place when the scalp has keratin or too much fat. After comparing the amount of moisture before and after care by a moisture measurement instrument, the amount of moisture has been outstandingly increased. As a result of observing hair root and hair shaft, hair root appeared to be less developed than healthy hair. These results showed that hair care is need to be constantly research and illuminate with regard to the proper care.

Research Progress in Composition, Classification and Influencing Factors of Hair

소천천,주성,하총분,초천,왕자적,가염 한국피부과학연구원 2023 아시안뷰티화장품학술지 Vol.21 No.3

Human hair is a natural fiber with keratin and keratin-related proteins as a main component. Externally, hair is a thin, pliable tube of dead, fully keratinized epithelial cells, while inside the skin, it is part of a single living hair follicle. In addition to a large amount of protein, hair also contains low levels of lipids and pigments. The hair also has its own ecological balance system. Although the lipid content in hair is much lower than the protein content, it plays an important role in hair and influences hair texture to some extent. For example, prevent hair breakage and thinning; To act as a barrier to moisture loss; and improve the gloss, elasticity and tensile strength of the hair stem. Environment, hair dressing and daily care can all cause hair damage to varying degrees. Factors such as ultraviolet light and chemicals can make hair dry, rough, dull, stiff and brittle by destroying the proteins, pigment sand lipid sin the hair. In this paper, the composition, classification and influencing factors of hair were reviewed. The composition and function of lipids in hair were investigated emphatically. It aims to improve people's understanding of the physical and chemical properties and structure of hair. It provides reference value for the research and development of hair cosmetics for different hair states and washing purposes. The function of hair lipids on hair is not accurate. In addition, there is still some controversy on the existing role of hair lipids, which needs further research.