전립선암을 유발시킨 누드 마우스에서 고단백식 및 성장호르몬이 종양의 성장과 체중의 변화에 미치는 영향

장석흔,우영남,권성원 大韓泌尿器科學會 1999 Korean Journal of Urology Vol.40 No.11

Impaired Cortisol and Growth Hormone Counterregulatory Responses among Severe Hypoglycemic Patients with Type 2 Diabetes Mellitus

유영아,장주영,박수연,안지현,김동림,김숙경,송기호 대한내분비학회 2019 Endocrinology and metabolism Vol.34 No.2

Background: Elevated levels of cortisol and growth hormone are critical counterregulatory responses to severe hypoglycemia. However, the proportion and clinical characteristics of patients with type 2 diabetes mellitus (DM) who fail to show appropriate cortisol and/or growth hormone secretion in response to severe hypoglycemia have not been investigated. Methods: We measured plasma cortisol and growth hormone levels in type 2 DM patients with severe hypoglycemia who visitedthe emergency department between 2006 and 2015. Results: Of 112 hypoglycemic patients, 23 (20.5%) had an impaired cortisol response (<18 μg/dL) and 82 patients (73.2%) had animpaired growth hormone response (<5 ng/mL). Nineteen patients (17.0%) had impaired responses to both cortisol and growth hormone. The patients with impaired responses of cortisol, growth hormone, and both hormones were significantly older and more likely to be female, and had higher admission rates, lower growth hormone levels, and lower adrenocorticotropic hormone levels thanthe patients with a normal hormonal response. Multivariate logistic regression analysis indicated that an impaired growth hormoneresponse was significantly associated with advanced age, shorter DM duration, a higher admission rate, and a higher body mass index (BMI). An impaired cortisol response was significantly associated with growth hormone levels. Patients with an impairedgrowth hormone response had higher admission rates than patients with a normal response. Conclusion: A considerable number of type 2 DM patients had impaired cortisol and/or growth hormone responses to severe hypoglycemia. Advanced age, shorter DM duration, and higher BMI were independently associated with an abnormal growth hormoneresponse.

Mechanism of Growth Hormone Action : Recent Developments - A Review

Sodhi, R.,Rajput, Y.S. Asian Australasian Association of Animal Productio 2001 Animal Bioscience Vol.14 No.12

The interaction of growth hormone with it's receptor results in dimerization of receptor, a feature known in action of certain cytokines. The interaction results in generation of number of signalling molecules. The involvement of Janus kinases, mitogen activated kinases, signal transduction and activator of transcription proteins, insulin like substrate, phosphatidylinositol 3-kinase, phospholipase C, protein kinase C is almost established in growth hormone action. There are still many missing links in explaining diversified activities of growth hormone. Amino acid sequence data for growth hormones and growth hormone receptors from a number of species have proved useful in understanding species specific effects of growth hormone. Complete understanding of growth hormone action can have implications in designing drugs for obtaining desired effects of growth hormone.

Efficacy and Safety of Sustained-Release Recombinant Human Growth Hormone in Korean Adults with Growth Hormone Deficiency

김영숙,이은직,홍재원,정윤석,김성운,조용욱,김진화,김병준 연세대학교의과대학 2014 Yonsei medical journal Vol.55 No.4

Purpose: The administration of recombinant human growth hormone in adults with growth hormone deficiency has been known to improve metabolic impairment and quality of life. Patients, however, have to tolerate daily injections of growth hormone. The efficacy, safety, and compliance of weekly administered sustained-release recombinant human growth hormone (SR-rhGH, DeclageTM) supplement in patients with growth hormone deficiency were evaluated. Materials and Methods: This trialis 12-week prospective, single-arm, open-label trial. Men and women aged ≥20 years with diagnosed growth hormone deficiency (caused by pituitary tumor, trauma and other pituitary diseases) were eligible for this study. Each subject was given 2 mg (6 IU) of SR-rhGH once a week, subcutaneously for 12 weeks. Efficacy and safety at baseline and within 30 days after the 12th injection were assessed and compared. Score of Assessment of Growth Hormone Deficiency in Adults (AGHDA score) for quality of life and serum IGF-1 level. Results: The IGF-1 level of 108.67±74.03 ng/mL was increased to 129.01±68.37 ng/mL (p=0.0111) and the AGHDA QoL score was decreased from 9.80±6.51 to 7.55±5.76 (p<0.0001) at week 12 compared with those at baseline. Adverse events included pain, swelling, erythema, and warmth sensation at the administration site, but many adverse events gradually disappeared during the investigation. Conclusion: Weekly administered SR-rhGH for 12 weeks effectively increased IGF-1 level and improved the quality of life in patients with GH deficiency without serious adverse events.

성장호르몬 결핍증에 의한 발기부전

최만수,남현종,강양호,하홍구,방성익,박남철,김영진,박현준 대한남성과학회 2008 The World Journal of Men's Health Vol.26 No.4

Growth hormone deficiency is the medical condition of inadequate production of growth hormone. Growth hormone deficiency in adults is not common, but it may feature a diminished, lean body mass, poor bone density and a number of physical and psychological symptoms, including poor memory, social withdrawal and even depression. Abnormally low growth hormone levels in adults typically result in a diminished quality of life and it can even be disabling. The physical symptoms include loss of strength, stamina, and musculature. Growth hormone deficiency can also impair the biological and physiological/functional substrate of penile erection, which can be, at least in part, restored by the normalization of the plasma levels of growth hormone. This is a report on a 63-year-old man who suffered with severe erectile dysfunction and loss of libido due to growth hormone deficiency. Upon growth hormone administration, his erectile function improved dramatically.

성장호르몬 결핍증과 특발성 저신장증 환아에서 성장호르몬의 치료 효과

강정철,최윤석,최인경,김호성,김덕희 대한소아과학회 2004 小兒科 Vol.47 No.3

The Effect of Human Growth Hormone on Thyroid Function in Normal Children

Kim, So Young,Lee, Byung Churl CATHOLIC MEDICAL CENTER 1993 Bulletin of the Clinical Research Institute Vol.21 No.1

Administration of human growth hormone to normal man and growth hormone deficient patients yield conflicting results concerning its impact on thyroid function. Most studies have casuistic or uncontrolled and have used pituitary derived growth hormone of varying purity, of ten contaminated with thyroid stimulating hormone. The aim of the present study was to evaluate the effects of recombinant human growth hormone on thyroid function in normal children. All 15 normal variant short stature children with aged 4.5-10.3 year had normal serum level of growth hormone and were taking no medications at the time of study. All children received recombinant human growth hormone in a dose of 0.25 IU/kg/day, subcutaneously for 5 days. Blood samples were obtained before the first injection and 24 hours after last injection of growth hormone, and serum was frozen at -20℃ for later analysis. Serum T_4, free T_4, T_3, reverse T_3, TSH and IGF-I concentration were measured by a radioimmunoassay. 1. The mean serum T_4 concentration decreased significantly from 9.28±0.55 ㎍/dl to 7.66±0.38 ㎍/dl. 2. The mean serum free T_4 concentration decreased significantly from 1.46±0.08 ng/dl to 1.21±0.07 ng/dl. 3. The mean serum T_3 concentration increased significantly from 1.46±0.06 ng/ml to 1.88±0.10 ng/ml. 4. The T_3 to T_4 ratio increased significantly from 16.3±0.9 to 25.3±1.8. 5. The mean serum reverse T_3 concentration was not changed siginificantly. 6. The mean serum TSH concentration decreased siginificantly from 2.13±0.21 μIU/ml to 1.50±0.14 μIU/ml. 7. The mean serum IGE-I concentration increased significantly from 165±30 ng/ml to 349±47 ng/ml. In conclusion, our data suggest growth hormone enhance the peripheral conversion of T_4 to T_3 and compensatory decrease in TSH secretion.

소의 theileriosis가 성장 hormone과 insulin-like growth factor-I에 미치는 영향

백병걸,변선윤,이존화,이호일,Baek, Byeong-kirl,Byoun, Sun-youn,Lee, John-wha,Lee, Ho-ill 대한수의학회 1997 大韓獸醫學會誌 Vol.37 No.2

Bovine theileriosis caused by Theileria sergenti is the tick-borne intraery- throcytic piroplasmosis, that occurs in most regions of Korea. It results in severe economic losses on a farm caused by anemia, milk production loss, abortion and death. This study was undertaken to confirm the effects of the growth hormone and the insulin-like growth factor-I which are associated in the growth of cattle infected by T sergenti. The blood of one hundred and twenty ten-month Holstein was collected and the prepared blood smear was stained with acridine orange to investigate their parasitemia. And the hematological profiles were observed. According to the value of the hematocrit, they were categorized into four groups : Group 1 was under 20 percent, groups 2 and 3 were from over 21 to under 30 percent and from over 31 to under 35 percent and group 4 was over 36 percent. As the value of the hematocrit decreased, parasitemia(%) in erythrocytes was observed to increase(Y=-1.064X + 30.537, r=0.660). The amounts of the growth hormone and the insulin-like growth factor-I in the serum were measured by the radioimmunoassay. The growth hormone in serum of the group 1, group 2, group 3 and group 4 were observed as $0.238{\pm}0.043nmol/l$, $0.21{\pm}0.024nmol/l$, $0.366{\pm}0.035nmol/l$ and $0.646{\pm}0.223nmol/l$, respectively. The quantitative of the insulin-like growth factor-I in the same groups were observed also as $209.686{\pm}18.94ng/ml$, $250.9{\pm}12.609ng/ml$, $279.3{\pm}8.883ng/ml$ and $365.9{\pm}22.45ng/ml$, respectively. It can be concluded that the growth hormone and the insulin-like growth factor-I were observed to decrease in severe anemia due to theileriosis.

원저 : 성장장애 흰쥐에서 경옥고(瓊玉膏)와 경옥고가녹용(瓊玉膏加鹿茸)의 성장효과 비교 연구

차윤엽 ( Yun Yeop Cha ) 한방비만학회 2009 한방비만학회지 Vol.9 No.1

Objectives This study was designed to evaluate the difference of between Kyungohkgo and Kyungohkgo Ga Nokyong effects on growth. Methods We divided male Sprague-Dawley rats into 6 groups. They were Normal group, Growth deficiency rat with insufficient nutrition diet group, Growth deficiency rat with 0.1% Kyungohkgo group, Growth deficiency rat with 0.2% Kyungohkgo group, Growth deficiency rat with 0.1% Kyungohkgo Ga Nokyong group and Growth deficiency rat with 0.2% Kyungohkgo Ga Nokyong group. They were administered for 5 weeks. We measured body weight, serum growth hormone, insulin-like growth factor and thyroid stimulating hormone, RBC, concentration of Hb and PCV ratio, total WBC and its composition, the values of plasma glutamic oxaloacetic transaminase(GOT) and glutamic pyruvic transaminase(GPT) activities. Results 1. In body weight, Kyungohkgo 0.1%, Kyungohkgo Ga Nokyong 0.1%, 0.2% groups were showed significantly different than control group. But That groups were not showed significantly different than each others. 2. In serum growth hormone, insulin- like growth factor and thyroid stimulating hormone, we obtained the results of tendency to increase in Kyungohkgo Ga Nokyong group, however these values showed no significantly different. 3. In the counts of RBC, Kyungohkgo group and Kyungohkgo Ga Nokyong group were showed significantly different than control group. But these values showed no significantly different. In the concentration of Hb, Kyungohkgo Ga Nokyong 0.2% group was showed significantly different than control group. Kyungohkgo Ga Nokyong 0.2% group and Kyungohkgo 0.2% group were showed significantly different than control group. 4. The counts of total WBC and its composition showed no significantly different in all treatment groups. 5. The values of plasma glutamic oxaloacetic transaminase(GOT) and glutamic pyruvic transaminase(GPT) activities showed no significantly different in all treatment groups. Conclusions So Kyungohkgo Ga Nokyong and Kyungohkgo have an effect of promoting growth of rats. And We know that the effect of Kyungohkgo Ga Nokyong is better than Kyungohkgo.

가토 모델에서 성장호르몬이 퇴행성 요추 추간판의 변화에 미치는 영향

박영진,한성호,황인경 고신대학교 의과대학 2011 고신대학교 의과대학 학술지 Vol.26 No.2

OBJECTIVES: Growth hormone is expected to delay the degenerative changes of the intervertebral disc and affect the initial recovery process of cartilage injury, but these effects are still open to disputes. METHODS: This researcher injected growth hormone to the intervertebral disc and subcutaneous tissue of rabbits whose degenerative change were induced artificially, and evaluated the treatment effects of growth hormone through a comparison between the injected and control groups of rabbits. The intervertebral discs between the 3th and 4th vertebrae were extracted 4 weeks after the administration of growth hormone and then histologically graded in a quantitative method. Changes in the height of the intervertebral discs were measured after the induction of degenerative changes. After four weeks of the treatment, then, the height changes were measured. RESULTS: In the subcutaneous-growth hormone injected group, any consistent, sequential, and progressive degeneration of the annular fibrosus was not observed through histopathological studies. The disc height also sequentially did not decrease from that at the time of the injury set in this study. CONCLUSIONS: Considering the histopathological findings of the study, the researcher suggests that subcutaneous injection of growth hormone will be a therapeutic model of disc degeneration. But further biochemical or electromicroscopic studies are necessary to clarify the mechanism of delay degenerative disc changes by growth hormone.