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현초에서 분리된 페놀성 화합물들의 흰쥐 수정체 유래 알도즈 환원효소 및 갈락티톨 생성 억제 효과
최세진,김진규,장재만,임순성 한국약용작물학회 2012 한국약용작물학회지 Vol.20 No.4
We evaluated the inhibitory effects of extracts and components of Geranium thunbergii on aldose reductase (AR) and galactitol formation in rat lenses with high levels of galactose as a part of our ongoing search of natural sources for therapeutic and preventive agents for diabetic complications. The inhibitory effects of water, methanol and ethanol extracts of G. thunbergii on rat lens AR (RLAR) were determined. Comparing inhibitory effects of various solvent extracts, ethanol extract showed RLAR inhibitory activity (IC50 values, 5.24 and 6.39μg/ml, respectively). The ethanol extract was fractionated to chloroform, ethyl acetate and water. Of these, the ethyl acetate fraction from ethanol extract of G. thunbergii exhibited RLAR inhibitory activity (IC50 value, 2.64μg/ml). In order to identify the bioactive components of ethyl acetate soluble fraction of ethanol extract from G. thunbergii, eight compounds, namely gallic acid (1), protocatechuic acid (2), p-hydroxybenzoic acid (3), brevifolin carboxylic acid (4), geraniin (5), ellagic acid (6), kaempferol-3-O-arabinofuranosyl-7-O-rhamnopyranoside (7), kaempferitrin (8) were isolated. The isolates were subjected to in vitro bioassays to evaluate their inhibitory activity on RLAR and galactitol formation in rat lenses. The ellagic tannins (5, 6) and flavonoid (7) exhibited strong inhibitory effects on RLAR. Also, these three compounds (5, 6 and 7) suppressed galactitol accumulation in rat lens under high galactose conditions, demonstrating the potential to prevent galactitol accumulation exo vivo. These results suggest that the extracts and components of G. thunbergii are a promising agent in the prevention or treatment of diabetic complications.
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Aldose Reductase Inhibitory Compounds from Xanthium strumarium
Ha Na Yoon,Min Young Lee,김진규,서홍원,임순성 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.9
As part of our ongoing search for natural sourcesof therapeutic and preventive agents for diabetic complications,we evaluated the inhibitory effects of components ofthe fruit of Xanthium strumarium (X. strumarium) on aldosereductase (AR) and galactitol formation in rat lenses withhigh levels of glucose. To identify the bioactive componentsof X. strumarium, 7 caffeoylquinic acids and 3 phenoliccompounds were isolated and their chemical structures wereelucidated on the basis of spectroscopic evidence and comparisonwith published data. The abilities of 10 X. strumarium-derived components to counteract diabeticcomplications were investigated by means of inhibitoryassays with rat lens AR (rAR) and recombinant human AR(rhAR). From the 10 isolated compounds, methyl-3,5-di-O-caffeoylquinate showed the most potent inhibition, withIC50 values of 0.30 and 0.67 lM for rAR and rhAR, respectively. In the kinetic analyses using Lineweaver–Burk plots of1/velocity and 1/substrate, methyl-3,5-di-O-caffeoylquinateshowed competitive inhibition of rhAR. Furthermore, methyl-3,5-di-O-caffeoylquinate inhibited galactitol formation in therat lens and in erythrocytes incubated with a high concentrationof glucose, indicating that this compound may be effectivein preventing diabetic complications.
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Shin, Kuk-Hyun,Chung, Myung-Sook,Cho, Tae-Soon The Pharmaceutical Society of Korea 1994 Archives of Pharmacal Research Vol.17 No.5
The ether extract from the roots of angelica clahurica was found to inhibit bovine lens aldose reductase (BLAR0 activity in vitro by 100% at 100.mu.g/ml. Systematic fractionation of the ether soluble fraction and subsequent active frctions monitorede by bioassy led to isolation of four furanocoumarins, isoimperatorin (I0, imperatorin (II), ter-O-methyl byakangelicin (III) and byakangelicin (IV), among which compound III and IV were identified as potential AR inhibitors, their $IC_{50}$ values being $2.8{\mu}M{\;}and{\;}6.2{\mu}M$, respectively. Galactosemic cataract formation tors, in rats treated with 40 g/kg/day of galactose was blocked almost completely throughout the exeprimental periods up to 44 days by i.p. administrations of byakangelicin (IV) at 50 mg/kg/day. In coincidence with the inhibitory action on cataract formation, the galactitol accumulation in rats treated with byakangelicin (IV) was found to be markedly prevented by approximately 80.5% compared to those of the contro. These results indicate that byakangelicin (IV), as a main principle of this plant, possesses high potential for a clinically useful drug of the future which prevents and/or improves sugar cataract as well as diabetic complications.
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Galactosemia: A Korean Patient and Literature Review
유승우,강미현,이용욱,장미영,김숙자,Yu, Seung Woo,Gang, Mi Hyeon,Lee, Yong Wook,Chang, Mea Young,Levy, Harvey L.,Kim, Sook Za The Korea Society of Inherited Metabolic Disease 2020 대한유전성대사질환학회지 Vol.20 No.1
고전적 갈락토스 혈증은 한국에서 드물게 발생하는 유전 대사 질환이다. 또한 한국인의 돌연변이 스펙트럼은 코카시안과 비코카시안의 돌연변이 스펙트럼이 다르다. 한국에서 고전적 갈락토스 혈증은 임상적으로 서방국가와 유사하지만 분자적 연구에 따르면 백인, 아프리카인, 미국인, 일본인 및 한국인에게 고유한 돌연변이가 나타났다. 고전적인 갈락토스 혈증은 신생아 스크리닝 검사로 조기 발견하여 식이요법을 할 경우 대사질환으로 인한 합병증이 예방될 수 있다고 생각되어 왔다. 한국의 고전적 갈락토스 혈증의 가장 최근의 사례에서 신생아 시기에 임상 증상이 시작되었다. 식이 치료를 통하여 합병증이 교정되어 정상화 되었다. 추가로 저자들은 25명의 고전적 갈락토스 혈증을 가진 돌연변이의 특징을 리뷰했다. Classic galactosemia is a rare genetic disorder in Korea and the mutation spectrum in Koreans differs from that of Caucasians and non-Caucasian Americans. Classic galactosemia is considered a metabolic complication that is preventable by early detection via newborn screening and dietary treatment. In this most recent case of Korean galactosemia, the patient showed early initiation of clinical symptoms, which manifested during the neonatal period. The patient achieved normalization via diet management to correct metabolic complications. In addition, we assessed the characteristics of mutations in 25 Korean galactosemia cases via a literature review of studies associated with classic galactosemia.
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