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- 주제어 : Ferric-nitrilotriacetate (검색결과 3 건)
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Ferric Nitrilotriacetate로 유도된 신장손상에 대한 품종별 콩의 방어활성
임지선,서지연,황영현,김정상,박지아 대한암예방학회 2009 Journal of cancer prevention Vol.14 No.4
Soybean is a rich source of phytochemicals as well as protein and lipid. Isoflavones have been reported to possess various health benefits including anti-carcinogenesis, anti-aging, and anti-oxidative activities while anthocyanins revealed a good antioxidant activity. Two varieties of soybean Aga No 3 and No 4, newly bred in Kyungpook National University, contain excessively high level of isoflavones, compared to regular varieties such as Daemang No 2 and Black Ilpoom No 1. Four varieties of soybean used in the present study revealed strong antioxidant activity as assessed by DPPH and DCFDA assay. In vivo experiment in which mice were treated with ferric nitrilotriacetate (Fe-NTA) known to induce kidney damage by oxidative stress demonstrated that diets containing anthocyanin-rich varieties such as Black Ilpoom No 1 and Aga No 4 were most protective from kidney damage induced by Fe-NTA.
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랫드에서의 Fe-NTA 유발 산화스트레스에 대한 차전초 에탄올 추출물의 전립선보호 효과
홍승택,이광원,홍충의,남미현,마원원,홍윤진,손다희,전수현 한국식품위생안전성학회 2011 한국식품위생안전성학회지 Vol.26 No.3
Plantago asiatica L. (P. asiatica) has been used as one of the popular folk medicines in Asia for human health care practices. Various activities of P. asiatica have been reported, such as anti-oxidant, anti-glycation,anti-inflammatory and hepatoprotective activity. Therefore, the potential of P. asiatica to reduce oxidative stress has been studied in several ways for over 20 years, especially at liver and kidney. However no investigation has been reported revealing its protective effect on prostate. Method : Treatment of P. asiatica leaf ethanolic extract (PLE) (1 g/kg body weight (b.w.), 2 g/kg b.w., or 4 g/kg b.w.) were given separately to animals for pretreatment once per day for 7days, and on the seventh day ferric nitrilotriacetate (Fe-NTA; 0.24 mmol Fe/kg b.w.), which is known as an oxidative stress-inducer at prostate, was administrated by i.p to negative control group. At the end of the study period, dissection was carried out for detecting the prostate protective effect of PLE. Result : Fe-NTA-treated animals produced reactive oxygen species (ROS) resulting in depletion of antioxidant biomaker, such as glutathione (GSH), glutathione reductase (GR), and glutathione s-transferase (GST) and increase of lipid peroxidation in prostate. However, PLE pretreatment resulted in an increase in the GSH, GST and GR levels concentration dependent manner and in an significant decrease in the levels of lipid peroxidation. Conclusion : Our data suggest that PLE may be effective in protecting oxidative stress-induced damage of prostate, and PLE may be an chemopreventive agent against Fe-NTA-mediated prostate oxidative damage.
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차전초 추출물을 투여한 랫드에서의 Fe-NTA 유발 산화스트레스에 대한 신장보호 효과
홍충의,이광원,홍승택,구윤창,양성용,이지영,이얀회이,하영민 한국식품위생안전성학회 2011 한국식품위생안전성학회지 Vol.26 No.2
Plantago asiatica L. (PA), which is widely distributed in Korea, Japan and China, has traditionally been used as a popular folk medicine for the treatment of liver diseases. A variety of activities of PA was reported, that is hepatoprotective, anti-inflammatory, anti-glycation and anti-oxidant effect. Ferric nitrilotriacetate (Fe-NTA) is a potent nephrotoxic agent and has been reported to induce renal proximal tubular necrosis. In the present study, pretreatment with PA extract (PAE) in Wistar rat followed by Fe-NTA i.p. treatment (13.5 mg Fe/kg body weight) was performed to detect the renal protective effect of PAE. Only Fe-NTA treated group showed increases in the level of serum blood urea nitrogen (BUN) and serum creatinine (Cr), and renal tissue malondialdehyde (MDA), product of lipid peroxidation. Moreover, the level of biomarkers indicate the antioxidants status, reduced glutathione (GSH), glutathione-S-transferase (GST) and glutathione reductase (GR) were decreased. However, PAE pre-treated group showed decreases in the levels of serum BUN, serum Cr and renal tissue MDA in concentration dependent manner and increases in the level of GSH, GST and GR. These results are significantly different (p < 0.05) to the other groups. Our data suggest that PAE may be used as an chemopreventive material against Fe-NTA-mediated renal oxidative stress.
ScienceON
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