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RISS 인기검색어
- 검색키워드
- 주제어 : Eugenia jambolana (검색결과 4 건)
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Cytotoxic, Trypanocidal, and Antifungal Activities of Eugenia jambolana L.
Karla K.A. dos Santos,Edinardo F.F. Matias,Saulo R. Tintino,Celestina E.S. Souza,Maria F.B.M. Braga,Gla´ucia M.M. Guedes,Miriam Rolo´n,Celeste Vega,Antonieta Rojas de Arias,Jose´ G.M. Costa,Irwin A. M 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.1
Chagas’ disease, caused by Trypanosoma cruzi, is considered a public health problem. Nowadays, chemotherapy is the only available treatment for this disease, and the drugs currently used, nifurtimox and benzonidazole, present high toxicity levels. Alternatives for replacing these drugs are natural extracts from Eugenia jambolana, a plant used in traditional medicine because of its antimicrobial and biological activities. An ethanol extract from E. jambolana was prepared. To research in vitro anti-epimastigote activity, T. cruzi CL-B5 clone was used. Epimastigotes were inoculated at a concentration of 1 · 105/mL in 200 lL of tryptose-liver infusion. For the cytotoxicity assay J774 macrophages were used. To examine antifungal activity, Candida albicans, Candida tropicalis, and Candida krusei were used. This is the first record of trypanocide activity for E. jambolana. The effective concentration capable of killing 50% of the parasites was 56.42 lg/mL. The minimum inhibitory concentration was £ 1,024 lg/mL. Metronidazole showed a potentiation of its antifungal effect when combined with the ethanol extract of E. jambolana. Thus our results indicate that E. jambolana could be a source of plantderived natural products with anti-epimastigote and antifungal modifying activity with moderate toxicity.
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Santosh Kumar Shukla,Suman Bala Sharma,Usha Rani Singh,Sayeed Ahmad,Ankur Maheshwari,Manmohan Misro,Shridhar Dwivedi 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.2
Preventive effects of hydroalcoholic extract of fruit pulp of Eugenia jambolana (HEEJ) on isoproterenol (ISP)-induced myocardial damage in rats were evaluated. Rats were pre-treated with HEEJ (100, 200, and 400 mg/kg) daily for 30 days. ISP (85 mg/kg bw) was administered on the 28th and 29th days at an interval of 24 h. Ischemic control group exhibited significant increases in oxidative stress parameters, markers of inflammation, cardiac damage markers, and apoptotic markers. Oral pre-treatment with HEEJ (100, 200, and 400 mg/kg bw) provided cardioprotective activity by decreasing levels of malondialdehyde, cardiac markers (serum glutamate oxaloacetate transaminase, creatine kinase-myocardial band, cardiac troponin I), and markers of inflammation (interleukin-6, C-reactive protein, and tumor necrosis factor alpha); and increased levels of superoxide dismutase and reduced glutathione. HEEJ (400 mg/kg bw) was found to exert significantly greater effects in comparison to HEEJ (100 and 200 mg/kg bw). Apoptotic marker Bcl-2 was increased, while Bax was decreased in pretreated rats, which was further confirmed by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay. The present study provides evidence that pre-treatment with HEEJ attenuates oxidative stress, apoptosis and improves cardiac architecture in ISP-induced rats and, hence, is cardioprotective.
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Sankhari, Jayanta M.,Jadeja, Ravirajsinh N.,Thounaojam, Menaka C.,Devkar, Ranjitsinh V.,Ramachandran, A.V. 경희한의학연구센터 2012 Oriental Pharmacy and Experimental Medicine Vol.12 No.2
The present study was aimed at evaluating protective role of Eugenia jambolana seed extract (EJSE) on high cholesterol diet (HCD) induced hyperlipidemia/hypercholesterolemia amounting to cardiac and hepatic oxidative stress. Serum markers of cardiac and hepatic damage, total lipid profile (serum, tissue and feces), lipid peroxidation, antioxidant status and histopathological changes in cardiac and hepatic tissue have been assessed in control, HCD fed and HCD+EJSE treated (100 mg/kg BW, p.o.) rats. It was observed that co-supplementation of EJSE to HCD fed rats significantly (p<0.05) minimized elevation in the serum, and tissue lipid profiles, decrement in the HDL level and resulted in higher elimination of lipids through feces. Also, EJSE successfully ameliorated HCD induced cardiac and hepatic oxidative stress (p<0.05) and histopathological damage. It can be concluded that, EJSE has the potential of preventing HCD induced experimental hypercholesterolemia and, related cardiac and hepatic oxidative stress. Its therapeutic potential against HCD induced hypercholesterolemia and subsequent oxidative stress mediated cardiac and hepatic damage is indicated.
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Suman B. Sharma,Reenu S. Tanwar,Afreena Nasir,Krishna M. Prabhu 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.4
Diabetes is accompanied by lipid abnormalities, which contribute significantly to cardiovascular morbidity and mortality in diabetic patients. We previously demonstrated the potent antihyperglycemic activity of the active principle (fraction II from Sephadex LH 20 chromatography [LH II]) isolated from ethanolic seed extract of Eugenia jambolana in diabetic rabbits. In the present study, the efficacy of LH II was evaluated for its hypolipidemic activity in alloxan-induced mildly diabetic (MD) and severely diabetic (SD) rabbits. Phytochemical investigation of LH II by various structural spectra showed the presence of saturated fatty acid, Δ5 lipid, and sterol. Oral administration of LH II (10 mg/kg of body weight) for 21 days resulted in improved glycemic control in both MD and SD rabbits. After treatment with LH II, serum total cholesterol, triglycerides, high-density lipoprotein cholesterol, and the total cholesterol/high-density lipoprotein cholesterol ratio were significantly improved. LH II also resulted in significant (P < .001) improvement in 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and levels of total lipids and glycogen in both MD and SD rabbits. Thus, the present study demonstrates that LH II possesses potent hypolipidemic activity and efficacy in both MD and SD rabbits.
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