에크린 한성종양에서 세포각질 폴리펩타이드의 발현에 관한 연구

강인경 ( In Kyung Kang ),김웅 ( Oong Kim ),최규철 ( Kyu Chul Choi ) 대한피부과학회 1996 大韓皮膚科學會誌 Vol.34 No.1

Background: Different distributions of cytokeratins (CKs) have been found in various layers of the epidermis and in the structure of cutaneous appendages. Benign tumors of the epidermis or cutaneous appendages usually retain the characteristic distribution of CKs of their origin. Objective and Method: To elucidate the nature and differentiation of various eccrine gland tumors, we performed immunohistochemical staining using a panel of monoclonal antibodies against CKs in a normal eccrire gland, syringoma, eccrine hidrocystoma, eccrine poroma and clear cell hidradenoma. The tissue distribution of various keratins in the normal eccrine gland was compared with that in varioas eccrine gland tumors. Results : With regard to CKs expression, the results indicated that syringoma represents a tumor differentiating toward both the uppermost part of the dermal duct and the lower intraepidermal duct, and eccrine hidrocystoma represents a tumor differentiating toward the luminal cell of the dermal duct of the eccrine gland. Eccrine poroma cells seemed to be most closed related to the uppermost dermal duct of eccrine gland. We also found that analyse distribution of CKs was insufficient to elucidate the histogenesis of clear cell hidradenoma. Conclusion : Analysing CKs is helpful in the analysis of epidermal neoplasms with differentiation toward the eccrine gland. (Kor J Dermatol 1996;34(1): 78-84)

Protease-Activated Receptor-2 Is Associated with Terminal Differentiation of Epidermis and Eccrine Sweat Glands

( Yong Sup Shin ),( Hyung Won Kim ),( Chang Deok Kim ),( Hyun Woo Kim ),( Jin Woon Park ),( Sunggyun Jung ),( Jeung Hoon Lee ),( Young Kwon Ko ),( Young Ho Lee ) 대한피부과학회 2015 Annals of Dermatology Vol.27 No.4

Background: Protease-activated receptor 2 (PAR-2) participates in various biological activities, including the regulation of epidermal barrier homeostasis, inflammation, pain perception, and melanosome transfer in the skin. Objective: To evaluate the basic physiological role of PAR-2 in skin. Methods: We investigated PAR-2 expression in human epidermis, skin tumors, and cultured epidermal cells using western blot and immunohistochemical analysis. Additionally, we examined the effect of the PAR-2 agonist, SLIGRL-NH2, on cultured keratinocytes. Results: Strong PAR-2 immunoreactivity was observed in the granular layer of normal human skin and the acrosyringium of the eccrine sweat glands. In contrast, weak PAR-2 immunoreactivity was seen in the granular layer of callused skin and in the duct and gland cells of the eccrine sweat glands. Interestingly, PAR-2 immunoreactivity was very weak or absent in the tumor cells of squamous cell carcinoma (SCC) and syringoma. PAR-2 was detected in primary keratinocytes and SV-40T-transformed human epidermal keratinocytes (SV-HEKs), an immortalized keratinocyte cell line, but not in SCC12 cells. SV-HEKs that were fully differentiated following calcium treatment displayed higher PAR-2 expression than undifferentiated SV-HEKs. Treatment of cultured SV-HEKs with PAR-2 agonist increased loricrin and filaggrin expression, a terminal differentiation marker. Conclusion: Our data suggest that PAR-2 is associated with terminal differentiation of epidermis and eccrine sweat glands. (Ann Dermatol 27(4) 364∼370, 2015)

한국인 태아피부의 에크린땀샘의 발육과정에 관한 연구 -조직학적 및 형태계측학적 연구-

조남복,이태진,지제근,송계용 대한병리학회 1997 Journal of Pathology and Translational Medicine Vol.31 No.2

A case of eccrine spiradenoma in old age

( Hong Jin Joo ),( Young Jun Woo ),( Ki Min Sohn ),( Jung Eun Kim ),( Hoon Kang ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Eccrine spiradenoma is an uncommon benign adnexal tumor of the eccrine sweat glands. It presents as a painful and slow-growing, solitary nodule on the head and neck, sometimes on the trunk. Malignant transformation is rare, presenting as rapid increase in size of a long-standing lesion. Although it can occur at any age, it occurs most commonly in young adults without any sex predilection. Herein, we report a case of eccrine spiradenoma of the scalp in old age. A 77-year-old man presented with slightly tender, solitary, 3 cm-sized, skin-colored, mushroom-like nodule on scalp for several years. Dermatological examination with punch biopsy was undertaken, followed by surgical excision of the lesion. Histopathological examination revealed a sharply demarcated nodular tumor in the dermis composed of sweat ducts and circular rosettes of basaloid cells without malignant transformation. The case was diagnosed as eccrine spiradenoma.

눈꺼풀에 발생한 에크린 관암 1예

김태협,이정혜,안정현,우경인,서연림,김윤덕,Tae Hyup Kim,Jung Hye Lee,Jung Hyun Ahn,Kyung In Woo,Yeon Lim Suh,Yoon Duck Kim 대한안과학회 2013 대한안과학회지 Vol.54 No.4

Purpose: Eccrine ductal carcinoma is an extremely rare tumor that arises in the eccrine sweat glands. The authors of the present study describe a case of an eyelid mass diagnosed as eccrine ductal carcinoma. Case summary: A 74-year-old woman visited our institute with a 3-month history of a mass in the left medial canthus. The lesion appeared as a solitary nodule with central ulceration. A magnetic resonance imaging (MRI) of the orbit showed a relatively well enhanced 0.8 cm x 0.8 cm-sized ovoid soft tissue mass. A mass excision was performed under frozen section control. The tumor was completely excised with margin clearance and medial canthal reconstruction was performed. Histopathological examination revealed a tumor composed of numerous duct-like structures lined with pleomorphic cuboidal epithelium that was diagnosed as eccrine ductal carcinoma of the eyelid. Conclusions: This is the first description of eccrine ductal carcinoma in a patient in Korea. The possibility of the eccrine ductal carcinoma should be considered in the differential diagnosis in an elderly patient with an eyelid mass.

Eccrine porocarcinoma on the cheek

Seo, Bommie Florence,Choi, Hyuk Joon,Jung, Sung-No Korean Cleft Palate-Craniofacial Association 2019 Archives of Craniofacial Surgery Vol.20 No.1

Eccrine porocarcinoma is a rare malignant tumor arising from the intraepidermal ductal portion of the eccrine sweat gland. It develops either spontaneously or from a long standing benign eccrine poroma. This entity usually affects older people and is commonly located on the lower extremities, the trunk, and the head. We report a case of eccrine porocarcinoma on the left cheek in an 85-year-old male. In our case, the tumor was treated with wide excision and postoperative adjuvant radiation therapy. The patient recovered well without local recurrence and distant metastasis during the 14-month follow-up period. Wide excision and postoperative adjuvant radiation therapy can be considered as a safe and effective treatment option in treating patients with eccrine porocarcinoma.

A case of eccrine spiradenoma on the arm

( Sin Wook Chun ),( Hyun Ok Son ),( Suk Young Lee ),( Jong Baik Kim ),( Han Gyu Choi ),( Han Kyoung Cho ),( Byung In Ro ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Eccrine spiradenoma is a benign uncommon neoplasm of skin adnexa which probably originates in the coil of the eccrine sweat gland. It presents usually as a solitary, slowly growing, sometimes painful, reddish-brown, and intradermal or deeply subcutaneous nodule. Lesions can arise on the head and trunk but also in a variety of locations. Histopathologically, eccrine spiradenoma may consist of one large, sharply demarcated lobule or several lobules that are often appear deeply basophilic because of the dense packing of nuclei on low magnification. The patient was 32-year-old woman with small subcutaneous soft nodule on the arm for 2 years. Due to its tenderness, the patient wanted it removed, and 4mm punch biopsy had been obtained. Histopathological examination had revealed the characteristic features of an eccrine spiradenoma.

Case Reports : Giant Vascular Eccrine Spiradenoma

( Min Ho Kim ),( Eujin Cho ),( Jeong Deuk Lee ),( Sang Hyun Cho ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.2s

Giant vascular eccrine spiradenomas (GVESs) are a rare variant of the eccrine spiradenoma that develops from the sweat gland. It is different from the eccrine spiradenoma in its larger size and greater degree of vascularity. Bleeding and/or ulceration are common clinical features of this tumor, and are the reason why it is often clinically confused with a vascular or malignant tumor. Here, a rare case of GVES without bleeding or ulceration is reported. (Ann Dermatol 23(S2) S197~S200, 2011)

Painful eccrine spiradenoma containing nerve fibers in the forearm: a case report

Tae Hyun Kim,Seong Heum Jeong,Hyun Jeong Ha,Chung Hun Kim 대한수부외과학회 2024 대한수부외과학회지 Vol.29 No.1

Eccrine spiradenomas are rare benign adnexal tumors that originate from the eccrine glands. They mainly arise in the head, neck, and upper trunk of young adults and are sometimes accompanied by pain and tenderness. Although spontaneous pain is a typical symptom of eccrine spiradenoma, the underlying mechanism remains unclear. We report the case of a patient who had a spiradenoma in the subcutaneous tissue of the left forearm that was accompanied by agonizing pain triggered by pressure. A 42-year-old man who had undergone surgical excision of a left forearm mass 5 years ago presented for relapsed pain and a palpable mass at the previous excision site. The agonizing pain had been triggered a few days ago, in response to even a slight touch. The mass measured approximately 0.8×0.8 mm, and ther e were no changes visible around the scar. Irregularly shaped masses, each measuring approximately 5 mm, were removed with a 2-mm safety margin from the subcutaneous fat. A histopathologic examination revealed the resected nodules were surrounded by delicate fibrous capsules, some parts of which contained blood vessels and prominent thickened nerve fibers. By the time of the 6-month follow-up, the masses had not recurred, and the biopsy site was well maintained without pain. We describe the surgical and histopathologic findings of an isolated eccrine spiradenoma accompanied by recurrent agonizing pain. The peculiar microscopic arrangement of the thickened nerve fibers encasing the nodule of eccrine spiradenoma may correlate with its pain mechanism.

Giant Vascular Eccrine Spiradenoma

김민호,조은진,이정덕,조상현 대한피부과학회 2011 Annals of Dermatology Vol.23 No.-

Giant vascular eccrine spiradenomas (GVESs) are a rare variant of the eccrine spiradenoma that develops from the sweat gland. It is different from the eccrine spiradenoma in its larger size and greater degree of vascularity. Bleeding and/or ulceration are common clinical features of this tumor,and are the reason why it is often clinically confused with a vascular or malignant tumor. Here, a rare case of GVES without bleeding or ulceration is reported. (Ann Dermatol 23(S2) S197∼S200, 2011)