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RISS 인기검색어
- 검색키워드
- 주제어 : Drymaria cordata (검색결과 2 건)
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Ngoupaye Gwladys Temkou,Adassi Maxwell Blesdel,Foutsop Aurelien Fossueh,Noungoua Chretien Mbeugangkeng,Yaya Joel,Kom Tatiana Diebo,Ngo Bum Elisabeth 경희대학교 융합한의과학연구소 2022 Oriental Pharmacy and Experimental Medicine Vol.22 No.1
Epilepsy is a chronic disease of the central nervous system that affects nearly 1% of the world’s population and remains a major public health problem in sub-Saharan. This study aimed at investigating anticonvulsant effects and acute toxicity of four Cameroonian medicinal plants: Malvaviscus arboreus (M. arboreus), Alchemilla kiwuensis (A. kiwuensis), and mixture of Drymaria cordata (D. cordata) and Markhamia lutea (M. lutea). Acute epileptic seizures were induced on Swiss mice of both sexes with pentylenetetrazole (70 mg/kg), picrotoxin (7.5 mg/kg) and strychnine (2.5 mg/kg). Acute toxicity and qualitative phytochemical tests of plants were further perfomed. M. arboreus protected 71.43% of subjects against pentylene- tetrazole-induced seizures at 688 mg/kg (p < 0.01) and 57.14% of subjects against picrotoxin-induced seizures at 1376 mg/ kg (p < 0.05) and had no effect on strychnine-induced seizures and death. A. kiwuensis protected 85.71% of subjects against pentylenetetrazole-induced seizures at 41.25 mg/kg (p < 0.001) and 57.14% of subjects against picrotoxin-induced seizures at 82.5 mg/kg (p < 0.05) and had no effect on strychnine-induced seizures and death. Mixture of D. cordata and M. lutea protected 71.43% of subjects against pentylenetetrazole-induced seizures at 1554 mg/kg (p < 0.01) and 28.57% of subjects against strychnine-induced seizures at 388.5 mg/kg and had no effect on picrotoxin-induced seizures. All the extracts were non-toxic in the acute toxicity test and their qualitative phytochemistry revealed bioactive compounds such as saponins, phenols and tannins. These results show that those various plants’ extracts are non-toxic and have anticonvulsant properties. They then could contribute to improve the treatment of epilepsy.
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Antioxidant C-glycosylflavones of Drymaria cordata (Linn.) Willd
Raymond N. Nono,Laurence K. Nzowa,Beaudelaire K. Ponou,Re´my B. Teponno,Te´lesphore B. Nguelefack,Luciano Barboni,Le´on A. Tapondjou,박희준 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.1
A new C-glycosylflavone, drymaritin E (6-C- (3-keto-b-digitoxopyranosyl)-40-O-(b-D-glucopyranosyl)- 7-methoxyl-5,40-dihydroxylflavone) 1 was isolated from the oily upper phase (SU) of the MeOH extract from aerial parts of Drymaria cordata together with two known compounds (cassiaoccidentalin A 2 and anemonin 3) and an inseparable mixture of two known C-glycosylflavones 5,40- dihydroxy-7-methoxyflavone-6-C-(200-O-a-L-rhamnopyranosyl)- b-D-glucopyranoside 4a and 5,7,30,40-tetrahydroxyflavone- 6-C-(200-O-a-L-rhamnopyranosyl)-b-D-glucopyranoside 4b. The alkaline hydrolysis of 3 led to a new hemisynthetic derivative, sodium anemonate (sodium 2-((1’E) 20-sodium-carboxylate-vinyl)-5-oxo-cyclohex- 1-ene carboxylate) 3a. The chemical structures were determined by spectroscopic methods (1H NMR, 13C NMR, 1H-1H COSY, HMBC, HSQC, and NOESY) and mass spectrometry (ESI–MS). C-glycosylflavones had significant free radical-scavenging activities on the radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). However, SU and compounds 3 and 3a exhibited no activity. In particular, compound 1 exhibited a concentration-dependent radical scavenging activity on DPPH with EC50 of 31.43 lg/mL.
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