항암 화학요법에 의한 피부 변화

정진호(Jin Ho Chung),조광현(Kwang Hyun Cho),김노경(Noe Kyung Kim) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.2

A clinical observation of cutaneous complications was made on 200 patients receiving cancer chemotherapy at the Department of Internal Medicine, Seoul National University from January through May, 1986. The results were as follows: 1. Among the 200 patients, 191 case(95. 5%) showed cutaneous complications 2. The cutaneous complications included the following; hyperpigmentation(14l cases, 70. 5%), alopecia(138 cases, 69.4%), nail change(118 cases, 59.0%), muco- sitis(47 cases, 23.5%), dryness of the skin(40 cases, 20.0%), seborrheic dermatitis(24 cases, 12. 2%), increase of seborrheic keratosis(11 cases, 5.6%), folliculitis or acneiform eruptions(9 cases, 4,5%), melasma(6 cases, 3.0%), gynecomastia(3 cases, 1.5%), vessel hardening or dimpling(3 cases, 1.5%), radiation recall(2 cases, 1.0%), hyperhydrosis(2 cases), photosensitivity(1 case, 0.5%), tissue necrosis(1 case), facial flushing(1 case), purpura(1 case) and obesity(1 case), 3 Steps were taken to determine the chemotherapeutic agents causing these cutaneous complications, though in some cases it was difficult in determining exaetlr which chemotherapeutic agent was the cause of the observed cutaneous complication.

Comparison of Clinical and Functional Outcomes Using Pectoralis Major and Cutaneous Free Flaps for Hypopharyngeal Squamous Cell Carcinoma

Lee, Taeyul,Chung, Chulhoon,Chang, Yongjoon,Kim, Jaehyun Korean Society of Plastic and Reconstructive Surge 2015 Archives of Plastic Surgery Vol.42 No.5

Background The purpose of this study was to compare postoperative morbidities and functional outcomes of pectoralis major myocutaneous (PMMC) flap and cutaneous free flap reconstruction approaches in hypopharyngeal squamous cell carcinoma patients. Methods We retrospectively reviewed records from 99 patients who underwent hypopharyngeal reconstruction with a cutaneous free flap (n=85) or PMMC flap (n=14) between 1995 and 2013. Morbidity was classified into hospitalization, medical, or flap-related complications. Functional outcomes were classified into oral re-alimentation and decannulation time. Results The overall flap-related complication rate was higher in the PMMC flap group (n=8, 57.1%; P=0.019), but the medical morbidity rate was higher in the cutaneous free flap group (n=68, 80%; P=0.006). The rate of pneumonia was higher in the cutaneous free flap group (n=48, 56.5%; P=0.020). Pulmonary premorbidity was the variable most significantly associated with pneumonia (odds ratio=3.012, P=0.012). There was no statistically significant difference in oral re-alimentation and decannulation time between the two groups. Conclusions Although the functional superiority of free flaps has been reported in many studies, our results do not support this hypothesis. One limitation of our study is the relatively smaller flap size and fewer PMMC flap cases compared with the cutaneous free flap group. The low postoperative medical morbidity incidence rate in the PMMC flap group was clinically significant; however, the free flap group had more flap-related complications. Thus, PMMC flaps should be considered a viable option, especially for patients with pulmonary premorbidities.

당뇨병 환자에서의 피부 증상 및 동반 질환에 관한 통계학적 연구

한종배(Jong Bae Han),김광수(Kwang Soo Kim),손숙자(Sook Ja Son),유형준(Hyung Joon Yoo) 대한피부과학회 1986 대한피부과학회지 Vol.24 No.2

Cutarieous manifest,ations and systemic complications were observed in 521 patient., with diabetes mellitus. The results were as follows: Total 70, 8% of patients had complications', In 16. 5%, cutaneous manifestation were observed. Systemic complications were observed in 27 6%, Both eutaneous manifestations and systemic complications were observed in 26 7% 2 The cutaneous mariifestations observed in 43 2%, were cutaneous infection, pruritus, shin spot, diabetic foit, peripheral edema, diahetic bulla, foot gangrene and rutieosis in the order of frequency, 3, The cutaneous manifestations were much more observed in patients with systemic complications than without them(p<0 05), and with longer duration more than 10 years history, 4. It seems to be no relationship between the cutancous manifestations and fasting blood sugar level.

Cutaneous complications following BCG vaccination

( Sang-hyeon Won ),( Kihyuk Shin ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Hoon-soo Kim ),( Byung-soo Kim ),( Moon-bum Kim ),( Hyun-chang Ko ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: Bacillus Calmette-Guerin (BCG) vaccination has been normally used to prevent severe infections caused by Mycobacterium tuberculosis. Although BCG vaccination is generally safe, some cutaneous complications may occur. However, cutaneous complications related to BCG infection are rarely investigated. Objectives: To investigate the clinical characteristics of cutaneous complications following BCG vaccination. Methods: We reviewed the clinical data of the patients who were referred to Pusan National University Hospitals (Busan and Yangsan) from 2002 to 2019. Among them, 24 patients were diagnosed with cutaneous complications following BCG vaccination, which can be classified as specific or non-specific type. Results: There was female predominance (M:F=1:2). There was a bimodal age distribution of the patients, from 0 to 3 years and 22 to 28 years. There were 18 specific type (75%) and 6 non-specific type (25%). In specific type cases, local abscess, disseminated infection, BCG reactivation in Kawasaki disease, lymphadenitis, papular tuberculid were found in 38.9%, 22.2%, 22.2%, 11.1%, and 5.6% of cases, respectively. In non-specific type cases, keloid formation was found in all cases. Conclusion: The most common cutaneous complications following BCG vaccination was local abscess in specific type, and keloid in non-specific type. This study suggests the diversity of cutaneous complications that may be found after BCG vaccination.

Cutaneous complications following transcatheter arterial chemoembolization (초)

( Eu Jin Cho ),( Kyung Eun Jung ),( Hei Sung Kim ),( Young Min Park ),( Hyung Ok Kim ),( Jun Young Lee ) 대한피부과학회 2011 초록집 Vol.49 No.10

인공모발 이식술 (Artificial Hair Implantation) 시행 후 발생한 피부 합병증 4예

최희창,최혜정,박영민,김형옥,김정원,장인강 대한피부과학회 2002 대한피부과학회지 Vol.40 No.12

The implantation of synthetic fibers into the human scalp to simulate natural hair has been shown to cause severe complications and be a possible danger to human health. The complications are frequent and include pain, pruritus, hemorrhage, infection, facial swelling. loss of natural hair, scarring and possible malignant degeneration of the surrounding scalp. We report herein four typical cases of severe cutaneous complications after artificial hair implantation. (Korean J Dermatol 2002;40(12) : 1594∼1597)

Risk Factors of and Treatments for Pharyngocutaneous Fistula Occurring after Oropharynx and Hypopharynx Reconstruction

Do, Su Bin,Chung, Chul Hoon,Chang, Yong Joon,Kim, Byeong Jun,Rho, Young Soo Korean Society of Plastic and Reconstructive Surge 2017 Archives of Plastic Surgery Vol.44 No.6

Background A pharyngocutaneous fistula is a common and difficult-to-manage complication after head and neck reconstruction. It can lead to serious complications such as flap failure, carotid artery rupture, and pharyngeal stricture, and may require additional surgery. Previous radiotherapy, a low serum albumin level, and a higher T stage have been proposed as contributing factors. We aimed to clarify the risk factors for pharyngocutaneous fistula in patients who underwent flap reconstruction and to describe our experiences in treating pharyngocutaneous fistula. Methods Squamous cell carcinoma cases that underwent flap reconstruction after cancer resection from 1995 to 2013 were analyzed retrospectively. We investigated several significant clinical risk factors. The treatment modality was selected according to the size of the fistula and the state of the surrounding tissue, with options including conservative management, direct closure, flap surgery, and pharyngostoma formation. Results A total of 127 cases (18 with fistulae) were analyzed. A higher T stage (P=0.048) and tube-type reconstruction (P=0.007) increased fistula incidence; other factors did not show statistical significance (P>0.05). Two cases were treated with conservative management, 1 case with direct closure, 4 cases with immediate reconstruction using a pectoralis major musculocutaneous flap, and 11 cases with direct closure (4 cases) or additional flap surgery (7 cases) after pharyngostoma formation. Conclusions Pharyngocutaneous fistula requires global management from prevention to treatment. In cases of advanced-stage cancer and tube-type reconstruction, a more cautious approach should be employed. Once it occurs, an accurate diagnosis of the fistula and a thorough assessment of the surrounding tissue are necessary, and aggressive treatment should be implemented in order to ensure satisfactory long-term results.

Risk Factors of and Treatments for Pharyngocutaneous Fistula Occurring after Oropharynx and Hypopharynx Reconstruction

도수빈,정철훈,장용준,김병준,노영수 대한성형외과학회 2017 Archives of Plastic Surgery Vol.44 No.6

Background A pharyngocutaneous fistula is a common and difficult-to-manage complication after head and neck reconstruction. It can lead to serious complications such as flap failure, carotid artery rupture, and pharyngeal stricture, and may require additional surgery. Previous radiotherapy, a low serum albumin level, and a higher T stage have been proposed as contributing factors. We aimed to clarify the risk factors for pharyngocutaneous fistula in patients who underwent flap reconstruction and to describe our experiences in treating pharyngocutaneous fistula. Methods Squamous cell carcinoma cases that underwent flap reconstruction after cancer resection from 1995 to 2013 were analyzed retrospectively. We investigated several significant clinical risk factors. The treatment modality was selected according to the size of the fistula and the state of the surrounding tissue, with options including conservative management, direct closure, flap surgery, and pharyngostoma formation. Results A total of 127 cases (18 with fistulae) were analyzed. A higher T stage (P=0.048) and tube-type reconstruction (P=0.007) increased fistula incidence; other factors did not show statistical significance (P>0.05). Two cases were treated with conservative management, 1 case with direct closure, 4 cases with immediate reconstruction using a pectoralis major musculocutaneous flap, and 11 cases with direct closure (4 cases) or additional flap surgery (7 cases) after pharyngostoma formation. Conclusions Pharyngocutaneous fistula requires global management from prevention to treatment. In cases of advanced-stage cancer and tube-type reconstruction, a more cautious approach should be employed. Once it occurs, an accurate diagnosis of the fistula and a thorough assessment of the surrounding tissue are necessary, and aggressive treatment should be implemented in order to ensure satisfactory long-term results.

A case of cutaneous angiosarcoma masqueraded as skin and soft tissue infection

( Young Gue Koh ),( Jun Ki Hong ),( Kui Young Park ),( Kapsok Li ),( Seong Jun Seo ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.72 No.2

Use of Amplatzer Vascular Plug to Treat a Biliary Cutaneous Fistula

Anna Maria Ierardi,Federico Fontana,Monica Mangini,Filippo Piacentino,Eugenio Cocozza,Emila Frankowska,Chiara Floridi,Gianpaolo Carrafiello 대한영상의학회 2013 Korean Journal of Radiology Vol.14 No.5

Several substances have been used in an attempt to sclerose biliary ducts associated with persistent biliary-cutaneous fistula (BCF). The AMPLATZER Vascular Plug (AVP; AGA Medical, USA) system is a recently developed endovascular occlusion device, introduced as an alternative to permanent embolic materials (metallic coils or acrylic glue), in the occlusion of large and medium-calibre arteries and veins. We report a successful use of the AVP to embolize BCF, developed after the removal of an internal-external biliary drainage.