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- 주제어 : Clinical and laboratory features (검색결과 4 건)
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백혜진(Hye Jin Baeg),김계영(Kae Young Kim),채동완(Dong Ywan Chae),이영천(Young Chun Lee),최문기(Moon Gi Choi),장연복(Yeon Bog Jang),오하영(Ha Young Oh),박정식(Jung Sik Park) 대한내과학회 1991 대한내과학회지 Vol.40 No.3
Tuberculosis is one of the major infectious disease in Korea, despite its prevalence has been falling. In renal Tuberculosis, there are considerable complications at the time of diagnosis, because of the long duration from exposure to onset of symptoms, which are usually non- specific. In spite of antituberculous chemotherapy, complications may progress and cause obstructive uropathy. In order to evaluate the clinical characteristics of the renal tuberculosis, we reviewed 70 cases of renal tuber- culosis who were admitted to the Hallym University haspital between January 1984 and December 1988, and follwing results were obtained. 1) Renal tuberculosis was predominent in 4th and 5th decades, average age was 39.8 years and males predominated in 1.8:l. 2) The most common presenting symptom was gross hematuria (45.7%), the flank pain, dysuria, nocturia, frequency and fever as a constitutional symptoms in that order. 3) Abnormal findings of urinanalysis were observed in 82.9% of cases and azotemia was found in 25.7%. Asymptomatic urinary abnormality was noted in 25.7%. 4) The positive findings of urine AFB staining in 27.1%,, positive urine AFB culture 5.7%, and 34.3% of cases showed characteristic histopathologic findings. Abnormal urographic findings were seen in 98.5%, and the left kidney was affected predominently (41.5%). 5) Previous extrarenal tuberculosis was noted in 42. 3% and its average duration was 9.3 years. Active extrarenal tuberculosis was associated in 14.3% of cases. 6) The most common complication was hydronephrosis and hydroureter (44.3%), then stone, and secondary infection in that order. 7) Among 6 azotemic patients who were followed more than 3 months after treatment, serum creatinine clearence level was decreased in 5 patients.
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COVID-19 소아 환자의 임상 양상 및 실험실적 특징: 체계적문헌고찰 및 메타분석
윤하영,조영아,이정,곽혜선,한지민 한국임상약학회 2020 한국임상약학회지 Vol.30 No.4
Background: Although the identification of clinical and laboratory features in pediatric COVID-19 patients is essential in establishing an appropriate treatment plan, a systematic review and meta-analysis on the topic has yet to be reported. Methods: We searched MEDLINE, Embase, and Web of Science to access clinical and laboratory characteristics as well as clinical outcomes of children with COVID-19 infection. A meta-analysis using random-effect model was performed to estimate pooled prevalence and 95% confidence intervals. Results: Among the 532 studies initially collected, 12 articles were finally included in the meta-analysis. Among the investigated 320 pediatric patients with COVID-19, fever (48.2%) and cough (39.3%) were the most common symptoms. Almost one third of patients (30.4%) were asymptomatic. In laboratory findings, only 11.4% of pediatric patients experienced lymphocytopenia. Increased inflammatory markers including c-reactive protein (18.6%) and procalcitonin (32.4%) were observed. Only a few patients needed mechanical ventilation and intensive care support, and only one death was reported. Conclusion: Pediatric patients with COVID-19 infection exhibited milder symptoms and more favorable outcomes compared to adults. However, considering the high rate of asymptomatic pediatric patients, close monitoring is required to prevent community infection in asymptomatic conditions and hidden disease progression.
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유한욱,Yoo, Han-Wook 대한유전성대사질환학회 2013 대한유전성대사질환학회지 Vol.13 No.1
Inherited metabolic disorders are individually rare but as a whole, they are nor rare. Since Archibald Garrod introduced a concept of "inborn error of metabolism" or "chemical individuality", more than 600 diseases are currently known, affecting approximately one in 500 newborns cumulatively. They frequently manifest with acute, life-threatening crisis that requires immediate specific intervention or they present with insidious diverse symptoms and signs involving multiple visceral organs or tissues as well as central nervous system, hampering a correct diagnosis. In addition, many pediatricians are not familiar with all diagnostic and therapeutic strategies for diverse inherited metabolic disorders. However, the prognosis of affected children are heavily dependent on rapid and effective treatment. In this lecture, practical guidelines for the specific diagnosis based on diverse clinical features of inherited metabolic disorders will be described. Many sophisticated laboratory tests are available for the confirmatory diagnosis of each disease, which is challenging to general pediatricians with respect to knowledge about biochemical metabolite assay test, enzymatic test and DNA diagnostic tests. Sample collections, indications, methods and interpretation of results in varying laboratory tests will be listed as well.
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