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- 검색키워드
- 주제어 : Antifertility (검색결과 9 건)
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Amaresh Maiti,Nithar Ranjan Madhu,Chanchal Kumar Manna 셀메드 세포교정의약학회 2013 TANG Vol.3 No.2
The paper provides a brief account of 11 plant species used by the tribal people of the district Purulia, West Bengal, India. Most of the plant species are common in this district and some have not been reported earlier for abortive purposes, pharmacology for preparation of medicines for antifertility. All these data were obtained from the tribal medicine men (ojha). At least 10 interview reports of various tribal medicine men were recorded. Parts of various medicinal plants were observed personally, collected and preserved as herbarium specimens for proper identification. The reports of various indigenous methods may help to give some clue in searching the potent contraceptives.
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Hannan, M.A.,Hossain, M.A.,Islam, M.T. Kyung Hee Oriental Medicine Research Center 2010 Oriental pharmacy and experimental medicine Vol.10 No.2
The seed powder of Abrus precatorius L. has traditionally been used as oral contraceptive agent by the women in some rural areas in Bangladesh. The present study aimed to examine the antifertility activity of A. precatorius seed extracts in experimental female rats. Finely ground seeds were extracted with aqueous acetone followed by successive partitioning with n-hexane, ethyl acetate (EtOAc), methanol (MeOH) and water. Water suspended crude seed powder, organic fractions of acetone extract and a standard contraceptive drug ($Nordette^{(R)}28$) were separately administered orally to the female rats for 30 days. n-Hexane, EtOAc and MeOH solubles at the doses of 2, 4 and 6 mg/rat/day, respectively and crude seed powder at 100 mg/rat/day exhibited 100% antifertility activity with lowest levels of serum luteinizing hormone (LH), follicle stimulating hormone (FSH) and $17{\beta}$-estradiol. Histological study of ovary and uterus of these rats exhibited reduced number of developing follicles and increased number of atretic follicles in the ovary, and fewer uterine glands with shrunken morphology, reduced endometrial height, poor vascularity and compact stroma in uterus. However, the activities of serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase and the body weight of the rats remained almost unaffected in all the seed extract treated rats compared to control. These results suggest that A. precatorius seed extracts reduced the levels of serum FSH, LH and $17{\beta}$-estradiol probably by affecting hypothalamic-pituitary-gonadal axis. The reduced levels of these hormones might have affected the oestrous cycle, follicular development, and subsequently the establishment of pregnancy in treated rats.
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MA Hannan,MA Hossain,MT Islam 경희대학교 융합한의과학연구소 2010 Oriental Pharmacy and Experimental Medicine Vol.10 No.2
The seed powder of Abrus precatorius L. has traditionally been used as oral contraceptive agent by the women in some rural areas in Bangladesh. The present study aimed to examine the antifertility activity of A. precatorius seed extracts in experimental female rats. Finely ground seeds were extracted with aqueous acetone followed by successive partitioning with n-hexane, ethyl acetate (EtOAc), methanol (MeOH) and water. Water suspended crude seed powder, organic fractions of acetone extract and a standard contraceptive drug (Nordette®28) were separately administered orally to the female rats for 30 days. n-Hexane, EtOAc and MeOH solubles at the doses of 2, 4 and 6mg/rat/day, respectively and crude seed powder at 100 mg/rat/day exhibited 100% antifertility activity with lowest levels of serum luteinizing hormone (LH), follicle stimulating hormone (FSH)and 17β-estradiol. Histological study of ovary and uterus of these rats exhibited reduced number of developing follicles and increased number of atretic follicles in the ovary, and fewer uterine glands with shrunken morphology, reduced endometrial height, poor vascularity and compact stroma in uterus. However, the activities of serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase and the body weight of the rats remained almost unaffected in all the seed extract treated rats compared to control. These results suggest that A. precatorius seed extracts reduced the levels of serum FSH, LH and 17β-estradiol probably by affecting hypothalamic-pituitary-gonadal axis. The reduced levels of these hormones might have affected the oestrous cycle, follicular development, and subsequently the establishment of pregnancy in treated rats.
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Antifertility Effect of Progesterone Antibodies in Mice
Yoon, Do-Young,Kim, Jae-Wha,Hwang, Soo-Weon,Choi, Myung-Ja,Choe, In-Seong,Kim, Jong-Bae,Chung, Tae-Wha The Pharmaceutical Society of Korea 1989 Archives of Pharmacal Research Vol.12 No.4
Early embryo development and implantation were arrested in ICR mice which were passively immunized with a mouse monoclonal progesterone amtibody given as a single intraperitoneal injection at 12 hrs or 60 hrs post coitum (p. c.). Unimplanted embryos were recovered from the reproductive tract of the antibody-treated mice and none of these progressed to the blastocyst stage. The most pronounced effect was an arrest of embryonic development at a stage prior to cavitation. The plasma progesterone concentration in the blood taken by carbiac puncture increased greatly after the treatment by virtue of high affinity binding by the antibody in circulation. The result showed that passive immunization against progesterone shortly after mating interfered with early hormone dependent steps which were essential for normal embryonic development.
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Ravichandiran, V,Suresh, B,Sathishkumar, MN,Elango, K,Srinivasan, R Kyung Hee Oriental Medicine Research Center 2007 Oriental pharmacy and experimental medicine Vol.7 No.2
In the present study, the hydro alcoholic extract of Moringa concanensis and their different fractions were evaluated for it's anti implantation, abortifacient, estrogenic and antiestrogenic activity. Hydro alcoholic extract of Moringa concanensis has showed potent antiimplantation and abortifacient activity at 200 mg/kg and 400 mg/kg respectively and marked estrogenic activity when administered individually and anti estrogenic activity was observed when administered along with ethinyl estradiol (1 ${\mu}g/rat/day$) as well as their different fractions of Moringa concanensis showed significant antiimplantation and abortifacient activity at 100 mg/kg. Moreover, all tested fractions showed significant anti estrogenic activity when administered simultaneously with ethinyl estradiol.
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Garg, Rekha,Kumari, Anita,Joshi, S.C.,Fahmi, Nighat Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.8
A new series of Mn(II) and Mo(VI) complexes containing the Schiff bases hydrazinecarbothioamide and hydrazinecarboxamide of 5,6-dimethyl-1H-indol-2,3-dione have been synthesized. The nature of bonding and the stereochemistry of the complexes have been deduced from elemental analyses, molecular weight determinations and spectral studies viz. electronic IR, ESR, $^1H$ NMR and $^{13}C$ NMR and X-ray diffraction spectral studies. The magnetic moment values of the manganese(II) complexes are in the range of 5.80-6.15 B.M. suggesting a high spin state of manganese in these complexes. The spectral data are consistent with a tetrahedral geometry around Mn(II) and an octahedral geometry for Mo(VI), in which the ligands act as bidentate chelating agents, coordinated through the nitrogen and sulfur/oxygen atoms. The ligands and their metal complexes have been tested against a number of pathogenic fungi and bacteria at different concentrations and were found to possess sufficient fungicidal and bactericidal properties. Further, the complexes were also tested for their antifertility activity in male albino rats and the results were indeed positive.
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Rekha Garg,Anita Kumari,S. C. Joshi,Nighat Fahmi 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.8
A new series of Mn(II) and Mo(VI) complexes containing the Schiff bases hydrazinecarbothioamide and hydrazinecarboxamide of 5,6-dimethyl-1H-indol-2,3-dione have been synthesized.The nature of bonding and the stereochemistry of the complexes have been deduced from elemental analyses, molecular weight determinations and spectral studies viz. electronic IR, ESR, 1H NMR and 13C NMR and X-ray diffraction spectral studies. The magnetic moment values of the manganese(II) complexes are in the range of 5.80-6.15 B.M. suggesting a high spin state of manganese in these complexes. The spectral data are consistent with a tetrahedral geometry around Mn(II) and an octahedral geometry for Mo(VI), in which the ligands act as bidentate chelating agents, coordinated through the nitrogen and sulfur/oxygen atoms. The ligands and their metal complexes have been tested against a number of pathogenic fungi and bacteria at different concentrations and were found to possess sufficient fungicidal and bactericidal properties. Further, the complexes were also tested for their antifertility activity in male albino rats and the results were indeed positive.
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3-chloro-1,2-propanediol(3-MCPD)의 독성학적 고찰
이국경(Kookkyung Lee) 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.1
3-monochloropropane-1,2-diol (3-MCPD) is a member of a group of compounds known collectively as chloropropanols, a group that include the genotoxic animal carcinogen, 1,3-dichloropropan-2-ol (1,3-DCP). 3-MCPD has been detected as a contaminant of several foods, food ingredients, including acid-hydrolysed vegetable protein, malts and soy sauces. Also 3-MCPD is a contaminant of polyamine flocculants used in the production of drinking water. It has given positive results in in vitro mutagenicity studies but negative results in in vivo mutagenicity test. 3-MCPD also itself is an animal carcinogen producing tumors at various sites in male F344 rats (mammary tissue, testes and preputial gland) and renal tubular adenomas and carcinoma in both sexes of F344 rats. However, except for the nephrotoxicity and antifertility in testes, renal tumor and mammary gland tumor could be promoted by chronic progressive nephropathy and spontaneous testicular tumor due to species-specificity of F344 rats, respectively. In addition, 3-MCPD has shown some effect on hormonal balance in F344 male rats. These results suggest that the additional test may be necessary to confirm the carcinogenicity and the possibility to be an endocrine disruptor.
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Patil, Sharanabasappa A.,Malashetty, Vijaykumar B.,Patil, Saraswati B. Kyung Hee Oriental Medicine Research Center 2003 Oriental pharmacy and experimental medicine Vol.3 No.3
Petroleum ether, chloroform and ethanol extracts of the seeds of Melia azedarach Linn. administered orally to male rats at the dose level of 25 mg/100 g body weight for 48 days showed antispermatogenic activity, as the number of spermatocytes, spermatids and spermatozoa was decreased. The total cholesterol content was increased while protein and glycogen contents were decreased. The acid phosphatase content was also decreased while that of alkaline phosphatase increased. At the same time the weight of caput and cauda epididymis, prostate gland, seminal vesicle and Levator Ani muscle was decreased indicating its antiandrogenic property. Of the three extracts, the petroleum ether extract was more potent in its antispermatogenic and antiandrogenic activities and did not produce any sings of toxicity upto a dose of 25 mg/100 g body weight oral administration. After subjecting it to preliminary phytochemical screening the petroleum ether extract showed positive tests for steroids and saponins.
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